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Raman Spectroscopy for Quantitative Analysis in the Pharmaceutical Industry.

Authors :
Jesus JISDS
Löbenberg R
Bou-Chacra NA
Source :
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques [J Pharm Pharm Sci] 2020; Vol. 23 (1), pp. 24-46.
Publication Year :
2020

Abstract

Raman spectroscopy is a very promising technique increasingly used in the pharmaceutical industry. Due to its development and improved instrumental versatility achieved over recent decades and through the application of chemometric methods, this technique has become highly precise and sensitive for the quantification of drug substances. Thus, it has become fundamental in identifying critical variables and their clinical relevance in the development of new drugs. In process monitoring, it has been used to highlight in-line real-time analysis, and it has been used more commonly since 2004 when the Food and Drug Administration (FDA) launched Process Analytical Technology (PAT), integrated with the concepts of Pharmaceutical Current Good Manufacturing Practices (CGMPs) for the 21st Century. The present review presents advances in the application of this tool in the development of pharmaceutical products and processes in the last six years.

Details

Language :
English
ISSN :
1482-1826
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Publication Type :
Academic Journal
Accession number :
32129739
Full Text :
https://doi.org/10.18433/jpps30649