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The authors explored adolescents' reasons for reading or not reading books. In individual interviews with 39 adolescents (ages 15 and 16) in the United Kingdom, they reported that reading books offered an opportunity to relax, learn, escape the real world, and become immersed; was exciting, developed their empathy skills, and provided a form of social capital. However, challenges to book reading included a lack of time; that it was too effortful; that it was not encouraged, was expensive, or was uncool, or that students had simply lost the habit or grown out of it. Implications for high school classrooms are discussed, and the researchers argue that time, space, and/or initiatives to read for pleasure are important. Collaborative work among researchers, teachers, and engaged/disengaged adolescent readers is essential to ensure that these initiatives are optimal and reach and resonate with their intended audience.

This article describes an empirical study of the ways in which one group of adaptors transformed the plays of William Shakespeare into the medium of the comic book for use in school classrooms. It explores the choices, dilemmas, processes and responsibilities they experienced in doing so. These adaptors had to tackle the burden of "Shakespeare"--what he has come to mean in world literature, the popular imagination, and education--as well as attempting to make the text both appealing and understandable to their intended readers--teenagers studying the plays in school. It is argued that they viewed this task as a pedagogic one and saw the notion of "trust" as central to it. The article therefore has a second aim, which is to use these empirical findings to explore the concept of "trust" and, in particular to outline its relevance for educational research. Using the work of the philosopher Katharine Hawley and the literary theorist Umberto Eco, it is shown that the relational concept of trust is a helpful way of articulating the process of adapting Shakespeare's work. In the conclusion the ways in which the concept might illuminate broader educational issues related to knowledge, assessment and learning are highlighted.

This paper is based on a long-term ethnography of an adult creative writing class situated in a major urban art gallery in the United Kingdom. It takes the claims of one group of older adults--that creative writing made them "feel younger"--as the starting point for exploring this connection further. It places these claims broadly within theories of learning in later life that advocate creative expression and reminiscence as important practices for educators of older adults. However, the main analysis employs anthropological theories of creativity and ageing in order to question the cultural assumptions about creativity and the period of older age informing theory and practice. The paper argues that the value of creative writing for the individuals studied lies both in the fact that it is a relational (rather than individual) process and a means of being in the present. These findings contradict traditional conceptions about creativity as future-oriented and older people as retrospective; they also raise questions about narratives of empowerment, individual agency and the importance of "reminiscence" in some of the literature on older adult learning.

This research examines the considerations of responsible Artificial Intelligence in the deployment of AI-based COVID-19 digital proximity tracking and tracing applications in two countries; the State of Qatar and the United Kingdom. Based on the alignment level analysis with the Good AI Society's framework and sentiment analysis of official tweets, the diagnostic analysis resulted in contrastive findings for the two applications. While the application EHTERAZ (Arabic for precaution) in Qatar has fallen short in adhering to the responsible AI requirements, it has contributed significantly to controlling the pandemic. On the other hand, the UK's NHS COVID-19 application has exhibited limited success in fighting the virus despite relatively abiding by these requirements. This underlines the need for obtaining a practical and contextual view for a comprehensive discourse on responsible AI in healthcare. Thereby offering necessary guidance for striking a balance between responsible AI requirements and managing pressures towards fighting the pandemic. [ABSTRACT FROM AUTHOR]

Type 1 diabetes is an autoimmune disease with rising incidence in high-income countries. Genetic and environmental predisposing factors contribute to the etiology of the disease, although their interaction is not sufficiently understood to allow for preventive action. Strongest known associations with genetic variation map to classical HLA class II genes. Because of its genetic complexity, the HLA region has been under-represented in genome-wide association studies, having potentially hindered the identification of relevant associations underlying the etiology of the disease. Here, we performed a comprehensive HLA-wide genetic association analysis of type 1 diabetes including multi-allelic and rare variants. We used high-density whole-exome sequencing data of the HLA region in the large UK Biobank dataset to apply gene-based association tests with a carefully defined type 1 diabetes phenotype (97 cases and 48,700 controls). Exon-based and single-variant association tests were used to complement the analysis. We replicated the known association of type 1 diabetes with the classical HLA-DQ gene. Tailoring the analysis toward rare variants, we additionally identified the lysine methyl transferase EHMT2 as associated. Deeper insight into genetic variation associated with disease as presented and discussed in detail here can help unraveling mechanistic details of the etiology of type 1 diabetes. More specifically, we hypothesize that genetic variation in EHMT2 could impact autoimmunity in type 1 diabetes development. [ABSTRACT FROM AUTHOR]

The majority of the nearly 400 existing local pig breeds are adapted to specific environments and human needs. The demand for large production quantities and the industrialized pig production have caused a rapid decline of many local pig breeds in recent decades. Black Slavonian pig and Turopolje pig, the latter highly threatened, are the two Croatian local indigenous breeds typically grown in extensive or semi-intensive systems. In order to guide a long-term breeding program to prevent the disappearance of these breeds, we analyzed their genetic diversity, inbreeding level and relationship with other local breeds across the world, as well as modern breeds and several wild populations, using high throughput genomic data obtained using the Illumina Infinium PorcineSNP60 v2 BeadChip. Multidimensional scaling analysis positioned Black Slavonian pigs close to the UK/North American breeds, while the Turopolje pig clustered within the Mediterranean breeds. Turopolje pig showed a very high inbreeding level (FROH>4Mb = 0.400 and FROH>8Mb = 0.332) that considerably exceeded the level of full-sib mating, while Black Slavonian pig showed much lower inbreeding (FROH>4Mb = 0.098 and FROH>8Mb = 0.074), indicating a planned mating strategy. In Croatian local breeds we identified several genome regions showing adaptive selection signals that were not present in commercial breeds. The results obtained in this study reflect the current genetic status and breeding management of the two Croatian indigenous local breeds. Given the small populations of both breeds, a controlled management activity has been implemented in Black Slavonian pigs since their commercial value has been recognized. In contrast, the extremely high inbreeding level observed in Turopolje pig argues for an urgent conservation plan with a long-term, diversity-oriented breeding program. [ABSTRACT FROM AUTHOR]

In European and many African, Middle Eastern and southern Asian populations, lactase persistence (LP) is the most strongly selected monogenic trait to have evolved over the past 10,000 years 1 . Although the selection of LP and the consumption of prehistoric milk must be linked, considerable uncertainty remains concerning their spatiotemporal configuration and specific interactions 2,3 . Here we provide detailed distributions of milk exploitation across Europe over the past 9,000 years using around 7,000 pottery fat residues from more than 550 archaeological sites. European milk use was widespread from the Neolithic period onwards but varied spatially and temporally in intensity. Notably, LP selection varying with levels of prehistoric milk exploitation is no better at explaining LP allele frequency trajectories than uniform selection since the Neolithic period. In the UK Biobank 4,5 cohort of 500,000 contemporary Europeans, LP genotype was only weakly associated with milk consumption and did not show consistent associations with improved fitness or health indicators. This suggests that other reasons for the beneficial effects of LP should be considered for its rapid frequency increase. We propose that lactase non-persistent individuals consumed milk when it became available but, under conditions of famine and/or increased pathogen exposure, this was disadvantageous, driving LP selection in prehistoric Europe. Comparison of model likelihoods indicates that population fluctuations, settlement density and wild animal exploitation-proxies for these drivers-provide better explanations of LP selection than the extent of milk exploitation. These findings offer new perspectives on prehistoric milk exploitation and LP evolution., (© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)