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A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay.
- Source :
-
Brazilian oral research [Braz Oral Res] 2015; Vol. 29. Date of Electronic Publication: 2015 Jun 16. - Publication Year :
- 2015
-
Abstract
- The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher's tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
- Subjects :
- Adult
Aged
Aged, 80 and over
Alcohol Drinking adverse effects
Alcohol Drinking epidemiology
Carcinoma, Squamous Cell therapy
Female
Humans
Male
Middle Aged
Mouth Neoplasms therapy
Prognosis
Risk Factors
Sex Distribution
Sex Factors
Smoking adverse effects
Smoking epidemiology
Time Factors
Tongue Neoplasms epidemiology
Tongue Neoplasms pathology
Tongue Neoplasms therapy
Tumor Burden
Uruguay epidemiology
Young Adult
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell pathology
Mouth Neoplasms epidemiology
Mouth Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1807-3107
- Volume :
- 29
- Database :
- MEDLINE
- Journal :
- Brazilian oral research
- Publication Type :
- Academic Journal
- Accession number :
- 26083090
- Full Text :
- https://doi.org/10.1590/1807-3107BOR-2015.vol29.0075