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1. Are Tech Savvy Students Tech Literate? Digital and Data Literacy Skills of First-Year College Students

Author

Kevin Mentzer, Mark Frydenberg, and Adam Patterson

Abstract

Much has been written on the skills and capabilities of a new generation raised with social media, smartphones, and immediate access to data and information via the Internet. Today's college students grew up using the Internet, where they both generate and consume data. But do incoming college students have the skills necessary to thrive in a digital world that requires the ability to generate, analyze, and share insights from data? This paper presents a study, performed at two small New England institutions each with a business focus, which examines the digital skill sets of first-year college students in relation to the skills they have developed before entering college. The authors also consider whether there is a "digital divide" among first-year college students in relation to their previous technology skills. When applying the Databilities framework for evaluating data literacy competencies, results show that teaching data literacy skills to first-year college students will be critical to their academic success as future information technology workers.

Published
2024

2. HBCU Adult Learner Initiative: A Focus on Black Rurality

Author

UNCF, Frederick D. Patterson Research Institute (FDPRI), Ascendium Education Group, Inc., Kamia F. Slaughter, and Nadrea Njoku

Abstract

In January 2024, UNCF's Frederick D. Patterson Research Institute (FDPRI) published "Adult Learner Initiative External Report," which outlined key findings and recommendations from an evaluation of the Adult Learner Initiative. To supplement and extend that work, Ascendium Education Group collaborated with FDPRI and Lumina Foundation to fund this portion of the evaluation, which centers Black, rural learners. Black, rural learners and other institutional actors at historically black colleges and universities (HBCUs) in North Carolina experience rurality in varied ways. Despite institutional characteristics and geospatial locations that contribute to the unique identities of HBCUs, actors offered nuanced considerations about rurality. Faculty, staff, and students understood rurality in the context of environmental, financial, and social factors in addition to services and programs tailored to rural students. This report engages rural data landscapes, scholarship on rural students, and empirical research about adult learners at HBCUs to explore rurality. Our overall approach is threefold: First, the authors use place-based data categories and nomenclature to situate HBCUs within rural discourses. Second, the authors position institutional and statewide strategic plans as critical documents that help contextualize researchers' and institutional actors' conceptions of rurality. Third, the authors frame HBCU actors' voices about place as essential contextual components for understanding institutional and community cultures and differentiating between HBCU environments.

Published
2024

3. PBM-VFL: Vertical Federated Learning with Feature and Sample Privacy

Author

Tran, Linh, Castiglia, Timothy, Patterson, Stacy, and Milanova, Ana

Subjects
Computer Science - Machine Learning
Abstract

We present Poisson Binomial Mechanism Vertical Federated Learning (PBM-VFL), a communication-efficient Vertical Federated Learning algorithm with Differential Privacy guarantees. PBM-VFL combines Secure Multi-Party Computation with the recently introduced Poisson Binomial Mechanism to protect parties' private datasets during model training. We define the novel concept of feature privacy and analyze end-to-end feature and sample privacy of our algorithm. We compare sample privacy loss in VFL with privacy loss in HFL. We also provide the first theoretical characterization of the relationship between privacy budget, convergence error, and communication cost in differentially-private VFL. Finally, we empirically show that our model performs well with high levels of privacy.

Published
2025

4. Privacy-Preserving Personalized Federated Prompt Learning for Multimodal Large Language Models

Author

Tran, Linh, Sun, Wei, Patterson, Stacy, and Milanova, Ana

Subjects
Computer Science - Machine Learning
Abstract

Multimodal Large Language Models (LLMs) are pivotal in revolutionizing customer support and operations by integrating multiple modalities such as text, images, and audio. Federated Prompt Learning (FPL) is a recently proposed approach that combines pre-trained multimodal LLMs such as vision-language models with federated learning to create personalized, privacy-preserving AI systems. However, balancing the competing goals of personalization, generalization, and privacy remains a significant challenge. Over-personalization can lead to overfitting, reducing generalizability, while stringent privacy measures, such as differential privacy, can hinder both personalization and generalization. In this paper, we propose a Differentially Private Federated Prompt Learning (DP-FPL) approach to tackle this challenge by leveraging a low-rank adaptation scheme to capture generalization while maintaining a residual term that preserves expressiveness for personalization. To ensure privacy, we introduce a novel method where we apply local differential privacy to the two low-rank components of the local prompt, and global differential privacy to the global prompt. Our approach mitigates the impact of privacy noise on the model performance while balancing the tradeoff between personalization and generalization. Extensive experiments demonstrate the effectiveness of our approach over other benchmarks., Comment: Accepted to ICLR 2025 main conference track

Published
2025

5. Development and Validation of the Provider Documentation Summarization Quality Instrument for Large Language Models

Author

Croxford, Emma, Gao, Yanjun, Pellegrino, Nicholas, Wong, Karen K., Wills, Graham, First, Elliot, Schnier, Miranda, Burton, Kyle, Ebby, Cris G., Gorskic, Jillian, Kalscheur, Matthew, Khalil, Samy, Pisani, Marie, Rubeor, Tyler, Stetson, Peter, Liao, Frank, Goswami, Cherodeep, Patterson, Brian, and Afshar, Majid

Subjects
Computer Science - Artificial Intelligence
Abstract

As Large Language Models (LLMs) are integrated into electronic health record (EHR) workflows, validated instruments are essential to evaluate their performance before implementation. Existing instruments for provider documentation quality are often unsuitable for the complexities of LLM-generated text and lack validation on real-world data. The Provider Documentation Summarization Quality Instrument (PDSQI-9) was developed to evaluate LLM-generated clinical summaries. Multi-document summaries were generated from real-world EHR data across multiple specialties using several LLMs (GPT-4o, Mixtral 8x7b, and Llama 3-8b). Validation included Pearson correlation for substantive validity, factor analysis and Cronbach's alpha for structural validity, inter-rater reliability (ICC and Krippendorff's alpha) for generalizability, a semi-Delphi process for content validity, and comparisons of high-versus low-quality summaries for discriminant validity. Seven physician raters evaluated 779 summaries and answered 8,329 questions, achieving over 80% power for inter-rater reliability. The PDSQI-9 demonstrated strong internal consistency (Cronbach's alpha = 0.879; 95% CI: 0.867-0.891) and high inter-rater reliability (ICC = 0.867; 95% CI: 0.867-0.868), supporting structural validity and generalizability. Factor analysis identified a 4-factor model explaining 58% of the variance, representing organization, clarity, accuracy, and utility. Substantive validity was supported by correlations between note length and scores for Succinct (rho = -0.200, p = 0.029) and Organized ($\rho = -0.190$, $p = 0.037$). Discriminant validity distinguished high- from low-quality summaries ($p < 0.001$). The PDSQI-9 demonstrates robust construct validity, supporting its use in clinical practice to evaluate LLM-generated summaries and facilitate safer integration of LLMs into healthcare workflows.

Published
2025

6. The Essentials of AI for Life and Society: An AI Literacy Course for the University Community

Author

Biswas, Joydeep, Fussell, Don, Stone, Peter, Patterson, Kristin, Procko, Kristen, Sabatini, Lea, and Xu, Zifan

Subjects
Computer Science - Artificial Intelligence, Computer Science - Computers and Society
Abstract

We describe the development of a one-credit course to promote AI literacy at The University of Texas at Austin. In response to a call for the rapid deployment of class to serve a broad audience in Fall of 2023, we designed a 14-week seminar-style course that incorporated an interdisciplinary group of speakers who lectured on topics ranging from the fundamentals of AI to societal concerns including disinformation and employment. University students, faculty, and staff, and even community members outside of the University, were invited to enroll in this online offering: The Essentials of AI for Life and Society. We collected feedback from course participants through weekly reflections and a final survey. Satisfyingly, we found that attendees reported gains in their AI literacy. We sought critical feedback through quantitative and qualitative analysis, which uncovered challenges in designing a course for this general audience. We utilized the course feedback to design a three-credit version of the course that is being offered in Fall of 2024. The lessons we learned and our plans for this new iteration may serve as a guide to instructors designing AI courses for a broad audience., Comment: Accepted to EAAI-25: The 15th Symposium on Educational Advances in Artificial Intelligence, collocated with AAAI-25

Published
2025

7. Para-Holomorphic Algebroids and Para-Complex Connections

Author

Patterson, Aidan

Subjects
Mathematics - Differential Geometry, Mathematics - Symplectic Geometry
Abstract

The goal of this paper is to develop the theory of Courant algebroids with integrable para-Hermitian vector bundle structures by invoking the theory of Lie bialgebroids. We consider the case where the underlying manifold has an almost para-complex structure, and use this to define a notion of para-holomorphic algebroid. We investigate connections on para-holomorphic algebroids and determine an appropriate sense in which they can be para-complex. Finally, we show through a series of examples how the theory of exact para-holomorphic algebroids with a para-complex connection is a generalization of both para-K\"{a}hler geometry and the theory of Poisson-Lie groups., Comment: 57 pages, Masters thesis accepted by the University of Waterloo 2022

Published
2025

8. Converting Time Series Data to Numeric Representations Using Alphabetic Mapping and k-mer strategy

Author

Ali, Sarwan, Ali, Tamkanat E, Khan, Imdad Ullah, and Patterson, Murray

Subjects
Computer Science - Machine Learning
Abstract

In the realm of data analysis and bioinformatics, representing time series data in a manner akin to biological sequences offers a novel approach to leverage sequence analysis techniques. Transforming time series signals into molecular sequence-type representations allows us to enhance pattern recognition by applying sophisticated sequence analysis techniques (e.g. $k$-mers based representation) developed in bioinformatics, uncovering hidden patterns and relationships in complex, non-linear time series data. This paper proposes a method to transform time series signals into biological/molecular sequence-type representations using a unique alphabetic mapping technique. By generating 26 ranges corresponding to the 26 letters of the English alphabet, each value within the time series is mapped to a specific character based on its range. This conversion facilitates the application of sequence analysis algorithms, typically used in bioinformatics, to analyze time series data. We demonstrate the effectiveness of this approach by converting real-world time series signals into character sequences and performing sequence classification. The resulting sequences can be utilized for various sequence-based analysis techniques, offering a new perspective on time series data representation and analysis.

Published
2024

9. Hilbert Curve Based Molecular Sequence Analysis

Author

Ali, Sarwan, Ali, Tamkanat E, Khan, Imdad Ullah, and Patterson, Murray

Subjects
Computer Science - Machine Learning, Quantitative Biology - Other Quantitative Biology
Abstract

Accurate molecular sequence analysis is a key task in the field of bioinformatics. To apply molecular sequence classification algorithms, we first need to generate the appropriate representations of the sequences. Traditional numeric sequence representation techniques are mostly based on sequence alignment that faces limitations in the form of lack of accuracy. Although several alignment-free techniques have also been introduced, their tabular data form results in low performance when used with Deep Learning (DL) models compared to the competitive performance observed in the case of image-based data. To find a solution to this problem and to make Deep Learning (DL) models function to their maximum potential while capturing the important spatial information in the sequence data, we propose a universal Hibert curve-based Chaos Game Representation (CGR) method. This method is a transformative function that involves a novel Alphabetic index mapping technique used in constructing Hilbert curve-based image representation from molecular sequences. Our method can be globally applied to any type of molecular sequence data. The Hilbert curve-based image representations can be used as input to sophisticated vision DL models for sequence classification. The proposed method shows promising results as it outperforms current state-of-the-art methods by achieving a high accuracy of $94.5$\% and an F1 score of $93.9\%$ when tested with the CNN model on the lung cancer dataset. This approach opens up a new horizon for exploring molecular sequence analysis using image classification methods.

Published
2024

10. Computing Gram Matrix for SMILES Strings using RDKFingerprint and Sinkhorn-Knopp Algorithm

Author

Ali, Sarwan, Mansoor, Haris, Chourasia, Prakash, Khan, Imdad Ullah, and Patterson, Murray

Subjects
Computer Science - Machine Learning
Abstract

In molecular structure data, SMILES (Simplified Molecular Input Line Entry System) strings are used to analyze molecular structure design. Numerical feature representation of SMILES strings is a challenging task. This work proposes a kernel-based approach for encoding and analyzing molecular structures from SMILES strings. The proposed approach involves computing a kernel matrix using the Sinkhorn-Knopp algorithm while using kernel principal component analysis (PCA) for dimensionality reduction. The resulting low-dimensional embeddings are then used for classification and regression analysis. The kernel matrix is computed by converting the SMILES strings into molecular structures using the Morgan Fingerprint, which computes a fingerprint for each molecule. The distance matrix is computed using the pairwise kernels function. The Sinkhorn-Knopp algorithm is used to compute the final kernel matrix that satisfies the constraints of a probability distribution. This is achieved by iteratively adjusting the kernel matrix until the marginal distributions of the rows and columns match the desired marginal distributions. We provided a comprehensive empirical analysis of the proposed kernel method to evaluate its goodness with greater depth. The suggested method is assessed for drug subcategory prediction (classification task) and solubility AlogPS ``Aqueous solubility and Octanol/Water partition coefficient" (regression task) using the benchmark SMILES string dataset. The outcomes show the proposed method outperforms several baseline methods in terms of supervised analysis and has potential uses in molecular design and drug discovery. Overall, the suggested method is a promising avenue for kernel methods-based molecular structure analysis and design.

Published
2024

11. Fake News Detection: Comparative Evaluation of BERT-like Models and Large Language Models with Generative AI-Annotated Data

Author

Raza, Shaina, Paulen-Patterson, Drai, and Ding, Chen

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

Fake news poses a significant threat to public opinion and social stability in modern society. This study presents a comparative evaluation of BERT-like encoder-only models and autoregressive decoder-only large language models (LLMs) for fake news detection. We introduce a dataset of news articles labeled with GPT-4 assistance (an AI-labeling method) and verified by human experts to ensure reliability. Both BERT-like encoder-only models and LLMs were fine-tuned on this dataset. Additionally, we developed an instruction-tuned LLM approach with majority voting during inference for label generation. Our analysis reveals that BERT-like models generally outperform LLMs in classification tasks, while LLMs demonstrate superior robustness against text perturbations. Compared to weak labels (distant supervision) data, the results show that AI labels with human supervision achieve better classification results. This study highlights the effectiveness of combining AI-based annotation with human oversight and demonstrates the performance of different families of machine learning models for fake news detection, Comment: Accepted in Knowledge and Information Systems Journal

Published
2024

12. Revealing Physical Mechanisms of Pattern Formation and Switching in Ecosystems via Nonequilibrium Landscape and Flux

Author

Su, Jie, Wu, Wei, Patterson, Denis, Levin, Simon Asher, and Wang, Jin

Subjects
Physics - Biological Physics, Nonlinear Sciences - Pattern Formation and Solitons
Abstract

Spatial patterns are widely observed in numerous nonequilibrium natural systems, often undergoing complex transitions and bifurcations, thereby exhibiting significant importance in many physical and biological systems such as embryonic development, ecosystem desertification, and turbulence. However, how spatial pattern formation emerges and how the spatial pattern switches are not fully understood. Here, we developed a landscape-flux field theory via the spatial mode expansion method to uncover the underlying physical mechanism of the pattern formation and switching. We identified the landscape and flux field as the driving force for spatial dynamics and applied this theory to the critical transitions between spatial vegetation patterns in semi-arid ecosystems, revealing that the nonequilibrium flux drives the switchings of spatial patterns. We uncovered how the pattern switching emerges through the optimal pathways and how fast this occurs via the speed of pattern switching. Furthermore, both the averaged flux and the entropy production rate exhibit peaks near pattern switching boundaries, revealing dynamical and thermodynamical origins for pattern transitions, and further offering early warning signals for anticipating spatial pattern switching. Our work thus reveals physical mechanisms on spatial pattern-switching in semi-arid ecosystems and, more generally, introduces a useful approach for quantifying spatial pattern switching in nonequilibrium systems, which further offers practical applications such as early warning signals for critical transitions of spatial patterns.

Published
2024

13. Shaping AI's Impact on Billions of Lives

Author

Cuéllar, Mariano-Florentino, Dean, Jeff, Doshi-Velez, Finale, Hennessy, John, Konwinski, Andy, Koyejo, Sanmi, Moiloa, Pelonomi, Pierson, Emma, and Patterson, David

Subjects
Computer Science - Artificial Intelligence, Computer Science - Computers and Society, Computer Science - Emerging Technologies, Computer Science - Machine Learning
Abstract

Artificial Intelligence (AI), like any transformative technology, has the potential to be a double-edged sword, leading either toward significant advancements or detrimental outcomes for society as a whole. As is often the case when it comes to widely-used technologies in market economies (e.g., cars and semiconductor chips), commercial interest tends to be the predominant guiding factor. The AI community is at risk of becoming polarized to either take a laissez-faire attitude toward AI development, or to call for government overregulation. Between these two poles we argue for the community of AI practitioners to consciously and proactively work for the common good. This paper offers a blueprint for a new type of innovation infrastructure including 18 concrete milestones to guide AI research in that direction. Our view is that we are still in the early days of practical AI, and focused efforts by practitioners, policymakers, and other stakeholders can still maximize the upsides of AI and minimize its downsides. We talked to luminaries such as recent Nobelist John Jumper on science, President Barack Obama on governance, former UN Ambassador and former National Security Advisor Susan Rice on security, philanthropist Eric Schmidt on several topics, and science fiction novelist Neal Stephenson on entertainment. This ongoing dialogue and collaborative effort has produced a comprehensive, realistic view of what the actual impact of AI could be, from a diverse assembly of thinkers with deep understanding of this technology and these domains. From these exchanges, five recurring guidelines emerged, which form the cornerstone of a framework for beginning to harness AI in service of the public good. They not only guide our efforts in discovery but also shape our approach to deploying this transformative technology responsibly and ethically.

Published
2024

14. FathomVerse: A community science dataset for ocean animal discovery

Author

Patterson, Genevieve, Daniels, Joost, Woodward, Benjamin, Barnard, Kevin, Sainz, Giovanna, Lundsten, Lonny, and Katija, Kakani

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Human-Computer Interaction
Abstract

Can computer vision help us explore the ocean? The ultimate challenge for computer vision is to recognize any visual phenomena, more than only the objects and animals humans encounter in their terrestrial lives. Previous datasets have explored everyday objects and fine-grained categories humans see frequently. We present the FathomVerse v0 detection dataset to push the limits of our field by exploring animals that rarely come in contact with people in the deep sea. These animals present a novel vision challenge. The FathomVerse v0 dataset consists of 3843 images with 8092 bounding boxes from 12 distinct morphological groups recorded at two locations on the deep seafloor that are new to computer vision. It features visually perplexing scenarios such as an octopus intertwined with a sea star, and confounding categories like vampire squids and sea spiders. This dataset can push forward research on topics like fine-grained transfer learning, novel category discovery, species distribution modeling, and carbon cycle analysis, all of which are important to the care and husbandry of our planet., Comment: 10 pages, 14 figures

Published
2024

15. An alignment problem

Author

McDaniel, Emma L., Mikler, Armin R., Tiwari, Chetan, and Patterson, Murray

Subjects
Computer Science - Data Structures and Algorithms, Computer Science - Computational Complexity
Abstract

This work concerns an alignment problem that has applications in many geospatial problems such as resource allocation and building reliable disease maps. Here, we introduce the problem of optimally aligning $k$ collections of $m$ spatial supports over $n$ spatial units in a $d$-dimensional Euclidean space. We show that the 1-dimensional case is solvable in time polynomial in $k$, $m$ and $n$. We then show that the 2-dimensional case is NP-hard for 2 collections of 2 supports. Finally, we devise a heuristic for aligning a set of collections in the 2-dimensional case.

Published
2024

16. The Volatile Composition and Activity Evolution of Main-Belt Comet 358P/PANSTARRS

Author

Hsieh, Henry H., Noonan, John W., Kelley, Michael S. P., Bodewits, Dennis, Pittichova, Jana, Thirouin, Audrey, Micheli, Marco, Knight, Matthew M., Bannister, Michele T., Chandler, Colin O., Holt, Carrie E., Hopkins, Matthew J., Kim, Yaeji, Moskovitz, Nicholas A., Oldroyd, William J., Patterson, Jack, Sheppard, Scott S., Tan, Nicole, Trujillo, Chadwick A., and Ye, Quanzhi

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We report the detection of water vapor associated with main-belt comet 358P/PANSTARRS on UT 2024 January 8-9 using the NIRSPEC instrument aboard JWST. We derive a water production rate of Q(H2O)=(5.0+/-0.2)x10^25 molecules/s, marking only the second direct detection of sublimation products of any kind from a main-belt comet, after 238P/Read. Similar to 238P, we find a remarkable absence of hypervolatile species, finding Q(CO2)<7.6x10^22 molecules/s, corresponding to Q(CO2)/Q(H2O)<0.2%. Upper limits on CH3OH and CO emission are also estimated. Photometry from ground-based observations show that the dust coma brightened and faded slowly over ~250 days in 2023-2024, consistent with photometric behavior observed in 2012-2013, but also indicate a ~2.5x decline in the dust production rate between these two periods. Dynamical dust modeling shows that the coma's morphology as imaged by JWST's NIRCAM instrument on 2023 November 22 can be reproduced by asymmetric dust emission from a nucleus with a mid-range obliquity (~80 deg) with a steady-state mass loss rate of ~0.8 kg/s. Finally, we find similar Afrho-to-gas ratios of log10(Afrho/Q(H2O))=-24.8+/-0.2 for 358P and log10(Afrho/QH2O)=-24.4+/-0.2 for 238P, suggesting that Afrho could serve as an effective proxy for estimating water production rates in other active main-belt comets. The confirmation of water vapor outgassing in both main-belt comets observed by JWST to date reinforces the use of recurrent activity near perihelion as an indicator of sublimation-driven activity in active asteroids., Comment: 32 pages, 13 figures. Accepted for publication in The Planetary Science Journal

Published
2024

17. EPIC: Enhancing Privacy through Iterative Collaboration

Author

Chourasia, Prakash, Lonkar, Heramb, Ali, Sarwan, and Patterson, Murray

Subjects
Computer Science - Machine Learning, Computer Science - Cryptography and Security
Abstract

Advancements in genomics technology lead to a rising volume of viral (e.g., SARS-CoV-2) sequence data, resulting in increased usage of machine learning (ML) in bioinformatics. Traditional ML techniques require centralized data collection and processing, posing challenges in realistic healthcare scenarios. Additionally, privacy, ownership, and stringent regulation issues exist when pooling medical data into centralized storage to train a powerful deep learning (DL) model. The Federated learning (FL) approach overcomes such issues by setting up a central aggregator server and a shared global model. It also facilitates data privacy by extracting knowledge while keeping the actual data private. This work proposes a cutting-edge Privacy enhancement through Iterative Collaboration (EPIC) architecture. The network is divided and distributed between local and centralized servers. We demonstrate the EPIC approach to resolve a supervised classification problem to estimate SARS-CoV-2 genomic sequence data lineage without explicitly transferring raw sequence data. We aim to create a universal decentralized optimization framework that allows various data holders to work together and converge to a single predictive model. The findings demonstrate that privacy-preserving strategies can be successfully used with aggregation approaches without materially altering the degree of learning convergence. Finally, we highlight a few potential issues and prospects for study in FL-based approaches to healthcare applications., Comment: Accepted at SIMBig 2024

Published
2024

18. Identifying Eccentricity in Binary Black Hole mergers using a Harmonic Decomposition of the Gravitational Waveform

Author

Patterson, Ben G., Tomson, Sharon Mary, and Fairhurst, Stephen

Subjects
General Relativity and Quantum Cosmology, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We show that the gravitational waveform emitted by a binary on an eccentric orbit can be naturally decomposed into a series of harmonics. The frequencies of these harmonics depend upon the radial frequency, $f_{\mathrm{r}}$, determined by the time to return to apoapsis, and the azimuthal frequency, $f_{\phi}$, determined by the time to complete one orbit relative to a fixed axis. These frequencies differ due to periapsis advance. Restricting to the (2, 2) multipole, we find that the frequencies can be expressed as $f = 2 f_{\phi} + k f_{\mathrm{r}}$. We introduce a straightforward method of generating these harmonics and show that the majority of the signal power is contained in the $k= -1, 0, 1$ harmonics for moderate eccentricities. We demonstrate that by filtering these three leading harmonics, we are able to obtain a good estimate of the orbital eccentricity from their relative amplitudes., Comment: 21 pages, 12 figures

Published
2024

19. Measurement Schemes for Quantum Linear Equation Solvers

Author

Patterson, Andrew and Lapworth, Leigh

Subjects
Quantum Physics
Abstract

Solving Computational Fluid Dynamics (CFD) problems requires the inversion of a linear system of equations, which can be done using a quantum algorithm for matrix inversion arxiv:1806.01838. However, the number of shots required to measure the output of the system can be prohibitive and remove any advantage obtained by quantum computing. In this work we propose a scheme for measuring the output of QSVT matrix inversion algorithms specifically for the CFD use case. We use a Quantum Signal Processing (QSP) based amplitude estimation algorithm arxiv:2207.08628 and show how it can be combined with the QSVT matrix inversion algorithm. We perform a detailed resource estimation of the amount of computational resources required for a single iteration of amplitude estimation, and compare the costs of amplitude estimation with the cost of not doing amplitude estimation and measuring the whole wavefunction. We also propose a measurement scheme to reduce the number of amplitudes measured in the CFD example by focusing on large amplitudes only. We simulate the whole CFD loop, finding that thus measuring only a small number of the total amplitudes in the output vector still results in an acceptable level of overall error., Comment: 23 pages, 10 figures

Published
2024

20. Atomic-Scale Imaging of Polymers and Precision Molecular Weight Analysis.

Author

Marathianos, Arkadios, Magiakos, Alexandros, Han, Yisong, Sanchez, Ana, Whitfield, Richard, Kammerer, Jochen, Anastasaki, Athina, Wilson, Paul, Patterson, Joseph, Barner-Kowollik, Christopher, and Liarou, Evelina

Abstract

Polymer design requires fine control over syntheses and a thorough understanding of their macromolecular structure. Herein, near-atomic level imaging of polymers is achieved, enabling the precise determination of one of the most important macromolecular characteristics: molecular weight. By judiciously designing and synthesizing different linear metal(loid)-rich homopolymers, subnanoscale polymer imaging is achieved through annular dark field-scanning transmission electron microscopy (ADF-STEM), owing to the incorporation of high Z atoms in the side chain of the monomeric units. The molecular weight of these polymers can be precisely determined by detecting and counting their metal(loid) atoms upon ADF-STEM imaging, at sample concentrations as low as 10 μg·mL-1. Notably, a commonly used C, H, and O-containing polymer (i.e., poly(methyl acrylate)) that was thus far inaccessible at the atomic scale is derivatized to allow for subnano-level imaging, thus expanding the scope of our approach toward the atomic-level visualization of commodity polymers.

Published
2024

21. Using multiplexed functional data to reduce variant classification inequities in underrepresented populations.

Author

Dawood, Moez, Fayer, Shawn, Pendyala, Sriram, Post, Mason, Kalra, Divya, Patterson, Karynne, Venner, Eric, Muffley, Lara, Fowler, Douglas, Rubin, Alan, Posey, Jennifer, Plon, Sharon, Lupski, James, Gibbs, Richard, Starita, Lea, Robles-Espinoza, Carla, Coyote-Maestas, Willow, and Gallego Romero, Irene

Subjects
All of Us, Benign, Equity, Genetic ancestry, Inequity, MAVE, Missense, Multiplexed assay of variant effects, Pathogenic, VUS, Variants of uncertain significance, gnomAD, Humans, Genetic Variation, BRCA1 Protein, Tumor Suppressor Protein p53, Databases, Genetic, Minority Groups, Gene Frequency, PTEN Phosphohydrolase
Abstract

BACKGROUND: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS). METHODS: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database. Then, we incorporated clinically calibrated MAVE data into the Clinical Genome Resources Variant Curation Expert Panel rules to automate VUS reclassification for BRCA1, TP53, and PTEN. RESULTS: Using two orthogonal statistical approaches, we show a higher prevalence (p ≤ 5.95e - 06) of VUS in individuals of non-European-like genetic ancestry across all medical specialties assessed in all three databases. Further, in the non-European-like genetic ancestry group, higher rates of Benign or Likely Benign and variants with no clinical designation (p ≤ 2.5e - 05) were found across many medical specialties, whereas Pathogenic or Likely Pathogenic assignments were increased in individuals of European-like genetic ancestry (p ≤ 2.5e - 05). Using MAVE data, we reclassified VUS in individuals of non-European-like genetic ancestry at a significantly higher rate in comparison to reclassified VUS from European-like genetic ancestry (p = 9.1e - 03) effectively compensating for the VUS disparity. Further, essential code analysis showed equitable impact of MAVE evidence codes but inequitable impact of allele frequency (p = 7.47e - 06) and computational predictor (p = 6.92e - 05) evidence codes for individuals of non-European-like genetic ancestry. CONCLUSIONS: Generation of saturation-style MAVE data should be a priority to reduce VUS disparities and produce equitable training data for future computational predictors.

Published
2024

22. Physical inactivity exacerbates pathologic inflammatory signalling at the single cell level in patients with systemic lupus

Author

Patterson, Sarah L, Van Phan, Hoang, Ye, Chun Jimmie, Lanata, Cristina, González, Sebastián Cruz, Park, Joonsuk, Criswell, Lindsey A, Barbour, Kamil E, Yazdany, Jinoos, Dall’Era, Maria, Sirota, Marina, Katz, Patricia, and Langelier, Charles R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Immunology, Lupus, Genetics, Human Genome, Women's Health, Clinical Research, Autoimmune Disease, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Inflammatory and immune system, Good Health and Well Being, Humans, Lupus Erythematosus, Systemic, Female, Male, Signal Transduction, Single-Cell Analysis, Adult, Middle Aged, Exercise, Inflammation, Cytokines, Gene Expression Profiling, Sedentary Behavior, Transcriptome, Leukocytes, Mononuclear, arthritis, Physical activity, Single transcriptomics, Lifestyle behaviors, Rheumatoid arthritis, Single cell transcriptomics, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundPhysical activity is an adjunctive therapy that improves symptoms in people living with systemic lupus erythematosus (SLE), yet the mechanisms underlying this benefit remain unclear.MethodsWe carried out a cohort study of 123 patients with SLE enrolled in the California Lupus Epidemiology Study (CLUES). The primary predictor variable was self-reported physical activity, which was measured using a previously validated instrument. We analyzed peripheral blood mononuclear cell (PBMC) single-cell RNA sequencing (scRNA-seq) data available from the cohort. From the scRNA-seq data, we compared immune cell frequencies, cell-specific gene expression, biological signalling pathways, and upstream cytokine activation states between physically active and inactive patients, adjusting for age, sex and race.FindingsWe found that physical activity influenced immune cell frequencies, with sedentary patients most notably demonstrating greater CD4+ T cell lymphopenia (Padj = 0.028). Differential gene expression analysis identified a transcriptional signature of physical inactivity across five cell types. In CD4+ and CD8+ T cells, this signature was characterized by 686 and 445 differentially expressed genes (Padj

Published
2024

23. A diet-dependent host metabolite shapes the gut microbiota to protect from autoimmunity.

Author

Alexander, Margaret, Upadhyay, Vaibhav, Rock, Rachel, Ramirez, Lorenzo, Trepka, Kai, Puchalska, Patrycja, Orellana, Diego, Ang, Qi, Whitty, Caroline, Turnbaugh, Jessie, Tian, Yuan, Dumlao, Darren, Nayak, Renuka, Patterson, Andrew, Newman, John, Crawford, Peter, and Turnbaugh, Peter

Subjects
CP: Immunology, CP: Microbiology, autoimmune disease, gut microbiome, immune activation, ketogenesis, ketogenic diet, lactobacillus, multiple sclerosis, neuroinflammation, nutrition, trytophan metabolism, Animals, Gastrointestinal Microbiome, Encephalomyelitis, Autoimmune, Experimental, Diet, Ketogenic, Mice, Autoimmunity, Mice, Inbred C57BL, Lactobacillus, 3-Hydroxybutyric Acid, Mice, Transgenic, Th17 Cells, Female
Abstract

Diet can protect from autoimmune disease; however, whether diet acts via the host and/or microbiome remains unclear. Here, we use a ketogenic diet (KD) as a model to dissect these complex interactions. A KD rescued the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis in a microbiota-dependent fashion. Dietary supplementation with a single KD-dependent host metabolite (β-hydroxybutyrate [βHB]) rescued EAE, whereas transgenic mice unable to produce βHB in the intestine developed more severe disease. Transplantation of the βHB-shaped gut microbiota was protective. Lactobacillus sequence variants were associated with decreased T helper 17 cell activation in vitro. Finally, we isolated an L. murinus strain that protected from EAE, which was phenocopied by a Lactobacillus metabolite enriched by βHB supplementation, indole lactate. Thus, diet alters the immunomodulatory potential of the gut microbiota by shifting host metabolism, emphasizing the utility of taking a more integrative approach to study diet-host-microbiome interactions.

Published
2024

24. Cell‐Specific Transposable Element and Gene Expression Analysis Across Systemic Lupus Erythematosus Phenotypes

Author

Cutts, Zachary, Patterson, Sarah, Maliskova, Lenka, Taylor, Kimberly E, Ye, Chun Jimmie, Dall'Era, Maria, Yazdany, Jinoos, Criswell, Lindsey A, Fragiadakis, Gabriela K, Langelier, Charles, Capra, John A, Sirota, Marina, and Lanata, Cristina M

Subjects
Biomedical and Clinical Sciences, Immunology, Genetics, Lupus, Autoimmune Disease, Women's Health, 2.1 Biological and endogenous factors, Inflammatory and immune system, Clinical sciences
Abstract

ObjectiveThere is an established yet unexplained link between interferon (IFN) and systemic lupus erythematosus (SLE). The expression of sequences derived from transposable elements (TEs) may contribute to SLE phenotypes, specifically production of type I IFNs and generation of autoantibodies.MethodsWe profiled cell-sorted RNA-sequencing data (CD4+ T cells, CD14+ monocytes, CD19+ B cells, and natural killer cells) from peripheral blood mononuclear cells of 120 patients with SLE and quantified TE expression identifying 27,135 TEs. We tested for differential TE expression across 10 SLE phenotypes, including autoantibody production and disease activity.ResultsWe found 731 differentially expressed (DE) TEs across all SLE phenotypes that were mostly cell specific and phenotype specific. DE TEs were enriched for specific families and open reading frames of viral genes encoded in TE sequences. Increased expression of DE TEs was associated with genes involved in antiviral activity, such as LY6E, ISG15, and TRIM22, and pathways such as IFN signaling.ConclusionThese findings suggest that expression of TEs contributes to activation of SLE-related mechanisms in a cell-specific manner, which can impact disease diagnostics and therapeutics.

Published
2024

25. Developing Consistency Among Undergraduate Graders Scoring Open-Ended Statistics Tasks

Author

Beckman, Matthew D., Burke, Sean, Fiochetta, Jack, Fry, Benjamin, Lloyd, Susan E., Patterson, Luke, and Tang, Elle

Subjects
Statistics - Other Statistics
Abstract

Undergraduate graders are frequently important contributors to the teaching team in post-secondary education settings. This study set out to investigate agreement for a team of undergraduate graders as they acquired training and experience for scoring responses to open-ended tasks. Results demonstrate compelling evidence that undergraduate students can develop the ability to establish and sustain substantial agreement with an instructor, especially when equipped with proper training and a high-quality scoring rubric., Comment: Supplemental materials for the preprint available by request from the first author

Published
2024

26. MIK: Modified Isolation Kernel for Biological Sequence Visualization, Classification, and Clustering

Author

Ali, Sarwan, Chourasia, Prakash, Mansoor, Haris, koirala, Bipin, and Patterson, Murray

Subjects
Computer Science - Machine Learning, Computer Science - Human-Computer Interaction, Statistics - Machine Learning
Abstract

The t-Distributed Stochastic Neighbor Embedding (t-SNE) has emerged as a popular dimensionality reduction technique for visualizing high-dimensional data. It computes pairwise similarities between data points by default using an RBF kernel and random initialization (in low-dimensional space), which successfully captures the overall structure but may struggle to preserve the local structure efficiently. This research proposes a novel approach called the Modified Isolation Kernel (MIK) as an alternative to the Gaussian kernel, which is built upon the concept of the Isolation Kernel. MIK uses adaptive density estimation to capture local structures more accurately and integrates robustness measures. It also assigns higher similarity values to nearby points and lower values to distant points. Comparative research using the normal Gaussian kernel, the isolation kernel, and several initialization techniques, including random, PCA, and random walk initializations, are used to assess the proposed approach (MIK). Additionally, we compare the computational efficiency of all $3$ kernels with $3$ different initialization methods. Our experimental results demonstrate several advantages of the proposed kernel (MIK) and initialization method selection. It exhibits improved preservation of the local and global structure and enables better visualization of clusters and subclusters in the embedded space. These findings contribute to advancing dimensionality reduction techniques and provide researchers and practitioners with an effective tool for data exploration, visualization, and analysis in various domains.

Published
2024

27. Position Specific Scoring Is All You Need? Revisiting Protein Sequence Classification Tasks

Author

Ali, Sarwan, Murad, Taslim, Chourasia, Prakash, Mansoor, Haris, Khan, Imdad Ullah, Chen, Pin-Yu, and Patterson, Murray

Subjects
Computer Science - Machine Learning
Abstract

Understanding the structural and functional characteristics of proteins are crucial for developing preventative and curative strategies that impact fields from drug discovery to policy development. An important and popular technique for examining how amino acids make up these characteristics of the protein sequences with position-specific scoring (PSS). While the string kernel is crucial in natural language processing (NLP), it is unclear if string kernels can extract biologically meaningful information from protein sequences, despite the fact that they have been shown to be effective in the general sequence analysis tasks. In this work, we propose a weighted PSS kernel matrix (or W-PSSKM), that combines a PSS representation of protein sequences, which encodes the frequency information of each amino acid in a sequence, with the notion of the string kernel. This results in a novel kernel function that outperforms many other approaches for protein sequence classification. We perform extensive experimentation to evaluate the proposed method. Our findings demonstrate that the W-PSSKM significantly outperforms existing baselines and state-of-the-art methods and achieves up to 45.1\% improvement in classification accuracy.

Published
2024

28. Measurement of the double-differential cross section of muon-neutrino charged-current interactions with low hadronic energy in the NOvA Near Detector

Author

Acero, M. A., Acharya, B., Adamson, P., Aliaga, L., Anfimov, N., Antoshkin, A., Arrieta-Diaz, E., Asquith, L., Aurisano, A., Back, A., Balashov, N., Baldi, P., Bambah, B. A., Bannister, E., Barros, A., Bashar, S., Bat, A., Bays, K., Bernstein, R., Bezerra, T. J. C., Bhatnagar, V., Bhattarai, D., Bhuyan, B., Bian, J., Booth, A. C., Bowles, R., Brahma, B., Bromberg, C., Buchanan, N., Butkevich, A., Calvez, S., Carroll, T. J., Catano-Mur, E., Cesar, J. P., Chatla, A., Chirco, R., Choudhary, B. C., Christensen, A., Cicala, M. F., Coan, T. E., Cooleybeck, A., Cortes-Parra, C., Coveyou, D., Cremonesi, L., Davies, G. S., Derwent, P. F., Ding, P., Djurcic, Z., Dobbs, K., Dolce, M., Doyle, D., Tonguino, D. Dueñas, Dukes, E. C., Dye, A., Ehrlich, R., Ewart, E., Filip, P., Frank, M. J., Gallagher, H. R., Gao, F., Giri, A., Gomes, R. A., Goodman, M. C., Groh, M., Group, R., Habig, A., Hakl, F., Hartnell, J., Hatcher, R., He, M., Heller, K., Hewes, V, Himmel, A., Horoho, T., Ivaneev, Y., Ivanova, A., Jargowsky, B., Jarosz, J., Johnson, C., Judah, M., Kakorin, I., Kaplan, D. M., Kalitkina, A., Kirezli-Ozdemir, B., Kleykamp, J., Klimov, O., Koerner, L. W., Kolupaeva, L., Kralik, R., Kumar, A., Kus, V., Lackey, T., Lang, K., Lesmeister, J., Lister, A., Liu, J., Lock, J. A., Lokajicek, M., MacMahon, M., Magill, S., Mann, W. A., Manoharan, M. T., Plata, M. Manrique, Marshak, M. L., Martinez-Casales, M., Matveev, V., Mehta, B., Messier, M. D., Meyer, H., Miao, T., Miller, W. H., Mishra, S., Mishra, S. R., Mislivec, A., Mohanta, R., Moren, A., Morozova, A., Mu, W., Mualem, L., Muether, M., Mulder, K., Myers, D., Naples, D., Nath, A., Nelleri, S., Nelson, J. K., Nichol, R., Niner, E., Norman, A., Norrick, A., Nosek, T., Oh, H., Olshevskiy, A., Olson, T., Ozkaynak, M., Pal, A., Paley, J., Panda, L., Patterson, R. B., Pawloski, G., Petti, R., Porter, J. C. C., Prais, L. R., Rabelhofer, M., Rafique, A., Raj, V., Rajaoalisoa, M., Ramson, B., Rebel, B., Roy, P., Samoylov, O., Sanchez, M. C., Falero, S. Sanchez, Shanahan, P., Sharma, P., Sheshukov, A., Shivam, Shmakov, A., Shorrock, W., Shukla, S., Singha, D. K., Singh, I., Singh, P., Singh, V., Smith, E., Smolik, J., Snopok, P., Solomey, N., Sousa, A., Soustruznik, K., Strait, M., Suter, L., Sutton, A., Sutton, K., Swain, S., Sweeney, C., Sztuc, A., Talukdar, N., Oregui, B. Tapia, Tas, P., Thakore, T., Thomas, J., Tiras, E., Titus, M., Torun, Y., Tran, D., Trokan-Tenorio, J., Urheim, J., Vahle, P., Vallari, Z., Villamil, J. D., Vockerodt, K. J., Wallbank, M., Weber, C., Wetstein, M., Whittington, D., Wickremasinghe, D. A., Wieber, T., Wolcott, J., Wrobel, M., Wu, S., Wu, W., Xiao, Y., Yaeggy, B., Yahaya, A., Yankelevich, A., Yonehara, K., Yu, Y., Zadorozhnyy, S., Zalesak, J., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

The NOvA collaboration reports cross-section measurements for $\nu_{\mu}$ charged-current interactions with low hadronic energy (maximum kinetic energy of 250 MeV for protons and 175 MeV for pions) in the NOvA Near Detector. The results are presented as a double-differential cross section as a function of the direct observables of the final-state muon kinematics. Results are also presented as a single-differential cross section as a function of the derived square of the four-momentum transfer, $Q^{2}$, and as a function of the derived neutrino energy. The data correspond to an accumulated 8.09$\times10^{20}$ protons-on-target (POT) in the neutrino mode of the NuMI beam, with a narrow band of neutrino energies peaked at 1.8 GeV. The analysis provides a sample of neutrino-nucleus interactions with an enhanced fraction of quasi-elastic and two-particle-two-hole (2p2h) interactions. This enhancement allows quantitative comparisons with various nuclear models. We find strong disagreement between data and theory-based models in various regions of the muon kinematic phase space, especially in the forward muon direction., Comment: 20 pages, 12 figures. The second version includes an additional citation and adds four previously missing authors

Published
2024

29. Measurement of d2sigma/d|q|dEavail in charged current neutrino-nucleus interactions at <Ev> = 1.86 GeV using the NOvA Near Detector

Author

Acero, M. A., Acharya, B., Adamson, P., Aliaga, L., Anfimov, N., Antoshkin, A., Arrieta-Diaz, E., Asquith, L., Aurisano, A., Back, A., Balashov, N., Baldi, P., Bambah, B. A., Bannister, E., Barros, A., Bashar, S., Bat, A., Bays, K., Bernstein, R., Bezerra, T. J. C., Bhatnagar, V., Bhattarai, D., Bhuyan, B., Bian, J., Booth, A. C., Bowles, R., Brahma, B., Bromberg, C., Buchanan, N., Butkevich, A., Calvez, S., Carroll, T. J., Catano-Mur, E., Cesar, J. P., Chatla, A., Chirco, R., Choudhary, B. C., Christensen, A., Cicala, M. F., Coan, T. E., Cooleybeck, A., Cortes-Parra, C., Coveyou, D., Cremonesi, L., Davies, G. S., Derwent, P. F., Ding, P., Djurcic, Z., Dobbs, K., Dolce, M., Doyle, D., Tonguino, D. Duenas, Dukes, E. C., Dye, A., Ehrlich, R., Ewart, E., Filip, P., Frank, M. J., Gallagher, H. R., Gao, F., Giri, A., Gomes, R. A., Goodman, M. C., Groh, M., Group, R., Habig, A., Hakl, F., Hartnell, J., Hatcher, R., He, M., Heller, K., Hewes, V, Himmel, A., Horoho, T., Ivaneev, Y., Ivanova, A., Jargowsky, B., Jarosz, J., Johnson, C., Judah, M., Kakorin, I., Kaplan, D. M., Kalitkina, A., Kirezli-Ozdemir, B., Kleykamp, J., Klimov, O., Koerner, L. W., Kolupaeva, L., Kralik, R., Kumar, A., Kuruppu, C. D., Kus, V., Lackey, T., Lang, K., Lesmeister, J., Lister, A., Liu, J., Lock, J. A., Lokajicek, M., MacMahon, M., Magill, S., Mann, W. A., Manoharan, M. T., Plata, M. Manrique, Marshak, M. L., Martinez-Casales, M., Matveev, V., Mehta, B., Messier, M. D., Meyer, H., Miao, T., Miller, W. H., Mishra, S., Mishra, S. R., Mohanta, R., Moren, A., Morozova, A., Mu, W., Mualem, L., Muether, M., Mulder, K., Myers, D., Naples, D., Nath, A., Nelleri, S., Nelson, J. K., Nichol, R., Niner, E., Norman, A., Norrick, A., Nosek, T., Oh, H., Olshevskiy, A., Olson, T., Ozkaynak, M., Pal, A., Paley, J., Panda, L., Patterson, R. B., Pawloski, G., Petti, R., Plunkett, R. K., Prais, L. R., Rabelhofer, M., Rafique, A., Raj, V., Rajaoalisoa, M., Ramson, B., Rebel, B., Roy, P., Samoylov, O., Sanchez, M. C., Falero, S. Sanchez, Shanahan, P., Sharma, P., Sheshukov, A., Shivam, Shmakov, A., Shorrock, W., Shukla, S., Singha, D. K., Singh, I., Singh, P., Singh, V., Smith, E., Smolik, J., Snopok, P., Solomey, N., Sousa, A., Soustruznik, K., Strait, M., Suter, L., Sutton, A., Sutton, K., Swain, S., Sweeney, C., Sztuc, A., Oregui, B. Tapia, Tas, P., Thakore, T., Thomas, J., Tiras, E., Torun, Y., Tran, D., Trokan-Tenorio, J., Urheim, J., Vahle, P., Vallari, Z., Villamil, J. D., Vockerodt, K. J., Wallbank, M., Wetstein, M., Whittington, D., Wickremasinghe, D. A., Wieber, T., Wolcott, J., Wrobel, M., Wu, S., Wu, W., Xiao, Y., Yaeggy, B., Yahaya, A., Yankelevich, A., Yonehara, K., Yu, Y., Zadorozhnyy, S., Zalesak, J., and Zwaska, R.

Subjects
High Energy Physics - Experiment
Abstract

Double- and single-differential cross sections for inclusive charged-current neutrino-nucleus scattering are reported for the kinematic domain 0 to 2 GeV/c in three-momentum transfer and 0 to 2 GeV in available energy, at a mean muon-neutrino energy of 1.86 GeV. The measurements are based on an estimated 995,760 muon-neutrino CC interactions in the scintillator medium of the NOvA Near Detector. The subdomain populated by 2-particle-2-hole reactions is identified by the cross-section excess relative to predictions for neutrino-nucleus scattering that are constrained by a data control sample. Models for 2-particle-2- hole processes are rated by chi-square comparisons of the predicted-versus-measured muon-neutrino CC inclusive cross section over the full phase space and in the restricted subdomain. Shortfalls are observed in neutrino generator predictions obtained using the theory-based Val`encia and SuSAv2 2p2h models., Comment: 20 pages, 14 figures

Published
2024

30. Demonstrating real-time and low-latency quantum error correction with superconducting qubits

Author

Caune, Laura, Skoric, Luka, Blunt, Nick S., Ruban, Archibald, McDaniel, Jimmy, Valery, Joseph A., Patterson, Andrew D., Gramolin, Alexander V., Majaniemi, Joonas, Barnes, Kenton M., Bialas, Tomasz, Buğdaycı, Okan, Crawford, Ophelia, Gehér, György P., Krovi, Hari, Matekole, Elisha, Topal, Canberk, Poletto, Stefano, Bryant, Michael, Snyder, Kalan, Gillespie, Neil I., Jones, Glenn, Johar, Kauser, Campbell, Earl T., and Hill, Alexander D.

Subjects
Quantum Physics
Abstract

Quantum error correction (QEC) will be essential to achieve the accuracy needed for quantum computers to realise their full potential. The field has seen promising progress with demonstrations of early QEC and real-time decoded experiments. As quantum computers advance towards demonstrating a universal fault-tolerant logical gate set, implementing scalable and low-latency real-time decoding will be crucial to prevent the backlog problem, avoiding an exponential slowdown and maintaining a fast logical clock rate. Here, we demonstrate low-latency feedback with a scalable FPGA decoder integrated into the control system of a superconducting quantum processor. We perform an 8-qubit stability experiment with up to $25$ decoding rounds and a mean decoding time per round below $1$ ${\mu}s$, showing that we avoid the backlog problem even on superconducting hardware with the strictest speed requirements. We observe logical error suppression as the number of decoding rounds is increased. We also implement and time a fast-feedback experiment demonstrating a decoding response time of $9.6$ ${\mu}s$ for a total of $9$ measurement rounds. The decoder throughput and latency developed in this work, combined with continued device improvements, unlock the next generation of experiments that go beyond purely keeping logical qubits alive and into demonstrating building blocks of fault-tolerant computation, such as lattice surgery and magic state teleportation., Comment: 11 pages, 4 figures, Supplementary Information

Published
2024

31. Improving Efficiency of Sampling-based Motion Planning via Message-Passing Monte Carlo

Author

Chahine, Makram, Rusch, T. Konstantin, Patterson, Zach J., and Rus, Daniela

Subjects
Computer Science - Robotics, 68T40, 62D05, 68T07, I.2.8, I.2.9
Abstract

Sampling-based motion planning methods, while effective in high-dimensional spaces, often suffer from inefficiencies due to irregular sampling distributions, leading to suboptimal exploration of the configuration space. In this paper, we propose an approach that enhances the efficiency of these methods by utilizing low-discrepancy distributions generated through Message-Passing Monte Carlo (MPMC). MPMC leverages Graph Neural Networks (GNNs) to generate point sets that uniformly cover the space, with uniformity assessed using the the $\cL_p$-discrepancy measure, which quantifies the irregularity of sample distributions. By improving the uniformity of the point sets, our approach significantly reduces computational overhead and the number of samples required for solving motion planning problems. Experimental results demonstrate that our method outperforms traditional sampling techniques in terms of planning efficiency.

Published
2024

32. Customizing Generated Signs and Voices of AI Avatars: Deaf-Centric Mixed-Reality Design for Deaf-Hearing Communication

Author

Chen, Si, Cheng, Haocong, Su, Suzy, Patterson, Stephanie, Kushalnagar, Raja, Wang, Qi, and Huang, Yun

Subjects
Computer Science - Human-Computer Interaction
Abstract

This study investigates innovative interaction designs for communication and collaborative learning between learners of mixed hearing and signing abilities, leveraging advancements in mixed reality technologies like Apple Vision Pro and generative AI for animated avatars. Adopting a participatory design approach, we engaged 15 d/Deaf and hard of hearing (DHH) students to brainstorm ideas for an AI avatar with interpreting ability (sign language to English, voice to English) that would facilitate their face-to-face communication with hearing peers. Participants envisioned the AI avatars to address some issues with human interpreters, such as lack of availability, and provide affordable options to expensive personalized interpreting service. Our findings indicate a range of preferences for integrating the AI avatars with actual human figures of both DHH and hearing communication partners. The participants highlighted the importance of having control over customizing the AI avatar, such as AI-generated signs, voices, facial expressions, and their synchronization for enhanced emotional display in communication. Based on our findings, we propose a suite of design recommendations that balance respecting sign language norms with adherence to hearing social norms. Our study offers insights on improving the authenticity of generative AI in scenarios involving specific, and sometimes unfamiliar, social norms.

Published
2024

33. The track-length extension fitting algorithm for energy measurement of interacting particles in liquid argon TPCs and its performance with ProtoDUNE-SP data

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Alex, N. S., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Alzás, P. Barham, Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Choi, G., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. 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Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

This paper introduces a novel track-length extension fitting algorithm for measuring the kinetic energies of inelastically interacting particles in liquid argon time projection chambers (LArTPCs). The algorithm finds the most probable offset in track length for a track-like object by comparing the measured ionization density as a function of position with a theoretical prediction of the energy loss as a function of the energy, including models of electron recombination and detector response. The algorithm can be used to measure the energies of particles that interact before they stop, such as charged pions that are absorbed by argon nuclei. The algorithm's energy measurement resolutions and fractional biases are presented as functions of particle kinetic energy and number of track hits using samples of stopping secondary charged pions in data collected by the ProtoDUNE-SP detector, and also in a detailed simulation. Additional studies describe the impact of the dE/dx model on energy measurement performance. The method described in this paper to characterize the energy measurement performance can be repeated in any LArTPC experiment using stopping secondary charged pions.

Published
2024

34. Evaluation of Large Language Models for Summarization Tasks in the Medical Domain: A Narrative Review

Author

Croxford, Emma, Gao, Yanjun, Pellegrino, Nicholas, Wong, Karen K., Wills, Graham, First, Elliot, Liao, Frank J., Goswami, Cherodeep, Patterson, Brian, and Afshar, Majid

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

Large Language Models have advanced clinical Natural Language Generation, creating opportunities to manage the volume of medical text. However, the high-stakes nature of medicine requires reliable evaluation, which remains a challenge. In this narrative review, we assess the current evaluation state for clinical summarization tasks and propose future directions to address the resource constraints of expert human evaluation.

Published
2024

35. HydroVision: LiDAR-Guided Hydrometric Prediction with Vision Transformers and Hybrid Graph Learning

Author

Roudbari, Naghmeh Shafiee, Eicker, Ursula, Poullis, Charalambos, and Patterson, Zachary

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Hydrometric forecasting is crucial for managing water resources, flood prediction, and environmental protection. Water stations are interconnected, and this connectivity influences the measurements at other stations. However, the dynamic and implicit nature of water flow paths makes it challenging to extract a priori knowledge of the connectivity structure. We hypothesize that terrain elevation significantly affects flow and connectivity. To incorporate this, we use LiDAR terrain elevation data encoded through a Vision Transformer (ViT). The ViT, which has demonstrated excellent performance in image classification by directly applying transformers to sequences of image patches, efficiently captures spatial features of terrain elevation. To account for both spatial and temporal features, we employ GRU blocks enhanced with graph convolution, a method widely used in the literature. We propose a hybrid graph learning structure that combines static and dynamic graph learning. A static graph, derived from transformer-encoded LiDAR data, captures terrain elevation relationships, while a dynamic graph adapts to temporal changes, improving the overall graph representation. We apply graph convolution in two layers through these static and dynamic graphs. Our method makes daily predictions up to 12 days ahead. Empirical results from multiple water stations in Quebec demonstrate that our method significantly reduces prediction error by an average of 10\% across all days, with greater improvements for longer forecasting horizons.

Published
2024

36. Improving 3D Semi-supervised Learning by Effectively Utilizing All Unlabelled Data

Author

Paul, Sneha, Patterson, Zachary, and Bouguila, Nizar

Subjects
Computer Science - Computer Vision and Pattern Recognition
Abstract

Semi-supervised learning (SSL) has shown its effectiveness in learning effective 3D representation from a small amount of labelled data while utilizing large unlabelled data. Traditional semi-supervised approaches rely on the fundamental concept of predicting pseudo-labels for unlabelled data and incorporating them into the learning process. However, we identify that the existing methods do not fully utilize all the unlabelled samples and consequently limit their potential performance. To address this issue, we propose AllMatch, a novel SSL-based 3D classification framework that effectively utilizes all the unlabelled samples. AllMatch comprises three modules: (1) an adaptive hard augmentation module that applies relatively hard augmentations to the high-confident unlabelled samples with lower loss values, thereby enhancing the contribution of such samples, (2) an inverse learning module that further improves the utilization of unlabelled data by learning what not to learn, and (3) a contrastive learning module that ensures learning from all the samples in both supervised and unsupervised settings. Comprehensive experiments on two popular 3D datasets demonstrate a performance improvement of up to 11.2% with 1% labelled data, surpassing the SOTA by a significant margin. Furthermore, AllMatch exhibits its efficiency in effectively leveraging all the unlabelled data, demonstrated by the fact that only 10% of labelled data reaches nearly the same performance as fully-supervised learning with all labelled data. The code of our work is available at: https://github.com/snehaputul/AllMatch., Comment: Accepted at the European Conference on Computer Vision, ECCV 2024

Published
2024

37. Rotationally Resolved Spectroscopy of a Single Polyatomic Molecule

Author

Calvin, Aaron, Brzeczek, Merrell, Kresch, Samuel, Lane, Elijah, Satterthwaite, Lincoln, Hawkins, Desi, and Patterson, David

Subjects
Physics - Chemical Physics
Abstract

We report the rotationally resolved spectrum of a single polyatomic molecular ion in the gas phase. Building upon the recently developed inelastic recoil spectroscopy (IRS) technique, we have achieved a spectral resolution sufficient to observe resolved rotational-vibrational transitions of a trapped cyclopropenyl cation, c-C3H3+. The high precision of IRS shown in this work presents an attractive platform for astrochemistry, single molecule chiral detection, and tests of fundamental physics.

Published
2024

38. Human-like Affective Cognition in Foundation Models

Author

Gandhi, Kanishk, Lynch, Zoe, Fränken, Jan-Philipp, Patterson, Kayla, Wambu, Sharon, Gerstenberg, Tobias, Ong, Desmond C., and Goodman, Noah D.

Subjects
Computer Science - Computation and Language
Abstract

Understanding emotions is fundamental to human interaction and experience. Humans easily infer emotions from situations or facial expressions, situations from emotions, and do a variety of other affective cognition. How adept is modern AI at these inferences? We introduce an evaluation framework for testing affective cognition in foundation models. Starting from psychological theory, we generate 1,280 diverse scenarios exploring relationships between appraisals, emotions, expressions, and outcomes. We evaluate the abilities of foundation models (GPT-4, Claude-3, Gemini-1.5-Pro) and humans (N = 567) across carefully selected conditions. Our results show foundation models tend to agree with human intuitions, matching or exceeding interparticipant agreement. In some conditions, models are ``superhuman'' -- they better predict modal human judgements than the average human. All models benefit from chain-of-thought reasoning. This suggests foundation models have acquired a human-like understanding of emotions and their influence on beliefs and behavior.

Published
2024

39. Accelerated detector in a superposed spacetime

Author

Goel, Lakshay, Patterson, Everett A., Preciado-Rivas, María Rosa, Torabian, Mahdi, Mann, Robert B., and Afshordi, Niayesh

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Theory, Quantum Physics
Abstract

In pursuit of a full-fledged theory of quantum gravity, operational approaches offer insights into quantum-gravitational effects produced by quantum superposition of different spacetimes not diffeomorphic to one another. Recent work applies this approach to superpose cylindrically identified Minkowski spacetimes (i.e. periodic boundary conditions) with different characteristic circumferences, where a two-level detector coupled to a quantum field residing in the spacetime exhibits resonance peaks in response at certain values of the superposed length ratios. Here, we extend this analysis to a superposition of cylindrically identified Rindler spacetimes, considering a two-level detector constantly accelerated in the direction orthogonal to the compact dimension. Similarly to previous work, we find resonance peaks in the detector response at rational ratios of the superposed compactified lengths, which we observe to be accentuated by the acceleration of the detector. Furthermore, for the first time we confirm the detailed balance condition due to acceleration in a superposition of spacetimes, commensurate with the Unruh effect in a single spacetime state. The resonant structure of detector response in the presence of event horizons, for the first time observed in 3+1 dimensions, may offer clues to the nature of black hole entropy in the full theory of quantum gravity., Comment: 8 + 12 pages, 7 + 2 figures

Published
2024

40. DANCE: Deep Learning-Assisted Analysis of Protein Sequences Using Chaos Enhanced Kaleidoscopic Images

Author

Murad, Taslim, Chourasia, Prakash, Ali, Sarwan, Khan, Imdad Ullah, and Patterson, Murray

Subjects
Computer Science - Machine Learning, Quantitative Biology - Quantitative Methods
Abstract

Cancer is a complex disease characterized by uncontrolled cell growth. T cell receptors (TCRs), crucial proteins in the immune system, play a key role in recognizing antigens, including those associated with cancer. Recent advancements in sequencing technologies have facilitated comprehensive profiling of TCR repertoires, uncovering TCRs with potent anti-cancer activity and enabling TCR-based immunotherapies. However, analyzing these intricate biomolecules necessitates efficient representations that capture their structural and functional information. T-cell protein sequences pose unique challenges due to their relatively smaller lengths compared to other biomolecules. An image-based representation approach becomes a preferred choice for efficient embeddings, allowing for the preservation of essential details and enabling comprehensive analysis of T-cell protein sequences. In this paper, we propose to generate images from the protein sequences using the idea of Chaos Game Representation (CGR) using the Kaleidoscopic images approach. This Deep Learning Assisted Analysis of Protein Sequences Using Chaos Enhanced Kaleidoscopic Images (called DANCE) provides a unique way to visualize protein sequences by recursively applying chaos game rules around a central seed point. we perform the classification of the T cell receptors (TCRs) protein sequences in terms of their respective target cancer cells, as TCRs are known for their immune response against cancer disease. The TCR sequences are converted into images using the DANCE method. We employ deep-learning vision models to perform the classification to obtain insights into the relationship between the visual patterns observed in the generated kaleidoscopic images and the underlying protein properties. By combining CGR-based image generation with deep learning classification, this study opens novel possibilities in the protein analysis domain.

Published
2024

41. Nearest Neighbor CCP-Based Molecular Sequence Analysis

Author

Ali, Sarwan, Chourasia, Prakash, Koirala, Bipin, and Patterson, Murray

Subjects
Quantitative Biology - Genomics, Computer Science - Artificial Intelligence, Computer Science - Computational Complexity, Computer Science - Machine Learning
Abstract

Molecular sequence analysis is crucial for comprehending several biological processes, including protein-protein interactions, functional annotation, and disease classification. The large number of sequences and the inherently complicated nature of protein structures make it challenging to analyze such data. Finding patterns and enhancing subsequent research requires the use of dimensionality reduction and feature selection approaches. Recently, a method called Correlated Clustering and Projection (CCP) has been proposed as an effective method for biological sequencing data. The CCP technique is still costly to compute even though it is effective for sequence visualization. Furthermore, its utility for classifying molecular sequences is still uncertain. To solve these two problems, we present a Nearest Neighbor Correlated Clustering and Projection (CCP-NN)-based technique for efficiently preprocessing molecular sequence data. To group related molecular sequences and produce representative supersequences, CCP makes use of sequence-to-sequence correlations. As opposed to conventional methods, CCP doesn't rely on matrix diagonalization, therefore it can be applied to a range of machine-learning problems. We estimate the density map and compute the correlation using a nearest-neighbor search technique. We performed molecular sequence classification using CCP and CCP-NN representations to assess the efficacy of our proposed approach. Our findings show that CCP-NN considerably improves classification task accuracy as well as significantly outperforms CCP in terms of computational runtime.

Published
2024

42. Electric field control of superconductivity and quantized anomalous Hall effects in rhombohedral tetralayer graphene

Author

Choi, Youngjoon, Choi, Ysun, Valentini, Marco, Patterson, Caitlin L., Holleis, Ludwig F. W., Sheekey, Owen I., Stoyanov, Hari, Cheng, Xiang, Taniguchi, Takashi, Watanabe, Kenji, and Young, Andrea F.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Superconductivity
Abstract

Inducing superconducting correlations in chiral edge states is predicted to generate topologically protected zero energy modes with exotic quantum statistics. Experimental efforts to date have focused on engineering interfaces between superconducting materials, typically amorphous metals, and semiconducting quantum Hall or quantum anomalous Hall (QAH) systems. However, the strong interfacial disorder inherent can prevent the formation of isolated topological modes. An appealing alternative is to use low-density flat band materials where the ground state can be tuned between intrinsic superconducting and quantum anomalous Hall states using only the electric field effect. However, quantized transport and superconductivity have not been simultaneously achieved. Here, we show that rhombohedral tetralayer graphene aligned to a hexagonal boron nitride substrate hosts a quantized anomalous Hall state at superlattice filling $\nu = -1$ as well as a superconducting state at $\nu \approx -3.1$ at zero magnetic field. Remarkably, gate voltage can also be used to actuate nonvolatile switching of the chirality in the quantum anomalous Hall state, allowing arbitrarily reconfigurable networks of topological edge modes in locally gated devices. Thermodynamic compressibility measurements further reveal a topologically ordered fractional Chern insulator at $\nu = 2/3$, also stable at zero magnetic field, enabling proximity coupling between superconductivity and fractionally charged edge modes. Finally, we show that integrating an additional transition metal dichalcogenide layer to the heterostructure enhances the maximum superconducting critical temperature and nucleates new superconducting pockets, while leaving the topology of $\nu = -1$ the quantum anomalous Hall state intact. Our results pave the way for hybrid interfaces between superconductors and topological edge states in the low-disorder limit.

Published
2024

43. DUNE Phase II: Scientific Opportunities, Detector Concepts, Technological Solutions

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D. M., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Barham~Alzás, P., Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chakraborty, S., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cortez, A. F. V., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farrell, S., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Fernández-Posada, D., Ferry, G., Fialova, E., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gaba, R., Gabrielli, A., M~Gago, A., Galizzi, F., Gallagher, H., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Gazzana, S., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, L., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, F. Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. M., Gwon, S., Habig, A., Hadavand, H., Haegel, L., Haenni, R., Hagaman, L., Hahn, A., Haiston, J., Hakenmüller, J., Hamernik, T., Hamilton, P., Hancock, J., Happacher, F., Harris, D. A., Hart, A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C. M., Hatcher, R., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Hellmuth, P., Henry, S., Hernández-García, J., Herner, K., Hewes, V., Higuera, A., Hilgenberg, C., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Holvey, T., Hoppe, E., Horiuchi, S., Horton-Smith, G. A., Houdy, T., Howard, B., Howell, R., Hristova, I., Hronek, M. S., Huang, J., Huang, R. G., Hulcher, Z., Ibrahim, M., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Oliveira, M. Ismerio, Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jena, D., Jentz, I., Ji, X., Jiang, C., Jiang, J., Jiang, L., Jipa, A., Jo, J. H., Joaquim, F. R., Johnson, W., Jollet, C., Jones, B., Jones, R., Jovancevic, N., Judah, M., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A. C., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kandemir, M., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Katsioulas, I., Kauther, A., Kazaryan, N., Ke, L., Kearns, E., Keener, P. T., Kelly, K. J., Kemp, E., Kemularia, O., Kermaidic, Y., Ketchum, W., Kettell, S. H., Khabibullin, M., Khan, N., Khvedelidze, A., Kim, D., Kim, J., Kim, M. J., King, B., Kirby, B., Kirby, M., Kish, A., Klein, J., Kleykamp, J., Klustova, A., Kobilarcik, T., Koch, L., Koehler, K., Koerner, L. W., Koh, D. H., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Kotler, I., Kovalcuk, M., Kozhukalov, V., Krah, W., Kralik, R., Kramer, M., Kreczko, L., Krennrich, F., Kreslo, I., Kroupova, T., Kubota, S., Kubu, M., Kudenko, Y., Kudryavtsev, V. A., Kufatty, G., Kuhlmann, S., Kulagin, S., Kumar, J., Kumar, P., Kumaran, S., Kunzmann, J., Kuravi, R., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kuźniak, M., Kvasnicka, J., Labree, T., Lackey, T., Lalău, I., Lambert, A., Land, B. J., Lane, C. E., Lane, N., Lang, K., Langford, T., Langstaff, M., Lanni, F., Lantwin, O., Larkin, J., Lasorak, P., Last, D., Laudrain, A., Laundrie, A., Laurenti, G., Lavaut, E., Laycock, P., Lazanu, I., LaZur, R., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeCompte, T., Legin, V., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Silverio, D. Leon, Lepin, L. M., -Y~Li, J., Li, S. W., Li, Y., Liao, H., Lin, C. S., Lindebaum, D., Linden, S., Lineros, R. A., Lister, A., Littlejohn, B. R., Liu, H., Liu, J., Liu, Y., Lockwitz, S., Lokajicek, M., Lomidze, I., Long, K., Lopes, T. V., Lopez, J., de Rego, I. López, López-March, N., Lord, T., LoSecco, J. M., Louis, W. C., Sanchez, A. Lozano, Lu, X. -G., Luk, K. B., Lunday, B., Luo, X., Luppi, E., MacFarlane, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., MacMahon, M., Maddalena, A., Madera, A., Madigan, P., Magill, S., Magueur, C., Mahn, K., Maio, A., Major, A., Majumdar, K., Mameli, S., Man, M., Mandujano, R. C., Maneira, J., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Corchado, S. Manthey, Manyam, V. N., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Markiewicz, T., Marques, F. Das Chagas, Marquet, C., Marshak, M., Marshall, C. M., Marshall, J., Martina, L., Martín-Albo, J., Martinez, N., Caicedo, D. A. Martinez, López, F. Martínez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Massari, C., Mastbaum, A., Matichard, F., Matsuno, S., Matteucci, G., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., McAskill, T., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Meazza, L., Meddage, V. C. N., Mefodiev, A., Mehta, B., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Mercuri, A. C. E. A., Meregaglia, A., Messier, M. D., Metallo, S., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Micallef, J., Miccoli, A., Michna, G., Milincic, R., Miller, F., Miller, G., Miller, W., Mineev, O., Minotti, A., Miralles, L., Miranda, O. G., Mironov, C., Miryala, S., Miscetti, S., Mishra, C. S., Mishra, P., Mishra, S. R., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Mogan, A., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montanino, D., Zetina, L. M. Montaño, Mooney, M., Moor, A. F., Moore, Z., Moreno, D., Moreno-Palacios, O., Morescalchi, L., Moretti, D., Moretti, R., Morris, C., Mossey, C., Moura, C. A., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Munteanu, L. J., Muramatsu, H., Muraz, J., Murphy, M., Murphy, T., Muse, J., Mytilinaki, A., Nachtman, J., Nagai, Y., Nagu, S., Nandakumar, R., Naples, D., Narita, S., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Nehm, A., Nelson, J. K., Neogi, O., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Nikolov, J., Niner, E., Nishimura, K., Norman, A., Norrick, A., Novella, P., Nowak, A., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J. P., Oh, S., Oh, S. B., Olivier, A., Olshevskiy, A., Olson, T., Onel, Y., Onishchuk, Y., Oranday, A., Gann, G. D. Orebi, Osbiston, M., Vélez, J. A. Osorio, O'Sullivan, L., Ormachea, L. Otiniano, Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pan, S., Panda, P., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papaleo, R., Papanestis, A., Papoulias, D., Paramesvaran, S., Paris, A., Parke, S., Parozzi, E., Parsa, S., Parsa, Z., Parveen, S., Parvu, M., Pasciuto, D., Pascoli, S., Pasqualini, L., Pasternak, J., Patrick, C., Patrizii, L., Patterson, R. B., Patzak, T., Paudel, A., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Pedreschi, E., Peeters, S. J. M., Pellico, W., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L. G., Gonzalez, Y. F. Perez, Pérez-Molina, L., Pernas, C., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pfaff, M., Pia, V., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Pincha, S., Pinchault, J., Pitts, K., Plows, K., Pollack, C., Pollman, T., Pompa, F., Pons, X., Poonthottathil, N., Popov, V., Poppi, F., Porter, J., Paix{ã}o, L. G. Porto, Potekhin, M., Potenza, R., Pozimski, J., Pozzato, M., Prakash, T., Pratt, C., Prest, M., Psihas, F., Pugnere, D., Qian, X., Queen, J., Raaf, J. L., Radeka, V., Rademacker, J., Radics, B., Raffaelli, F., Rafique, A., Raguzin, E., Rai, M., Rajagopalan, S., Rajaoalisoa, M., Rakhno, I., Rakotondravohitra, L., Ralte, L., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ray, R., Razafinime, H., Rea, E. M., Real, J. S., Rebel, B., Rechenmacher, R., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renner, E., Renshaw, A., Rescia, S., Resnati, F., Diego~Restrepo, Reynolds, C., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Ricol, J. S., Rigan, M., Rincón, E. V., Ritchie-Yates, A., Ritter, S., Rivera, D., Rivera, R., Robert, A., Rocha, J. L. Rocabado, Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Rosauro-Alcaraz, S., Rosier, P., Ross, D., Rossella, M., Rossi, M., Ross-Lonergan, M., Roy, N., Roy, P., Rubbia, C., Ruggeri, A., Ruiz, G., Russell, B., Ruterbories, D., Rybnikov, A., Sacerdoti, S., Saha, S., Sahoo, S. K., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M. C., Bravo, A. Sánchez, Sánchez-Castillo, A., Sanchez-Lucas, P., Sandberg, V., Sanders, D. A., Sanfilippo, S., Sankey, D., Santoro, D., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Sarra, I., Savage, G., Savinov, V., Scanavini, G., Scaramelli, A., Scarff, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Schuld, B., Segade, A., Segreto, E., Selyunin, A., Senadheera, D., Senise, C. R., Sensenig, J., Seo, S. H., Shaevitz, M. H., Shanahan, P., Sharma, P., Kumar, R., Poudel, S. Sharma, Shaw, K., Shaw, T., Shchablo, K., Shen, J., Shepherd-Themistocleous, C., Sheshukov, A., Shi, J., Shi, W., Shin, S., Shivakoti, S., Shoemaker, I., Shooltz, D., Shrock, R., Siddi, B., Siden, M., Silber, J., Simard, L., Sinclair, J., Sinev, G., Singh, J., Singh, L., Singh, P., Singh, V., Chauhan, S. Singh, Sipos, R., Sironneau, C., Sirri, G., Siyeon, K., Skarpaas, K., Smedley, J., Smith, E., Smith, J., Smith, P., Smolik, J., Smy, M., Snape, M., Snider, E. L., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Sousa, A., Soustruznik, K., Spinella, F., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stalder, D., Stancari, M., Stanco, L., Steenis, J., Stein, R., Steiner, H. M., Lisbôa, A. F. Steklain, Stepanova, A., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Subash, J., Surdo, A., Suter, L., Sutera, C. M., Sutton, K., Suvorov, Y., Svoboda, R., Swain, S. K., Szczerbinska, B., Szelc, A. M., Sztuc, A., Taffara, A., Talukdar, N., Tamara, J., Tanaka, H. A., Tang, S., Taniuchi, N., Casanova, A. M. Tapia, Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tatar, E., Tayloe, R., Tedeschi, D., Teklu, A. M., Vidal, J. Tena, Tennessen, P., Tenti, M., Terao, K., Terranova, F., Testera, G., Thakore, T., Thea, A., Thomas, S., Thompson, A., Thorn, C., Timm, S. C., Tiras, E., Tishchenko, V., Todorović, N., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Tran, D., Travaglini, R., Trevor, J., Triller, E., Trilov, S., Truchon, J., Truncali, D., Trzaska, W. H., Tsai, Y., Tsai, Y. -T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tu, S. Z., Tufanli, S., Tunnell, C., Turnberg, S., Turner, J., Tuzi, M., Tyler, J., Tyley, E., Tzanov, M., Uchida, M. A., González, J. Ureña, Urheim, J., Usher, T., Utaegbulam, H., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W. F., Van Berg, R., Van de Water, R. G., Forero, D. V., Vannozzi, A., Van Nuland-Troost, M., Varanini, F., Oliva, D. Vargas, Vasina, S., Vaughan, N., Vaziri, K., Vázquez-Ramos, A., Vega, J., Ventura, S., Verdugo, A., Vergani, S., Verzocchi, M., Vetter, K., Vicenzi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Villa, E., Viola, S., Viren, B., Hernandez, A. P. Vizcaya, Vuong, Q., Waldron, A. V., Wallbank, M., Walsh, J., Walton, T., Wang, H., Wang, J., Wang, L., Wang, M. H. L. S., Wang, X., Wang, Y., Warburton, K., Warner, D., Warsame, L., Wascko, M. O., Waters, D., Watson, A., Wawrowska, K., Weber, A., Weber, C. M., Weber, M., Wei, H., Weinstein, A., Westerdale, S., Wetstein, M., Whalen, K., White, A., Whitehead, L. H., Whittington, D., Wilhlemi, J., Wilking, M. J., Wilkinson, A., Wilkinson, C., Wilson, F., Wilson, R. J., Winter, P., Wisniewski, W., Wolcott, J., Wolfs, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wospakrik, M., Wresilo, K., Wret, C., Wu, S., Wu, W., Wurm, M., Wyenberg, J., Xiao, Y., Xiotidis, I., Yaeggy, B., Yahlali, N., Yandel, E., Yang, J., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zapata, O., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhao, M., Zhivun, E., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The international collaboration designing and constructing the Deep Underground Neutrino Experiment (DUNE) at the Long-Baseline Neutrino Facility (LBNF) has developed a two-phase strategy toward the implementation of this leading-edge, large-scale science project. The 2023 report of the US Particle Physics Project Prioritization Panel (P5) reaffirmed this vision and strongly endorsed DUNE Phase I and Phase II, as did the European Strategy for Particle Physics. While the construction of the DUNE Phase I is well underway, this White Paper focuses on DUNE Phase II planning. DUNE Phase-II consists of a third and fourth far detector (FD) module, an upgraded near detector complex, and an enhanced 2.1 MW beam. The fourth FD module is conceived as a "Module of Opportunity", aimed at expanding the physics opportunities, in addition to supporting the core DUNE science program, with more advanced technologies. This document highlights the increased science opportunities offered by the DUNE Phase II near and far detectors, including long-baseline neutrino oscillation physics, neutrino astrophysics, and physics beyond the standard model. It describes the DUNE Phase II near and far detector technologies and detector design concepts that are currently under consideration. A summary of key R&D goals and prototyping phases needed to realize the Phase II detector technical designs is also provided. DUNE's Phase II detectors, along with the increased beam power, will complete the full scope of DUNE, enabling a multi-decadal program of groundbreaking science with neutrinos.

Published
2024

44. Superconductivity and spin canting in spin-orbit proximitized rhombohedral trilayer graphene

Author

Patterson, Caitlin L., Sheekey, Owen I., Arp, Trevor B., Holleis, Ludwig F. W., Koh, Jin Ming, Choi, Youngjoon, Xie, Tian, Xu, Siyuan, Redekop, Evgeny, Babikyan, Grigory, Zhou, Haoxin, Cheng, Xiang, Taniguchi, Takashi, Watanabe, Kenji, Jin, Chenhao, Lantagne-Hurtubise, Etienne, Alicea, Jason, and Young, Andrea F.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Graphene and transition metal dichalcogenide flat-band systems show similar phase diagrams, replete with magnetic and superconducting phases. An abiding question has been whether magnetic ordering competes with superconductivity or facilitates pairing. The advent of crystalline graphene superconductors enables a new generation of controlled experiments to probe the microscopic origin of superconductivity. For example, recent studies of Bernal bilayer graphene show a dramatic increase in the observed domain and critical temperature $T_c$ of superconducting states in the presence of enhanced spin-orbit coupling; the mechanism for this enhancement, however, remains unclear. Here, we show that introducing spin-orbit coupling in rhombohedral trilayer graphene (RTG) via substrate proximity effect generates new superconducting pockets for both electron and hole doping, with maximal $T_c\approx$ 300mK three times larger than in RTG encapsulated by hexagonal boron nitride alone. Using local magnetometry and thermodynamic compressibility measurements, we show that superconductivity straddles an apparently continuous transition between a spin-canted state with a finite in-plane magnetic moment and a state with complete spin-valley locking. This transition is reproduced in our Hartree-Fock calculations, where it is driven by the competition between spin-orbit coupling and the carrier-density-tuned Hund's interaction. Our experiment suggests that the enhancement of superconductivity by spin-orbit coupling is driven not by a change in the ground state symmetry or degeneracy but rather by a quantitative change in the canting angle. These results align with a recently proposed mechanism for the enhancement of superconductivity in spin-orbit coupled rhombohedral multilayers, in which fluctuations in the spin-canting order contribute to the pairing interaction.

Published
2024

45. Design and Control of Modular Soft-Rigid Hybrid Manipulators with Self-Contact

Author

Patterson, Zach J., Sologuren, Emily, Della Santina, Cosimo, and Rus, Daniela

Subjects
Computer Science - Robotics
Abstract

Soft robotics focuses on designing robots with highly deformable materials, allowing them to adapt and operate safely and reliably in unstructured and variable environments. While soft robots offer increased compliance over rigid body robots, their payloads are limited, and they consume significant energy when operating against gravity in terrestrial environments. To address the carrying capacity limitation, we introduce a novel class of soft-rigid hybrid robot manipulators (SRH) that incorporates both soft continuum modules and rigid joints in a serial configuration. The SRH manipulators can seamlessly transition between being compliant and delicate to rigid and strong, achieving this through dynamic shape modulation and employing self-contact among rigid components to effectively form solid structures. We discuss the design and fabrication of SRH robots, and present a class of novel control algorithms for SRH systems. We propose a configuration space PD+ shape controller and a Cartesian impedance controller, both of which are provably stable, endowing the soft robot with the necessary low-level capabilities. We validate the controllers on SRH hardware and demonstrate the robot performing several tasks. Our results highlight the potential for the soft-rigid hybrid paradigm to produce robots that are both physically safe and effective at task performance., Comment: 23 pages, 7 figures

Published
2024

46. Quantum Computation of Electronic Structure with Projector Augmented-Wave Method and Plane Wave Basis Set

Author

Ivanov, Aleksei V., Patterson, Andrew, Bothe, Marius, Sünderhauf, Christoph, Berntson, Bjorn K., Mortensen, Jens Jørgen, Kuisma, Mikael, Campbell, Earl, and Izsák, Róbert

Subjects
Quantum Physics, Physics - Chemical Physics
Abstract

Quantum simulation of materials is a promising application area of quantum computers. In order to realize this promise, finding ways to reduce quantum resources while maintaining the accuracy of results will be necessary. In electronic structure calculations on classical computer the reduction of resources has been achieved by using the projector augmented-wave method (PAW) and plane wave basis sets. In this work, we present an implementation of the PAW with plane waves for quantum computation of the energy. We first generalize the approach to many-body wavefunctions and develop the unitary version of the PAW which preserves the orthonormality of orbitals. Then, we provide a linear-combination-of-unitaries decomposition which explicitly accounts for the atomic two-body PAW correction and provide the corresponding block encodings of the Hamiltonian used in qubitized quantum phase estimation. We then estimate quantum resources for crystalline solids using down-sampling to estimate the energy within chemical accuracy with respect to the full basis set limit, and also consider a supercell approach which is more suitable for calculations of defect states. We provide the quantum resources for energy estimation of a nitrogen-vacancy defect centre in diamond which is a challenging system for classical algorithms and a quintessential problem in the studies of quantum point defects.

Published
2024

47. Fed-RD: Privacy-Preserving Federated Learning for Financial Crime Detection

Author

Khan, Md. Saikat Islam, Gupta, Aparna, Seneviratne, Oshani, and Patterson, Stacy

Subjects
Computer Science - Computational Engineering, Finance, and Science
Abstract

We introduce Federated Learning for Relational Data (Fed-RD), a novel privacy-preserving federated learning algorithm specifically developed for financial transaction datasets partitioned vertically and horizontally across parties. Fed-RD strategically employs differential privacy and secure multiparty computation to guarantee the privacy of training data. We provide theoretical analysis of the end-to-end privacy of the training algorithm and present experimental results on realistic synthetic datasets. Our results demonstrate that Fed-RD achieves high model accuracy with minimal degradation as privacy increases, while consistently surpassing benchmark results.

Published
2024

48. First Measurement of the Total Inelastic Cross-Section of Positively-Charged Kaons on Argon at Energies Between 5.0 and 7.5 GeV

Author

DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Adriano, C., Aduszkiewicz, A., Aguilar, J., Akbar, F., Allison, K., Monsalve, S. Alonso, Alrashed, M., Alton, A., Alvarez, R., Alves, T., Amar, H., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M. P., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antic, D., Antoniassi, M., Antonova, M., Antoshkin, A., Aranda-Fernandez, A., Arellano, L., Diaz, E. Arrieta, Arroyave, M. A., Asaadi, J., Ashkenazi, A., Asner, D., Asquith, L., Atkin, E., Auguste, D., Aurisano, A., Aushev, V., Autiero, D., Azam, M. B., Azfar, F., Back, A., Back, H., Back, J. J., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baldini, W., Baldonedo, J., Baller, B., Bambah, B., Banerjee, R., Barao, F., Barbu, D., Barenboim, G., Barham~Alzás, P., Barker, G. J., Barkhouse, W., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, D., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Bathe-Peters, L., Battat, J. B. R., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. L. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Belchior, E., Bell, G., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Benjamin, D., Neves, F. Bento, Berger, J., Berkman, S., Bernal, J., Bernardini, P., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, A. T., Bezerra, T. J., Bhat, A., Bhatnagar, V., Bhatt, J., Bhattacharjee, M., Bhattacharya, M., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F. D., Blazey, G. C., Blucher, E., Bodek, A., Bogenschuetz, J., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Merlo, R. Borges, Borkum, A., Bostan, N., Bouet, R., Boza, J., Bracinik, J., Brahma, B., Brailsford, D., Bramati, F., Branca, A., Brandt, A., Bremer, J., Brew, C., Brice, S. J., Brio, V., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Buergi, J., Bundock, A., Burgardt, D., Butchart, S., V., G. Caceres, Cagnoli, I., Cai, T., Calabrese, R., Calcutt, J., Calivers, L., Calvo, E., Caminata, A., Camino, A. F., Campanelli, W., Campani, A., Benitez, A. Campos, Canci, N., Capó, J., Caracas, I., Caratelli, D., Carber, D., Carceller, J. M., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carrara, N., Carroll, L., Carroll, T., Carter, A., Casarejos, E., Casazza, D., Forero, J. F. Castaño, Castaño, F. A., Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cerna, C., Cervelli, A., Villanueva, A. Cervera, Chakraborty, K., Chakraborty, S., Chalifour, M., Chappell, A., Charitonidis, N., Chatterjee, A., Chen, H., Chen, M., Chen, W. C., Chen, Y., Chen-Wishart, Z., Cherdack, D., Chi, C., Chiapponi, F., Chirco, R., Chitirasreemadam, N., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Chowdhury, B., Christian, D., Chukanov, A., Chung, M., Church, E., Cicala, M. F., Cicerchia, M., Cicero, V., Ciolini, R., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Cohen, A., Collazo, J., Collot, J., Conley, E., Conrad, J. M., Convery, M., Copello, S., Cova, P., Cox, C., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Crone, G., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Curciarello, F., Cussans, D., Dai, J., Dalager, O., Dallavalle, R., Dallaway, W., D'Amico, R., da Motta, H., Dar, Z. A., Darby, R., Peres, L. Da Silva, David, Q., Davies, G. S., Davini, S., Dawson, J., De Aguiar, R., De Almeida, P., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, De Jong, P., Sanchez, P. Del Amo, De la Torre, A., De Lauretis, G., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Monache, G. Delle, Delmonte, N., De Lurgio, P., Demario, R., De Matteis, G., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Denton, P., Deptuch, G. W., De Roeck, A., De Romeri, V., Detje, J. P., Devine, J., Dharmapalan, R., Dias, M., Diaz, A., Díaz, J. S., Díaz, F., Di Capua, F., Di Domenico, A., Di Domizio, S., Di Falco, S., Di Giulio, L., Ding, P., Di Noto, L., Diociaiuti, E., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M. J., Domenici, D., Domine, L., Donati, S., Donon, Y., Doran, S., Douglas, D., Doyle, T. A., Dragone, A., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dugas, K., Dunne, P., Dutta, B., Duyang, H., Dwyer, D. A., Dyshkant, A. S., Dytman, S., Eads, M., Earle, A., Edayath, S., Edmunds, D., Eisch, J., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C. O., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Fajt, L., Falcone, A., Fani', M., Farnese, C., Farrell, S., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Ferry, G., Fialova, E., Fields, L., Filip, P., Filkins, A., Filthaut, F., Fine, R., Fiorillo, G., Fiorini, M., Fogarty, S., Foreman, W., Fowler, J., Franc, J., Francis, K., Franco, D., Franklin, J., Freeman, J., Fried, J., Friedland, A., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gaba, R., Gabrielli, A., M~Gago, A., Galizzi, F., Gallagher, H., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Ganguly, S., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardim, F., Gardiner, S., Gastler, D., Gauch, A., Gauvreau, J., Gauzzi, P., Gazzana, S., Ge, G., Geffroy, N., Gelli, B., Gent, S., Gerlach, L., Ghorbani-Moghaddam, Z., Giammaria, T., Gibin, D., Gil-Botella, I., Gilligan, S., Gioiosa, A., Giovannella, S., Girerd, C., Giri, A. K., Giugliano, C., Giusti, V., Gnani, D., Gogota, O., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goswami, S., Gotti, C., Goudeau, J., Goudzovski, E., Grace, C., Gramellini, E., Gran, R., Granados, E., Granger, P., Grant, C., Gratieri, D. R., Grauso, G., Green, P., Greenberg, S., Greer, J., Griffith, W. C., Groetschla, F. T., Grzelak, K., Gu, L., Gu, W., Guarino, V., Guarise, M., Guenette, R., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Guo, F. Y., Gupta, A., Gupta, V., Gurung, G., Gutierrez, D., Guzowski, P., Guzzo, M. 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Subjects
High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

ProtoDUNE Single-Phase (ProtoDUNE-SP) is a 770-ton liquid argon time projection chamber that operated in a hadron test beam at the CERN Neutrino Platform in 2018. We present a measurement of the total inelastic cross section of charged kaons on argon as a function of kaon energy using 6 and 7 GeV/$c$ beam momentum settings. The flux-weighted average of the extracted inelastic cross section at each beam momentum setting was measured to be 380$\pm$26 mbarns for the 6 GeV/$c$ setting and 379$\pm$35 mbarns for the 7 GeV/$c$ setting.

Published
2024
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49. Adult Learner Initiative External Report

Author

UNCF, Frederick D. Patterson Research Institute (FDPRI), Lumina Foundation, Keeley Webb Copridge, Nadrea R. Njoku, Yanesia Norris, Kamia F. Slaughter, Josephy Emery-Kuaho, and Alexus Laster

Abstract

To support and enhance educational attainment in the United States, the Lumina Foundation established a national goal of 60% of adults earning a high-quality credential by 2025. To achieve this goal, the Lumina Foundation expanded its funding to the adult learner population in 2017 by establishing the Adult Promise Initiative. The organization recognizes and values diversity, equity, and inclusion in its work and understands how minority-serving institutions, such as Historically Black Colleges and Universities (HBCUs), are integral to the proliferation of Black adult learners. Recognizing the tremendous impact HBCUs have on the educational attainment of Black Adult Learners, we must identify their curricular and co-curricular best practices that are critical to the academic success of this population. This report will provide an overview of these best practices for faculty, staff, and students of the five HBCUs participating in the Lumina Adult Learner Initiative grant. The organization of this report will include a brief review of the Adult Learner Initiative grant and its components, followed by the best practices frequently discussed among faculty, staff, and students participating in the grant and recommendations. The authors will then review Lumina's philanthropic approach to the grant. Lastly, how staff and administrators define capacity-building for the adult learner population will be examined.

Published
2024

50. Learning from Indigenous Perspectives: Wellbeing in the Early Years

Author

Monica McGlynn-Stewart, Nicola Maguire, Lori Budge, Ana-Luisa Sales, and Elise Patterson

Abstract

This three-year qualitative research study examined the knowledge and experiences of 20 early years educators while introducing Indigenous perspectives and pedagogies on Land-Based Learning in10 urban childcare centers. Educators were introduced to Indigenous perspectives and pedagogies through workshops with Indigenous speakers and Indigenous-authored picture books. These perspectives included the importance of supporting children to develop responsive and caring relationships to the Land for their own wellbeing and for the wellbeing of all their fellow creatures. Supported by their educators, the children increased their sense of belonging in the world, expressed gratitude for their fellow creatures, and recognized and enacted their responsibility to care for nature.

Published
2024

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