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1. Endoscopic submucosal dissection for rectal neuroendocrine tumours: A multicentric retrospective study

Author

Rimondi, Alessandro, Despott, Edward J, Chacchi, Rocio, Lazaridis, Nikolaos, Costa, Deborah, Bucalau, Ana-Maria, Mandair, Dalvinder, Pioche, Mathieu, Rivory, Jérome, Santos-Antunes, Joao, Marques, Margarida, Ramos-Zabala, Felipe, Barbaro, Federico, Pimentel-Nunes, Pedro, Dinis-Ribeiro, Mario, Albeniz, Eduardo, Tantau, Marcel, Spada, Cristiano, Lemmers, Arnaud, Caplin, Martyn, Toumpanakis, Christos, and Murino, Alberto

Published
2024
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2. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, Lopez-Gomez, Marta, Cachero, Alba, Ferrarese, Alberto, Ripoll, Cristina, La Mura, Vincenzo, Bosch, Jaime, and García-Pagán, Juan Carlos

Published
2024
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3. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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4. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria-Vega, Erasmus, Hans-Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Robic, Marie Angèle, Conejo, Irene, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar, Guardascione, Maria Anna, Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Pavesi, Marco, Garcia-Pagán, Juan Carlos, Jansen, Christian, and Bañares, Rafael

Published
2020
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5. Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis – An international cohort study

Author

Demcsák, Alexandra, Soós, Alexandra, Kincses, Lilla, Capunge, Ines, Minkov, Georgi, Kovacheva-Slavova, Mila, Nakov, Radislav, Wu, Dong, Huang, Wei, Xia, Qing, Deng, Lihui, Hollenbach, Marcus, Schneider, Alexander, Hirth, Michael, Ioannidis, Orestis, Vincze, Áron, Bajor, Judit, Sarlós, Patrícia, Czakó, László, Illés, Dóra, Izbéki, Ferenc, Gajdán, László, Papp, Mária, Hamvas, József, Varga, Márta, Kanizsai, Péter, Bóna, Ernő, Mikó, Alexandra, Váncsa, Szilárd, Juhász, Márk Félix, Ocskay, Klementina, Darvasi, Erika, Miklós, Emőke, Erőss, Bálint, Szentesi, Andrea, Párniczky, Andrea, Casadei, Riccardo, Ricci, Claudio, Ingaldi, Carlo, Mastrangelo, Laura, Jovine, Elio, Cennamo, Vincenzo, Marino, Marco V., Barauskas, Giedrius, Ignatavicius, Povilas, Pelaez-Luna, Mario, Rios, Andrea Soriano, Turcan, Svetlana, Tcaciuc, Eugen, Małecka-Panas, Ewa, Zatorski, Hubert, Nunes, Vitor, Gomes, Antonio, Gonçalves, Tiago Cúrdia, Freitas, Marta, Constantino, Júlio, Sá, Milene, Pereira, Jorge, Mateescu, Bogdan, Constantinescu, Gabriel, Sandru, Vasile, Negoi, Ionut, Ciubotaru, Cezar, Negoita, Valentina, Bunduc, Stefania, Gheorghe, Cristian, Barbu, Sorin, Tantau, Alina, Tantau, Marcel, Dumitru, Eugen, Suceveanu, Andra Iulia, Tocia, Cristina, Gherbon, Adriana, Litvin, Andrey, Shirinskaya, Natalia, Rabotyagova, Yliya, Bezmarevic, Mihailo, Hegyi, Péter Jenő, Han, Jimin, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Comas, Eva Pijoan, Garcia, Daniel de la Iglesia, Cuadrado, Andrea Jardi, Castiñeira, Adriano Quiroga, Chang, Yu-Ting, Chang, Ming-Chu, Kchaou, Ali, Tlili, Ahmed, Kacar, Sabite, Gökbulut, Volkan, Duman, Deniz, Kani, Haluk Tarik, Altintas, Engin, Chooklin, Serge, Chuklin, Serhii, Gougol, Amir, Papachristou, George, and Hegyi, Péter

Published
2020
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Author

Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, Lopez-Gomez, Marta, Balcar, Lorenz, Mandorfer, Mattias, Hernández-Gea, Virginia, Procopet, Bogdan, Meyer, Elias Laurin, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Samaniego, Luis Ibáñez, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Herrera, Elba Llop, Laleman, Wim, Palazón Azorín, José María, Alonso, Jose Castellote, Gluud, Lise Lotte, Ferreira, Carlos Noronha, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Grønbæk, Henning, Hernandez Guerra, Manuel Nicolas, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan Gonzalez, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Catalina, María Vega, Albillos, Agustín, Rudler, Marika, Tapias, Edilmar Alvarado, Guardascione, Maria Anna, Tantau, Marcel, Schwarzer, Rémy, Reiberger, Thomas, Laursen, Stig Borbjerg, and Lopez-Gomez, Marta

Abstract

Background & Aims Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice for high-risk acute variceal bleeding (AVB; i.e., Child-Turcotte-Pugh [CTP] B8-9+active bleeding/C10-13). Nevertheless, some ‘non-high-risk’ patients have poor outcomes despite the combination of non-selective beta-blockers and endoscopic variceal ligation for secondary prophylaxis. We investigated prognostic factors for re-bleeding and mortality in ‘non-high-risk’ AVB to identify subgroups who may benefit from more potent treatments (i.e., TIPS) to prevent further decompensation and mortality. Methods A total of 2,225 adults with cirrhosis and variceal bleeding were prospectively recruited at 34 centres between 2011-2015; for the purpose of this study, case definitions and information on prognostic indicators at index AVB and on day 5 were further refined in low-risk patients, of whom 581 (without failure to control bleeding or contraindications to TIPS) who were managed by non-selective beta-blockers/endoscopic variceal ligation, were finally included. Patients were followed for 1 year. Results Overall, 90 patients (15%) re-bled and 70 (12%) patients died during follow-up. Using clinical routine data, no meaningful predictors of re-bleeding were identified. However, re-bleeding (included as a time-dependent co-variable) increased mortality, even after accounting for differences in patient characteristics (adjusted cause-specific hazard ratio: 2.57; 95% CI 1.43-4.62; p = 0.002). A nomogram including CTP, creatinine, and sodium measured at baseline accurately (concordance: 0.752) stratified the risk of death. Conclusion The majority of ‘non-high-risk’ patients with AVB have an excellent prognosis, if treated according to current recommendations. However, about one-fifth of patients, i.e. those with CTP ≥8 and/or high creatinine levels or hyponatremia, have a considerable risk of death within 1 year of the index, Background & Aims: Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice for high-risk acute variceal bleeding (AVB; i.e., Child-Turcotte-Pugh [CTP] B8-9+active bleeding/C10-13). Nevertheless, some ‘non-high-risk’ patients have poor outcomes despite the combination of non-selective beta-blockers and endoscopic variceal ligation for secondary prophylaxis. We investigated prognostic factors for re-bleeding and mortality in ‘non-high-risk’ AVB to identify subgroups who may benefit from more potent treatments (i.e., TIPS) to prevent further decompensation and mortality. Methods: A total of 2,225 adults with cirrhosis and variceal bleeding were prospectively recruited at 34 centres between 2011-2015; for the purpose of this study, case definitions and information on prognostic indicators at index AVB and on day 5 were further refined in low-risk patients, of whom 581 (without failure to control bleeding or contraindications to TIPS) who were managed by non-selective beta-blockers/endoscopic variceal ligation, were finally included. Patients were followed for 1 year. Results: Overall, 90 patients (15%) re-bled and 70 (12%) patients died during follow-up. Using clinical routine data, no meaningful predictors of re-bleeding were identified. However, re-bleeding (included as a time-dependent co-variable) increased mortality, even after accounting for differences in patient characteristics (adjusted cause-specific hazard ratio: 2.57; 95% CI 1.43-4.62; p = 0.002). A nomogram including CTP, creatinine, and sodium measured at baseline accurately (concordance: 0.752) stratified the risk of death. Conclusion: The majority of ‘non-high-risk’ patients with AVB have an excellent prognosis, if treated according to current recommendations. However, about one-fifth of patients, i.e. those with CTP ≥8 and/or high creatinine levels or hyponatremia, have a considerable risk of death within 1 year of the index bleed. Future clinical trials should

Published
2024

9. Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations

Author

Párniczky, Andrea, Lantos, Tamás, Tóth, Eszter Margit, Szakács, Zsolt, Gódi, Szilárd, Hágendorn, Roland, Illés, Dóra, Koncz, Balázs, Márta, Katalin, Mikó, Alexandra, Mosztbacher, Dóra, Németh, Balázs Csaba, Pécsi, Dániel, Szabó, Anikó, Szücs, Ákos, Varjú, Péter, Szentesi, Andrea, Darvasi, Erika, Erőss, Bálint, Izbéki, Ferenc, Gajdán, László, Halász, Adrienn, Vincze, Áron, Szabó, Imre, Pár, Gabriella, Bajor, Judit, Sarlós, Patrícia, Czimmer, József, Hamvas, József, Takács, Tamás, Szepes, Zoltán, Czakó, László, Varga, Márta, Novák, János, Bod, Barnabás, Szepes, Attila, Sümegi, János, Papp, Mária, Góg, Csaba, Török, Imola, Huang, Wei, Xia, Qing, Xue, Ping, Li, Weiqin, Chen, Weiwei, Shirinskaya, Natalia V., Poluektov, Vladimir L., Shirinskaya, Anna V., Hegyi, Péter Jenő, Bátovský, Marian, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Lopez-Diaz, Javier, Dominguez-Munoz, J. Enrique, Molero, Xavier, Pando, Elizabeth, Ruiz-Rebollo, María Lourdes, Burgueño-Gómez, Beatriz, Chang, Yu-Ting, Chang, Ming-Chu, Sud, Ajay, Moore, Danielle, Sutton, Robert, Gougol, Amir, Papachristou, Georgios I., Susak, Yaroslav Mykhailovych, Tiuliukin, Illia Olehovych, Gomes, António Pedro, Oliveira, Maria Jesus, Aparício, David João, Tantau, Marcel, Kurti, Floreta, Kovacheva-Slavova, Mila, Stecher, Stephanie-Susanne, Mayerle, Julia, Poropat, Goran, Das, Kshaunish, Marino, Marco Vito, Capurso, Gabriele, Małecka-Panas, Ewa, Zatorski, Hubert, Gasiorowska, Anita, Fabisiak, Natalia, Ceranowicz, Piotr, Kuśnierz-Cabala, Beata, Carvalho, Joana Rita, Fernandes, Samuel Raimundo, Chang, Jae Hyuck, Choi, Eun Kwang, Han, Jimin, Bertilsson, Sara, Jumaa, Hanaz, Sandblom, Gabriel, Kacar, Sabite, Baltatzis, Minas, Varabei, Aliaksandr Vladimir, Yeshy, Vizhynis, Chooklin, Serge, Kozachenko, Andriy, Veligotsky, Nikolay, and Hegyi, Péter

Published
2019
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10. Predicting survival in patients with ‘non-high-risk’ acute variceal bleeding receiving β-blockers+ligation to prevent re-bleeding

Author

Balcar, Lorenz, primary, Mandorfer, Mattias, additional, Hernández-Gea, Virginia, additional, Procopet, Bogdan, additional, Meyer, Elias Laurin, additional, Giráldez, Álvaro, additional, Amitrano, Lucio, additional, Villanueva, Candid, additional, Thabut, Dominique, additional, Samaniego, Luis Ibáñez, additional, Silva-Junior, Gilberto, additional, Martinez, Javier, additional, Genescà, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop Herrera, Elba, additional, Laleman, Wim, additional, Palazón Azorín, José María, additional, Castellote Alonso, Jose, additional, Gluud, Lise Lotte, additional, Noronha Ferreira, Carlos, additional, Cañete, Nuria, additional, Rodríguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose Luis, additional, Grønbæk, Henning, additional, Hernandez Guerra, Manuel Nicolas, additional, Sassatelli, Romano, additional, Dell'Era, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan Gonzalez, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Krag, Aleksander, additional, Nevens, Frederik, additional, Calleja, Jose Luis, additional, Jansen, Christian, additional, Vega Catalina, María, additional, Albillos, Agustín, additional, Rudler, Marika, additional, Tapias, Edilmar Alvarado, additional, Guardascione, Maria Anna, additional, Tantau, Marcel, additional, Schwarzer, Rémy, additional, Reiberger, Thomas, additional, Laursen, Stig Borbjerg, additional, Lopez-Gomez, Marta, additional, Cachero, Alba, additional, Ferrarese, Alberto, additional, Ripoll, Cristina, additional, La Mura, Vincenzo, additional, Bosch, Jaime, additional, and García-Pagán, Juan Carlos, additional

Published
2023
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11. Evaluating the Efficacy of Resect-and-Discard and Resect-and-Retrieve Strategies for Diminutive Colonic Polyps.

Author

Groza, Andrei Lucian, Miutescu, Bogdan, Tefas, Cristian, Popa, Alexandru, Ratiu, Iulia, Sirli, Roxana, Popescu, Alina, Motofelea, Alexandru Catalin, and Tantau, Marcel

Subjects
ADENOMATOUS polyps, POLYPS, LOGISTIC regression analysis, COLORECTAL cancer, COLON polyps, ODDS ratio
Abstract

Background and Objectives: Diminutive polyps present a unique challenge in colorectal cancer (CRC) prevention strategies. This study aims to assess the characteristics and variables of diminutive polyps in a Romanian cohort, intending to develop a combined resect-and-retrieve or resect-and-discard strategy that reduces the need for an optical diagnosis. Materials and Methods: A prospective cohort study was conducted at two endoscopy centers in Romania from July to December 2021. Adult patients undergoing colonoscopies where polyps were identified and resected were included. Endoscopic procedures employed advanced diagnostic features, including blue-light imaging (BLI) and narrow-band imaging (NBI). Logistic regression analysis was utilized to determine factors impacting the probability of adenomatous polyps with high-grade dysplasia (HGD). Results: A total of 427 patients were included, with a mean age of 59.42 years (±11.19), predominantly male (60.2%). The most common indication for a colonoscopy was lower gastrointestinal symptoms (42.6%), followed by screening (28.8%). Adequate bowel preparation was achieved in 87.8% of cases. The logistic regression analysis revealed significant predictors of HGD in adenomatous polyps: age (OR = 1.05, 95% CI: 1.01–1.08, p = 0.01) and polyp size (>5 mm vs. ≤5 mm, OR = 4.4, 95% CI: 1.94–10.06, p < 0.001). Polyps classified as Paris IIa, Ip, and Isp were significantly more likely to harbor HGD compared to the reference group (Is), with odds ratios of 6.05, 3.68, and 2.7, respectively. Conclusions: The study elucidates significant associations between the presence of HGD in adenomatous polyps and factors such as age, polyp size, and Paris classification. These findings support the feasibility of a tailored approach in the resect-and-discard and resect-and-retrieve strategies for diminutive polyps, potentially optimizing CRC prevention and intervention practices. Further research is warranted to validate these strategies in broader clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Multicenter Evaluation of Clinical Efficacy and Safety of Per-oral Endoscopic Myotomy in Children

Author

Choné, Adrien, Familiari, Pietro, von Rahden, Burkhard, Desai, Pankaj, Inoue, Haruhiro, Shimamura, Yuto, Eleftheriadis, Nikos, Yamashita, Kanefumi, Khashab, Mouen A., Shiwaku, Hinorari, Seewald, Stefan, Draganov, Peter V., Alvarez, Lybil B. Mendoza, Chaussade, Stanislas, Tantau, Marcel, Abraham, Mathew, Marks, Jeffrey, Arevalo, Gabriel, Albéniz, Eduardo, Mion, Francois, Roman, Sabine, Rivory, Jérôme, Dubois, Rémi, Lachaux, Alain, Benech, Nicolas, Subtil, Fabien, Ponchon, Thierry, Barret, Maximilien, and Pioche, Mathieu

Published
2019
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13. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, for the International Variceal Bleeding Observational Study Group; Baveno Cooperation, Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, and for the International Variceal Bleeding Observational Study Group; Baveno Cooperation

Abstract

[Background & Aims] Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis., [Methods] Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD., [Results] The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29–0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH., [Conclusions] Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

14. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, Genesca, Joan, Villagrasa, Ares, Hernandez-Gea, Virginia, Bataller, Ramon, Giraldez, Alvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibanez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J. M., Castellote, Jose, Rodrigues, Susana L., Gluud, Lise N., Ferreira, Carlos, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf L., Mundi, Jose, Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco G., Abraldes, Juan, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gomez, Manuel, Tantau, Marcel A., Guardascione, Maria, Alvarado, Edilmar, Rudler, Marika, Banares, Rafael, Martinez, Javier A., Robic, Marie, Jansen, Christian L., Calleja, Jose, Nevens, Frederik, Gluud, Lise Lotte, Bosch, Jaime, Ventura-Cots, Meritxell C., Garcia-Pagan, Juan, and Genesca, Joan

Abstract

Background & AimsAlcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. MethodsMulticentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. ResultsThe prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. ConclusionsContrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

15. Zenker’s peroral endoscopic myotomy for management of large Zenker’s diverticulum

Author

Zhang, Linda Y., additional, Hernández Mondragón, Oscar, additional, Pioche, Mathieu, additional, Steinway, Steven N., additional, Nieto, Jose, additional, Ujiki, Michael B., additional, VanDruff, Vanessa N., additional, Kim, Raymond E., additional, Canakis, Andrew, additional, Tantau, Marcel, additional, Tantau, Alina, additional, Pop, Anamaria, additional, Jacques, Jérémie, additional, Lajin, Michael, additional, Desai, Pankaj, additional, Shrigiriwar, Apurva, additional, Bejjani, Michael, additional, Kumta, Nikhil A., additional, and Khashab, Mouen A., additional

Published
2023
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19. Endoscopic diagnosis and management of esophagogastric variceal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

Gralnek, Ian M., additional, Camus Duboc, Marine, additional, Garcia-Pagan, Juan Carlos, additional, Fuccio, Lorenzo, additional, Karstensen, John Gásdal, additional, Hucl, Tomas, additional, Jovanovic, Ivan, additional, Awadie, Halim, additional, Hernandez-Gea, Virginia, additional, Tantau, Marcel, additional, Ebigbo, Alanna, additional, Ibrahim, Mostafa, additional, Vlachogiannakos, Jiannis, additional, Burgmans, Marc C., additional, Rosasco, Robyn, additional, and Triantafyllou, Konstantinos, additional

Published
2022
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20. Endoscopic diagnosis and management of esophagogastric variceal hemorrhage:European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

Gralnek, Ian M., Camus Duboc, Marine, Garcia-Pagan, Juan Carlos, Fuccio, Lorenzo, Karstensen, John Gásdal, Hucl, Tomas, Jovanovic, Ivan, Awadie, Halim, Hernandez-Gea, Virginia, Tantau, Marcel, Ebigbo, Alanna, Ibrahim, Mostafa, Vlachogiannakos, Jiannis, Burgmans, Marc C., Rosasco, Robyn, Triantafyllou, Konstantinos, Gralnek, Ian M., Camus Duboc, Marine, Garcia-Pagan, Juan Carlos, Fuccio, Lorenzo, Karstensen, John Gásdal, Hucl, Tomas, Jovanovic, Ivan, Awadie, Halim, Hernandez-Gea, Virginia, Tantau, Marcel, Ebigbo, Alanna, Ibrahim, Mostafa, Vlachogiannakos, Jiannis, Burgmans, Marc C., Rosasco, Robyn, and Triantafyllou, Konstantinos

Abstract

1: ESGE recommends that patients with compensated advanced chronic liver disease (ACLD; due to viruses, alcohol, and/or nonobese [BMI < 30 kg/m2] nonalcoholic steatohepatitis) and clinically significant portal hypertension (hepatic venous pressure gradient [HVPG] > 10 mmHg and/or liver stiffness by transient elastography > 25 kPa) should receive, if no contraindications, nonselective beta blocker (NSBB) therapy (preferably carvedilol) to prevent the development of variceal bleeding.Strong recommendation, moderate quality evidence. 2: ESGE recommends that in those patients unable to receive NSBB therapy with a screening upper gastrointestinal (GI) endoscopy that demonstrates high risk esophageal varices, endoscopic band ligation (EBL) is the endoscopic prophylactic treatment of choice. EBL should be repeated every 2-4 weeks until variceal eradication is achieved. Thereafter, surveillance EGD should be performed every 3-6 months in the first year following eradication.Strong recommendation, moderate quality evidence. 3: ESGE recommends, in hemodynamically stable patients with acute upper GI hemorrhage (UGIH) and no history of cardiovascular disease, a restrictive red blood cell (RBC) transfusion strategy, with a hemoglobin threshold of ≤ 70 g/L prompting RBC transfusion. A post-transfusion target hemoglobin of 70-90 g/L is desired.Strong recommendation, moderate quality evidence. 4 : ESGE recommends that patients with ACLD presenting with suspected acute variceal bleeding be risk stratified according to the Child-Pugh score and MELD score, and by documentation of active/inactive bleeding at the time of upper GI endoscopy.Strong recommendation, high quality of evidence. 5 : ESGE recommends the vasoactive agents terlipressin, octreotide, or somatostatin be initiated at the time of presentation in patients with suspected acute variceal bleeding and be continued for a duration of up to 5 days.Strong recommendation, high quality evidence. 6 : ESGE recommends an

Published
2022

21. ZENKER'S PERORAL ENDOSCOPIC MYOTOMY (Z-POEM) FOR MANAGEMENT OF LARGE ZENKER'S DIVERTICULUM

Author

Zhang, Linda Y., primary, Steinway, Steven N., additional, VanDruff, Vanessa N., additional, Pop, Anamaria, additional, Canakis, Andrew, additional, Bejjani, Michael, additional, Ujiki, Michael, additional, Pioche, Mathieu, additional, Kumta, Nikhil A., additional, Kim, Raymond E., additional, Tantau, Marcel, additional, Tantau, Alina, additional, Hernández Mondragón, Oscar V., additional, and Khashab, Mouen A., additional

Published
2022
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23. Angled-tip vs. straight-tip guidewire in ERCP: a randomized, multicenter study.

Author

Hausmann, Johanes, Lefa, Foteini, Filmann, Natalie, Eickhoff, Axel, Zeuzem, Stefan, Herrmann, Eva, Tantau, Marcel, and Albert, Jörg

Subjects
INTRAHEPATIC bile ducts, GALLSTONES, BILE ducts, TREATMENT effectiveness
Abstract

Endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay for interventional treatment of biliopancreatic diseases, and guidewires are decisive for successful treatment. A randomized, multicenter, open-label study was conducted in patients in whom a guidewire was required in ERCP. Success rate and duration of the investigation were evaluated by randomly applying hydrophilic guidewires with a straight tip (ST) or an angled tip (AT) configuration, with normal (type NF) or enhanced (type EF) flexibility. Randomization was stratified by indication, i.e., stricture of the intra-hepatic bile ducts, stricture of the extrahepatic bile ducts, obstruction by bile duct stones, or interventions involving the pancreas. Cross-over was allowed if the initially allocated guidewire did not result in treatment success. Four hundred fifty-three patients were included, and 422 were finally analyzed. In 363 procedures (86%), the initially allocated wirés use resulted in treatment success. The success rate for using a guidewire with an angled tip configuration was 87.5 vs. 79.9% in a straight tip configuration (p = 0.049), and in negotiating an intrahepatic stricture the success rate was 90.7 vs. 69.1%, respectively (p = 0.008). No significant differences were observed in other indications. Procedural duration time did not differ in between the treatment groups. ERCP guidewires with an angled tip were more frequently successful when compared to straight tipped wires and most successful in treating intrahepatic strictures. Guidewires with standard vs. enhanced tip flexibility showed equal success rates in all indications. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Romanian Guidelines for the Diagnosis and Treatment of GERD-induced Respiratory Manifestations

Author

Drug, Vasile Liviu, primary, Antoniu, Sabina, primary, Oana, Barboi Bogdana, primary, Arghir, Oana Cristina, primary, Bancila, Ion, primary, Bataga, Simona, primary, Brisc, Ciprian, primary, Cijevschi-Prelipcean, Cristina, primary, Ciocîrlan, Mihai, primary, Ciortescu, Irina, primary, David, Liliana, primary, Deleanu, Oana Claudia, primary, Diculescu, Mircea, primary, Dimitriu, Anca, primary, Dobru, Daniela, primary, Dumitru, Eugen, primary, Gheonea, Dan Ionut, primary, Gheorghe, Cristian, primary, Goldis, Adrian, primary, Jinga, Mariana, primary, Man, Milena, primary, Mateescu, Bogdan, primary, Manuc, Mircea, primary, Mihai, Catalina, primary, Mihaltan, Florin, primary, Mihaescu, Traian, primary, Nedelcu, Laurentiu, primary, Negreanu, Lucian, primary, Pop, Carmen Monica, primary, Rajnoveanu, Ruxandra, primary, Saftoiu, Adrian, primary, Seicean, Andrada, primary, Sporea, Ioan, primary, Stanciu, Carol, primary, Surdea-Blaga, Teodora, primary, Tantau, Marcel, primary, Todea, Doina, primary, Trifan, Anca Victorita, primary, Ulmeanu, Ruxandra, primary, Iov, Diana Elena, primary, and Dumitrascu, Dan Lucian, primary

Published
2022
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26. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramon, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, J M, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L, Ferreira, Carlos N, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria A, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martinez, Javier, Robic, Marie A, Jansen, Christian, Calleja, Jose L, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagan, Juan C, and Genescà, Joan

Subjects
alcohol, upper gastrointestinal bleeding, cirrhosis, alcohol-related hepatitis, 610 Medicine & health, abstinence
Abstract

BACKGROUND & AIMS Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis. METHODS Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. RESULTS The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29-0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. CONCLUSIONS Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2021
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31. Management of patients after failed peroral endoscopic myotomy: a multicenter study

Author

Ichkhanian, Yervant, additional, Assis, Daniella, additional, Familiari, Pietro, additional, Ujiki, Michael, additional, Su, Baily, additional, Khan, Sarah R., additional, Pioche, Mathieu, additional, Draganov, Peter V., additional, Cho, Joo young, additional, Eleftheriadis, Nikolas, additional, Barret, Maximilien, additional, Haji, Amyn, additional, Velanovich, Vic, additional, Tantau, Marcel, additional, Marks, Jeffrey M., additional, Bapaye, Amol, additional, Sedarat, Alireza, additional, Albeniz, Eduardo, additional, Bechara, Robert, additional, Kumta, Nikhil A., additional, Costamagna, Guido, additional, Perbtani, Yaseen B., additional, Patel, Mehul, additional, Sippey, Megan, additional, Korrapati, Sravan K., additional, Jain, Rishabh, additional, Estremera, Fermín, additional, El Zein, Mohamad H., additional, Brewer Gutierrez, Olaya I., additional, and Khashab, Mouen A., additional

Published
2020
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33. Impact of prior treatment on feasibility and outcomes of Zenker’s peroral endoscopic myotomy (Z-POEM)

Author

Sanaei, Omid, additional, Ichkhanian, Yervant, additional, Mondragón, Oscar V. Hernández, additional, Nieto, Jose, additional, Krishnan, Arunkumar, additional, Tantau, Marcel, additional, Tantau, Alina, additional, Desai, Pankaj N., additional, Ginsberg, Gregory G., additional, Saumoy, Monica, additional, Deshmukh, Ameya, additional, Attaar, Mikhail, additional, Farha, Jad, additional, Jovani, Manol, additional, Al-Ghamdi, Sarah S., additional, Ujiki, Michael, additional, and Khashab, Mouen A., additional

Published
2020
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37. Long-term outcomes of per-oral endoscopic myotomy in achalasia patients with a minimum follow-up of 4 years: a multicenter study

Author

Brewer Gutierrez, Olaya I., additional, Moran, Robert A., additional, Familiari, Pietro, additional, Dbouk, Mohamad H., additional, Costamagna, Guido, additional, Ichkhanian, Yervant, additional, Seewald, Stefan, additional, Bapaye, Amol, additional, Cho, Joo Young, additional, Barret, Maximilien, additional, Eleftheriadis, Nikolas, additional, Pioche, Mathieu, additional, Hayee, Bu' Hussain, additional, Tantau, Marcel, additional, Ujiki, Michael, additional, Landi, Rosario, additional, Invernizzi, Martina, additional, Yoo, In Kyung, additional, Roman, Sabine, additional, Haji, Amyn, additional, Hedberg, H. Mason, additional, Parsa, Nasim, additional, Mion, Francois, additional, Fayad, Lea, additional, Kumbhari, Vivek, additional, Agarwalla, Anant, additional, Ngamruengphong, Saowanee, additional, Sanaei, Omid, additional, Ponchon, Thierry, additional, and Khashab, Mouen A., additional

Published
2020
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39. OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., Stanley, Adrian J., Hernandez-Gea, Virginia, Procopet, Bogdan, Giraldez, Alvaro, Sanchez, Candido V., Thabut, Dominique, Ibanez-Samaniego, Luis, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, Jose M., Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Canete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L., Gronbaek, Henning, Hernandez-Guerra, Manuel, Sassatelli, Romano, Dellera, Alessandra, Senzolo, Marco, Abraldes, Juan, Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Jansen, Christian, Robic, Marie A., Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar A., Guardascione, Maria A., Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Garcia-Pagan, Juan C., and Krag, Aleksander

Published
2019
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40. Predictive factors of failure to control bleeding and 6-week mortality after variceal hemorrhage in liver cirrhosis - a tertiary referral center experience.

Author

Matei, Daniela, Crisan, Dana, Procopet, Bogdan, Groza, Ioana, Furnea, Bogdan, Levi, Cristina, and Tantau, Marcel

Subjects
CIRRHOSIS of the liver, ACUTE kidney failure, HEMORRHAGE, PROGNOSIS, MORTALITY, GASTROINTESTINAL hemorrhage
Abstract

Introduction: Mortality from variceal bleeding remains high despite the therapeutic progress in severe cirrhosis. Understanding the predictive factors of failure to control bleeding (FTB) and mortality will lead to better future therapies. Comorbidities are thought to be important prognostic factors for variceal bleeding. The aim of the study was to assess the factors associated with FTB and with 42-day mortality and to evaluate the influence of comorbidities on these patients' prognosis.Material and Methods: We prospectively included in the study all consecutive patients with cirrhosis and variceal bleeding presenting to the emergency room and we followed them up over 6 weeks. CirCom score and Charlson index were used for the assessment of comorbidities.Results: Of the 138 patients included in the study, 27 (19.5%) were considered to have FTB. Child C class (74.07% vs. 32.43%, p < 0.001), Meld score (20.5 vs. 16.00, p = 0.004) and creatinine level (1.04 vs. 0.81, p = 0.01) were associated with FTB, but only Child class was independently associated with FTB in multivariate analysis (OR = 2.94, p = 0.006). Mortality at 42 days (21.7%) was influenced by the severity of the disease assessed through Child class (76.66% vs. 30.55% - Child C, p < 0.001) and MELD score (21.00 vs. 16.00, p < 0.001). Creatinine level (1.00 vs. 0.7, p = 0.02) and acute kidney injury (26.66% vs. 7.40%, p = 0.009) were also prognostic factors for the 6-week mortality. Comorbidities did not influence the mortality (CirCom > 1 (16.7% vs. 21.3%, p = 0.76) or Charlson index > 4 (36% vs. 47.2%, p = 0.41).Conclusions: The severity of cirrhosis is an important prognostic factor for FTB and 42-day mortality. Identifying the factors associated with early mortality may help selecting patients needing more than conventional therapy. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Management of patients after failed peroral endoscopic myotomy: a multicenter study.

Author

Ichkhanian, Yervant, Assis, Daniella, Familiari, Pietro, Ujiki, Michael, Su, Baily, Khan, Sarah R., Pioche, Mathieu, Draganov, Peter V., Cho, Joo young, Eleftheriadis, Nikolas, Barret, Maximilien, Haji, Amyn, Velanovich, Vic, Tantau, Marcel, Marks, Jeffrey M., Bapaye, Amol, Sedarat, Alireza, Albeniz, Eduardo, Bechara, Robert, and Kumta, Nikhil A.

Subjects
ESOPHAGEAL surgery, RESEARCH, RESEARCH methodology, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, TREATMENT effectiveness, COMPARATIVE studies, SEVERITY of illness index, ESOPHAGEAL achalasia, ENDOSCOPY
Abstract

Background: Although peroral endoscopic myotomy (POEM) is highly effective for the management of achalasia, clinical failures may occur. The optimal management of patients who fail POEM is not well known. This study aimed to compare the outcomes of different management strategies in patients who had failed POEM.Methods: This was an international multicenter retrospective study at 16 tertiary centers between January 2012 and November 2019. All patients who underwent POEM and experienced persistent or recurrent symptoms (Eckardt score > 3) were included. The primary outcome was to compare the rates of clinical success (Eckardt score ≤ 3) between different management strategies. RESULTS : 99 patients (50 men [50.5 %]; mean age 51.4 [standard deviation (SD) 16.2]) experienced clinical failure during the study period, with a mean (SD) Eckardt score of 5.4 (0.3). A total of 29 patients (32.2 %) were managed conservatively and 70 (71 %) underwent retreatment (repeat POEM 33 [33 %], pneumatic dilation 30 [30 %], and laparoscopic Heller myotomy (LHM) 7 [7.1 %]). During a median follow-up of 10 (interquartile range 3 - 20) months, clinical success was highest in patients who underwent repeat POEM (25 /33 [76 %]; mean [SD] Eckardt score 2.1 [2.1]), followed by pneumatic dilation (18/30 [60 %]; Eckardt score 2.8 [2.3]), and LHM (2/7 [29 %]; Eckardt score 4 [1.8]; P = 0.12). A total of 11 patients in the conservative group (37.9 %; mean Eckardt score 4 [1.8]) achieved clinical success. CONCLUSION : This study comprehensively assessed an international cohort of patients who underwent management of failed POEM. Repeat POEM and pneumatic dilation achieved acceptable clinical success, with excellent safety profiles. [ABSTRACT FROM AUTHOR]

Published
2021
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42. Botulinum toxin for the treatment of hypercontractile esophagus: Results of a double-blind randomized sham-controlled study

Author

Choné, Adrien, Familiari, Pietro, von Rahden, Burkhard, Desai, Pankaj, Inoue, Haruhiro, Shimamura, Yuto, Eleftheriadis, Nikos, Yamashita, Kanefumi, Khashab, Mouen, Shiwaku, Hinorari, Seewald, Stefan, Draganov, Peter, Alvarez, Lybil, Chaussade, Stanislas, Tantau, Marcel, Abraham, Mathew, Marks, Jeffrey, Arevalo, Gabriel, Albéniz, Eduardo, Dubois, Rémi, Lachaux, Alain, Benech, Nicolas, Ponchon, Thierry, Barret, Maximilien, Mion, Francois, Marjoux, Sophie, Subtil, Fabien, Pioche, Mathieu, Rivory, Jérôme, Roman, Sabine, Zerbib, Frank, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Myotomy, Adult, Male, Physiology, medicine.medical_treatment, Achalasia, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, medicine, Humans, Esophageal Motility Disorders, Esophagus, Botulinum Toxins, Type A, ComputingMilieux_MISCELLANEOUS, Aged, [STAT.AP]Statistics [stat]/Applications [stat.AP], Endocrine and Autonomic Systems, business.industry, Gastroenterology, Middle Aged, medicine.disease, Botulinum toxin, Dysphagia, 3. Good health, medicine.anatomical_structure, Esophageal motility disorder, Neuromuscular Agents, 030220 oncology & carcinogenesis, Anesthesia, 030211 gastroenterology & hepatology, Female, medicine.symptom, business, [STAT.ME]Statistics [stat]/Methodology [stat.ME], medicine.drug
Abstract

Introduction Botulinum toxin injection is known to be efficient to treat achalasia. We conducted a randomized trial in order to evaluate its efficacy to treat symptomatic hypercontractile esophageal disorders as characterized by esophageal high-resolution manometry. Methods Patients with significant dysphagia and/or thoracic pain related to an hypercontractile esophageal motility disorder as defined by the Chicago Classification were randomized to receive an injection of botulinum toxin (100 U in 10 points in the distal part of the esophageal wall) or a sham procedure. Symptoms were assessed at 3 months with the Eckardt score. Patients could receive a first or second botulinum toxin injection 1 month later if symptoms persisted. Results Twenty-three patients (13 women, mean age 60 years) were included: 13 received botulinum toxin injection, and 10 a sham procedure. The improvement of symptoms at 3 months was significant compared to baseline, but similar in the active treatment and sham procedure arms. However, there was no change in quality of life scores. Seventeen patients received a second injection at 4 months. There was a significant trend toward improvement of symptoms up to the end of follow-up at 12 months, without a significant relationship with the administration of botulinum toxin. Discussion Botulinum toxin injection is not superior to a sham procedure to improve symptoms related to hypercontractile esophageal disorders, suggesting an important placebo effect in for this type of disease. This observation must be taken into account when evaluating more aggressive therapies such as endoscopic myotomy (clinicaltrials.gov: NCT01955174).

Published
2019
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43. SRED-ARCE Recommendations for Minimally Invasive Interventions During the COVID-19 Pandemic in Romania

Author

Saftoiu, Adrian, primary, Tomulescu, Victor, primary, Tantau, Marcel, primary, Gheorghe, Cristian, primary, Dumitru, Eugen, primary, Mateescu, Bogdan, primary, Negreanu, Lucian, primary, Jinga, Mariana, primary, Seicean, Andrada, primary, Ciocirlan, Mihai, primary, Drug, Vasile, primary, Manuc, Mircea, primary, Popescu, Razvan, primary, Tiu, Calin, primary, Bintintan, Vasile, primary, Calu, Valentin, primary, Turlin, Valeriu, primary, Turcu, Florin, primary, Zaharie, Florin, primary, Ulmeanu, Dan, primary, Brebu, Dan, primary, Nicolau, Alexandru, primary, Litescu, Mircea, primary, Diaconescu, Bogdan, primary, Duta, Ciprian, primary, and Copaescu, Catalin, primary

Published
2020
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45. Liver Stiffness Assessed by Ultrasound Shear Wave Elastography from General Electric Accurately Predicts Clinically Significant Portal Hypertension in Patients with Advanced Chronic Liver Disease

Author

Stefanescu, Horia, additional, Rusu, Corina, additional, Lupsor-Platon, Monica, additional, Nicoara Farcau, Oana, additional, Fischer, Petra, additional, Grigoras, Crina, additional, Horhat, Adelina, additional, Stancu, Oana, additional, Ardelean, Andreea, additional, Tantau, Marcel, additional, Badea, Radu, additional, and Procopet, Bogdan, additional

Published
2019
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46. Endoscopic sphincterotoMy for delayIng choLecystectomy in mild acute biliarY pancreatitis (EMILY study): protocol of a multicentre randomised clinical trial

Author

Kucserik, Levente Pál, primary, Márta, Katalin, additional, Vincze, Áron, additional, Lázár, György, additional, Czakó, László, additional, Szentkereszty, Zsolt, additional, Papp, Mária, additional, Palatka, Károly, additional, Izbéki, Ferenc, additional, Altorjay, Áron, additional, Török, Imola, additional, Barbu, Sorin, additional, Tantau, Marcel, additional, Vereczkei, András, additional, Bogár, Lajos, additional, Dénes, Márton, additional, Németh, Imola, additional, Szentesi, Andrea, additional, Zádori, Noémi, additional, Antal, Judit, additional, Lerch, Markus M, additional, Neoptolemos, John, additional, Sahin-Tóth, Miklós, additional, Petersen, Ole H, additional, Kelemen, Dezső, additional, and Hegyi, Péter, additional

Published
2019
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47. 468 INTERNATIONAL MULTICENTER STUDY ON THE MANAGEMENT OF PATIENTS AFTER FAILED PERORAL ENDOSCOPIC MYOTOMY (POEM)

Author

Assis, Daniella, primary, Brewer Gutierrez, Olaya I., additional, Sloan, Joshua A., additional, Albeniz, Eduardo, additional, Vosoughi, Kia, additional, CHO, JOO YOUNG, additional, Ichkhanian, Yervant, additional, Draganov, Peter V., additional, Perbtani, Yaseen B., additional, Familiari, Pietro, additional, Yang, Juliana, additional, Barret, Maximilien, additional, Runge, Thomas, additional, Pioche, Mathieu, additional, Sedarat, Alireza, additional, Marks, Jeffrey M., additional, Sippey, Megan, additional, AbiMansour, Jad P., additional, Ujiki, Michael, additional, Su, Bailey, additional, Bechara, Robert, additional, Tantau, Marcel, additional, Patel, Mehul, additional, Velanovich, Vic, additional, Parsa, Nasim, additional, Haji, Amyn, additional, Kumta, Nikhil A., additional, Bapaye, Amol, additional, Korrapati, Sravan K., additional, Jain, Rishabh, additional, El Zein, Mohamad H., additional, Meybodi, Mohamad Aghaie, additional, Eleftheriadis, Nikolas P., additional, and Khashab, Mouen A., additional

Published
2019
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48. 551 OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., primary, Stanley, Adrian J., additional, Hernandez-Gea, Virginia, additional, Procopet, Bogdan, additional, Giráldez, Alvaro, additional, Sanchez, Cándido V., additional, Thabut, Dominique, additional, Ibañez-Samaniego, Luís, additional, Martinez, Javier, additional, Genesca, Joan, additional, Bureau, Christophe, additional, Trebicka, Jonel, additional, Llop, Elba, additional, Laleman, Wim, additional, Palazon, Jose M., additional, Castellote, Jose, additional, Rodrigues, Susana, additional, Gluud, Lise L., additional, Ferreira, Carlos Noronha, additional, Barceló, Rafael, additional, Cañete, Nuria, additional, Rodriguez, Manuel, additional, Ferlitsch, Arnulf, additional, Mundi, Jose L., additional, Grønbæk, Henning, additional, Hernández-Guerra, Manuel, additional, Sassatelli, Romano, additional, Dellera, Alessandra, additional, Senzolo, Marco, additional, Abraldes, Juan, additional, Romero-Gómez, Manuel, additional, Zipprich, Alexander, additional, Casas, Meritxell, additional, Masnou, Helena, additional, Primignani, Massimo, additional, Nevens, Frederik, additional, Jansen, Christian, additional, Robic, Marie A., additional, Conejo, Irene, additional, Catalina, María-Vega, additional, Albillos, Agustin, additional, Rudler, Marika, additional, Alvarado, Edilmar A., additional, Guardascione, Maria A., additional, Tantau, Marcel, additional, Bosch, Jaime, additional, Torres, Ferran, additional, Garcia-Pagán, Juan C., additional, and Krag, Aleksander, additional

Published
2019
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50. THU-270-Severe alcoholic hepatitis has no influence on prognosis of variceal bleeding in patients with alcoholic cirrhosis

Author

Fischer, Petra, primary, Fodor, Andreea, additional, Horhat, Adelina, additional, Matei, Daniela, additional, Imbuzan, Maria, additional, Iuhasz, Ingrit, additional, Nicoara-Farcau, Oana, additional, Bumbu, Andreea, additional, Sparchez, Zeno, additional, Tantau, Marcel, additional, Stefanescu, Horia, additional, and Procopet, Bogdan, additional

Published
2019
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