1. Investigation of HER-2 codon 655 single nucleotide polymorphism frequency and c-ErbB-2 protein expression alterations in gastric cancer patients.
- Author
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Satiroglu-Tufan NL, Bir F, and Calli-Demirkan N
- Subjects
- Adult, Aged, Aged, 80 and over, Carcinoma, Adenosquamous chemistry, Case-Control Studies, Female, Gastritis genetics, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Receptor, ErbB-2 analysis, Risk Factors, Stomach Neoplasms chemistry, Turkey, Carcinoma, Adenosquamous genetics, Codon genetics, Gene Expression Regulation, Neoplastic genetics, Genes, erbB-2 genetics, Polymorphism, Single Nucleotide, Receptor, ErbB-2 genetics, Stomach Neoplasms genetics
- Abstract
Aim: To investigate both whether the risk of gastric cancer is associated with the Ile/Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2) transmembrane domain-coding region at codon 655 and the suggested existence of HER-2 expression in gastric cancer cases in a Turkish patient group., Methods: Polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) strategy was used to analyze the presence of HER-2 SNP at codon 655. c-erbB-2 expression pattern was analyzed by immunohistochemistry. The results were compared between gastric carcinoma group and chronic gastritis group, as well as between clinicopathological parameters and carcinoma., Results: Results showed that Ile/Val genotype accounted for 20% within the Turkish gastric carcinoma group, and none in chronic gastritis group, and this genotyping was associated with stage IV gastric cancers (P=0.04). Positive membranous HER-2 immunoreactivity, on the other hand, accounted for 24% within the Turkish gastric carcinoma group and none from chronic gastritis cases; further, it was correlated with intestinal type carcinomas (P=0.007), and stage III-IV carcinomas (P=0.004)., Conclusion: These observations imply that the tested HER-2 SNP may participate in the development and progression of gastric cancer. Thus, after confirming these results with large sample groups, HER-2 codon 655 SNP and/or c-erbB-2 overexpression may also be used as a poor prognostic indicator for gastric carcinomas.
- Published
- 2006
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