1. A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay.
- Author
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Oliveira ML, Wagner VP, Sant'ana Filho M, Carrard VC, Hugo FN, and Martins MD
- Subjects
- Adult, Aged, Aged, 80 and over, Alcohol Drinking adverse effects, Alcohol Drinking epidemiology, Carcinoma, Squamous Cell therapy, Female, Humans, Male, Middle Aged, Mouth Neoplasms therapy, Prognosis, Risk Factors, Sex Distribution, Sex Factors, Smoking adverse effects, Smoking epidemiology, Time Factors, Tongue Neoplasms epidemiology, Tongue Neoplasms pathology, Tongue Neoplasms therapy, Tumor Burden, Uruguay epidemiology, Young Adult, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell pathology, Mouth Neoplasms epidemiology, Mouth Neoplasms pathology
- Abstract
The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher's tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
- Published
- 2015
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