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1. Gravity-assisted continuous flow peritoneal dialysis technique use in acute kidney injury in children: a randomized, crossover clinical trial

Author

Nourse, Peter, McCulloch, Mignon, Coetzee, Ashton, Bunchman, Tim, Picca, Stefano, Rusch, Jody, and Brooks, Andre

Subjects
Continuous ambulatory peritoneal dialysis -- Patient outcomes, Peritoneal dialysis -- Patient outcomes, Acute renal failure -- Risk factors -- Prevention, Children -- Health aspects, Ultrafiltration -- Health aspects, Health
Abstract

Background Our previously demonstrated continuous flow peritoneal dialysis (CFPD) technique in children with acute kidney injury (AKI), although effective, was manpower heavy and expensive due to the high-volume pumps required. The aim of this study was to develop and test a novel gravity-driven CFPD technique in children using readily available, inexpensive equipment and to compare this technique to conventional PD. Methods After development and initial in vitro testing, a randomised crossover clinical trial was conducted in 15 children with AKI requiring dialysis. Patients received both conventional PD and CFPD sequentially, in random order. Primary outcomes were measures of feasibility, clearance and ultrafiltration (UF). Secondary outcomes were complications and mass transfer coefficients (MTC). Paired t-tests were used to compare PD and CFPD outcomes. Results Median (range) age and weight of participants were 6.0 (0.2-14) months and 5.8 (2.3-14.0) kg, respectively. The CFPD system was easily and rapidly assembled. There were no serious adverse events attributed to CFPD. Mean ± SD UF was significantly higher on CFPD compared to conventional PD (4.3 ± 3.15 ml/kg/h vs. 1.04 ± 1.72 ml/kg/h; p < 0.001). Clearances for urea, creatinine and phosphate for children on CFPD were 9.9 ± 3.10 ml/min/1.73 m.sup.2, 7.9 ± 3.3 ml/min/1.73 m.sup.2 and 5.5 ± 1.5 ml/min/1.73 m.sup.2 compared to conventional PD with values of 4.3 ± 1.68 ml/min/1.73 m.sup.2, 3.57 ± 1.3 ml/min/1.73 m.sup.2 and 2.53 ± 0.85 ml/min/1.73 m.sup.2, respectively (all p < 0.001). Conclusion Gravity-assisted CFPD appears to be a feasible and effective way to augment ultrafiltration and clearances in children with AKI. It can be assembled from readily available non-expensive equipment. Graphical abstract, Author(s): Peter Nourse [sup.1] , Mignon McCulloch [sup.1] , Ashton Coetzee [sup.1] , Tim Bunchman [sup.2] , Stefano Picca [sup.3] , Jody Rusch [sup.4] , Andre Brooks [sup.5] , Hilton [...]

Published
2023
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2. Long-term Effects of Kidney Transplantation Compared With Dialysis on Intima–media Thickness in Children—Results From the 4C-T Study

Author

Grabitz, Carl, Sugianto, Rizky I., Doyon, Anke, Azukaitis, Karolis, Anarat, Ali, Bacchetta, Justine, Bayazit, Aysun K., Bulut, Ipek K., Caliskan, Salim, Canpolat, Nur, Duzova, Ali, Habbig, Sandra, Harambat, Jerome, Kiyak, Aysel, Longo, Germana, Obrycki, Lukasz, Paripovic, Dusan, Söylemezoğlu, Oğuz, Thurn-Valsassina, Daniela, Yilmaz, Alev, Shroff, Rukshana, Schaefer, Franz, Schmidt, Bernhard M.W., Melk, Anette, Cortina, Gerard, Arbeiter, Klaus, Dusek, Jiri, Harambat, Jerome, Ranchin, Bruno, Fischbach, Michel, Zaloszyc, Ariane, Querfeld, Uwe, Gellermann, Jutta, Habbig, Sandra, Liebau, Max, Galiano, Matthias, Büscher, Rainer, Gimpel, Charlotte, Kemper, Matthias, Oh, Jun, Melk, Anette, Thurn-Valassina, Daniela, Doyon, Anke, Wühl, Elke, Schaefer, Franz, John, Ulrike, Wygoda, Simone, Jeck, Nicola, Kranz, Birgitta, Wigger, Marianne, Mencarelli, Francesca, Lugani, Francesca, Testa, Sara, Montini, Giovanni, Morello, William, Vidal, Enrico, Benetti, Elisa, Murer, Luisa, Matteucci, Ciara, Picca, Stefano, Gesù, Ospedale Bambino, Jankauskiene, Augustina, Azukaitis, Karolis, Zurowska, Aleksandra, Zagozozon, Ilona, Drodz, Dorota, Urasinski, Tomasz, Litwin, Mieczyslaw, Niemirska, Anna, Obrycki, Lukasz, Szczepanska, Maria, Texeira, Ana, Peco-Antic, Amira, Paripovic, Dusan, Simonetti, Giacomo, Laube, Guido, Anarat, Ali, Bayazit, Aysun K., Yalcinkaya, Fatos, Baskin, Esra, Cakar, Nilgun, Soylemezoglu, Oguz, Duzova, Ali, Bilginer, Yelda, Erdogan, Hakan, Donmez, Osman, Balat, Ayse, Kiyak, Aysel, Caliskan, Salim, Canpolat, Nur, Civilibal, Mahmut, Candan, Cengiz, Emre, Sevinc, Yilmaz, Alev, Alpay, Harika, Ozcelik, Gul, Mir, Sevgi, Sözeri, Betul, Bulut, Ipek K., Aksu, Nejat, Yavascan, Onder, Tabel, Yilmaz, Ertan, Pelin, Yilmaz, Ebru, and Shroff, Rukshana

Published
2024
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5. Dialysis modalities for the management of pediatric acute kidney injury

Author

de Galasso, Lara, Picca, Stefano, and Guzzo, Isabella

Subjects
Acute renal failure -- Care and treatment, Hemodialysis -- Methods, Pediatric research -- Methods, Health
Abstract

Acute kidney injury (AKI) is an increasingly frequent complication among hospitalized children. It is associated with high morbidity and mortality, especially in neonates and children requiring dialysis. The different renal replacement therapy (RRT) options for AKI have expanded from peritoneal dialysis (PD) and intermittent hemodialysis (HD) to continuous RRT (CRRT) and hybrid modalities. Recent advances in the provision of RRT in children allow a higher standard of care for increasingly ill and young patients. In the absence of evidence indicating better survival with any dialysis method, the most appropriate dialysis choice for children with AKI is based on the patient's characteristics, on dialytic modality performance, and on the institutional resources and local practice. In this review, the available dialysis modalities for pediatric AKI will be discussed, focusing on indications, advantages, and limitations of each of them., Author(s): Lara de Galasso [sup.1] , Stefano Picca [sup.1] , Isabella Guzzo [sup.1] Author Affiliations: (1) grid.414125.7, 0000 0001 0727 6809, Division of Nephrology and Dialysis, Department of Pediatrics, Bambino [...]

Published
2020
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6. Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy

Author

Raina, Rupesh, Bedoyan, Jirair K., Lichter-Konecki, Uta, Jouvet, Philippe, Picca, Stefano, Mew, Nicholas Ah, Machado, Marcel C., Chakraborty, Ronith, Vemuganti, Meghana, Grewal, Manpreet K., Bunchman, Timothy, Sethi, Sidharth Kumar, Krishnappa, Vinod, McCulloch, Mignon, Alhasan, Khalid, Bagga, Arvind, Basu, Rajit K., Schaefer, Franz, Filler, Guido, and Warady, Bradley A.

Published
2020
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9. Primary Hyperoxaluria

Author

Picca, Stefano, Colombini, Elisa, Cochat, Pierre, Warady, Bradley A, editor, Schaefer, Franz, editor, and Alexander, Steven R., editor

Published
2017
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10. Acute dialysis in children: results of a European survey

Author

Guzzo, Isabella, de Galasso, Lara, Mir, Sevgi, Bulut, Ipek Kaplan, Jankauskiene, Augustina, Burokiene, Vilmanta, Cvetkovic, Mirjana, Kostic, Mirjana, Bayazit, Aysun Karabay, Yildizdas, Dincer, Schmitt, Claus Peter, Paglialonga, Fabio, Montini, Giovanni, Yilmaz, Ebru, Oh, Jun, Weber, Lutz, Taylan, Christina, Hayes, Wesley, Shroff, Rukshana, Vidal, Enrico, Murer, Luisa, Mencarelli, Francesca, Pasini, Andrea, Teixeira, Ana, Afonso, Alberto Caldas, Drozdz, Dorota, Schaefer, Franz, Picca, Stefano, and For the ESCAPE Network

Published
2019
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12. Effect of haemodiafiltration vs conventional haemodialysis on growth and cardiovascular outcomes in children – the HDF, heart and height (3H) study

Author

Shroff, Rukshana, Bayazit, Aysun, Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agbas, Ayse, Anarat, Ali, Aoun, Bilal, Bakkaloglu, Sevcan, Bhowruth, Devina, Borzych-Dużałka, Dagmara, Bulut, Ipek Kaplan, Büscher, Rainer, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Smith, Colette, Spasojevic, Brankica, Vidal, Enrico, Vondrák, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schaefer, Franz, and Schmitt, Claus Peter

Published
2018
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13. Chronic haemodialysis in small children: a retrospective study of the Italian Pediatric Dialysis Registry

Author

Paglialonga, Fabio, Consolo, Silvia, Pecoraro, Carmine, Vidal, Enrico, Gianoglio, Bruno, Puteo, Flora, Picca, Stefano, Saravo, Maria Teresa, Edefonti, Alberto, and Verrina, Enrico

Subjects
Hemodialysis -- Methods -- Physiological aspects -- Patient outcomes -- Research, Health
Abstract

Background Chronic haemodialysis (HD) in small children has not been adequately investigated. Methods This was a retrospective investigation of the use of chronic HD in 21 children aged Results The median age of the 21 children at start of HD was 11.4 [interquartile range (IQR) 6.2-14.6] months, and HD consisted mainly of haemodiafiltration for 3-4 h in [greater than or equal to]4 sessions/week. A total of 51 central venous catheters were placed, and the median survival of tunnelled and temporary lines was 349 and 31 days, respectively (p < 0.001). Eight children (38 %) showed evidence of central vein thrombosis. Although 19 % of patients received growth hormone and 63.6 % received enteral feeding, the weight and height of these patients remained suboptimal. During the HD period the haemoglobin level increased in all patients, but not to normal levels (from 8.5 to 9.6 g/dl) despite erythropoietin administration (503-600 U/kg/week). The hospitalisation rate was 1.94/patient-year. Seventeen patients underwent renal transplantation at a median age of 3.0 years. Four patients, all affected by severe comorbidities, died during follow-up (in 2 cases due to absence of a vascular access). The 5- and 10-year cumulative survival was 82.4 and 68.7 %, respectively. Conclusions Extracorporeal dialysis is feasible in children aged, Author(s): Fabio Paglialonga[sup.1] , Silvia Consolo[sup.1] , Carmine Pecoraro[sup.2] , Enrico Vidal[sup.3] , Bruno Gianoglio[sup.4] , Flora Puteo[sup.5] , Stefano Picca[sup.6] , Maria Teresa Saravo[sup.2] , Alberto Edefonti[sup.1] , Enrico [...]

Published
2016
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14. Continuous renal replacement therapy in children: fluid overload does not always predict mortality

Author

de Galasso, Lara, Emma, Francesco, Picca, Stefano, Di Nardo, Matteo, Rossetti, Emanuele, and Guzzo, Isabella

Subjects
Bone marrow transplantation -- Research -- Health aspects, Congenital heart defects -- Research -- Care and treatment, Renal replacement therapy -- Research -- Health aspects, Health
Abstract

Background Mortality among critically ill children requiring continuous renal replacement therapy (CRRT) is high. Several factors have been identified as outcome predictors. Many studies have specifically reported a positive association between the fluid overload at CRRT initiation and the mortality of critically ill pediatric patients. Methods This study is a retrospective single-center analysis including all patients admitted to the pediatric intensive care unit (PICU) of our hospital who received CRRT between 2000 and 2012. One hundred thirty-one patients were identified and subsequently classified according to primary disease. Survival rates, severity of illness and fluid balance differed among subgroups. The primary outcome was patient survival to PICU discharge. Results Overall survival to PICU discharge was 45.8 %. Based on multiple regression analysis, mortality was independently associated with onco-hematological disease [odds ratio (OR) 11.7, 95 % confidence interval (CI) 1.3-104.7; p = 0.028], severe multiple organ dysfunction syndrome (MODS) (OR 5.1, 95 % CI 1.7-15; p = 0.003) and hypotension (OR 11.6, 95 % CI 1.4-93.2; p = 0.021). In the subgroup analysis, a fluid overload (FO) of more than 10 % (FO>10 %) at the beginning of CRRT seems to be a negative predictor of mortality (OR 10.9, 95 % CI 0.78-152.62; p = 0.07) only in children with milder disease (renal patients). Due to lack of statistical power, the independent effect of fluid overload on mortality could not be analyzed in all subgroups of patients. Conclusions In children treated with CRRT the underlying diagnosis and severity of illness are independent risk factors for mortality. The degree of FO is a negative predictor only in patients with milder disease., Author(s): Lara de Galasso[sup.1] , Francesco Emma[sup.2] , Stefano Picca[sup.2] , Matteo Di Nardo[sup.3] , Emanuele Rossetti[sup.3] , Isabella Guzzo[sup.2] Author Affiliations: (1) Nephrology and Dialysis A Unit, 'Sapienza' University [...]

Published
2016
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15. Short-term survival of hyperammonemic neonates treated with dialysis

Author

Picca, Stefano, Dionisi-Vici, Carlo, Bartuli, Andrea, De Palo, Tommaso, Papadia, Francesco, Montini, Giovanni, Materassi, Marco, Donati, Maria Alice, Verrina, Enrico, Schiaffino, Maria Cristina, Pecoraro, Carmine, Iaccarino, Emilia, Vidal, Enrico, Burlina, Alberto, and Emma, Francesco

Subjects
Hemodialysis -- Comparative analysis -- Health aspects, Hyperammonemia -- Research -- Care and treatment -- Diagnosis -- Patient outcomes, Peritoneal dialysis -- Comparative analysis -- Health aspects, Health
Abstract

Background In severe neonatal hyperammonemia, extracorporeal dialysis (ECD) provides higher ammonium clearance than peritoneal dialysis (PD). However, there are limited outcome data in relation to dialysis modality. Methods Data from infants with hyperammonemia secondary to inborn errors of metabolism (IEM) treated with dialysis were collected in six Italian centers and retrospectively analyzed. Results Forty-five neonates born between 1990 and 2011 were enrolled in the study. Of these, 23 were treated with PD and 22 with ECD (14 with continuous venovenous hemodialysis [CVVHD], 5 with continuous arteriovenous hemodialysis [CAVHD], 3 with hemodialysis [HD]). Patients treated with PD experienced a shorter duration of predialysis coma, while those treated with HD had a shorter ammonium decay time compared with all the other patients (p < 0.05). No difference in ammonium reduction rate was observed between patients treated with PD, CAVHD or CVVHD. Carbamoyl phosphate synthetase deficiency (CPS) was significantly associated with increased risk of death (OR: 9.37 [1.52-57.6], p = 0.016). Predialysis ammonium levels were significantly associated with a composite end-point of death or neurological sequelae (adjusted OR: 1.13 [1.02-1.27] per 100 [mu]mol/l, p = 0.026). No association was found between outcome and dialysis modality. Conclusions In this study, a delayed ECD treatment was not superior to PD in improving the short-term outcome of neonates with hyperammonemia secondary to IEM. Electronic supplementary material The online version of this article (doi:10.1007/s00467-014-2945-x) contains supplementary material, which is available to authorized users, Author(s): Stefano Picca[sup.1] , Carlo Dionisi-Vici[sup.2] , Andrea Bartuli[sup.3] , Tommaso De Palo[sup.4] , Francesco Papadia[sup.5] , Giovanni Montini[sup.6] , Marco Materassi[sup.7] , Maria Alice Donati[sup.8] , Enrico Verrina[sup.9] , [...]

Published
2015
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28. Contributors

Author

Abaterusso, Cataldo, primary, Ahern, Stéphane P., additional, Aisa, Maria Cristina, additional, Albright, Robert C., additional, Alfaro, Vicente, additional, Al-Khafaji, Ali, additional, Allo, Jean-Christophe, additional, Amerling, Richard, additional, Amore, Alessandro, additional, Anderson, Robert J., additional, Andreucci, Michele, additional, Andreucci, Vittorio E., additional, Andrikos, Emilios, additional, Arroyo, Vicente, additional, Arthur, John M., additional, Ash, Stephen R., additional, Assanelli, Emilio, additional, Aucella, Filippo, additional, Bagshaw, Sean M., additional, Balafa, Olga, additional, Balbi, André Luís, additional, Baldwin, Ian, additional, Ballestri, Marco, additional, Bargman, Joanne M., additional, Barletta, Gina-Marie, additional, Barletta, Jeffrey F., additional, Barozzi, Libero, additional, Barsoum, Rashad S., additional, Beaulieu, Monica, additional, Beer-Stolz, Donna, additional, Bellomo, Rinaldo, additional, Bernardo, Jose, additional, Bertolotto, Michele, additional, Bestoso, John T., additional, Betro, Gerard A., additional, Bhattacharya, Mallar, additional, Bihl, Geoffrey R., additional, Blot, Stijn I., additional, Boer, Willem, additional, Boim, Mirian A., additional, Bonello, Monica, additional, Bonventre, Joseph V., additional, Booth, A.D., additional, Bourke, Edmund, additional, Braitberg, George, additional, Brancaccio, Diego, additional, Brendolan, Alessandra, additional, Brezzi, Brigida, additional, Brodie, James C., additional, Brophy, Patrick D., additional, Brown, Ryan, additional, Bucala, Richard, additional, Buckmaster, Jonathan, additional, Budisavljevic, Milos N., additional, Bunchman, Timothy E., additional, Burdmann, Emmanuel A., additional, Bussolati, Benedetta, additional, Butkus, Matthew A., additional, Buzzelli, Daniela, additional, Calzavacca, Paolo, additional, Camussi, Giovanni, additional, Canaud, Bernard, additional, Cano, Noël J.M., additional, Cantaluppi, Vincenzo, additional, Capasso, Giovambattista, additional, Cappelli, Gianni, additional, Carlesso, Eleonora, additional, Casino, Francesco G., additional, Castillo, Leticia, additional, Cerutti, Roberta, additional, Chawla, Lakhmir S., additional, Chionh, Chang Yin, additional, Chiu, Alexander, additional, Chow, May T., additional, Chugh, Kirpal S., additional, Cianciaruso, Bruno, additional, Cignarelli, Mauro, additional, Claessens, Yann-Erick, additional, Clark, John A., additional, Clark, William R., additional, Cohen, David J., additional, Cohen, Scott D., additional, Constable, Peter, additional, Coppo, Rosanna, additional, Corey, Howard E., additional, Cozzolino, Mario, additional, Craig, Maureen, additional, Cramer, Carl H., additional, Crandall, Mark, additional, Cravedi, Paolo, additional, Crepaldi, Carlo, additional, Crew, R. John, additional, Cronin, Donald F., additional, Cruz, Dinna N., additional, Canton, Antonio Dal, additional, Dan, Maurizio, additional, D'Angelo, Angela, additional, Davenport, Andrew, additional, Davies, Andrew R., additional, Dear, James W., additional, Gasperi, Andrea De, additional, Dell'Aquila, Roberto, additional, Rocca, Giorgio Della, additional, Prete, Dorella Del, additional, Delude, Russell L., additional, Depner, Thomas, additional, Derchi, Lorenzo E., additional, Devarajan, Prasad, additional, Waele, Jan J. De, additional, Dhainaut, Jean-François, additional, Diaz-Buxo, José A., additional, Micco, Lucia Di, additional, Divino-Filho, José Carolina, additional, Doernberg, Sarah, additional, Doig, Gordon S., additional, Dries, David J., additional, Drudi, Francesco Maria, additional, Druml, Wilfred, additional, Duke, Graeme, additional, Durward, Andrew, additional, Egi, Moritoki, additional, Esposito, Ciro, additional, Evenepoel, Pieter, additional, Faga, Teresa, additional, Fan, Sheung Tat, additional, Feinfeld, Donald A., additional, Féraille, Eric, additional, Fernández, Javier, additional, Finfer, Simon, additional, Fink, Mitchell P., additional, Finkel, Kevin W., additional, Flessner, Michael F., additional, Formica, Marco, additional, Forni, Lui G., additional, Fortenberry, James D., additional, French, Craig, additional, Fumagalli, Roberto, additional, Furlanut, Mario, additional, Fute, Micheline Djouguela, additional, Gabriel, Daniela Ponce, additional, Galassi, Andrea, additional, Galbusera, Miriam, additional, Galli, Francesco, additional, Galli, Giovanni, additional, Gallieni, Maurizio, additional, Gallo, Giampiero, additional, Gambaro, Giovanni, additional, Gammill, Hilary S., additional, Gangemi, Ezio Nicola, additional, Gao, Dayong, additional, Garwood, Susan, additional, Garzotto, Francesco, additional, Gatti, Antonietta M., additional, Gattinoni, Luciano, additional, Geibel, John P., additional, George, Stephen, additional, Gesualdo, Loreto, additional, Gibney, R.T. Noel, additional, Gipson, Debbie S., additional, Glezerman, Ilya G., additional, Glorieux, Griet, additional, Goldstein, Stuart L., additional, Golper, Thomas A., additional, Gowrishankar, Manjula, additional, Grandi, Fabio, additional, Gregoretti, Cesare, additional, Grinnell, Brian W., additional, Groeneveld, A.B. Johan, additional, Gruber, Steven J., additional, Guadagni, Gualtiero, additional, Gunnerson, Kyle J., additional, Gupta, Akanksha, additional, Gura, Victor, additional, Guzzo, Isabella, additional, Hackbarth, Richard, additional, Halperin, Mitchell L., additional, Harbord, Nikolas, additional, Haymann, Jean-Philippe, additional, Heffner, Alan C., additional, Hennessy, Anthony J., additional, Heyman, Samuel N., additional, Hill, Graham L., additional, Hilton, Philip J., additional, Himmelfarb, Jonathan, additional, Hirasawa, Hiroyuki, additional, Hoenich, Nicholas A., additional, Holdsworth, Stephen R., additional, Holley, Anthony, additional, Honoré, Patrick M., additional, Hoste, Eric A.J., additional, House, Andrew A., additional, Huang, David T., additional, Huang, Zhongping, additional, Hubmayr, Rolf D., additional, Hughes, Alun D., additional, Humes, H. David, additional, Ikizler, T. Alp, additional, Imberti, Barbara, additional, Ing, Todd S., additional, Jaber, Bertrand L., additional, Janvier, Gérard, additional, Jeyabalan, Arundhathi, additional, Jha, Vivekanand, additional, Joannes-Boyau, Olivier, additional, Joannidis, Michael, additional, Jones, Daryl A., additional, Jörres, Achim, additional, Kamel, Kamel S., additional, Kamp, Ryan C., additional, Kannan, Neeta, additional, Kaplan, Lewis J., additional, Karacan, Özgür, additional, Karajala-Subramanyam, Vijay, additional, Kaushal, Gur P., additional, Kellum, John A., additional, Kemper, Markus J., additional, Khan, Asjad, additional, Khanna, Ramesh, additional, Kher, Vijay, additional, Kimmel, Paul L., additional, Kindgen-Milles, Detlef, additional, Kitching, A. Richard, additional, Kjellstrand, Carl M., additional, Kohn, Orly F., additional, Kooienga, Laura A., additional, Kooman, Jeroen P., additional, Kotanko, Peter, additional, Krediet, Raymond T., additional, Kroon, A.A., additional, Kuang, Dingwei, additional, Kuhlmann, Martin K., additional, Kuiper, Jan Willem, additional, Lam, Man-Fai, additional, Lamacchia, Olga, additional, Lameire, Norbert, additional, Langenberg, Christoph, additional, Lauri, Gianfranco, additional, Leblanc, Martine, additional, Ledebo, Ingrid, additional, Lentini, Paolo, additional, Leonard, Edward F., additional, Letteri, Jeffrey J., additional, Leunissen, Karel M., additional, Leverve, Xavier M., additional, Levin, Adeera, additional, Leypoldt, John K., additional, Liangos, Orfeas, additional, Licari, Elisa, additional, Lieberthal, Wilfred, additional, Linden, Peter K., additional, Lipman, Jeffrey, additional, Liu, Kathleen D., additional, Liu, Shiguang, additional, Livigni, Sergio, additional, Lo, Wai-Kei, additional, Lugano, Manuela, additional, Lui, Sing-Leung, additional, Lupo, Antonio, additional, Luyckx, Valerie A., additional, Macias, William L., additional, Madden, Nicholas, additional, Madore, François, additional, Majors, Daniel S., additional, Mancini, Elena, additional, Mangione, Filippo, additional, Mankad, Sunil, additional, Manzini, Pier Paolo, additional, Marangella, Martino, additional, Marenzi, Giancarlo, additional, Mariano, Filippo, additional, Marik, Paul E., additional, Marini, John J., additional, Marquis, François, additional, Marshall, John C., additional, Marshall, Mark R., additional, Mathew, Roy, additional, Matsuda, Kenichi, additional, Matthay, Michael A., additional, Maxvold, Norma J., additional, May, Clive N., additional, McCauley, Jerry, additional, McCunn, Maureen, additional, McKenna, Joseph, additional, Mehta, Ravindra L., additional, Mele, Caterina, additional, Merouani, Aicha, additional, Mesnard, Laurent, additional, Messa, Piergiorgio, additional, Metnitz, Philipp G.H., additional, Misra, Madhukar, additional, Mitzner, Steffen R., additional, Mizock, Barry A., additional, Mokhlesi, Babak, additional, Molitoris, Bruce A., additional, Morelli, Andrea, additional, Morgan, Thomas John, additional, Morigi, Marina, additional, Mount, Peter, additional, Mucelli, Roberto Pozzi, additional, Mueller, Bruce A., additional, Murray, Patrick, additional, Murugan, Raghavan, additional, Nakamura, Masataka, additional, Nalesso, Federico, additional, Nester, Carla M., additional, Nissenson, Allen, additional, Nolph, Karl, additional, Ocampo, Catalina, additional, Oda, Shigeto, additional, Okusa, Mark D., additional, Opal, Steven M., additional, Opdam, Helen, additional, Osswald, Hartmut, additional, Straaten, Heleen M. Oudemans–van, additional, Padalino, Massimo A., additional, Paden, Matthew L., additional, Paganini, Emil P., additional, Palevsky, Paul M., additional, Panat, Mani John, additional, Paolini, Francesco, additional, Parikh, Dipen, additional, Patroniti, Nicolò, additional, Pavlica, Pietro, additional, de La Garanderie, Didier Payen, additional, Pea, Federico, additional, Peng, Zhiyong, additional, Perazella, Mark A., additional, Perego, Angelo F., additional, Pereira, Estela Regina, additional, Pérez, Evans R. Fernández, additional, Perico, Norberto, additional, Pertica, Nicoletta, additional, Pertosa, Giovanni, additional, Peruzzi, Licia, additional, Petras, Dimitris, additional, Pham, Phuong-Chi, additional, Pham, Phuong-Thu, additional, Phoon, Richard K.S., additional, Picca, Stefano, additional, Piccinni, Pasquale, additional, Pinsk, Maury N., additional, Pinsky, Michael R., additional, Piroddi, Marta, additional, Plamondon, Isabelle, additional, Plank, Lindsay D., additional, Plötz, Frans B., additional, Poghosyan, Lusine, additional, Polanco, Natalia, additional, Polanco, Patricio M., additional, Polaschegg, Hans Dietrich, additional, Ponikvar, Rafael, additional, Porecca, Silvia, additional, Portilla, Didier, additional, Powell, T. Brian, additional, Quigley, Raymond, additional, Rabb, Hamid, additional, Ragaller, Maximilian, additional, Rampino, Teresa, additional, Ranpuria, Reena, additional, Rastogi, Anjay, additional, Ratanarat, Ranistha, additional, Raza, Naem, additional, Reade, Michael C., additional, Reeves, John H., additional, Reiter, Karl, additional, Remuzzi, Giuseppe, additional, Ricci, Zaccaria, additional, Ricksten, Sven-Erik, additional, Ridel, Christophe, additional, Rifai, Kinan, additional, Ring, Troels, additional, Riopel, Julie, additional, Rocha, Eduardo, additional, Roessler, Eric, additional, Rona, Roberto, additional, Ronco, Claudio, additional, Rondeau, Eric, additional, Rosen, Seymour, additional, Rosenberger, Christian, additional, Rowan, Shane, additional, Roy, Thomas, additional, Saab, Georges, additional, Sadahiro, Tomohito, additional, Sala, Carla, additional, Sala, Chiara, additional, Salama, Alan D., additional, Salmon, Adrian, additional, Salvatori, Gabriela, additional, Sam, Ramin, additional, Sandoval, Ruben M., additional, Santoro, Antonio, additional, Saotome, Takao, additional, Sappington, Penny L., additional, Sarma, J. Vidya, additional, Savige, Judy, additional, Schena, Francesco Paolo, additional, Schepers, Eva, additional, Schetz, Miet, additional, Schmidt, Gregory A., additional, Schor, Nestor, additional, Schusterschitz, Nicola, additional, Segoloni, Giuseppe, additional, Shah, Nirva, additional, Shah, Shamik H., additional, Shah, Sudhir V., additional, Sharfuddin, Asif A., additional, Shaw, Andrew, additional, Shiga, Hidetoshi, additional, Shoji, Hisataka, additional, Shukla, Ashutosh, additional, Simpson, Fiona, additional, Singbartl, Kai, additional, Singer, Mervyn, additional, Solez, Kim, additional, Sowinski, Kevin M., additional, Stafford-Smith, Mark, additional, Stange, Jan, additional, Stefanelli, Luca, additional, Stein, Deborah M., additional, Stella, Maurizio, additional, Stellin, Giovanni, additional, Story, David A., additional, Subramanian, Sanjay, additional, Swärd, Kristina, additional, Symons, Jordan M., additional, Tai, Kian Bun, additional, Tattersall, James, additional, Tedeschi, Luisa, additional, Teitelbaum, Isaac, additional, Teixeira, Vicente P. Castro, additional, Tetta, Ciro, additional, Thakar, Charuhas V., additional, Theilen, Hermann, additional, Thomas, Karl W., additional, Tolwani, Ashita, additional, Trepiccione, Francesco, additional, Triolo, Giorgio, additional, Tsang, Jennifer L.Y., additional, Tutal, Emre, additional, Uchino, Shigehiko, additional, Unruh, Mark, additional, Vail, G. Matthew, additional, Valentino, Massimo, additional, Vallon, Volker, additional, Van Biesen, Wim, additional, van der Sande, Frank M., additional, Vandijck, Dominique M., additional, Vanholder, Raymond, additional, Varghese, Sanju A., additional, Venkataraman, Ramesh, additional, Venkatesh, Bala, additional, Verbine, Anton, additional, Vincent, Jean-Louis, additional, Vinsonneau, Christophe, additional, Visvanathan, Ravindran, additional, Voinescu, Alexandra, additional, Walters, Scott, additional, Wan, Li, additional, Ward, Peter A., additional, Ward, Richard A., additional, Warrillow, Stephen, additional, Webb, Steve, additional, Whitlow, Kenneth Scott, additional, Wieslander, Anders, additional, Wilkinson, Alan H., additional, Wille, Keith, additional, Winchester, James Frank, additional, Wu, Christine, additional, Yassin, James, additional, Yeun, Jane Y., additional, Yip, Terence Pok-Siu, additional, Yu, Alex W., additional, Zacchia, Miriam, additional, Zaida, Najam, additional, Zamperetti, Nereo, additional, Zappitelli, Michael, additional, and Zarbock, Alexander, additional

Published
2009
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29. Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment

Author

Cochat, Pierre, Hulton, Sally-Anne, Acquaviva, Cécile, Danpure, Christopher J., Daudon, Michel, De Marchi, Mario, Fargue, Sonia, Groothoff, Jaap, Harambat, Jérôme, Hoppe, Bernd, Jamieson, Neville V., Kemper, Markus J., Mandrile, Giorgia, Marangella, Martino, Picca, Stefano, Rumsby, Gill, Salido, Eduardo, Straub, Michael, and van Woerden, Christiaan S.

Published
2012
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31. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Mir, Sevgi, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Smith, Michelle, Klaus, Guenter, Ardissino, Gianluigi, Testa, Sara, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Peruzzi, Licia, Arbeiter, Klaus, Jankauskiene, Augustina, Grenda, Ryszard, Litwin, Mieczyslaw, Neuhaus, Thomas J., Fang, Zhiyin, Dusek, Jiri, Matteucci, Chiara, Azukaitis, Karolis, Picca, Stefano, Ju, Wenjun, Thurn-Valsassina, Daniela, Kirchner, Marietta, Wigger, Marianne, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Vidal, Enrico, TABEL, YILMAZ, Gimpel, Charlotte, ERTAN, PELİN, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Rosales, Alejandra, Zaloszyc, Ariane, Gellermann, Jutta, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Murer, Luisa, Drozdz, Dorota, Coppo, Rosanna, Lugani, Francesca, Zurowska, Aleksandra, Zaniew, Marcin, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Bayazit, Aysun, DÜZOVA, ALİ, BİLGİNER, YELDA, ÇALIŞKAN, Salim, CANPOLAT, Nur, Civilibal, Mahmut, Shroff, Rukshana, Soezeri, Betul, Kranz, Brigitta, Mencarelli, Francesca, Dorn, Brigitte, Nair, Viji, Yalcinkaya, Fatos, Baskin, Esra, Cakar, Nilgun, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Alpay, Harika, Rachin, Bruno, Szczepanska, Maria, Erdogan, Hakan, DÖNMEZ, OSMAN, Balat, Ayse, Aksu, Nejat, Tabel, Yilmaz, Ertan, Pelin, Yilmaz, Ebru, Bakkaloglu, Aysin, ÖZALTIN, FATİH, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Fydryk, Janusz, Urasinski, Tomasz, KARABAY BAYAZIT, AYSUN, Niemirska, Anna, KAPLAN BULUT, İPEK, Paripovic, Dusan, Harambat, Jerome, ÇAKAR, NİLGÜN, ALPAY, HARİKA, Çukurova Üniversitesi, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı., Dönmez, Osman, AAA-8778-2021, Clinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Department of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, United States, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany, Department of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany, Department of Pediatric Nephrology, Cukurova University, Adana, Turkey, Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children`s Memorial Health Institute, Warsaw, Poland, Department of Pediatric Nephrology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Ankara University, Ankara, Turkey, Department of Pediatric Nephrology, University Children's Hospital, Belgrade, Serbia, Department of Pediatrics, Bordeaux University Hospital, Bordeaux, France, Department of Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey, Division of Nephrology, Dialysis, Transplantation, University of Genoa, G. Gaslini Institute, Genoa, Italy, Pediatric Nephrology Unit, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, Department of Pediatric Nephrology, Haseki Educational and Research Hospital, Istanbul, Turkey, Department of Pediatric Nephrology, Bursa Yuksek Ihtisas Teaching and Researching Hospital, Bursa, Turkey, Pediatric Nephrology, Charité Children's Hospital, Berlin, Germany, Pediatric Nephrology, Dialysis and Transplantation Unit, Department of Woman's and Child's Health, University-Hospital of Padova, Padova, Italy, Department of Pediatric Nephrology, Faculty of Medicine, İnönü University, Malatya, Turkey, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Department of Pediatric Nephrology, Celal Bayar University, Manisa, Turkey, Department of Pediatric Nephrology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey, Department of Pediatric Nephrology, Charité University, Berlin, Germany, and Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany

Subjects
Male, 0301 basic medicine, Chronic kidney failure, Physiology, Protein function, Medizin, 030232 urology & nephrology, Comorbidity, Urine, urologic and male genital diseases, Gastroenterology, 0302 clinical medicine, Pathology, Urology & nephrology, Estimated glomerular filtration rate, Disease course, pediatric CKD, Child, Priority journal, Kidney, female genital diseases and pregnancy complications, CKD progression, chronic kidney disease, epidermal growth factor, 3. Good health, Risk-factors, Proteinuria, medicine.anatomical_structure, Nephrology, Systolic blood pressure, Glomerulus filtration rate, Biomarker (medicine), Female, Glomerular filtration rate, Cohort analysis, Age factors, Human, medicine.medical_specialty, Adolescent, Urinary system, Excretion, Predictive value, Renal function, Follow-up studies, Major clinical study, Urinalysis, Pathophysiology, Article, Roles, 03 medical and health sciences, Age, Internal medicine, Post-hoc analysis, medicine, Humans, Predictive value of tests, Post hoc analysis, Renal insufficiency, chronic, Prospective study, Disease exacerbation, Egf, Disease progression, Renal replacement therapy, business.industry, Follow up, medicine.disease, Glomerulopathy, Chronic Kidney Failure, Kidney Diseases, Young-adults, Biological marker, 030104 developmental biology, Risk factors, Risk factor, Prediction, business, Prospective studies, Controlled study, Biomarkers, Kidney disease
Abstract

PubMedID: 31005273 Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6–17 years with baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m2. uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for

Published
2019

32. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study

Author

Shroff, Rukshana, Smith, Colette, Ranchin, Bruno, Bayazit, Aysun K., Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agbas, Ayse, Aitkenhead, Helen, Anarat, Ali, Aoun, Bilal, Aofolaju, Daley, Bakkaloglu, Sevcan Azime, Bhowruth, Devina, Borzych-Duzalka, Dagmara, Bulut, Ipek Kaplan, Buescher, Rainer, Deanfield, John, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish D., Spasojevic, Brankica, Stronach, Lynsey, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schmitt, Claus Peter, Schaefer, Franz, Shroff, Rukshana, Smith, Colette, Ranchin, Bruno, Bayazit, Aysun K., Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agbas, Ayse, Aitkenhead, Helen, Anarat, Ali, Aoun, Bilal, Aofolaju, Daley, Bakkaloglu, Sevcan Azime, Bhowruth, Devina, Borzych-Duzalka, Dagmara, Bulut, Ipek Kaplan, Buescher, Rainer, Deanfield, John, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish D., Spasojevic, Brankica, Stronach, Lynsey, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schmitt, Claus Peter, and Schaefer, Franz

Abstract

Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher 2-microglobulin. The HDF cohort had lower 2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required.

Published
2019

33. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Azukaitis, Karolis, Ju, Wenjun, Kirchner, Marietta, Nair, Viji, Smith, Michelle, Fang, Zhiyin, Thurn-Valsassina, Daniela, Bayazit, Aysun, Niemirska, Anna, Canpolat, Nur, Bulut, Ipek Kaplan, Yalcinkaya, Fatos, Paripovic, Dusan, Harambat, Jerome, Cakar, Nilgun, Alpay, Harika, Lugani, Francesca, Mencarelli, Francesca, Civilibal, Mahmut, Erdogan, Hakan, Gellermann, Jutta, Vidal, Enrico, Tabel, Yilmaz, Gimpel, Charlotte, Ertan, Pelin, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Arbeiter, Klaus, Rosales, Alejandra, Dusek, Jiri, Zaloszyc, Ariane, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Wigger, Marianne, Testa, Sara, Murer, Luisa, Matteucci, Chiara, Jankauskiene, Augustina, Drozdz, Dorota, Zurowska, Aleksandra, Zaniew, Marcin, Litwin, Mieczyslaw, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Duzova, Ali, Bilginer, Yelda, Caliskan, Salim, Mir, Sevgi, Soezeri, Betul, Kranz, Brigitta, Dorn, Brigitte, Baskin, Esra, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Shroff, Rukshana, Rachin, Bruno, Szczepanska, Maria, Donmez, Osman, Balat, Ayse, Aksu, Nejat, Yilmaz, Ebru, Bakkaloglu, Aysin, Ozaltin, Fatih, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Klaus, Guenter, Ardissino, Gianluigi, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Picca, Stefano, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Fydryk, Janusz, Urasinski, Tomasz, Coppo, Rosanna, Peruzzi, Licia, Grenda, Ryszard, Neuhaus, Thomas J., Azukaitis, Karolis, Ju, Wenjun, Kirchner, Marietta, Nair, Viji, Smith, Michelle, Fang, Zhiyin, Thurn-Valsassina, Daniela, Bayazit, Aysun, Niemirska, Anna, Canpolat, Nur, Bulut, Ipek Kaplan, Yalcinkaya, Fatos, Paripovic, Dusan, Harambat, Jerome, Cakar, Nilgun, Alpay, Harika, Lugani, Francesca, Mencarelli, Francesca, Civilibal, Mahmut, Erdogan, Hakan, Gellermann, Jutta, Vidal, Enrico, Tabel, Yilmaz, Gimpel, Charlotte, Ertan, Pelin, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Arbeiter, Klaus, Rosales, Alejandra, Dusek, Jiri, Zaloszyc, Ariane, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Wigger, Marianne, Testa, Sara, Murer, Luisa, Matteucci, Chiara, Jankauskiene, Augustina, Drozdz, Dorota, Zurowska, Aleksandra, Zaniew, Marcin, Litwin, Mieczyslaw, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Duzova, Ali, Bilginer, Yelda, Caliskan, Salim, Mir, Sevgi, Soezeri, Betul, Kranz, Brigitta, Dorn, Brigitte, Baskin, Esra, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Shroff, Rukshana, Rachin, Bruno, Szczepanska, Maria, Donmez, Osman, Balat, Ayse, Aksu, Nejat, Yilmaz, Ebru, Bakkaloglu, Aysin, Ozaltin, Fatih, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Klaus, Guenter, Ardissino, Gianluigi, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Picca, Stefano, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Fydryk, Janusz, Urasinski, Tomasz, Coppo, Rosanna, Peruzzi, Licia, Grenda, Ryszard, and Neuhaus, Thomas J.

Abstract

Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD.

Published
2019

37. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study

Author

Shroff, Rukshana, Smith, Colette, Ranchin, Bruno, Bayazit, Aysun K., Stefanidis, Constantinos J., Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Agba, Ayşe, Aitkenhead, Helen, Anarat, Ali, Aoun, Bilal, Aofolaju, Daley, Bakkaloglu, Sevcan Azime, Bhowruth, Devina, Borzych-Duza, Dagmara, Bulut, Ipek Kaplan, Büscher (R.), Rainer, Deanfield, John, Dempster, Claire, Duzova, Ali, Habbig, Sandra, Hayes, Wesley, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslaw, Mayes, Mark, Mir, Sevgi, Nemec, Rose, Obrycki, Lukasz, Paglialonga, Fabio, Picca, Stefano, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish D., Spasojevic, Brankica, Stronach, Lynsey, Vidal, Enrico, Vondrák, Karel, Yilmaz, Alev, Zaloszyc, Ariane, Fischbach, Michel, Schmitt, Claus Peter, Schaefer, Franz, Ağbaş, Ayşe, Borzych-Dużałka, Dagmara, Çukurova Üniversitesi, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, and Ege Üniversitesi

Subjects
Male, medicine.medical_treatment, 030232 urology & nephrology, Medizin, Blood Pressure, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, law.invention, Kidney Failure, Hemoglobins, 0302 clinical medicine, Randomized controlled trial, law, cardiovascular disease, Chronic, Child, hemodialysis, integumentary system, Headache, General Medicine, Hospitalization, C-Reactive Protein, Nephrology, Parathyroid Hormone, Child, Preschool, Cohort, Hypertension, Cardiology, Female, Hemodialysis, carotid intima-media thickness, children, growth, hemodiafiltration (HDF), Adolescent, Dizziness, Humans, Kidney Failure, Chronic, Muscle Cramp, Patient Reported Outcome Measures, Phosphates, Renal Dialysis, Young Adult, beta 2-Microglobulin, Body Height, Hemodiafiltration, medicine.medical_specialty, Mean arterial pressure, Renal function, 03 medical and health sciences, Clinical Research, Internal medicine, medicine, Preschool, Dialysis, business.industry, Propensity score matching, Observational study, business
Abstract

EgeUn###, Background Hypertension and cardiovascular disease are common in children undergoing dialysis. Studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, but data for children are scarce. Methods The HDF, Heart and Height study is a nonrandomized observational study comparing outcomes on conventional hemodialysis (HD) versus postdilution online HDF in children. Primary outcome measures were annualized changes in carotid intima-media thickness (cIMT) SD score and height SD score. Results We enrolled 190 children from 28 centers; 78 on HD and 55 on HDF completed 1-year follow-up. The groups were comparable for age, dialysis vintage, access type, dialysis frequency, blood flow, and residual renal function. At 1 year, cIMT SD score increased significantly in children on HD but remained static in the HDF cohort. On propensity score analysis, HD was associated with a +0.47 higher annualized cIMT SD score compared with HDF. Height SD score increased in HDF but remained static in HD. Mean arterial pressure SD score increased with HD only. Factors associated with higher cIMT and mean arterial pressure SD-scores were HD group, higher ultrafiltration rate, and higher 2-microglobulin. The HDF cohort had lower 2-microglobulin, parathyroid hormone, and high-sensitivity C-reactive protein at 1 year; fewer headaches, dizziness, or cramps; and shorter postdialysis recovery time. Conclusions HDF is associated with a lack of progression in vascular measures versus progression with HD, as well as an increase in height not seen in the HD cohort. Patient-related outcomes improved among children on HDF correlating with improved BP control and clearances. Confirmation through randomized trials is required., National Institute for Health ResearchNational Institute for Health Research (NIHR); Kidney Research UKKidney Research UK (KRUK); Fresenius Medical Care, R.S. holds a Career Development Fellowship with the National Institute for Health Research. The 3H study was sponsored by Kidney Research UK. Part sponsorship was obtained from Fresenius Medical Care.

Published
2018

38. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Azukaitis, Karolis, primary, Ju, Wenjun, additional, Kirchner, Marietta, additional, Nair, Viji, additional, Smith, Michelle, additional, Fang, Zhiyin, additional, Thurn-Valsassina, Daniela, additional, Bayazit, Aysun, additional, Niemirska, Anna, additional, Canpolat, Nur, additional, Bulut, Ipek Kaplan, additional, Yalcinkaya, Fatos, additional, Paripovic, Dusan, additional, Harambat, Jerome, additional, Cakar, Nilgun, additional, Alpay, Harika, additional, Lugani, Francesca, additional, Mencarelli, Francesca, additional, Civilibal, Mahmut, additional, Erdogan, Hakan, additional, Gellermann, Jutta, additional, Vidal, Enrico, additional, Tabel, Yilmaz, additional, Gimpel, Charlotte, additional, Ertan, Pelin, additional, Yavascan, Onder, additional, Melk, Anette, additional, Querfeld, Uwe, additional, Wühl, Elke, additional, Kretzler, Matthias, additional, Schaefer, Franz, additional, Arbeiter, Klaus, additional, Rosales, Alejandra, additional, Dusek, Jiri, additional, Zaloszyc, Ariane, additional, Liebau, Max, additional, Weber, Lutz, additional, Muschiol, Evelin, additional, Büscher, Rainer, additional, Oh, Jun, additional, Thurn-Valassina, Daniela, additional, Haffner, Dieter, additional, John, Ulrike, additional, Wygoda, Simone, additional, Jeck, Nikola, additional, Wigger, Marianne, additional, Testa, Sara, additional, Murer, Luisa, additional, Matteucci, Chiara, additional, Jankauskiene, Augustina, additional, Azukaitis, Karolis, additional, Drozdz, Dorota, additional, Zurowska, Aleksandra, additional, Zaniew, Marcin, additional, Litwin, Mieczyslaw, additional, Nimierska, Anna, additional, Teixeira, Ana, additional, Peco-Antic, Amira, additional, Laube, Guido, additional, Anarat, Ali, additional, Duzova, Ali, additional, Bilginer, Yelda, additional, Caliskan, Salim, additional, Mir, Sevgi, additional, Sözeri, Betül, additional, Kranz, Brigitta, additional, Dorn, Brigitte, additional, Baskin, Esra, additional, Soylemezoglu, Oguz, additional, Emre, Sevinc, additional, Candan, Cengiz, additional, Kiyak, Aysel, additional, Ozcelik, Gul, additional, Shroff, Rukshana, additional, Rachin, Bruno, additional, Szczepanska, Maria, additional, Donmez, Osman, additional, Balat, Ayse, additional, Aksu, Nejat, additional, Yilmaz, Ebru, additional, Bakkaloglu, Aysin, additional, Ozaltin, Fatih, additional, Sallay, Peter, additional, Drożdż, Dorota, additional, Bonzel, Klaus-Eugen, additional, Wingen, Anna-Margrete, additional, Żurowska, Aleksandra, additional, Balasz, Irena, additional, Trivelli, Antonella, additional, Perfumo, Francesco, additional, Müller-Wiefel, Dirk-Erhard, additional, Möller, Kerstin, additional, Offner, Gisela, additional, Enke, Barbara, additional, Hadtstein, Charlotte, additional, Mehls, Otto, additional, Hohbach-Hohenfellner, Katharina, additional, Jeck, Nickola, additional, Klaus, Günter, additional, Ardissino, Gianluigi, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Niaudet, Patrick, additional, Afonso, Alberto Caldas, additional, Fernandes-Teixeira, Ana, additional, Dušek, Jiri, additional, Picca, Stefano, additional, Berg, Ulla B., additional, Celsi, Giovanni, additional, Fischbach, Michel, additional, Terzic, Joelle, additional, Fydryk, Janusz, additional, Urasinski, Tomasz, additional, Coppo, Rosanna, additional, Peruzzi, Licia, additional, Grenda, Ryszard, additional, and Neuhaus, Thomas J., additional

Published
2019
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40. Effects of Hemodiafiltration versus Conventional Hemodialysis in Children with ESKD: The HDF, Heart and Height Study

Author

Shroff, Rukshana, primary, Smith, Colette, additional, Ranchin, Bruno, additional, Bayazit, Aysun K., additional, Stefanidis, Constantinos J., additional, Askiti, Varvara, additional, Azukaitis, Karolis, additional, Canpolat, Nur, additional, Ağbaş, Ayşe, additional, Aitkenhead, Helen, additional, Anarat, Ali, additional, Aoun, Bilal, additional, Aofolaju, Daley, additional, Bakkaloglu, Sevcan Azime, additional, Bhowruth, Devina, additional, Borzych-Dużałka, Dagmara, additional, Bulut, Ipek Kaplan, additional, Büscher, Rainer, additional, Deanfield, John, additional, Dempster, Claire, additional, Duzova, Ali, additional, Habbig, Sandra, additional, Hayes, Wesley, additional, Hegde, Shivram, additional, Krid, Saoussen, additional, Licht, Christoph, additional, Litwin, Mieczyslaw, additional, Mayes, Mark, additional, Mir, Sevgi, additional, Nemec, Rose, additional, Obrycki, Lukasz, additional, Paglialonga, Fabio, additional, Picca, Stefano, additional, Samaille, Charlotte, additional, Shenoy, Mohan, additional, Sinha, Manish D., additional, Spasojevic, Brankica, additional, Stronach, Lynsey, additional, Vidal, Enrico, additional, Vondrák, Karel, additional, Yilmaz, Alev, additional, Zaloszyc, Ariane, additional, Fischbach, Michel, additional, Schmitt, Claus Peter, additional, and Schaefer, Franz, additional

Published
2019
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42. Effects of Haemodiafiltration (HDF) vs Conventional Haemodialysis (HD) on Growth and Cardiovascular Markers in children – Data From The HDF vs HD (3H) Study

Author

Shroff, Rukshana, DÜZOVA, ALİ, ÇALIŞKAN, Salim, Canpolat, Nur, Azukaitis, Karolis, Askiti, Varvara, Stefanidis, Constantinos, Anon, Bilal, Bakkaloglu, Sevcan, Borzych-Duzalka, Dagmara, Hayes, Wesley, Habbig, Sandra, Krid, Saoussen, Hegde, Shivram, Mayes, Mark, Licht, Christoph, Litwin, Mieczyslaw, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Spasojevic, Brankica, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Fischbach, Michel, Schaefer, Franz, Smith, Colette, Schmitt, Claus, and KARABAY BAYAZIT, AYSUN

Published
2017

43. HAEMODIAFILTRATION (HDF) IS ASSOCIATED WITH SUPERIOR FLU ID CONTROL AND REDUCED CARDIOVASCULAR RISK PROFILE COMPARED TO CONVENTIONAL HAEMODIALYSIS (HD) - DATA FROM THE HDF VS HD (3H) STUDY

Author

Fischbach, Michel, Schmitt, Claus, Schaefer, Franz, Bakkaloglu, Sevcan, Azukaitis, Karolis, Canpolat, Nur, Askiti, Varvara, ÇALIŞKAN, Salim, Borzych-duzalka, Dagmara, DÜZOVA, ALİ, Habbig, Sandra, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslav, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, KARABAY BAYAZIT, AYSUN, Stefanidis, Constantinos, Smith, Colette, Bhowruth, Devina, Shroff, Rukshana, Sinha, Manish, Shenoy, Mohan, and Hegde, Shivram

Published
2017

44. Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study

Author

Basu, Rajit K, primary, Kaddourah, Ahmad, additional, Goldstein, Stuart L, additional, Akcan-Arikan, Ayse, additional, Arnold, Megan, additional, Cruz, Cody, additional, Goldsworthy, Michele, additional, Jaimon, Nancy, additional, Alexander, Stephen, additional, Festa, Marino, additional, Hahn, Deirdre, additional, Brown, Lauren, additional, Jeon, Ari, additional, Deep, Akash, additional, Askenazi, David, additional, Bagshaw, Sean, additional, Morgan, Catherine, additional, Alobaidi, Rashid, additional, Basu, Rajit, additional, Cooper, David, additional, Goldstein, Stuart, additional, Mottes, Theresa, additional, Terrell, Tara, additional, Arnold, Patricia, additional, Metcalf, Christina, additional, Woodley, Shalayna, additional, Bogdanović, Radovan, additional, Stajić, Natasa, additional, Kovacevic, Branko, additional, Peco-Antic, Amira, additional, Paripovic, Aleksandra, additional, Brophy, Patrick, additional, Bunchman, Timothy, additional, Williams, Duane, additional, Hoot, Michelle, additional, Chadha, Vimal, additional, Davis, Keefe, additional, Dharnidharka, Vikas, additional, Walther, Leslie, additional, Faustino, Vincent, additional, Taft, Janet, additional, Tala, Joana, additional, Gist, Katja, additional, Soranno, Danielle, additional, Ha, Il Soo, additional, Kang, Hee Gyung, additional, Hackbarth, Richard, additional, Avendt-Reeber, Mary, additional, Butler, Chloe, additional, DeGraaf, Doug, additional, Eding, Dawn, additional, Hautala, Nathalie, additional, Ndika, Akunne, additional, Hidayati, Eka Laksmi, additional, Huang, Songming, additional, Kennedy, Sean, additional, Didsbury, Madeleine, additional, Kushartono, Hari, additional, Prasetyo, Risky, additional, Mammen, Cherry, additional, Paden, Matthew, additional, Stone, Cheryl, additional, Picca, Stefano, additional, Connola, Federica, additional, Schneider, James, additional, Sweberg, Todd, additional, Kessel, Aaron, additional, Selewski, David, additional, Hieber, Susan, additional, Spasojević-Dimitrijeva, Brankica, additional, Ivanisevic, Ivana, additional, Putnik, Jovana, additional, Ristic, Snezana, additional, Sutherland, Scott, additional, Staples, Amy, additional, Wong, Craig, additional, Hadid, Senan, additional, Joseph, Catherine, additional, Woroniecki, Robert, additional, Zappitelli, Michael, additional, Elsaerafy, Noha, additional, and Zaritsky, Joshua, additional

Published
2018
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45. HAEMODIAFILTRATION (HDF) IS ASSOCIATED WITH SUPERIOR FLU ID CONTROL AND REDUCED CARDIOVASCULAR RISK PROFILE COMPARED TO CONVENTIONAL HAEMODIALYSIS (HD) - DATA FROM THE HDF VS HD (3H) STUDY

Author

Shroff, Rukshana, Bayazit, Aysun, Stefanidis, Constantinos, Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Bakkaloglu, Sevcan, Caliskan, Salim, Bhowruth, Devina, Borzych-duzalka, Dagmara, Duzova, Ali, Habbig, Sandra, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslav, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Smith, Colette, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Fischbach, Michel, Schmitt, Claus, Schaefer, Franz, Shroff, Rukshana, Bayazit, Aysun, Stefanidis, Constantinos, Askiti, Varvara, Azukaitis, Karolis, Canpolat, Nur, Bakkaloglu, Sevcan, Caliskan, Salim, Bhowruth, Devina, Borzych-duzalka, Dagmara, Duzova, Ali, Habbig, Sandra, Hegde, Shivram, Krid, Saoussen, Licht, Christoph, Litwin, Mieczyslav, Paglialonga, Fabio, Picca, Stefano, Ranchin, Bruno, Samaille, Charlotte, Shenoy, Mohan, Sinha, Manish, Smith, Colette, Vidal, Enrico, Vondrak, Karel, Yilmaz, Alev, Fischbach, Michel, Schmitt, Claus, and Schaefer, Franz

Published
2017

46. Normal 25-hydroxyvitamin D levels are associated with less proteinuria and attenuate renal failure progression in children with CKD

Author

Shroff, Rukshana, Aitkenhead, Helen, Costa, Nikola, Trivelli, Antonella, Litwin, Mieczyslaw, Picca, Stefano, Anarat, Ali, Sallay, Peter, Ozaltin, Fatih, Zurowska, Aleksandra, Jankauskiene, Augustina, Montini, Giovanni, Charbit, Marina, Schaefer, Franz, Wühl, Elke, ESCAPE Trial Group, University of Zurich, and Shroff, Rukshana

Subjects
2727 Nephrology, 10036 Medical Clinic, 610 Medicine & health
Published
2016

47. NORMAL 25-HYDROXYVITAMIN D LEVELS ARE ASSOCIATED WITH LESS PROTEINURIA AND ATTENUATE RENAL FAILURE PROGRESSION IN CHILDREN WITH CHRONIC KIDNEY DISEASE

Author

Shroff, Rukshana, Trivelli, Antonella, Litwin, Mieczyslaw, Picca, Stefano, Anarat, Ali, Sallay, Peter, Ozaltin, Fatih, and Çukurova Üniversitesi

Subjects
urologic and male genital diseases
Abstract

52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation -- MAY 28-31, 2015 -- London, ENGLAND WOS: 000361215100331 … European Renal Assoc, European Dialysis & Transplant Assoc

Published
2015

48. Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD

Author

Shroff, Rukshana, primary, Aitkenhead, Helen, additional, Costa, Nikola, additional, Trivelli, Antonella, additional, Litwin, Mieczyslaw, additional, Picca, Stefano, additional, Anarat, Ali, additional, Sallay, Peter, additional, Ozaltin, Fatih, additional, Zurowska, Aleksandra, additional, Jankauskiene, Augustina, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Schaefer, Franz, additional, and Wühl, Elke, additional

Published
2016
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