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351. Measurement of the reaction γ*p→φp in deep inelastic e+p scattering at HERA

Author

M. Derrick, D. Krakauer, S. Magill, D. Mikunas, B. Musgrave, J.R. Okrasinski, J. Repond, R. Stanek, R.L. Talaga, H. Zhang, M.C.K. Mattingly, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, P. Bruni, G. Cara Romeo, G. Castellini, L. Cifarelli, F. Cindolo, A. Contin, M. Corradi, I. Gialas, P. Giusti, G. Iacobucci, G. Laurenti, G. Levi, A. Margotti, T. Massam, R. Nania, F. Palmonari, A. Polini, G. Sartorelli, Y.Zamora Garcia, A. Zichichi, C. Amelung, A. Bornheim, J. Crittenden, R. Deffner, T. Doeker, M. Eckert, L. Feld, A. Frey, M. Geerts, M. Grothe, H. Hartmann, K. Heinloth, L. Heinz, E. Hilger, H.-P. Jakob, U.F. Katz, S. Mengel, E. Paul, M. Pfeiffer, Ch. Rembser, D. Schramm, J. Stamm, R. Wedemeyer, S. Campbell-Robson, A. Cassidy, W.N. Cottingham, N. Dyce, B. Foster, S. George, M.E. Hayes, G.P. Heath, H.F. Heath, D. Piccioni, D.G. Roff, R.J. Tapper, R. Yoshida, M. Arneodo, R. Ayad, M. Capua, A. Garfagnini, L. Iannotti, M. Schioppa, G. Susinno, A. Caldwell, N. Cartiglia, Z. Jing, W. Liu, J.A. Parsons, S. Ritz, F. Sciulli, P.B. Straub, L. Wai, S. Yang, Q. Zhu, P. Borzemski, J. Chwastowski, A. Eskreys, Z. Jakubowski, M.B. Przybycień, M. Zachara, L. Zawiejski, L. Adamczyk, B. Bednarek, K. Jeleń, D. Kisielewska, T. Kowalski, M. Przybycień, E. Rulikowska-Zarȩbska, L. Suszycki, J. Zaja̧c, Z. Duliński, A. Kotański, G. Abbiendi, L.A.T. Bauerdick, U. Behrens, H. Beier, J.K. Bienlein, G. Cases, O. Deppe, K. Desler, G. Drews, M. Flasiński, D.J. Gilkinson, C. Glasman, P. Göttlicher, J. Große-Knetter, T. Haas, W. Hain, D. Hasell, H. Heßling, Y. Iga, K.F. Johnson, P. Joos, M. Kasemann, R. Klanner, W. Koch, U. Kötz, H. Kowalski, J. Labs, A. Ladage, B. Löhr, M. Löwe, D. Lüke, J. Mainusch, O. Mańczak, J. Milewski, T. Monteiro, J.S.T. Ng, D. Notz, K. Ohrenberg, K. Piotrzkowski, M. Roco, M. Rohde, J. Roldán, U. Schneekloth, W. Schulz, F. Selonke, B. Surrow, T. Voß, D. Westphal, G. Wolf, U. Wollmer, C. Youngman, W. Zeuner, H.J. Grabosch, A. Kharchilava, S.M. Mari, A. Meyer, S. Schlenstedt, N. Wulff, G. Barbagli, E. Gallo, P. Pelfer, G. Maccarrone, S. De Pasquale, L. Votano, A. Bamberger, S. Eisenhardt, T. Trefzger, S. Wölfle, J.T. Bromley, N.H. Brook, P.J. Bussey, A.T. Doyle, D.H. Saxon, L.E. Sinclair, M.L. Utley, A.S. Wilson, A. Dannemann, U. Holm, D. Horstmann, R. Sinkus, K. Wick, B.D. Burow, L. Hagge, E. Lohrmann, N. Pavel, G. Poelz, W. Schott, F. Zetsche, T.C. Bacon, N. Brümmer, I. Butterworth, V.L. Harris, G. Howell, B.H.Y. Hung, L. Lamberti, K.R. Long, D.B. Miller, A. Prinias, J.K. Sedgbeer, D. Sideris, A.F. Whitfield, U. Mallik, M.Z. Wang, S.M. Wang, J.T. Wu, P. Cloth, D. Filges, S.H. An, G.H. Cho, B.J. Ko, S.B. Lee, S.W. Nam, H.S. Park, S.K. Park, S. Kartik, H.-J. Kim, R.R. McNeil, W. Metcalf, V.K. Nadendla, F. Barreiro, J.P. Fernandez, R. Graciani, J.M. Hernández, L. Hervás, L. Labarga, M. Martinez, J. del Peso, J. Puga, J. Terron, J.F. de Trocóniz, F. Corriveau, D.S. Hanna, J. Hartmann, L.W. Hung, J.N. Lim, C.G. Matthews, P.M. Patel, M. Riveline, D.G. Stairs, M. St-Laurent, R. Ullmann, G. Zacek, T. Tsurugai, V. Bashkirov, B.A. Dolgoshein, A. Stifutkin, G.L. Bashindzhagyan, P.F. Ermolov, L.K. Gladilin, Yu.A. Golubkov, V.D. Kobrin, I.A. Korzhavina, V.A. Kuzmin, O.Yu. Lukina, A.S. Proskuryakov, A.A. Savin, L.M. Shcheglova, A.N. Solomin, N.P. Zotov, M. Botje, F. Chlebana, J. Engelen, M. de Kamps, P. Kooijman, A. Kruse, A. van Sighem, H. Tiecke, W. Verkerke, J. Vossebeld, M. Vreeswijk, L. Wiggers, E. de Wolf, R. van Woudenberg, D. Acosta, B. Bylsma, L.S. Durkin, J. Gilmore, C. Li, T.Y. Ling, P. Nylander, I.H. Park, T.A. Romanowski, D.S. Bailey, R.J. Cashmore, A.M. Cooper-Sarkar, R.C.E. Devenish, N. Harnew, M. Lancaster, L. Lindemann, J.D. McFall, C. Nath, V.A. Noyes, A. Quadt, J.R. Tickner, H. Uijterwaal, R. Walczak, D.S. Waters, F.F. Wilson, T. Yip, A. Bertolin, R. Brugnera, R. Carlin, F. Dal Corso, M. De Giorgi, U. Dosselli, S. Limentani, M. Morandin, M. Posocco, L. Stanco, R. Stroili, C. Voci, F. Zuin, J. Bulmahn, R.G. Feild, B.Y. Oh, J.J. Whitmore, G. D'Agostini, G. Marini, A. Nigro, E. Tassi, J.C. Hart, N.A. McCubbin, T.P. Shah, E. Barberis, T. Dubbs, C. Heusch, M. Van Hook, W. Lockman, J.T. Rahn, H.F.-W. Sadrozinski, A. Seiden, D.C. Williams, J. Biltzinger, R.J. Seifert, O. Schwarzer, A.H. Walenta, G. Zech, H. Abramowicz, G. Briskin, S. Dagan, A. Levy, J.I. Fleck, M. Inuzuka, T. Ishii, M. Kuze, S. Mine, M. Nakao, I. Suzuki, K. Tokushuku, K. Umemori, S. Yamada, Y. Yamazaki, M. Chiba, R. Hamatsu, T. Hirose, K. Homma, S. Kitamura, T. Matsushita, K. Yamauchi, R. Cirio, M. Costa, M.I. Ferrero, S. Maselli, C. Peroni, R. Sacchi, A. Solano, A. Staiano, M. Dardo, D.C. Bailey, F. Benard, M. Brkic, C.-P. Fagerstroem, G.F. Hartner, K.K. Joo, G.M. Levman, J.F. Martin, R.S. Orr, S. Polenz, C.R. Sampson, D. Simmons, R.J. Teuscher, J.M. Butterworth, C.D. Catterall, T.W. Jones, P.B. Kaziewicz, J.B. Lane, R.L. Saunders, J. Shulman, M.R. Sutton, B. Lu, L.W. Mo, W. Bogusz, J. Ciborowski, J. Gajewski, G. Grzelak, M. Kasprzak, M. Krzyżanowski, K. Muchorowski, R.J. Nowak, J.M. Pawlak, T. Tymieniecka, A.K. Wróblewski, J.A. Zakrzewski, A.F. Żarnecki, M. Adamus, C. Coldewey, Y. Eisenberg, D. Hochman, U. Karshon, D. Revel, D. Zer-Zion, W.F. Badgett, J. Breitweg, D. Chapin, R. Cross, S. Dasu, C. Foudas, R.J. Loveless, S. Mattingly, D.D. Reeder, S. Silverstein, W.H. Smith, A. Vaiciulis, M. Wodarczyk, S. Bhadra, M.L. Cardy, W.R. Frisken, M. Khakzad, W.N. Murray, and W.B. Schmidke

Subjects
Quark, Physics, Nuclear and High Energy Physics, Particle physics, Meson, Proton, 010308 nuclear & particles physics, Perturbative QCD, HERA, 7. Clean energy, 01 natural sciences, Zeus (malware), Gluon, Nuclear physics, Pomeron, 0103 physical sciences, High Energy Physics::Experiment, Nuclear Experiment, 010306 general physics
Abstract

The production of φ mesons in the reaction e+p → e+φp (φ → K+K−), for 7 Q 2 GeV 2 and virtual photon-proton centre of mass energies (W) in the range 42–134 GeV, has been studied with the ZEUS detector at HERA. When compared to lower energy data at similar Q 2, the results show that the γ ∗ p → φp cross section rises strongly with W. This behaviour is similar to that previously found for the γ ∗ p → ϱ 0 p cross section. This strong dependence cannot be explained by production through soft pomeron exchange. It is, however, consistent with perturbative QCD expectations, where it reflects the rise of the gluon momentum density in the proton at small x. The ratio of σ(φ) σ(ϱ 0 ) , which has previously been determined by ZEUS to be 0.065 ± 0.013 (stat.) in photoproduction at a mean W of 70 GeV, is measured to be 0.18 ± 0.05 (stat.) ± 0.03 (syst.) at a mean Q 2 of 12.3 GeV2 and mean W of ≈ 100 GeV and is thus approaching at large Q 2 the value of 2 9 predicted from the quark charges of the vector mesons and a flavour independent production mechanism.

352. Dijet angular distributions in direct and resolved photoproduction at HERA

Author

M. Derrick, D. Krakauer, S. Magill, D. Mikunas, B. Musgrave, J.R. Okrasinski, J. Repond, R. Stanek, R.L. Talaga, H. Zhang, M.C.K. Mattingly, G. Bari, M. Basile, L. Bellagamba, D. Boscherini, A. Bruni, G. Bruni, P. Bruni, G. Cara Romeo, G. Castellini, L. Cifarelli, F. Cindolo, A. Contin, M. Corradi, I. Gialas, P. Giusti, G. Iacobucci, G. Laurenti, G. Levi, A. Margotti, T. Massam, R. Nania, F. Palmonari, A. Polini, G. Sartorelli, Y. Zamora Garcia, A. Zichichi, C. Amelung, A. Bornheim, J. Crittenden, R. Deffner, T. Doeker, M. Eckert, L. Feld, A. Frey, M. Geerts, M. Grothe, H. Hartmann, K. Heinloth, L. Heinz, E. Hilger, H.-P. Jakob, U.F. Katz, S. Mengel, E. Paul, M. Pfeiffer, Ch. Rembser, D. Schramm, J. Stamm, R. Wedemeyer, S. Campbell-Robson, A. Cassidy, W.N. Cottingham, N. Dyce, B. Foster, S. George, M.E. Hayes, G.P. Heath, H.F. Heath, D. Piccioni, D.G. Roff, R.J. Tapper, R. Yoshida, M. Arneodo, R. Ayad, M. Capua, A. Garfagnini, L. Iannotti, M. Schioppa, G. Susinno, A. Caldwell, N. Cartiglia, Z. Jing, W. Liu, J.A. Parsons, S. Ritz, F. Sciulli, P.B. Straub, L. Wai, S. Yang, Q. Zhu, P. Borzemski, J. Chwastowski, A. Eskreys, Z. Jakubowski, M.B. Przybycień, M. Zachara, L. Zawiejski, L. Adamczyk, B. Bednarek, K. Jeleń, D. Kisielewska, T. Kowalski, M. Przybycień, E. Rulikowska-Zarȩbska, L. Suszycki, J. Zaja̧c, Z. Duliński, A. Kotański, G. Abbiendi, L.A.T. Bauerdick, U. Behrens, H. Beier, J.K. Bienlein, G. Cases, O. Deppe, K. Desler, G. Drews, M. Flasiński, D.J. Gilkinson, C. Glasman, P. Göttlicher, J. Große-Knetter, T. Haas, W. Hain, D. Hasell, H. Heßling, Y. Iga, K.F. Johnson, P. Joos, M. Kasemann, R. Klanner, W. Koch, U. Kötz, H. Kowalski, J. Labs, A. Ladage, B. Löhr, M. Löwe, D. Lüke, J. Mainusch, O. Mańczak, J. Milewski, T. Monteiro, J.S.T. Ng, D. Notz, K. Ohrenberg, K. Piotrzkowski, M. Roco, M. Rohde, J. Roldán, U. Schneekloth, W. Schulz, F. Selonke, B. Surrow, T. Voß, D. Westphal, G. Wolf, U. Wollmer, C. Youngman, W. Zeuner, H.J. Grabosch, A. Kharchilava, S.M. Mari, A. Meyer, S. Schlenstedt, N. Wulff, G. Barbagli, E. Gallo, P. Pelfer, G. Maccarrone, S. De Pasquale, L. Votano, A. Bamberger, S. Eisenhardt, T. Trefzger, S. Wölfle, J.T. Bromley, N.H. Brook, P.J. Bussey, A.T. Doyle, D.H. Saxon, L.E. Sinclair, M.L. Utley, A.S. Wilson, A. Dannemann, U. Holm, D. Horstmann, R. Sinkus, K. Wick, B.D. Burow, L. Hagge, E. Lohrmann, G. Poelz, W. Schott, F. Zetsche, T.C. Bacon, N. Brümmer, I. Butterworth, V.L. Harris, G. Howell, B.H.Y. Hung, L. Lamberti, K.R. Long, D.B. Miller, N. Pavel, A. Prinias, J.K. Sedgbeer, D. Sideris, A.F. Whitfield, U. Mallik, M.Z. Wang, S.M. Wang, J.T. Wu, P. Cloth, D. Filges, S.H. An, G.H. Cho, B.J. Ko, S.B. Lee, S.W. Nam, H.S. Park, S.K. Park, S. Kartik, H.-J. Kim, R.R. McNeil, W. Metcalf, V.K. Nadendla, F. Barreiro, J.P. Fernandez, R. Graciani, J.M. Hernández, L. Hervás, L. Labarga, M. Martinez, J. del Peso, J. Puga, J. Terron, J.F. de Trocóniz, F. Corriveau, D.S. Hanna, J. Hartmann, L.W. Hung, J.N. Lim, C.G. Matthews, P.M. Patel, M. Riveline, D.G. Stairs, M. St-Laurent, R. Ullmann, G. Zacek, T. Tsurugai, V. Bashkirov, B.A. Dolgoshein, A. Stifutkin, G.L. Bashindzhagyan, P.F. Ermolov, L.K. Gladilin, Yu.A. Golubkov, V.D. Kobrin, I.A. Korzhavina, V.A. Kuzmin, O.Yu. Lukina, A.S. Proskuryakov, A.A. Savin, L.M. Shcheglova, A.N. Solomin, N.P. Zotov, M. Botje, F. Chlebana, J. Engelen, M. de Kamps, P. Kooijman, A. Kruse, A. van Sighem, H. Tiecke, W. Verkerke, J. Vossebeld, M. Vreeswijk, L. Wiggers, E. de Wolf, R. van Woudenberg, D. Acosta, B. Bylsma, L.S. Durkin, J. Gilmore, C. Li, T.Y. Ling, P. Nylander, I.H. Park, T.A. Romanowski, D.S. Bailey, R.J. Cashmore, A.M. Cooper-Sarkar, R.C.E. Devenish, N. Harnew, M. Lancaster, L. Lindemann, J.D. McFall, C. Nath, V.A. Noyes, A. Quadt, J.R. Tickner, H. Uijterwaal, R. Walczak, D.S. Waters, F.F. Wilson, T. Yip, A. Bertolin, R. Brugnera, R. Carlin, F. Dal Corso, M. De Giorgi, U. Dosselli, S. Limentani, M. Morandin, M. Posocco, L. Stanco, R. Stroili, C. Voci, F. Zuin, J. Bulmahn, R.G. Feild, B.Y. Oh, J.J. Whitmore, G. D'Agostini, G. Marini, A. Nigro, E. Tassi, J.C. Hart, N.A. McCubbin, T.P. Shah, E. Barberis, T. Dubbs, C. Heusch, M. Van Hook, W. Lockman, J.T. Rahn, H.F.-W. Sadrozinski, A. Seiden, D.C. Williams, J. Biltzinger, R.J. Seifert, O. Schwarzer, A.H. Walenta, G. Zech, H. Abramowicz, G. Briskin, S. Dagan, A. Levy, J.I. Fleck, M. Inuzuka, T. ishii, M. Kuze, S. Mine, M. Nakao, I. Suzuki, K. Tokushuku, K. Umemori, S. Yamada, Y. Yamazaki, M. Chiba, R. Hamatsu, T. Hirose, K. Homma, S. Kitamura, T. Matsushita, K. Yamauchi, R. Cirio, M. Costa, M.I. Ferrero, S. Maselli, C. Peroni, R. Sacchi, A. Solano, A. Staino, M. Dardo, D.C. Bailey, F. Benard, M. Brkic, C.-P. Fagerstroem, G.F. Hartner, K.K. Joo, G.M. Levman, J.F. Martin, R.S. Orr, S. Polenz, C.R. Sampson, D. Simmons, R.J. Teuscher, J.M. Butterworth, C.D. Catterall, T.W. Jones, P.B. Kaziewicz, J.B. Lane, R.L. Saunders, J. Shulman, M.R. Sutton, B. Lu, L.W. Mo, W. Bogusz, J. Ciborowski, J. Gajewski, G. Grzelak, M. Kasprzak, M. Krzyżanowski, K. Muchorowski, R.J. Nowak, J.M. Pawlak, T. Tymieniecka, A.K. Wróblewski, J.A. Zakrzewski, A.F. Żarnecki, M. Adamus, C. Coldewey, Y. Eisenberg, D. Hochman, U. Karshon, D. Revel, D. Zer-Zion, W.F. Badgett, J. Breitweg, D. Chapin, R. Cross, S. Dasu, C. Foudas, R.J. Loveless, S. Mattingly, D.D. Reeder, S. Silverstein, W.H. Smith, A. Vaiciulis, M. Wodarczyk, S. Bhadra, M.L. Cardy, W.R. Frisken, M. Khakzad, W.N. Murray, W.B. Schmidke, and ZEUS at HERA (IHEF, IoP, FNWI)

Subjects
Nuclear and High Energy Physics, Particle physics, COLLISIONS, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, FOS: Physical sciences, Jet (particle physics), PPBAR COLLIDER, PROTON, 01 natural sciences, 7. Clean energy, law.invention, CROSS-SECTIONS, High Energy Physics - Experiment, Nuclear physics, EVENTS, High Energy Physics - Experiment (hep-ex), GAMMA-P INTERACTIONS, MONTE-CARLO, law, 0103 physical sciences, Invariant mass, 010306 general physics, Collider, Nuclear Experiment, Quantum chromodynamics, Physics, ZEUS (particle detector), 010308 nuclear & particles physics, High Energy Physics::Phenomenology, ZEUS, ZEUS BARREL CALORIMETER, HERA, Rest frame, Gluon, PARTON DISTRIBUTIONS, HARD SCATTERING, High Energy Physics::Experiment
Abstract

Jet photoproduction, where the two highest transverse energy ($\ETJ$) jets have $\ETJ$ above 6 GeV and a jet-jet invariant mass above 23~GeV, has been studied with the ZEUS detector at the HERA $ep$ collider. Resolved and direct photoproduction samples have been separated. The cross section as a function of the angle between the jet-jet axis and the beam direction in the dijet rest frame has been measured for the two samples. The measured angular distributions differ markedly from each other. They agree with the predictions of QCD calculations, where the different angular distributions reflect the different spins of the quark and gluon exchanged in the hard subprocess., 20 pages including 4 figures

353. Study of D* (2010)± production in ep collisions at HERA

Author

A. Nigro, Yasunori Yamazaki, J. Kochocki, B. Gutjahr, H. Hultschig, John Hart, L. M. Shcheglova, A. Prinias, D. Haun, E. Barberis, A. N. Solomin, U. Mallik, R. R. McNeil, K. Desler, M. Lancaster, W. Koch, F. Selonke, E. Hilger, A.F. Whitfield, S.M. Mari, J.T. Wu, K. Charchuła, Giuseppe Iacobucci, M. Krzyżanowski, W. Metcalf, H. Beier, Tadeusz Kowalski, J. Große-Knetter, A. Bruni, D. Daniels, U. Holm, B.Y. Oh, M. Löwe, Y Zhang, D.D. Reeder, B. Diekmann, M. Wodarczyk, G. Poelz, J. Mollen, J. Zaja̧c, P. B. Kaziewicz, L. Köpke, L. Lamberti, H. Uijterwaal, Lutz Feld, J. J. Whitmore, C. Li, Rosario Nania, Sung Keun Park, Nicolo Cartiglia, N. Pavel, I. Suzuki, G.R. Smith, Krzysztof Piotrzkowski, P. Bruni, Costas Foudas, J.F. Zhou, Christian Nemoz, Giancarlo Susinno, Vladimir Bashkirov, L.W. Mo, K. K. Joo, Y. Iga, Cristiana Peroni, N. Dyce, A. Meyer, G. Briskin, Mariusz Przybycien, M. Corradi, Tobias M. Haas, William S. Lockman, G. Grzelak, Matthias Kasemann, K. M. Furutani, D. Westphal, D. Notz, R. J. Cashmore, S. Nickel, M. Derrick, D. B. Miller, C. Voci, B. Surrow, S.H. An, T. Tymieniecka, M. Zachara, S. Mengel, J. Mainusch, D. Schramm, C. A. Heusch, Ada Solano, R. S. Orr, R.S. Gilmore, H.J. Grabosch, S. H. Yon, T. W. Jones, Anna Goussiou, G. L. Bashindzhagyan, N. P. Zotov, W.B. Schmidke, R. J. Teuscher, Shoichi Yamada, R.C.E. Devenish, Avto Kharchilava, W. Schott, Cd Catterall, T. C. Bacon, U. Kötz, A. Dannemann, H.G.J.M. Tiecke, F. Benard, O. Mańczak, G. F. Hartner, Roberto Carlin, Q. Zhu, I. Fleck, U. Karshon, J.B. Lane, Gy. Wolf, Rr Rau, J.A. O'Mara, Marcel Vreeswijk, S. Limentani, Kenneth Long, K. Wick, S. De Pasquale, Luis Hervas, S. Ritz, D. Boscherini, Marco Schioppa, S. Magill, J. Gajewski, B. Behrens, O. Deppe, T. Doeker, A. Caldwell, M. Roco, J.D. McFall, V. K. Nadendla, R. J. Nowak, G. Bari, G. Laurenti, J. Del Peso, P. G. Pelfer, J. Repond, Masashi Hazumi, G. Castellini, R.L. Talaga, T. Tsurugai, K. Ohrenberg, M. Van Hook, L.E. Sinclair, S.S. Wilson, P. Luffman, A. Frey, A. Bertolin, B. Bednarek, P.F. Ermolov, C. Rembser, J. Bulmahn, K.W. McLean, P.B. Straub, H. Zhang, H.-P. Jakob, A. Ladage, S. Söldner-Rembold, K. Homma, Samuel Silverstein, R. L. Saunders, J. F. Martin, M.B. Crombie, R. Seidlein, E. Lohrmann, J.S.T. Ng, M. Basile, W. H. Smith, P. Giusti, M. Brkic, E. Badura, D. Zer-Zion, J. F. de Trocóniz, L. Zawiejski, Roberto Cirio, A. Byrne, Fernando Barreiro, Robert Stanek, A. Mass, N. Wulff, P. Joos, J. Stamm, F. Zetsche, E. Stiliaris, K. Eskreys, I. Gialas, M.C.K. Mattingly, L. S. Durkin, R. Yoshida, L. Wai, J. Schroeder, R. Brugnera, R. Hamatsu, J. Puga, N. A. McCubbin, V. A. Kuzmin, D. C. Bailey, Cg Matthews, Luca Stanco, Mário Costa, D. Hasell, G. Zacek, Mauro Morandin, G. D'Agostini, M. Z. Wang, B. Foster, S. Bhadra, J. K. Sedgbeer, R. Imlay, L. W. Hung, T. Y. Ling, T. Yip, Jens Hartmann, L. Iannotti, M. De Giorgi, C. Youngman, Y. Zamora Garcia, V. D. Kobrin, T. Dubbs, Y. Nakamitsu, Katsuo Tokushuku, T.P. Shah, S. M. Wang, Ulf Behrens, F.S. Chlebana, Federico Cindolo, W. Bogusz, S. Eisenhardt, W. Hain, L. Lindemann, G. Bruni, Simon George, Umberto Dosselli, R. J. Seifert, Giovanni Abbiendi, I. H. Park, Tachishige Hirose, D. H. Saxon, T. Voß, A. Bargende, J. M. Pawlak, G.A. Blair, Leszek Adamczyk, M.I. Ferrero, M. Adamus, G. Marini, A.K. Wróblewski, A. Bamberger, Masami Chiba, D. Mikunas, Janusz Chwastowski, Klaus Kurt Desch, Luisa Cifarelli, A. M. Cooper-Sarkar, L. K. Gladilin, Neville Harnew, S. Dagan, W. Schulz, Robert Klanner, A. Vaiciulis, E. Tassi, Gm Levman, Djp Norman, I. Ali, Ben Bylsma, J. Milewski, A. Quadt, E. A. De Wolf, J. Biltzinger, H. Hartmann, D. S. Bailey, M. Khakzad, M. L. Cardy, P. Göttlicher, K. Honscheid, Yu. A. Golubkov, Y. Eisenberg, M.A.J. Botje, R. G. Feild, D. Krakauer, K. Yamauchi, H. Kowalski, M. Eckert, L. Bellagamba, M. St.Laurent, E. Paul, D.J. Gilkinson, M. Kuze, F. Dal Corso, S. Kartik, E. Rulikowska-Zarȩbska, Douglas Gingrich, Francois Corriveau, R. Walczak, H. F.W. Sadrozinski, Ricardo Graciani, K. Heinloth, Giuseppe Barbagli, L. Hagge, F. Sciulli, D. Revel, T. Hasegawa, J. Roldán, Roberto Sacchi, A. Leich, C. Glasman, B. Hubbard, C. P. Fagerstroem, F. Palmonari, A. Stifutkin, Sridhara Dasu, S. Mine, S Campbell-Robson, Halina Abramowicz, A.S. Proskuryakov, Giuseppe Levi, K. Muchorowski, W.F. Badgett, K. Jelen, T. Ishii, A. Kotański, L.A.T. Bauerdick, T.L. Short, R.J. Tapper, Amedeo Staiano, U. F. Katz, A. Freidhof, B. Lu, M. Posocco, W.R. Frisken, G. Sartorelli, Aharon Levy, T.J. Llewellyn, J. N. Lim, J. M. Hernandez, Debades Bandyopadhyay, J. K. Bienlein, R. van Woudenberg, G.P. Heath, M. de Kamps, B. Musgrave, D. Filges, R. Sinkus, S. W. Nam, R. Stroili, Antonino Zichichi, A. Bernstein, J.J. Engelen, P.M. Kooijman, U. Schneekloth, H. J. Kim, R. Wedemeyer, Giovanni Maccarrone, Thomas Trefzger, S. Schlenstedt, P. J. Bussey, A. Cassidy, I. Butterworth, M. Nakahata, D. S. Hanna, M. L. Utley, S. M. Hong, E. Gallo, Andrea Contin, James Crittenden, S. Yang, A. Kruse, Anselmo Margotti, P. Cloth, L.W. Wiggers, K. Prytz, Danuta Kisielewska, Ta Romanowski, T. Massam, E. McCliment, Y. Nagasawa, R. Ayad, H.F. Heath, G. Cases, T. Neumann, B. Löhr, A. Seiden, F. F. Wilson, J. A. Zakrzewski, M. Grothe, C.J.S. Morgado, Michele Arneodo, S. Kitamura, J. Ciborowski, M. Chiarini, J.A. Parsons, R. Ullmann, J. Shulman, Juan Terron, M. Kasprzak, Jonathan Butterworth, G. Cara Romeo, C. Fordham, A. Eskreys, Lucia Votano, A. T. Doyle, L. Labarga, Wouter Verkerke, C. Nath, H. Heßling, G. Geitz, B. Y. H. Hung, A. A. Savin, B. D. Burow, W.N. Murray, G. Anzivino, M. Nakao, P. Borzemski, G. Drews, G. Zech, M. Flasiński, R. Schattevoy, A.S. Wilson, M. Dardo, C. Coldewey, L. Suszycki, A. H. Walenta, B. A. Dolgoshein, P. Morawitz, Aleksander Filip Żarnecki, Silvia Maselli, D. Lüke, A. Polini, D. Acosta, Dg Stairs, D. Horstmann, R. Timellini, A. Dake, N. H. Brook, V. L. Harris, M. Rohde, R. Loveless, J. Labs, M. H. Suh, M. Geerts, K. Blankenship, C.R. Sampson, Jeffrey T. Rahn, P. M. Patel, V.A. Noyes, and Zeus (IHEF, IoP, FNWI)

Subjects
Nuclear and High Energy Physics, Particle physics, Meson, Proton, LUND MONTE-CARLO, photoproduction, charmed meson production, FOS: Physical sciences, 01 natural sciences, Zeus (malware), JET FRAGMENTATION, Charm quark, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), CHARM PHOTOPRODUCTION, GAMMA-P INTERACTIONS, 0103 physical sciences, Charm (quantum number), 010306 general physics, Quantum chromodynamics, Physics, ZEUS, LEADING-ORDER QCD, PARTON DISTRIBUTIONS, CROSS-SECTION, HARD SCATTERING, HEAVY QUARKS, E+E-PHYSICS, 010308 nuclear & particles physics, HERA, Gluon
Abstract

We report the first observation of charmed mesons with the ZEUS detector at HERA using the decay channel ${\rm D}^{*+}\rightarrow (\Do \rightarrow {\rm K}^-\pi^+)\pi^+$ (+ c.c.). Clear signals in the mass difference $\Delta M$=$M$(D$^*$)--$M$(D$^0)$ as well as in the $M(K\pi)$ distribution at the D$^0$ mass are found. The $ep$ cross section for inclusive \DSpm\ production with $Q^2, Comment: 19 pages, latex, 3 figures appended as uuencoded file

354. Measurement of the $$\sum {^ - \to ne^ - \bar v} $$ rate and search for ΔQ=−ΔS transitions in Σ+→ne + ν decay

Author

F. Eisele, V. Hepp, H. Filthuth, H. Ebenhöh, G. Zech, E. Leitner, R. Engelmann, and T. Thouw

Subjects
Physics, Nuclear and High Energy Physics, Nuclear magnetic resonance, Branching fraction, Atomic physics, Bar (unit)
Abstract

In a bubble chamber experiment about 2×106Σ±-decays have been measured to separateΣ±→ne±¯ν events from the two-body modes. NoΣ+→ne+ν event was found whereas 607Σ−→ne−¯ν decays could be identified. The data yield for the ΔQ=−ΔS decay an upper limit: $$\frac{{\Gamma \left( {\sum {^ + } \to ne^ + v} \right)}}{{\Gamma \left( {\sum {^ - } \to ne^ - v} \right)}}< 1.9 x 10^{ - 2} (90\% confidence level)$$ and the branching ratio: $$\frac{{\Gamma \left( {\sum {^ - } \to ne^ - v} \right)}}{{\Gamma \left( {\sum {^ - } \to n\pi ^ - } \right)}} = (1.09 \pm 0.06) x 10^{ - 3} .$$

Published
1974
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355. A posteriori image-correcting 'deconvolution' by holographic fourier-transform division

Author

G. W. Stroke and R. G. Zech

Subjects
Physics, Digital image correlation, business.industry, Holography, General Physics and Astronomy, Image processing, Division (mathematics), Image (mathematics), law.invention, symbols.namesake, Optics, Fourier transform, law, symbols, A priori and a posteriori, Deconvolution, business
Abstract

Division of spatial field distributions in the Fourier-transform domain for “resolution-retrieving”, “corrective” image deconvolution of the “smearing” resulting from extended “instrument functions” in optical imaging, spectroscopy and radio-astronomy may be accomplished by a “two-filter” holographic scheme.

Published
1967
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356. PULSED LASER REFLECTION HOLOGRAMS

Author

L. D. Siebert and R. G. Zech

Subjects
Pulsed laser, Optics, Materials science, Physics and Astronomy (miscellaneous), Virtual image, business.industry, law, Ruby laser, Holography, Reflection (computer graphics), business, law.invention
Abstract

A single‐mode pulsed ruby laser was used to record reflection holograms. A photograph of the virtual image of a hologram of one of the authors is shown.

Published
1968
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357. A measurement of radiative λ decays

Author

E. Leitner, H. Filthuth, H. Frehse, V. Hepp, G. Zech, N. Baggett, F. Eisele, and M. Baggett

Subjects
Physics, Nuclear and High Energy Physics, Pion, Photon, Proton, Branching fraction, Radiative transfer, Radiative decay, Hydrogen bubble, Atomic physics
Abstract

The radiative decay mode λ → p π p − γ was studied in the 81 cm Saclay hydrogen bubble chamber. From 72 radiative λ decays with stopping pion and proton we obtain for the branching ratio Λ(λ → p π − γ, p π ∗ −s MeV /c) Λ(λ → p π − ) = (1.32 ±0.22) × 10 −3 which is in good agreement with theoretical predictions.

Published
1972
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358. Transparent electrophotographic films for optical data storage applications

Author

R. G. Zech, L. M. Ralston, and J. F. Dirks

Subjects
3D optical data storage, Materials science, business.industry, Materials Science (miscellaneous), Holography, High resolution, Diffraction efficiency, Environmental integrity, Industrial and Manufacturing Engineering, law.invention, Optics, law, Computer data storage, Optoelectronics, Holographic memory, Business and International Management, business, Holographic recording
Abstract

The experimental evaluation of a transparent electrophotographic (TEP) film is reported. The objective of the evaluation was to determine the suitability of TEP films for optical data storage applications, especially those using holography. The characteristics of TEP films that motivated the evaluation are good sensitometric and holographic recording responses, relatively high resolution, and a number of attractive applications properties, e.g., long shelf life, good environmental integrity, and exceptional image permanence. In addition, TEP films have an add-on capability. A general description of TEP films is given, and sensitometric and holographic data are summarized for an experimental TEP film.

Published
1977
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359. 171. F�nf Jahre Erfahrungen mit der Gewebebank

Author

Harald Tscherne, G. Zech, D. Rogge, and W. HeBe

Subjects
Gynecology, medicine.medical_specialty, Cardiothoracic surgery, business.industry, medicine, Surgery, Vascular surgery, business, Abdominal surgery
Abstract

Die Unfallchirurgische Klinik der Medizinischen Hochschule Hannover fuhrte von 1972-1976 185 Transplantationen allogenen Gewebes durch, die sich in 39 Sehnen-, 2 Nerven-, 136 Knochen- und 8 Knochen-Knorpel-Transplantate gliedern. 69 Praparate wurden in Cialit konserviert. Dabei zeigten die 27 Knochen-Transplantate bei unvollstandigem Einbau 6 Infekte. Seit 1974 wird daher eine Kaltekonservierung bei - 70°C durchgefuhrt mit nur 2 Infekten bei 106 Knochentransplantationen. In 60 Fallen wurden mit gutem Ergebnis Hoftkopfe als Spendermaterial verwendet.

Published
1977
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360. Heat-Processed Photoresist for Holographic Data Storage Applications

Author

R. G. Zech, J. C. Dwyer, H. Fichter, and M. Lewis

Subjects
Argon, Materials science, business.industry, Materials Science (miscellaneous), Holography, chemistry.chemical_element, Photoresist, Holographic data storage, Diffraction efficiency, Laser, Industrial and Manufacturing Engineering, law.invention, Optics, chemistry, law, Optoelectronics, Sensitivity (control systems), Business and International Management, Photographic emulsion, business
Abstract

The experimental evaluation of a new heat-processed photoresist is reported with reference to holographic data storage applications. Two attractive features of the photoresist are (1) holographic reconstruction parameters comparable to the best photographic emulsions and (2) orthochromatic exposure sensitivity optimized for the 488-nm line of an argon laser. The preparation, use, and general properties of the photoresist are discussed, and relevant experimental data for important holographic parameters such as diffraction efficiency and storage density are presented.

Published
1973
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361. Photographic Realization of an Image-Deconvolution Filter for Holographic Fourier-Transform Division

Author

George W. Stroke and Richard G. Zech

Subjects
Deblurring, business.industry, Computer science, General Engineering, Holography, General Physics and Astronomy, Filter (signal processing), Division (mathematics), law.invention, symbols.namesake, Optics, Fourier transform, law, symbols, A priori and a posteriori, Point (geometry), business, Realization (systems), Algorithm
Abstract

The theory of the photographic realization of the Fourier-transform filter required for the authors' method (Phys. Letters, 25A, (1967) 89) of a posteriori image-correcting `deconvolution' by holographic Fourier-transform division is given. Subsequent to the first presentation of this work, the author's method of Phys. Letters 25A, (1967) 89 has now been experimentally verified by A. W. Lohmann and H. W. Werlich [Phys. Letters 25A (1967) 570] for two-dimensional “black-on-white” objects (point and letter), and for the deblurring of the photograph of a three-dimensional object by G. W. Stroke, G. Indebetouw and C. Puech [Phys. Letters, 26A (1968) 443].

Published
1968
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362. Hand-Held Holography

Author

R. G. Zech, George W. Stroke, G. Indebetouw, A. Funkhouser, and Carl D. Leonard

Subjects
Optics, Materials science, law, business.industry, Hand held, General Engineering, White light, Holography, business, Holographic recording, Laser light, law.invention
Published
1967
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366. Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo.

Author

Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, Zech G, Li Z, Hessler G, Schreuder H, Elshorst B, Krack A, Kurz M, Heubel C, and Scheidler S

Abstract

To increase the chemical space around the well-known GalNAc-ligand as ASGPR-binder, a high-throughput screening campaign was performed, testing approximately 550,000 compounds. After evaluation of the potential screening hits, only one compound, which showed high similarity with guanosine nucleosides, was chosen for further profiling. Crystal structure analysis revealed the coordination of the Ca 2+ -ion within the ASGPR-binding site by the cis -diol motif of the ribose unit as well as an additional π-π-interaction of the purine heterocycle to tryptophan-243. Based on these findings, guanosine was attached via the 5'-OH group to a recently described morpholino-based nucleotide using two different linker units. The resulting morpholino-guanosine building blocks were conjugated to the 5'-end of a literature-known transthyretin targeting small interfering RNA (siRNA), leading to trivalent siRNA-guanosine conjugates, which were tested for their TTR knockdown and exhibited similar potencies as the analogous GalNAc-conjugates in vitro and in vivo.

Published
2025
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367. Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders.

Author

Ruf S, Rajagopal S, Kadnur SV, Hallur MS, Rani S, Kristam R, Swaminathan S, Zope BR, Gondrala PK, Swamy I, Putta VPRK, Kandan S, Zech G, Schreuder H, Rudolph C, Elvert R, Czech J, Birudukota S, Siddiqui MA, Anand NN, Mane VS, Dittakavi S, Suresh J, Gosu R, Ramesh M, Yura T, Dhakshinamoorthy S, and Kannt A

Subjects
Animals, Humans, Mice, Glucose, Niacinamide metabolism, Niacinamide pharmacology, Obesity drug therapy, Metabolic Diseases drug therapy, Nicotinamide N-Methyltransferase metabolism
Abstract

Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA). Overexpression of NNMT and the presence of the active metabolite MNA is associated with a number of diseases including metabolic disorders. We conducted a high-throughput screening campaign that led to the identification of a tricyclic core as a potential NNMT small molecule inhibitor series. Elaborate medicinal chemistry efforts were undertaken and hundreds of analogs were synthesized to understand the structure activity relationship and structure property relationship of this tricyclic series. A lead molecule, JBSNF-000028, was identified that inhibits human and mouse NNMT activity, reduces MNA levels in mouse plasma, liver and adipose tissue, and drives insulin sensitization, glucose modulation and body weight reduction in a diet-induced obese mouse model of diabetes. The co-crystal structure showed that JBSNF-000028 binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain). JBSNF-000028 was inactive against a broad panel of targets related to metabolism and safety. Interestingly, the improvement in glucose tolerance upon treatment with JBSNF-000028 was also observed in NNMT knockout mice with diet-induced obesity, pointing towards the glucose-normalizing effect that may go beyond NNMT inhibition. JBSNF-000028 can be a potential therapeutic option for metabolic disorders and developmental studies are warranted., (© 2022. The Author(s).)

Published
2022
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368. Delayed on- and off-retinal responses of cones pathways in regular cannabis users: An On-Off flash electroretinogram case-control study.

Author

Schwitzer T, Schwan R, Albuisson E, Bugin C, Zech G, Angioi-Duprez K, Bernardin F, and Laprévote V

Subjects
Case-Control Studies, Electroretinography, Photic Stimulation, Retina, Cannabis
Abstract

The retina is considered a useful area for investigating synaptic transmission abnormalities in neuropsychiatric disorders, including as a result of using cannabis, the most widely consumed illicit substance in the developed world. The impact of regular cannabis use on retinal function has already been evaluated, using pattern and flash electroretinogram (ERG) to demonstrate a delay in ganglion and bipolar cell response. Using multifocal ERG, it was showed that the delay to be preferentially located in the central retina. ERG tests do not separately examine the impact of cannabis on the On and Off pathways. The purpose of this study is to assess On and Off pathway function using On-Off ERG. We conducted an On-Off ERG test in 42 regular cannabis users and 26 healthy controls. The protocol was compliant with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards. Amplitude and peak time were measured for the a-, b- and d-waves. Results in the regular cannabis users showed a significant increase in the latencies of both the b- and the d-wave (p = 0.020, p = 0.022, respectively, Mann-Whitney U test), with no change in the wave amplitudes. A-wave peak time and amplitude were unchanged. These findings are reflective of an effect of regular cannabis use on the On and Off pathways and are consistent with previous findings which also identified increases in retinal neuron response times. We confirm here that regular cannabis use impacts the post-receptoral cones pathway at the level of bipolar cells, affecting the On and Off pathways., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
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369. Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.

Author

Kannt A, Rajagopal S, Hallur MS, Swamy I, Kristam R, Dhakshinamoorthy S, Czech J, Zech G, Schreuder H, and Ruf S

Subjects
Animals, Binding Sites, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, High-Throughput Screening Assays, Humans, Ligands, Mice, Microsomes, Liver drug effects, Microsomes, Liver enzymology, Models, Molecular, Niacinamide metabolism, Nicotinamide N-Methyltransferase metabolism, Rats, Substrate Specificity drug effects, Enzyme Inhibitors therapeutic use, Metabolic Diseases drug therapy, Metabolic Diseases enzymology, Nicotinamide N-Methyltransferase antagonists & inhibitors
Abstract

Nicotinamide- N -methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S -adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle. Its expression in several cancer cell lines has been widely discussed in the literature, and recent work established a link between NNMT expression and metabolic diseases. Here we describe our approach to identify potent small molecule inhibitors of NNMT featuring different binding modes as elucidated by X-ray crystallographic studies.

Published
2021
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370. Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis.

Author

Mishra A, Castañeda TR, Bader E, Elshorst B, Cummings S, Scherer P, Bangari DS, Loewe C, Schreuder H, Pöverlein C, Helms M, Jones S, Zech G, Licher T, Wagner M, Schudok M, de Hoop M, Plowright AT, Atzrodt J, Kannt A, Laitinen I, and Derdau V

Abstract

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life-threatening, yet noninvasively differentiating NASH from simple steatosis is challenging. Herein, bifunctional probes have been developed that target the hepatocyte-specific asialoglycoprotein receptor (ASGPR), the expression of which decreases during NASH progression. The results show that the probes allow longitudinal, noninvasive monitoring of ASGPR levels by positron emission tomography in the newly developed rat model of NASH. The probes open new possibilities for research into early diagnosis of NASH and development of drugs to slow or reverse its progression., Competing Interests: The authors declare no conflict of interest., (© 2020 The Authors. Published by Wiley‐VCH GmbH.)

Published
2020
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371. Lumbar Radiculitis as a Complication of Vaccination against Tick-Borne Encephalitis: A Differential Diagnosis of Low Back Pain and Nerve Root Compression.

Author

Kingston C, Zech G, Pauli C, and Walker U

Abstract

Serious adverse reactions following immunisation with adult tick-borne encephalitis (TBE) vaccines are rare, but when they occur, they most frequently involve the nervous system. We present a case of a female patient who developed a sensory and motor L4 monoradiculopathy following self-injection of an inactivated vaccine against TBE in the ipsilateral quadriceps muscle. The motor and sensory L4 dysfunction vanished after 12 months. TBE vaccine-induced radiculopathy should be considered as a mimic of spinal root compression., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2020 Craig Kingston et al.)

Published
2020
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372. N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.

Author

Boldron C, Besse A, Bordes MF, Tissandié S, Yvon X, Gau B, Badorc A, Rousseaux T, Barré G, Meneyrol J, Zech G, Nazare M, Fossey V, Pflieger AM, Bonnet-Lignon S, Millet L, Briot C, Dol F, Hérault JP, Savi P, Lassalle G, Delesque N, Herbert JM, and Bono F

Subjects
Acute Coronary Syndrome prevention & control, Adenosine Diphosphate pharmacology, Administration, Oral, Animals, Binding, Competitive, CHO Cells, Cricetinae, Cricetulus, Humans, Indoles chemical synthesis, Indoles metabolism, Injections, Intravenous, Male, Models, Chemical, Molecular Structure, Platelet Aggregation Inhibitors chemical synthesis, Platelet Aggregation Inhibitors metabolism, Purinergic P2 Receptor Antagonists chemical synthesis, Purinergic P2 Receptor Antagonists metabolism, Pyridazines chemical synthesis, Pyridazines metabolism, Rats, Rats, Sprague-Dawley, Receptors, Purinergic P2Y12 genetics, Thrombosis prevention & control, Indoles pharmacology, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors pharmacology, Purinergic P2 Receptor Antagonists pharmacology, Pyridazines pharmacology, Receptors, Purinergic P2Y12 metabolism
Abstract

In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization process leading to the identification of the preclinical candidate SAR216471. It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. SAR216471 displays potent in vivo antiplatelet and antithrombotic activities and has the potential to differentiate from other antiplatelet agents.

Published
2014
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373. Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Author

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, and Nazaré M

Subjects
Animals, CHO Cells, Cricetinae, Cricetulus, Glutamic Acid chemistry, Glutamic Acid pharmacology, Humans, Molecular Docking Simulation, Piperazines chemistry, Piperazines pharmacology, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors chemical synthesis, Platelet Aggregation Inhibitors chemistry, Platelet Aggregation Inhibitors pharmacology, Purinergic P2Y Receptor Antagonists chemistry, Purinergic P2Y Receptor Antagonists pharmacology, Pyrazoles chemistry, Pyrazoles pharmacology, Quantitative Structure-Activity Relationship, Radioligand Assay, Stereoisomerism, Glutamic Acid analogs & derivatives, Glutamic Acid chemical synthesis, Piperazines chemical synthesis, Purinergic P2Y Receptor Antagonists chemical synthesis, Pyrazoles chemical synthesis, Receptors, Purinergic P2Y12 metabolism
Abstract

A series of novel, highly potent P2Y₁₂ antagonists as inhibitors of platelet aggregation based on a phenylpyrazole glutamic acid piperazine backbone is described. Exploration of the structural requirements of the substituents by probing the structure-activity relationship along this backbone led to the discovery of the N-acetyl-(S)-proline cyclobutyl amide moiety as a highly privileged motif. Combining the most favorable substituents led to remarkably potent P2Y₁₂ antagonists displaying not only low nanomolar binding affinity to the P2Y₁₂ receptor but also a low nanomolar inhibition of platelet aggregation in the human platelet rich plasma assay with IC₅₀ values below 50 nM. Using a homology and a three-dimensional quantitative structure-activity relationship model, a binding hypothesis elucidating the impact of several structural features was developed.

Published
2012
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374. Limits for the central production of Theta+ and Xi(--)pentaquarks in 920-GeV pA collisions.

Author

Abt I, Adams M, Agari M, Albrecht H, Aleksandrov A, Amaral V, Amorim A, Aplin SJ, Aushev V, Bagaturia Y, Balagura V, Bargiotti M, Barsukova O, Bastos J, Batista J, Bauer C, Bauer TS, Belkov A, Belkov A, Belotelov I, Bertin A, Bobchenko B, Böcker M, Bogatyrev A, Bohm G, Bräuer M, Bruinsma M, Bruschi M, Buchholz P, Buran T, Carvalho J, Conde P, Cruse C, Dam M, Danielsen KM, Danilov M, Castro SD, Deppe H, Dong X, Dreis HB, Egorytchev V, Ehret K, Eisele F, Emeliyanov D, Essenov S, Fabbri L, Faccioli P, Feuerstack-Raible M, Flammer J, Fominykh B, Funcke M, Garrido L, Giacobbe B, Gläss J, Goloubkov D, Golubkov Y, Golutvin A, Golutvin I, Gorbounov I, Gorisek A, Gouchtchine O, Goulart DC, Gradl S, Gradl W, Grimaldi F, Groth-Jensen J, Guilitsky Y, Hansen JD, Hernández JM, Hofmann W, Hott T, Hulsbergen W, Husemann U, Igonkina O, Ispiryan M, Jagla T, Jiang C, Kapitza H, Karabekyan S, Karpenko N, Keller S, Kessler J, Khasanov F, Kiryushin Y, Klinkby E, Knöpfle KT, Kolanoski H, Korpar S, Krauss C, Kreuzer P, Krizan P, Krücker D, Kupper S, Kvaratskheliia T, Lanyov A, Lau K, Lewendel B, Lohse T, Lomonosov B, Männer R, Masciocchi S, Massa I, Matchikhilian I, Medin G, Medinnis M, Mevius M, Michetti A, Mikhailov Y, Mizuk R, Muresan R, Zur Nedden M, Negodaev M, Nörenberg M, Nowak S, Núñez Pardo de Vera MT, Ouchrif M, Ould-Saada F, Padilla C, Peralta D, Pernack R, Pestotnik R, Piccinini M, Pleier MA, Poli M, Popov V, Pose A, Pose D, Prystupa S, Pugatch V, Pylypchenko Y, Pyrlik J, Reeves K, Ressing D, Rick H, Riu I, Robmann P, Rostovtseva I, Rybnikov V, Sánchez F, Sbrizzi A, Schmelling M, Schmidt B, Schreiner A, Schröder H, Schwartz AJ, Schwarz AS, Schwenninger B, Schwingenheuer B, Sciacca F, Semprini-Cesari N, Shuvalov S, Silva L, Smirnov K, Sözüer L, Solunin S, Somov A, Somov S, Spengler J, Spighi R, Spiridonov A, Stanovnik A, Staric M, Stegmann C, Subramania HS, Symalla M, Tikhomirov I, Titov M, Tsakov I, Uwer U, van Eldik C, Vassiliev Y, Villa M, Vitale A, Vukotic I, Wahlberg H, Walenta AH, Walter M, Wang JJ, Wegener D, Werthenbach U, Wolters H, Wurth R, Wurz A, Zaitsev Y, Zavertyaev M, Zech G, Zeuner T, Zhelezov A, Zheng Z, Zimmermann R, Zivko T, and Zoccoli A

Abstract

We have searched for Theta+(1540) and Xi(--)(1862) pentaquark candidates in proton-induced reactions on C, Ti, and W targets at midrapidity and square root of s = 41.6 GeV. In 2 x 10(8) inelastic events we find no evidence for narrow (sigma approximately 5 MeV) signals in the Theta+ --> pK0(S) and Xi(--) --> Xi- pi- channels; our 95% C.L. upper limits (UL) for the inclusive production cross section times branching fraction B dsigma/dy/(y approximately 0) are (4-16) mub/N for a Theta+ mass between 1521 and 1555 MeV, and 2.5 mub/N for the Xi(--). The UL of the yield ratio of Theta+/Lambda(1520) < (3-12)% is significantly lower than model predictions. Our UL of B Xi(--)/Xi(1530)0 < 4% is at variance with the results that have provided the first evidence for the Xi(--).

Published
2004
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375. Synthesis of a polymer-bound galactosylamine and its application as an immobilized chiral auxiliary in stereoselective syntheses of piperidine and amino acid derivatives.

Author

Zech G and Kunz H

Subjects
Chromatography, Liquid, Chromatography, Thin Layer, Indicators and Reagents, Magnetic Resonance Spectroscopy, Mass Spectrometry, Molecular Conformation, Polymers, Spectrophotometry, Ultraviolet, Stereoisomerism, Amino Acids chemical synthesis, Galactosamine chemistry, Piperidines chemical synthesis
Abstract

A 2,3,4-tri-O-pivaloylated beta-D-galactopyranosyl azide bearing a hydroxy-functionalized spacer unit at the C-6 position of the galactose was synthesized and immobilized on the solid phase by using a polymer-bound chlorosilane. The azide was reduced to the corresponding galactopyranosylamine, which served as a versatile chiral auxiliary in highly diastereoselective Ugi four-component condensation reactions at ambient temperature. Fluoride-induced cleavage from the polymeric support furnished N-glycosylated N-acylated alpha-amino acid amides. The reaction of the immobilized galactosylamine with aldehydes gave rise to the corresponding aldimines, which underwent a domino Mannich-Michael condensation reaction with Danishefsky's diene at ambient temperature to yield 2-substituted 5,6-didehydropiperidin-4-ones on the solid phase. Subsequent cleavage with tetra-n-butylammonium fluoride delivered the N-glycosylated products in high yields, purities, and diastereoselectivities. A chemoselective 1,4-hydride addition to the polymer-bound dehydropiperidinones was achieved in the presence of the bulky oxygenophilic Lewis acid methylaluminum [bis(2,6-di-tert-butyl-4-methylphenoxide)]. The conjugate addition of cyano-modified Gilman reagents to the immobilized dehydropiperidinones furnished 2,6-cis-substituted piperidine derivatives as the major diastereomers that were isolated after cleavage from the support.

Published
2004
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377. Nucleophilically assisted and cationic ring-opening polymerization of tin-bridged [1]ferrocenophanes.

Author

Baumgartner T, Jäkle F, Rulkens R, Zech G, Lough AJ, and Manners I

Abstract

To obtain mechanistic insight, detailed studies of the intriguing "spontaneous" ambient temperature ring-opening polymerization (ROP) of tin-bridged [1]ferrocenophanes Fe(eta-C(5)H(4))(2)SnR(2) 3a (R = t-Bu) and 3b (R = Mes) in solution have been performed. The investigations explored the influence of non-nucleophilic additives such as radicals and radical traps, neutral and anionic nucleophiles, Lewis acids, protic species, and other cationic electrophiles. Significantly, two novel methodologies and mechanisms for the ROP of strained [1]ferrocenophanes are proposed based on this study. First, as the addition of amine nucleophiles such as pyridine was found to strongly accelerate the polymerization rate in solution, a new nucleophilicallyassisted ROP methodology was proposed. This operates at ambient temperature in solution even in the presence of chlorosilanes but, unlike the anionic polymerization of ferrocenophanes, does not involve cyclopentadienyl anions. Second, the addition of small quantities of the electrophilic species H(+) and Bu(3)Sn(+) was found to lead to a cationic ROP process. These studies suggest that the "spontaneous" ROP of tin-bridged [1]ferrocenophanes may be a consequence of the presence of spurious, trace quantities of Lewis basic or acidic impurities. The new ROP mechanisms reported are likely to be of general significance for the ROP of other metallocenophanes (e.g., for thermal ROP in the melt) and for other metallacycles containing group 14 elements.

Published
2002
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378. Dipolar recoupling in NOESY-type 1H-1H NMR experiments under HRMAS conditions.

Author

Thieme K, Zech G, Kunz H, Spiess HW, and Schnell I

Abstract

[structure: see text]. The concept of dipolar recoupling is introduced to 1H-1H NOESY experiments performed under HRMAS conditions. Dipole-dipole couplings are selectively recoupled during the mixing period, while MAS ensures high resolution in the spectral dimensions. Incoherent dipolar exchange is replaced by amplified coherent processes, such that time scales for polarization transfer are shortened, and dipolar double-quantum techniques become applicable. In this way, dipole-dipole couplings, as well as J-couplings, can be individually measured.

Published
2002
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380. Limitations of the evaluation of adnexal masses by its macroscopic aspects, cytology and biopsy.

Author

Dietrich M, Osmers RG, Grobe G, Zech G, Suren A, Krauss T, Sander H, Fischer G, and Kuhn W

Subjects
Biopsy, Cyst Fluid cytology, Diagnosis, Differential, False Negative Reactions, Female, Humans, Laparotomy, Ovarian Cysts classification, Ovarian Cysts surgery, Ovarian Neoplasms classification, Ovarian Neoplasms surgery, Ovary diagnostic imaging, Postmenopause, Premenopause, Prospective Studies, Sensitivity and Specificity, Ultrasonography, Ovarian Cysts pathology, Ovarian Neoplasms pathology
Abstract

To investigate the relevance of intraoperative macroscopic evaluation of adnexal masses a prospective study was conducted from June 1st, 1993 to May 31st, 1994, which included 57 premenopausal and 60 postmenopausal women, who underwent laparotomy because of a cystic adnexal mass. The surgeons were asked to classify the tumor intraoperatively as benign or malignant and to assign to histologic groups. In addition cytology of the cyst fluid and a biopsy from the cystic wall were evaluated. Comparison of these items with the results of permanent section diagnosis revealed the tendency of the surgeons to underestimate adnexal masses depending on patients' age and the complexity of the tumor, despite of the knowledge of preoperative ultrasonographic findings. Sufficient cytolologic examination was possible in only one third of aspirates and only 21% of the examined postmenopausal malignant neoplasms have correctly been diagnosed by cytology. Evaluation of the biopsy specimens demonstrates a marked percentage of false negatives with respect to benign tumors (30% of non-functional benign neoplasms in the premenopause were assessed as functional cysts) as well as malignant neoplasms (only 72% were diagnosed correctly in the postmenopause group). In conclusion intraoperative subjective assessment, cytology and representative biopsies do not necessarily concur with the definitive histological diagnosis.

Published
1999
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382. [Neurogenic impotence].

Author

Biedert S, Alken P, and Zech-Uber G

Subjects
Humans, Male, Nervous System physiopathology, Erectile Dysfunction physiopathology, Nervous System Diseases physiopathology, Penis innervation
Abstract

Until recently, the management of impotence was mainly concerned with the distinction of psychogenic from organic causes of erectile failure. Patients with the former were offered psychosexual counselling, while surgery, principally in the form of prosthesis implantation, was reserved for those with organic impotence. With the identification of pharmacologic regimes that can successfully induce erection, it has become necessary to distinguish between vascular and neurogenic causes of erectile failure, since it is mainly the latter patient group that can profit from an intracavernosal injection therapy with papaverine and phentolamine. Neurogenic erectile failure is further classified according to lesion localization and underlying disease.

Published
1989

383. [Neurogenic bladder disorders].

Author

Zech-Uber G, Alken P, and Biedert S

Subjects
Brain physiopathology, Cauda Equina physiopathology, Humans, Peripheral Nerves physiopathology, Spinal Cord physiopathology, Urinary Bladder, Neurogenic drug therapy, Urinary Bladder innervation, Urinary Bladder, Neurogenic physiopathology
Abstract

The past 15 years have witnessed an explosion of new knowledge concerning the anatomy, neurophysiology, and pharmacology of the lower urinary tract. Knowledge of the localization of a neurologic lesion-suprapontine, suprasacral, cauda equina, or peripheral nerves-rather than the type of disease allows a more "rational approach" to the diagnosis and therapy of neurogenic voiding disorders. More specifically, advances in pharmacological understanding enable us, at least in theory, to treat voiding disorders according to their types of dysfunction: drugs to promote bladder emptying that exert their predominant effect on bladder and bladder outlet respectively, and those promoting bladder storage with the corresponding objectives. We discuss the problem that many theoretically sound drugs are, in fact, not clinically efficacious, probably due to incomplete understanding of the physiology of normal micturition and its neurogenic disorders.

Published
1989

384. [Acute and subacute organic psychoses with altered consciousness. Attempt at classifying severity].

Author

Biedert S, Hewer W, and Zech-Uber G

Subjects
Adult, Aged, Coma diagnosis, Confusion diagnosis, Consciousness Disorders etiology, Delirium diagnosis, Female, Humans, Male, Middle Aged, Neurocognitive Disorders etiology, Prognosis, Psychoses, Substance-Induced diagnosis, Retrospective Studies, Cognition Disorders diagnosis, Consciousness Disorders diagnosis, Neurocognitive Disorders diagnosis, Psychiatric Status Rating Scales
Abstract

We have retrospectively investigated 71 patients with ICD-9 diagnoses 293.0 or 293.1, who were treated in our clinic in 1987, with respect to the maximum severity of altered consciousness. On the basis of an available neurological grading into "clouding of consciousness", "confusional state", "delirium", "stupor", and "coma", and from knowledge of the underlying somatic disease, we have developed prognostic criteria: Disorders of heart and circulation associated with acute organic mental disorder (with altered consciousness) carry a fair prognosis for recovery of the mental disorder in approximately two-thirds of all patients affected, even in advanced age. The same statement is valid with respect to drug-induced acute organic mental disorders, whereas most cases of cerebrovascular disorders with mental disturbances proceed to chronic forms of organic mental disorder. We believe that the clinical descriptive terms referred to above allow easy grading of states of acutely/subacutely altered consciousness, thereby providing prognostic criteria for the course of the disease.

Published
1989

385. [Late results of 160 surgically treated head fractures].

Author

Muggler E, Hell K, Huber D, von Laak E, Meier-Liehl T, Müller C, Müller KH, Sauer K, Schmit-Neuerburg KP, Thelen E, Wahl HG, and Zech G

Subjects
Accidents, Home, Accidents, Traffic, Adolescent, Adult, Age Factors, Aged, Child, Female, Humans, Male, Middle Aged, Postoperative Complications, Time Factors, Tibial Fractures surgery
Published
1975

391. [Conservative or surgical management of humerus-shaft fractures].

Author

Muhr G, Tscherne H, and Zech G

Subjects
Adult, Aged, Bone Nails, Bone Plates, Bone Screws, Casts, Surgical, Female, Fracture Fixation, Internal, Fracture Fixation, Intramedullary, Fractures, Bone complications, Humans, Humeral Fractures surgery, Middle Aged, Humeral Fractures therapy
Published
1973

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