1. Probiotic Ingestion, Obesity, and Metabolic-Related Disorders: Results from NHANES, 1999-2014.
- Author
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Lau E, Neves JS, Ferreira-Magalhães M, Carvalho D, and Freitas P
- Subjects
- Adult, Cross-Sectional Studies, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 epidemiology, Diabetes Mellitus, Type 2 microbiology, Dysbiosis, Dyslipidemias diagnosis, Dyslipidemias epidemiology, Dyslipidemias microbiology, Female, Humans, Hypertension diagnosis, Hypertension epidemiology, Hypertension microbiology, Male, Middle Aged, Obesity diagnosis, Obesity epidemiology, Obesity microbiology, Prevalence, Protective Factors, Risk Assessment, Risk Factors, United States epidemiology, Diabetes Mellitus, Type 2 prevention & control, Dyslipidemias prevention & control, Gastrointestinal Microbiome, Gastrointestinal Tract microbiology, Hypertension prevention & control, Obesity prevention & control, Probiotics administration & dosage, Yogurt microbiology
- Abstract
Gut microbiota dysbiosis has been recognized as having key importance in obesity- and metabolic-related diseases. Although there is increasing evidence of the potential benefits induced by probiotics in metabolic disturbances, there is a lack of large cross-sectional studies to assess population-based prevalence of probiotic intake and metabolic diseases. Our aim was to evaluate the association of probiotic ingestion with obesity, type 2 diabetes, hypertension, and dyslipidemia. A cross-sectional study was designed using data from the National Health and Nutrition Examination Survey (NHANES), 1999-2014. Probiotic ingestion was considered when a subject reported consumption of yogurt or a probiotic supplement during the 24-hour dietary recall or during the Dietary Supplement Use 30-Day questionnaire. We included 38,802 adults and 13.1% reported probiotic ingestion. The prevalence of obesity and hypertension was lower in the probiotic group (obesity-adjusted Odds Ratio (OR): 0.84, 95% CI 0.76-0.92, p < 0.001; hypertension-adjusted OR: 0.79, 95% CI 0.71-0.88, p < 0.001). Accordingly, even after analytic adjustments, body mass index (BMI) was significantly lower in the probiotic group, as were systolic and diastolic blood pressure and triglycerides; high-density lipoprotein (HDL) was significantly higher in the probiotic group for the adjusted model. In this large-scale study, ingestion of probiotic supplements or yogurt was associated with a lower prevalence of obesity and hypertension., Competing Interests: The authors declare no conflict of interest.
- Published
- 2019
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