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This case study investigated the strategies used by a school principal who successfully leads an educational centre in a vulnerable context. This article aims to explore how a school in a vulnerable context can be strengthened by the actions implemented by the principal and his leadership based on social and pedagogical commitment. Initially, the key aspects identified by the school community in the principal's identity were analysed, and subsequently compared with their own perception to understand their professional development and leadership practices. The findings identify three main strategies that have been implemented to improve the school climate: (1) building relationships and involving the community in educational change; (2) enhancing cooperative work and the joint vision of the school-professional learning communities; and (3) give children a voice, respect children and fight for equal opportunities. Comprehensive keys to professional practice are drawn from these findings.

The COVID-19 pandemic has prompted profound changes in Higher Education. Thus, policymakers in different national contexts worldwide needed to design alternative responses to deal with new educational scenarios. In Spain, rethinking educational management in Higher Education remains an issue of current debate. Methodological readjustments towards virtual teaching, the digital divide due to socio-economic and cultural issues of the students, unequal access to education, or a decrease in internationalization have been some of the most significant adversities faced during this time. Amid this crisis, the measures taken by political leaders and university managers played an essential role. This study aims to provide an overview of the policy measures developed during this period, describing some of the most important decisions taken by different universities in Spain. To this end, an exploration based on secondary data from extensive literature reviews is carried out to construct a descriptive analysis of the measures implemented in Spanish universities. The findings highlight the coordinated action of the Spanish university system and the staunch defense of face-to-face teaching. This health crisis has also highlighted the deficits of this level of education and shed light on its future. Spain faces major challenges in the field of higher education. Consequently, the Spanish university system must begin building the foundations for educational innovation and training education professionals without fear of online scenarios. Finally, this article also proposes suggestions to guide policymakers in dealing with future adverse situations.

This study describes the life story of two female principals who carry out their work in particularly challenging schools in the Spanish educational context. This work is part of two larger international (ISSPP) and national research projects that aim to study the professional identity of school leaders. In this case, our objective was to analyse the construction of a leadership identity when faced with the challenges of working in a difficult school context, and to identify the main strategies adopted to achieve educational improvement in such adverse situations. The findings reveal that leading with others -- and not over others -- was key to achieving change. Our participating principals developed a style of leadership that is distributed and oriented towards values of social justice in an attempt to eradicate inequality and discrimination in their schools. Being a woman was also a determining factor in this professional performance. Learning from 'the flight of the geese' was the essence of these professional stories, facing challenges with professional values of empathy, active listening, companionship, and commitment. Finally, we discuss the implications of this work for future research and professional practice.

Many institutions, social and political groups are warning of the risks associated with the early sexualization of childhood. These agents appeal to the responsibility of the media to avoid creating content that may lead to childhood sexualization and that is easily accessible to all audiences. Responding to this demand and through a cross-cultural Spain-China approach, this work focuses on the analysis of the perception of girls' sexualization in the fashion stylings disseminated by the media. A survey of 750 Communication and Advertising university students in Spain (N=449) and in China (N=301) was carried out. Five latent sexualization factors identified confirm that perceived sexualization in girls' fashion styling is a multi-dimensional phenomenon that occurs from the combined use of multiple sexualizing attributes. The country of origin (Spain or China) has been associated with the perception of sexualization and the identified latent sexualizing factors. Finally, an explanatory and highly effective predictive model has been obtained for this type of childhood sexualization in terms of the factors and country of origin. Conclusions suggest that it is necessary to reinforce the training of communication professionals and minors to avoid creating images of sexualized girls through certain styling codes.

The arrival of COVID-19 had a major impact on all sectors of the population, especially education. The closure of schools and later the health measures adopted forced schools to a rapid conversion towards a digital scenario. Faced with this crisis situation, the existence of school leaders became even more essential. For this reason, in order to face this challenge, it is necessary to establish a school management that moves towards horizontality, social justice and professional commitment. Using a qualitative approach, we offer the story of a female principal who leads in a challenge context. The findings reveal how fighting windmills was one of the predominant sensations throughout this period. This manuscript also describes the different leadership strategies developed. It also points out the different supports and obstacles experienced by the professional team of the school. Finally, we discuss new horizons within the field of school leadership in times of crisis.

As a result of the economic and social changes that have taken place in recent decades, the role of women in the workplace has changed significantly. The entry of women into traditionally masculine positions has supposed a dramatic cultural change (Inglehart & Baker, 2000). The present research aims to explore how gender influenced the female school principals participating in the study in addition to studying the main milestones and challenges they faced in constructing a school leadership identity. Due to the peculiarities of the Spanish context, it is of great importance to explore the gender gap that exists in school management and how school principals deal with this situation. In this article, the authors provide a brief overview of international research on the field of leadership, gender, and school management. Subsequently, the scientific literature at the Spanish level showing the situation involving female principals is reviewed. After presenting the methodological design for the study, the authors then describe the narratives of the participants and conclude with a series of recommendations for future research.

This article present a case study of a principal who successfully leads a disadvantaged school in Spain. Through his life story, we investigate the personal and professional factors that have shaped his current professional identity, and we identify the main successful educational practices that the principal has implemented in order to achieve improvements in educational outcomes. Findings reveal a set of professional practices that have been invigorated from his leadership for the improvement of education. In short, he is committed to leading by appreciating the voice of the child and having respect for the children and it is this that forms part of the collective ideology of the school and is the most outstanding role of his professional identity.

The aim of this paper is to analyze the evolution of bank liquidity regulations, considering the global regulatory framework applicable to financial institutions, from the beginning of the banking and liquidity crisis in 2007–2008 to the present. The new liquidity requirements under Basel III regulations are defined. An analysis is made of the recent evolution of credit institutions in Spain from different banking prisms to determine how the new banking regulation and supervision, following the start of supervisory powers by the European Central Bank at the end of 2014, has affected them. The methodology applied has been firstly the literature review, followed by a compilation and analysis of the financial and statistical evidence available on the main Spanish financial institutions, from the European Central Bank and the Bank of Spain, as well as information published by other agencies and the financial institutions themselves. It concludes with a reflection and analysis of the outlook for the sector once the most recent impacts, derived from COVID-19, and the supply crisis with the rise in global inflation and the increase in interest rates have been overcome. It can be stated that credit institutions in Spain have significantly improved their liquidity position over the last 15 years. [ABSTRACT FROM AUTHOR]

This study tested social cognitive career theory (SCCT) in the technological domain with 2,359 high-school students in Asturias (Spain). Path analyses were run to determine the influence of gender on the SCCT model and to explain the influence of personal (emotional state, gender-role attitudes), contextual (perceived social supports and barriers), and cognitive (self-efficacy beliefs, outcome expectations) variables on technological interest. The results almost entirely confirm the SCCT model for Spanish high-school students in both the boys' and girls' samples. Further, the results show that girls and boys do not differ significantly as far as the different variables are concerned.

In this work, we propose a novel methodology in order to automatically optimize the location of the sampling points for a water quality monitoring network in an estuary, in such a way that any unknown pollution source can be identified (both in intensity and location) from the data supplied by those sampling points. In the central part of the article, after a rigorous mathematical formulation of the environmental problem, the full details of its numerical implementation are given. Finally, we present and analyze the results when applying the above proposed technique to study a real case in Ría of Vigo (northwestern Spain). [ABSTRACT FROM AUTHOR]

Background: Children and adolescents with disabilities engage in low levels of moderate-to-vigorous intensity physical activity (MVPA), which may create the onset of a sedentary lifestyle. In light of this, MVPA levels must be quantified with a valid tool such as accelerometry. This study aimed to: (i) analyze the accuracy of Evenson cut-points by estimating MVPA and sedentary behavior (SB) in children and adolescents with disabilities; (ii) define new equations to estimate energy expenditure (EE) with the GT3X+ accelerometer in this population and particularly in those with cerebral palsy (CP); (iii) define specific GT3X+ cut-points to estimate MVPA in those with CP. Methods: A total of 23 children and adolescents with disabilities (10 ± 3 years; 44%females) participated in the study. GT3X+-counts and oxygen uptake (VO2) were measured in four laboratory walking conditions. Results: (i) Evenson cut-points were accurate; (ii) new equations were defined to effectively predict EE; (iii) specific GT3X+ cut-points (VM ≥ 702 counts·min−1; Y-Axis ≥ 360 counts·min−1) were defined for estimating MVPA levels in children and adolescents with CP. Conclusions: The use of specific cut-points for ActiGraph GT3X+ seems to be accurate to estimate MVPA levels in children and adolescents with disabilities and, particularly, in those with CP, at least in laboratory conditions. [ABSTRACT FROM AUTHOR]

A rapid response action carried out against the invasion of water hyacinth (Eichhornia crassipes) in the Guadalquivir River branch in Seville (Southern Spain) is described and analyzed. Removal was implemented and coordinated by the regional environmental Council, National security forces and public companies. Immediately after its detection, the distribution and abundance of water hyacinth, and the possible origin of introduction were assessed as the basis for selecting a feasible removal method. Plants were scattered across 110 ha and a perimeter of 8.4 km. A total biomass of 1,931 kg (fresh weight) was removed between May and December 2021 by combining manual removal from water using inflatable boats, floating booms, wetsuits and fishing waders, as well as removal from the shore. In total, the action cost ca. €22,500. Most biomass (83%) was removed during the initial control phase (one month). However, most of the efforts and costs (83%) were made in the following seven months, especially for monitoring and follow-up treatments. Rapid response avoided the growth, blooming and spread that could be expected in summer, coinciding with the optimal growing conditions. Moreover, rapid response reduced ca. 50 times the biomass and control costs with respect to a delayed action (i.e., after summer). Despite the fact that monitoring required a higher effort and cost than the initial control phase, it altogether represented a great cost saving as the invasion was kept at bay. The coordination between the regional Council, National security forces and public companies has taken advantage of the specific strengths of each one of them, achieving the shortest possible response time. [ABSTRACT FROM AUTHOR]

Background: Since May 2022, a new outbreak of monkeypox has been reported in several countries, including Spain. The clinical and epidemiological characteristics of the cases in this outbreak may differ from those in earlier reports. Objectives: To document the clinical and epidemiological characteristics of cases of monkeypox in the current outbreak. Methods: We conducted a prospective cross‐sectional study in multiple medical facilities in Spain to describe the cases of monkeypox in the 2022 outbreak. Results: In total, 185 patients were included. Most cases started with primarily localized homogeneous papules, not pustules, in the probable area of inoculation, which could be cutaneous or mucous, including single lesions. Generalized small pustules appeared later in some of them. Heterogeneous lesions occurred during this generalized phase. All patients had systemic symptoms. Less common lesions included mucosal ulcers (including pharyngeal ulcers and proctitis) and monkeypox whitlows. Four patients were hospitalized, none died. Smallpox vaccination and well‐controlled HIV disease were not associated with markers of severity. Contact during sex is the most likely mechanism of transmission. In this outbreak, cases have been described in men who have sex with men and are strongly associated with high‐risk sexual behaviours. Seventy‐six per cent of the patients had other sexually transmitted diseases upon screening. Conclusions: The clinical findings in this outbreak differ from previous findings and highly suggest contact transmission and initiation at the entry site. The characterization of the epidemiology of this outbreak has implications for control. What is already known about this topic?Monkeypox eruption is described as consisting of pustules.The roles of HIV and previous smallpox vaccination in the prognosis are unknown.The transmission route was initially described as respiratory droplets and was later suggested to be via sexual contact. What does this study add?Initial lesions at the probable inoculation area were homogeneous and papular (pseudopustules). Generalized small pustules appeared later in some of them. Heterogeneous lesions occurred during this generalized phase. All patients had systemic symptoms.Less common signs included mucosal ulcers (including pharyngeal ulcers and proctitis) and monkeypox whitlows. Well‐controlled HIV and previous smallpox vaccination were not associated with severity. No patient died.The data support the hypothesis of transmission via contact during sex. Although this might change, the outbreak is currently limited mostly to men who have sex with men, with high‐risk factors for sexually transmitted diseases. [ABSTRACT FROM AUTHOR]

The high mortality rate due to COVID-19 has necessitated the mass vaccination against SARS-CoV-2 to induce protective humoral and cellular immunity. (1) Objective: To study the dynamics of SARS-CoV-2-specific B cells after two doses of the Pfizer-BioNTech SARS-CoV-2 vaccine. (2) Methods: Immunophenotyping and cellular cultures were used to determine the kinetics of B-cell subpopulations and vaccine responses in volunteers before and seven days, three months and seven months after the second dose in Spain (n = 19). (3) Results: Seven days after immunisation, memory B cells and plasmablasts expressing receptors for factors implicated in the maturation of plasma cells were augmented in blood. Three months after vaccination, SARS-CoV-2 spike-specific plasmablasts disappeared from circulation while spike-specific memory-B cells circulated, with heterogeneous dynamics among individuals. (4) Conclusion: After vaccination, specific plasmablasts equipped with receptors for maturation factors were quickly generated and disappeared rapidly from the blood, while specific memory B cells circulated for at least seven months. [ABSTRACT FROM AUTHOR]

The application of Augmented Reality (AR), a technology that complements and enriches the live view of a place with virtual elements, is a relatively new approach that has been demonstrated to be useful as an educational tool for the interpretation of geological and geographic features. In addition, it is a technology consistent with challenges related to enhancing the geotourism experience in geologically diverse terrains, and consistent with the sustainable use of resources in rural and natural areas. The focus of AR in this contribution is primarily for academic use. Here, we developed a pioneering AR project, at the San Isidro Pass, located in the north-west of the Iberian Peninsula, more specifically, in the central-eastern sector of the Cantabrian Mountain range (the Asturian Massif) and the northern slope of the Sierra de Sentiles. This is a high mountain area where the low incidence of Pliocene and Quaternary fluvial erosion has favored the preservation of a great geodiversity. In this case study, the approaches of geology and physical geography as subjects in official university studies have been used as a reference framework. Fieldwork was carried out to design an itinerary, or geotrail, of Points of Interest (POIs), that highlight the geological values of this montane region by visualising and interpreting nine glacial and periglacial landscapes using dynamic graphic resources (animated videos, panoramic and spherical tours and rotating and expandable 3D models combining conventional terrestrial photography and 360° photography, aerial photography, thematic cartography, etc.) composed by graphic processing software. The result is the design of AR tools which could be used by public and private entities as a product suitable for university teaching but also a work that could guide other geoeducational actions or institutional action for official heritage recognition. In isolation, these POIs function as 'geosites'; when combined in sequence (POI 1 to POI 9), these POIs function as a 'geotrail' to highlight the diversity of glacial and periglacial landscapes and their sedimentary deposits; when viewed as an ensemble, POIs combine to be similar to a 'geopark' that emphasises glacial and periglacial landscapes and sedimentary deposits. [ABSTRACT FROM AUTHOR]

Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Among 110 reported in the literature, 17 are BF1 intersubtype recombinant, most of which are of South American origin. Among these, all 5 identified in the Southern Cone and neighboring countries, except Brazil, derive from a common recombinant ancestor related to CRF12_BF, which circulates widely in Argentina, as deduced from coincident breakpoints and clustering in phylogenetic trees. In a HIV-1 molecular epidemiological study in Spain, we identified a phylogenetic cluster of 20 samples from 3 separate regions which were of F1 subsubtype, related to the Brazilian strain, in protease-reverse transcriptase (Pr-RT) and of subtype B in integrase. Remarkably, 14 individuals from this cluster (designated BF9) were Paraguayans and only 4 were native Spaniards. HIV-1 transmission was predominantly heterosexual, except for a subcluster of 6 individuals, 5 of which were men who have sex with men. Ten additional database sequences, from Argentina (n = 4), Spain (n = 3), Paraguay (n = 1), Brazil (n = 1), and Italy (n = 1), branched within the BF9 cluster. To determine whether it represents a new CRF, near full-length genome (NFLG) sequences were obtained for 6 viruses from 3 Spanish regions. Bootscan analyses showed a coincident BF1 recombinant structure, with 5 breakpoints, located in p17 gag , integrase, gp120, gp41- rev overlap, and nef , which was identical to that of two BF1 recombinant viruses from Paraguay previously sequenced in NFLGs. Interestingly, none of the breakpoints coincided with those of CRF12_BF. In a maximum likelihood phylogenetic tree, all 8 NFLG sequences grouped in a strongly supported clade segregating from previously identified CRFs and from the CRF12_BF "family" clade. These results allow us to identify a new HIV-1 CRF, designated CRF66_BF. Through a Bayesian coalescent analysis, the most recent common ancestor of CRF66_BF was estimated around 1984 in South America, either in Paraguay or Argentina. Among Pr-RT sequences obtained by us from HIV-1-infected Paraguayans living in Spain, 14 (20.9%) of 67 were of CRF66_BF, suggesting that CRF66_BF may be one of the major HIV-1 genetic forms circulating in Paraguay. CRF66_BF is the first reported non-Brazilian South American HIV-1 CRF_BF unrelated to CRF12_BF. [ABSTRACT FROM AUTHOR]

Importance: Active search for pulmonary embolism (PE) may improve outcomes in patients hospitalized for exacerbations of chronic obstructive pulmonary disease (COPD).Objective: To compare usual care plus an active strategy for diagnosing PE with usual care alone in patients hospitalized for COPD exacerbation.Design, Setting, and Participants: Randomized clinical trial conducted across 18 hospitals in Spain. A total of 746 patients were randomized from September 2014 to July 2020 (final follow-up was November 2020).Interventions: Usual care plus an active strategy for diagnosing PE (D-dimer testing and, if positive, computed tomography pulmonary angiogram) (n = 370) vs usual care (n = 367).Main Outcomes and Measures: The primary outcome was a composite of nonfatal symptomatic venous thromboembolism (VTE), readmission for COPD, or death within 90 days after randomization. There were 4 secondary outcomes, including nonfatal new or recurrent VTE, readmission for COPD, and death from any cause within 90 days. Adverse events were also collected.Results: Among the 746 patients who were randomized, 737 (98.8%) completed the trial (mean age, 70 years; 195 [26%] women). The primary outcome occurred in 110 patients (29.7%) in the intervention group and 107 patients (29.2%) in the control group (absolute risk difference, 0.5% [95% CI, -6.2% to 7.3%]; relative risk, 1.02 [95% CI, 0.82-1.28]; P = .86). Nonfatal new or recurrent VTE was not significantly different in the 2 groups (0.5% vs 2.5%; risk difference, -2.0% [95% CI, -4.3% to 0.1%]). By day 90, a total of 94 patients (25.4%) in the intervention group and 84 (22.9%) in the control group had been readmitted for exacerbation of COPD (risk difference, 2.5% [95% CI, -3.9% to 8.9%]). Death from any cause occurred in 23 patients (6.2%) in the intervention group and 29 (7.9%) in the control group (risk difference, -1.7% [95% CI, -5.7% to 2.3%]). Major bleeding occurred in 3 patients (0.8%) in the intervention group and 3 patients (0.8%) in the control group (risk difference, 0% [95% CI, -1.9% to 1.8%]; P = .99).Conclusions and Relevance: Among patients hospitalized for an exacerbation of COPD, the addition of an active strategy for the diagnosis of PE to usual care, compared with usual care alone, did not significantly improve a composite health outcome. The study may not have had adequate power to assess individual components of the composite outcome.Trial Registration: ClinicalTrials.gov Identifier: NCT02238639. [ABSTRACT FROM AUTHOR]

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The Gréixer Rhyolitic Complex is one of the most important manifestations of the post-Variscan Permo-Carboniferous volcanism of the Catalan Pyrenees. This volcanic complex is represented by a > 800 m thick, > 12 km wide, intra-caldera succession, mostly composed of strongly-welded, lava-like rheomorphic rhyolitic pyroclastic rocks. Previous studies have attributed a Lower Permian age to this caldera complex and interpreted it as having resulted from the gravitational collapse of a central volcanic edifice after a large-volume explosive event, mostly represented by widespread extra-caldera pyroclastic deposits (the Castellar de n'Hug Ignimbritic Member), which was radially emplaced from the caldera structure. However, new stratigraphic, structural, geochemical, and geochronological data reveal that this co-genetic relationship between the inferred intra- and extra-caldera deposits does not exist. On the contrary, each of these two successions of pyroclastic deposits resulted from a different volcanic event, which had occurred within a time span of 15 Ma. Moreover, the geochemical signature of these volcanic rocks shows a different magma source for each case, with a clear crustal origin for the Gréixer Rhyolitic Complex and a mixed mantle-crustal origin for the Castellar de n'Hug Ignimbrite Member. The apparent stratigraphic correlation between both successions is the result of the Alpine tectonics, which put together different late and post-Variscan Permo-Carboniferous rocks that had originated in different areas and at different times. • The Gréixer Rhyolitic Complex is distinctive geological element of the Pyrenees. • It corresponds to a rheomorphic rhyolitic pyroclastic rocks intra-caldera succession. • U-Th dating gave a Stephanian C age (303 Ma years, Gzhelian) for these rhyolitic rocks. • The Gréixer Rhyolitic Complex has a clear crustal signature. [ABSTRACT FROM AUTHOR]

Varroosis is the disease caused by the ectoparasitic mite Varroa destructor, one of the most destructive diseases of honeybees. In Spain, there is great concern because there are many therapeutic failures after acaricide treatments intended to control varroosis outbreaks. In some of these cases it is not clear whether such failures are due to the evolution of resistance. Therefore, it is of high interest the development of methodologies to test the level of resistance in mite populations. In this work, a simple bioassay methodology was used to test whether some reports on low efficacy in different regions of Spain were in fact related to reduced Varroa sensitivity to the most used acaricides. This bioassay proved to be very effective in evaluating the presence of mites that survive after being exposed to acaricides. In the samples tested, the mortality caused by coumaphos ranged from 2 to 89%; for tau-fluvalinate, it ranged from 5 to 96%. On the other hand, amitraz caused 100% mortality in all cases. These results suggest the presence of Varroa resistant to coumaphos and fluvalinate in most of the apiaries sampled, even in those where these active ingredients were not used in the last years. The bioassay technique presented here, either alone or in combination with other molecular tools, could be useful in detecting mite populations with different sensitivity to acaricides, which is of vital interest in selecting the best management and/or acaricide strategy to control the parasite in apiaries. [ABSTRACT FROM AUTHOR]

Many institutions, social and political groups are warning of the risks associated with the early sexualization of childhood. These agents appeal to the responsibility of the media to avoid creating content that may lead to childhood sexualization and that is easily accessible to all audiences. Responding to this demand and through a cross-cultural Spain-China approach, this work focuses on the analysis of the perception of girls' sexualization in the fashion stylings disseminated by the media. A survey of 750 Communication and Advertising university students in Spain (N=449) and in China (N=301) was carried out. Five latent sexualization factors identified confirm that perceived sexualization in girls' fashion styling is a multi-dimensional phenomenon that occurs from the combined use of multiple sexualizing attributes. The country of origin (Spain or China) has been associated with the perception of sexualization and the identified latent sexualizing factors. Finally, an explanatory and highly effective predictive model has been obtained for this type of childhood sexualization in terms of the factors and country of origin. Conclusions suggest that it is necessary to reinforce the training of communication professionals and minors to avoid creating images of sexualized girls through certain styling codes. [ABSTRACT FROM AUTHOR]

Objectives: We report the results of the reverse transcriptase (RT)/protease (PR) transmitted drug resistance (TDR) prevalence study in 2018, focusing on doravirine resistance-associated mutations and the differences observed when Stanford or French National Agency for AIDS Research (ANRS)/Spanish Network of AIDS Research (RIS)/IAS-USA resistance interpretation algorithms are used to describe clinically relevant resistance.Methods: We used the WHO 2009 list to investigate the prevalence of NNRTI, NRTI and PI TDR, in treatment-naive HIV-1-infected patients, adding mutations E138A/G/K/Q/R, V106I, V108I, V179L, G190Q, H221Y, F227C/L/V, M230IDR, L234I, P236L and Y318F in RT. The prevalence of doravirine resistance-associated mutations, as described by Soulie et al. in 2019, was evaluated. Clinically relevant TDR was investigated using the latest versions of ANRS, RIS, IAS-USA and Stanford algorithms.Results: NNRTI mutations were detected in 82 of 606 (13.5%) patients. We found 18 patients (3.0%) with NRTI mutations and 5 patients (0.8%) with PI mutations. We detected 11 patients harbouring doravirine resistance-associated mutations (prevalence of 1.8%). Furthermore, we observed important differences in clinically relevant resistance to doravirine when ANRS/RIS (0.7%), IAS-USA (0.5%) or Stanford algorithms (5.0%) were used. V106I, which was detected in 3.8% of the patients, was the main mutation driving these differences. V106I detection was not associated with any of the clinical, demographic or virological characteristics of the patients.Conclusions: The prevalence of NRTI and PI TDR remains constant in Spain. Doravirine TDR is very infrequent by RIS/ANRS/IAS-USA algorithms, in contrast with results using the Stanford algorithm. Further genotype-phenotype studies are necessary to elucidate the role of V106I in doravirine resistance. [ABSTRACT FROM AUTHOR]

Mafic microgranular enclaves from polygenetic and monogenetic swarms in the Gredos sector of the Central System batholith (central Spain) were sampled and studied to elucidate field, geochronological, and geochemical relations. Among-enclave variations in terms of major elements demonstrate contamination with the pelitic country rocks, and not with the host granitic magma. Magmatic enclaves from monogenetic swarms in Gredos are interpreted as fragments from the chilled margins generated at the sidewall of ascent conduits. In situ U-Pb zircon age determinations by sensitive high-resolution ion microprobe yielded two sets of ages. One corresponds to the ages of crystallization at 290 ± 3.1 Ma and 300 ± 3.4 Ma of two enclaves from two different monogenetic swarms. These ages are slightly younger than the zircon ages of the host granodiorites (ca. 319-312 Ma). A secondary set of ages present in the two studied samples (at 322 ± 6.7 Ma and 320 ± 8.5 Ma) corresponds to the age of the main Variscan regional migmatization of host Neoproterozoic pelitic metasediments. These older ages are interpreted as xenocrystic cores that were derived from the pelitic host during magma ascent. Together with the geochemical relations, they prove quenching against the regional host in conduits and not against the host granodiorite as classically thought. Monogenetic swarms can be seen as high-energy pulses denoting the switching from steady-state to transient flow regimes within magma ascent conduits. By contrast, polygenetic swarms are generated by collapse of accumulated resisters of igneous and metamorphic origin that were previously present in migmatites at the top of subhorizontal, layer-type intrusions. [ABSTRACT FROM AUTHOR]

Copyright of Enfermería Global is the property of Servicio de Publicaciones de la Universidad de Murcia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The aim of this study is to describe and understand experiences related to social support for women with fibromyalgia who suffer from sexual dysfunction. An interpretive qualitative research methodology based on Gadamer’s philosophical hermeneutics was used. Data collection included a focus group and in-depth interviews with 13 women who averaged 44.8 years of age and 14.3 years since being diagnosed with fibromyalgia. Data were analyzed using Fleming’s method and two themes were identified: “searching for understanding in socio-family support” and “lack of formal support regarding fibromyalgia patient’s sexuality.” The partner constitutes the main support for women with fibromyalgia. Although they can find understanding and social support in patient associations, they lack formal support from health care professionals. Women demand trusted and expert professionals, like sexologists and nurses, to carry out a multidisciplinary approach to tackle sexual dysfunction associated with fibromyalgia. [ABSTRACT FROM AUTHOR]

Purpose: Hospital mortality related to adverse drug reactions (ADRs) is a relevant clinical problem with major health and economic consequences. We conducted a study to assess hospital mortality related to ADRs, the drugs most frequently involved, and the possible risk factors associated with fatal ADRs. Methods: A retrospective observational study was conducted, reviewing the clinical records of 1388 consecutive adult patients (18-101 years) who died during a 22-month period in a tertiary hospital in Southern Europe (Granada, Spain). The main outcome was the prevalence of hospital death suspected to be related to administered drugs. Results: Out of the 1388 adult deaths studied, 256 (18.4 %) were suspected of being related to drugs. Drugs were suspected of causing death in 146 inpatients (10.5 %) and contributing to death in 110 (7.9 %). Drugs related to death were administered during the hospital stay in 161 cases (11.5 %) and before hospital admission in 95 (6.84 %). The most frequent fatal ADRs were cardiac arrhythmia, gastrointestinal bleeding, and respiratory failure. The drugs most frequently involved in fatal ADRs were antithrombotics (anticoagulants or antiplatelets) (23 %), psychotropic drugs (21.2 %), and digoxin (11.3 %). Independent risk factors for ADR-related death were the presence of ≥4 diseases (OR = 1.43) and the receipt of ≥10 drugs (OR = 3.24), but no significant association with gender or age was found. Conclusions: A high percentage of hospital deaths were suspected of being associated with ADRs, especially in patients with comorbidity and/or polypharmacy. Antithrombotics, psychotropics, and digoxin were the drugs most frequently associated with in-hospital drug-related deaths. [ABSTRACT FROM AUTHOR]

Background: In gynecology, there is a paucity of scientific studies on surgery-related mortality, and only a few isolated figures can be found for certain procedures. There are few statistics from hospitals, cities, or countries. Objective: The aim of this research was to study the mortality between 2000 and 2010 in patients who underwent surgery in the gynecology department of the General University Hospital of Albacete, Albacete, Spain, with a particular focus on the causes of death and potential adverse effects related to these deaths, to improve health care quality. Materials and Methods: Design: This was a retrospective descriptive study of a case series. Methods: All data were taken from the medical histories at the hospital. The study included patients who underwent scheduled inpatient surgery ( n = 4617). Results: During these 11 years, 14/4617 (0.3%) patients who underwent surgery in the department died. Among the 14 women who died, 13 (92.85%) had cancer and 11 died from a cause directly related to the tumor condition, rather than from the surgery itself. Among the remaining 3 (0.06%) patients, death was the result of a surgical and/or postoperative complication: 2 patients had diagnosed bilateral pulmonary thromboembolism and 1 had undiagnosed intraoperative intestinal perforation that caused septic shock with a fatal outcome. No deaths were associated with abdominal hysterectomy, laparoscopy-laparotomy for benign conditions, other vaginal surgeries, or vulvectomy. Conclusions: The mortality associated with gynecologic surgery at the General University Hospital of Albacete is extremely low, which is reassuring for its patients, and this may be because the patient population is at lower risk for mortality. (J GYNECOL SURG 32:43) [ABSTRACT FROM AUTHOR]

• Hunting-yield models produce precise general abundance patterns over new time periods. • Model performance decreases at fine scale resolution and in extrapolation areas. • Model assessment is required before they can be applied to policy making. While reliable estimates of species abundance distribution are required for wildlife management and are greatly needed at broad spatial scales, such information is scarce. In this context, the usefulness of spatial modelling as a tool for predicting game species relative abundance and distribution from hunting yield data was studied. Hunting yield data is affected by several factors related to species management, hunting regulations, and hunting efficacy and some doubts have been raised about the use or reliability of this data for large-scale modelling. Some years ago, Acevedo et al. (2014) calibrated five spatially explicit models (one per bioregion) by using hunting yield data for wild boar Sus scrofa (from hunting seasons 2006 to 2009) for approximately 60% of mainland Spain. After internal validation, the models were extrapolated to produce predictions of species relative abundance for the whole mainland country. Here, we reviewed these previous models to evaluate their predictive performance on new data (from hunting seasons 2014 to 2018) in areas where the models had been calibrated (interpolation areas) and also when projected into new ones (extrapolation areas). Our results showed that the previous models were able to forecast current general patterns of wild boar relative abundance with population growth rates equivalent to those reported by other authors, although differences between bioregions were observed. Performance on interpolation areas was higher than that obtained on extrapolation areas. Accuracy of model predictions decreased when fine resolution assessment at hunting ground level was carried out. Our results suggest that spatial models calibrated on hunting yields could be a good option to predict general wild boar relative abundance distribution patterns, although critical assessment is needed, since models can fail when they are extrapolated to areas for which no information is available and at fine scale resolution. These results represent a step forward in the use of hunting yields for describing ranges of species relative abundance at large spatial scales. [ABSTRACT FROM AUTHOR]

This paper assesses the impact of the economic recession caused by the global financial crisis on income poverty and deprivation in Italy and Spain to identify the most vulnerable groups and to guide policy makers. We consider the main socioeconomic and demographic characteristics of individuals impacting on their labor market status. The analysis is carried out separately for male and females to detect possible gender differences. Our results show the growth of material deprivation. Furthermore, the higher exposure of females to income poverty and material deprivation is verified in both countries despite of the efforts made to close the gender gaps in their labor markets. [ABSTRACT FROM AUTHOR]

ABSTRACT: Labour Societies and Cooperatives are both Social Economy enterprises, but with noticeable differences, some of which are imposed by legislation in Spain. The aim of this paper is to study whether such differences affect their management capacity and, in particular, efficiency. In doing so, Data Envelopment Analysis techniques and the metafrontier approach proposed by O'Donnell et al. (2008) are used on a sample of Spanish Labour Societies and Cooperatives belonging to the building industry. Scores of technical efficiency and metafrontier ratios are computed at firm level and, as a novel contribution to existing literature in this field of research, at input-specific level. The main finding shows that Cooperatives enjoy some technological advantages over Labour Societies, particularly in regard to the management of labour, fixed assets and current assets. [ABSTRACT FROM AUTHOR]

Due to the fact that drug consumption in young people is a matter of great interest in our society, more and more surveys have studied about it, to the point of existing a great amount of unconnected epidemiologic data nowadays, which lack coherence and haven't been properly related. Considering this situation, this paper proposes an integrated analysisof the current situation of tobacco, alcohol, cannabis and other illegal drugs consumption in Spanish adolescents. Besides, in this discourse, it is exposed the influence of social, cultural and political factors, that is, factors that may be responsible either of the decrease or stabilization in some substances or of the increase in others. In line with this explanation, we propose some recommendations for the prevention of substance use in Spanish young people. [ABSTRACT FROM AUTHOR]

The article explores the concept of denomination in a professional association in Spanish law, distinguishing between objective and subjective denomination. The author associates the concept of objective association with an association that has been certified. The question of when the consensus on which entities have stopped being partners can be revoked is also explored.

The article discusses the concept of arbitration in professional associations and partnerships within the framework of Spanish law. The revision of Spanish laws to permit the inscription of clauses of arbitration into partnership contracts is chronicled. The concept of corporate arbitration within the field of jurisprudence is also explored.

Culturally sensitive and valid assessments of participation in occupations are needed for Spanish-speaking children to enhance services offered to this population. The purpose of this study was to assess the validity and reliability of the newly developed Spanish version of the Children's Assessment of Participation and Enjoyment and Preferences for Activities of Children, the Evaluación de Participacion y Disfrute de los Niños y Preferencias de las Actividades de los Niños (EPDN/PAN). The sample included 249 children with and without disabilities, aged 6 to 15 years. Statistically significant differences (p < 0.05) in the participation of children with disabilities and children without disabilities, and between younger and older children were found. No statistical significant differences were found between males and females in the dimensions of participation assessed. Adequate internal consistency (0.70–0.92) was found for the PAN scale and the Overall and Informal domain scores of the EPDN-Intensity scale. Further study is needed to evaluate the formal domain scale and gender differences by activity types. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

In order to survive periods of adverse cold climatic conditions, plant requirements are satisfied by means of physiological adaptations to prevent cells from freezing. Thus, the growth of woody plants in temperate regions slows down and they enter into a physiological state called dormancy. In order to identify the chilling and heat requirements to overcome the dormancy period of Cupressaceae pollen type in the south of Europe, we have carried out our study with aerobiological data from a 10-year (1996-2005) period in Ponferrada, León (Spain). For the chilling requirements the best result was with a threshold temperature of 7.1°C and an average of 927 CH. Calculation of heat requirements was carried out with maximum temperature, with 490 growth degree days (GDD) needed, with a threshold temperature of 0°C. We have used the 2002-2003, 2003-2004 and 2004-2005 periods in order to determine the real validity of the model. We have not used these years in developing the models. The dates predicted differ in only a few days from those observed: in 2002-2003 there was a difference of 11 days, in 2003-2004 predicted and observed dates were the same, but in 2004-2005 the difference obtained was of 43 days. [ABSTRACT FROM AUTHOR]

Background: Recent evidence suggests that the alpha1-antitrypsin [AT] gene may play a role in the pathogenesis of the fibromyalgia syndrome [FMS]. The objective of the present study is to compare the AT gene frequency between FMS patients and the general population [GP] from the central region of the Asturias Province in Northern Spain. Method: The AT proteinase inhibitor phenotypes were characterized by isoelectric focusing on serum from a cohort of 250 individual FMS subjects, who fulfilled the American College Rheumatology criteria for FMS, and on serum from a control cohort of 1,111 GP subjects. The FMS subjects [238 females and 12 males] were enlisted from an outpatient hospital clinic setting. The mean age of the FMS cohort was of 49.02 years. The GP control cohort [45 percent males and 55 percent females] was enrolled using an epidemiological technique of simple random sampling in the general population from the same region of Asturias. The GP sample size was 1,111, the mean age was of 46.2 years. Mean outcome measures were AT-PI phenotyping characterization [performed by isoelectric focusing] and AT serum concentration [measured by nephelometry]. Results: Calculated mean allele frequencies for PI*S and PI*Z [the two most frequent AT deficiency alleles] were 64 [95 percent confidence interval [CI]: 45-90] and 40 [CI: 25-62] per 1,000, respectively, for the FMS cohort, as compared with 100 [CI: 88-113] and 19.7 [CI: 14.5-26.6] per 1,000 for the GP cohort. Calculated prevalences [Hardy-Weinberg statistics formula] were 1/14 in FMS Versus 1/29 in GP for MZ; 1/195 in FMS versus 1/254 in GP for SZ; and 1/625 in FMS versus 1/2,573 in GP for ZZ. For PI*Z, the calculated odd ratio among FMS versus GP was 2.06 [CI: 1.16-3.63]. A binomial proof [contrast hypothesis] stated that FMS AT-Z gene frequency differed significantly from the GP Z gene frequency [P = 0.007]. Conclusion: The most common AT severe-deficient allele [i.e., PI*Z] has been found with a two-fold higher frequency in the FMS cohort than in the GP cohort. The high odds ratio found for PI*Z indicates a significant difference for PI*Z frequency in the FMS cohort as compared with the GP cohort. Our findings suggest that AT deficiency might play an important role in FMS development and clinical expression in, at least, a subset of FMS subjects. [ABSTRACT FROM AUTHOR]

Simple Summary: Varroa destructor, a parasitic mite of Apis mellifera, is causing severe damages to honey bee colonies worldwide. There are very few acaricides available to manage the parasite, and so the evolution of the mite's resistance to acaricides poses a serious threat to controlling the mite. Using a combined approach that includes bioassays and genotyping, we estimated the expected efficacy of the treatments with acaricide products based on coumaphos, amitraz, and pyrethroids in apiaries from one of the most important beekeeping regions in Spain. This information was shared with the beekeeping community so that they can take informed and scientific-based decisions in the most convenient way to manage the parasite. Varroa destructor is an ectoparasitic mite causing devastating damages to honey bee colonies around the world. Its impact is considered a major factor contributing to the significant seasonal losses of colonies recorded every year. Beekeepers usually rely on a reduced set of acaricides to manage the parasite, usually the pyrethroids tau-fluvalinate or flumethrin, the organophosphate coumaphos, and the formamidine amitraz. However, the evolution of resistance in the mite populations is leading to an unsustainable scenario with almost no alternatives to reach an adequate control of the mite. Here, we present the results from the first large-scale and extensive monitoring of the susceptibility to acaricides in the Comunitat Valenciana, one of the most prominent apicultural regions in Spain. Our ultimate goal is to provide beekeepers with timely information to help them decide what would be the best alternative for a long-term control of the mites in their apiaries. Our data show that there is a significant variation in the expected efficacy of coumaphos and pyrethroids across the region, indicating the presence of a different ratio of resistant individuals to these acaricides in each population. On the other hand, the expected efficacy of amitraz was more consistent, though slightly below the expected efficacy according to the label. [ABSTRACT FROM AUTHOR]

Nowadays we are witnessing a significant change in content consumption. This, together with the global health situation, has caused some behaviors to accelerate. This research focuses on the specific case of the lockdown in Spain and the coincidence with the launch of the fourth season of Money Heist compared to the launch of season three. Starting with a review of the theoretical framework, in which the related concepts of coronavirus, television, and Video on Demand (VOD) platforms are presented, the importance of transmedia communication is also introduced. The methodological aspect is developed through content analysis and in-depth interviews. The tool used on the first methodology has been Twlets. With regard to the sources, the specific bibliography of the audiovisual sector, the official profile of the series on Twitter and personal interviews with professionals from the communication department of the production company, Vancouver Media, and from the series directing were taken into account. The methodology used to carry out this work has been the analysis of quantitative–qualitative content of the various sources consulted. The results of the study are presented in graphs, crossing the data from the different sources to detect the strategies of marketing and communication used for the release of the fourth season of the series. These results reflect the change in the communication strategy, the behavior of the social audience of the Twitter account of Money Heist (La Casa de Papel) and its relationship with the period of lockdown in Spain. [ABSTRACT FROM AUTHOR]

The article offers information on a study which investigated the association between combined antiretroviral therapy and the risk of HIV transmission in stable heterosexual serodiscordant couples. Accordingly, 648 couples from an HIV clinic in Madrid, Spain were recruited to participate in the cross sectional and prospective cohort study. It briefly describes the design, size and duration of the study. Also presented in details are the research findings and possible source of bias.

Abstract: Background: The overall seroprevalence of HTLV infection among pregnant women in Spain is below 0.02% and accordingly universal antenatal screening is not recommended. However, as the number of immigrants has significantly increased during the last decade, this population might warrant specific considerations. Objective: To evaluate the seroprevalence of HTLV infection among immigrant pregnant women living in Spain. Methods: From January 2009 to December 2010 a cross-sectional study was carried out in all foreign pregnant women attended at 14 Spanish clinics. All were tested for HTLV antibodies using a commercial enzyme-immunoassay, being reactive samples confirmed by Western blot or PCR. Results: A total of 3337 foreign pregnant women were examined. Their origin was as follows: Latin America 1579 (47%), North Africa 507 (16%), East Europe 606 (18%), Sub-Saharan Africa 316 (9%), North America and West Europe 116 (3.5%) and Asia and Australia 163 (5%). A total of 7 samples were confirmed as HTLV positive, of which 6 were HTLV-1 and 1 HTLV-2. HTLV-1 infection was found in 5 women coming from Latin America and 1 from Morocco. The only woman with HTLV-2 came from Ghana. The overall HTLV seroprevalence was 0.2%, being 0.3% among Latin Americans and 0.2% among Africans. It was absent among women coming from other regions. Conclusions: The seroprevalence of HTLV infection among foreign pregnant women in Spain is 0.2%, being all cases found in immigrants from Latin America and Africa. Given the benefit of preventing vertical transmission, antenatal screening should be recommended in pregnant women coming from these regions. [Copyright &y& Elsevier]

Abstract: Background: HIV-1 group M is classified into 9 subtypes and recombinants (CRFs/URFs). Variants other than subtype B (non-B) cause 90% of infections worldwide. HIV is often subtyped using automated tools instead of the gold-standard phylogenetic analysis. We evaluated the reliability of subtyping tools vs. phylogeny in a panel of HIV-1 pol sequences from the cohort of naïve patients of the HIV/AIDS Spanish Research Network (CoRIS). Methods: HIV-1 subtyping was performed using seven automated subtyping tools (Stanford, Geno2pheno, Rega, NCBI, EuResist, STAR, TherapyEdge) in HIV-1 pol sequences from 670 CoRIS patients previously subtyped by phylogeny (587 subtype B/83 non-B). Sensitivity with respect to phylogeny was assessed. Results: Most tools correctly classified subtype B, although up to 15% of non-B sequences were wrongly identified as B depending on the tool. For subtype B and CRF02_AG identification, Stanford/NCBI and Geno2pheno/Rega presented the highest/lowest sensitivities, respectively. EuResist and Geno2pheno correctly classified all 13 non-B “pure”subtypes at pol. The efficacy of all subtyping tools dropped clearly when identifying recombinants different from CRF02_AG. Only NCBI05, Rega and STAR identified URF, but with very low sensitivities. NCBI classified the highest number of subtypes B as non-B, and overestimated recombinants, especially when including references of 2009. Conclusions: Automated tools are useful for subtype B identification, although they present serious limitations in classifying variants uncommon in developed regions, especially recombinants. Their sensitivity depends on the prevalence of non-B variants in the population, and decreases drastically when the frequency of recombinants increases. Furthermore, HIV-1 variant distribution differs according to the tool used. [ABSTRACT FROM AUTHOR]

The implementation of the law 5/2000 for the regulation of Criminal Responsibility for Minors has led to a change in interventions in cases of juvenile offenders. This law promotes the educational and rehabilitative aims of the measures imposed. However, the focus of the media on the most serious cases has generated considerable alarm in society in general. The aim of this study is to determine the social perception of Law 5/2000. For this purpose, a sample of 936 people from the Autonomous Region of the Canary Islands was surveyed. The main results indicate that there is a significant lack of knowledge about the law and that people tend to think that the measures taken are not as effective as studies carried out in connection with this subject have shown. Nevertheless, the people surveyed are more in favour of educational measures than of measures that penalize. These results are discussed in connection with the importance that community factors have in dealing with juvenile delinquency, and in particular, in the power of social pressure to modify legislation, and of the community to assume responsibility for the reinsertion of juvenile offenders. [ABSTRACT FROM AUTHOR]

The article presents a study that assesses the effect of a program of HIV counseling and testing on the sexual risk behavior of steady heterosexual serodiscordant couples. It states that 564 couples that had attended had participated in counseling and testing of HIV in Madrid, Spain from 1989 to 2007. It notes that data including sociodemographic, epidemiologic, and behaviors are obtained. It concludes that diagnosis and counseling reduces sexual risk behaviors.

The Early Aptian Oceanic Anoxic Event 1a (OAE1a, 120 Ma) is associated to massive burial of organic matter in marine sediments, is recorded in all major ocean basins and is considered an excellent example of an OAE. Previous studies have documented the stable C-isotope stratigraphy of OAE1a through different sections worldwide. Nevertheless, detailed high-resolution records across the entire event are still required to accurately determine the precise timing and rates of the different environmental and biotic changes that occurred during the OAE1aWith this aim, four overlapping sediment cores, designated D1 to D4, have been obtained from the Aptian Almadich Formation (ca. 200 m. thick) at Cau section (Alicante province, SE Spain), where deposition occurred on a highly subsiding sector of a tilted block, located in the distal parts of the Prebetic Platform. Previous work on the exposed Aptian succession at Cau has focused on the stratigraphy, bioevents, C-isotope stratigraphy, and organic and elemental geochemistry, and on reconstructing pCO2 [1] These studies reveal that the Cau section represents an excellent site to investigate OAE1a, based on its unusually high thickness and stratigraphic continuity, and the quality and preservation of fossils and the geochemical signatures.To fully sample the Almadich succession four drills were planned: three of which were completed in the autumn of 2015 [2], and the fourth in the autumn of 2017. Systematic sampling of the cores for C- and O-isotope geochemistry, minor- and trace-elemental analysis, biomarkers, and micropaleontology, was performed. Gamma-ray logs, carbonate carbon-isotope (δ13Ccarb) data and cut-core images, have been the main basis used for correlation of the cores. Cores D3 and D4 show an overlap of about 16 m (lowest part of D3 correlates with the highest part of the D4 core). Cores D2 and D3 overlap by about 5 m and D1 and D2 by about 11 m. These overlaps have allowed us to obtain a complete C-isotope profile, in which the C-isotope segments differentiated by Menegatti et al. (1998) [3] and Bralower et al. (1999) [4] have been identified. Here we present the C-isotope stratigraphy, together with associated facies types, magnetic susceptibility measured from core in the laboratory, and geophysical log profiles measured down-hole. Correlation of the C-isotope profiles of the four cores demonstrates a number of features. The upper parts of the cores, showing visual evidence of oxidation, record erratic and lower δ13Ccarb values than the corresponding intervals in core sampled below the surface weathering zone. Similarly, outcrop carbonate C-isotope values are generally lower than those obtained from the cores. This poses a potential problem of correlation between outcrop and core profiles if the absolute values of the δ13Ccarb profiles are to be considered. Acknowledgements: This work is a contribution of research project CGL2014-55274-P (Government of Spain) and Research Group RNM-200 (PAIDI).References: [1] Naafs et al. (2016). Nat. Geosc. 9 (2), 135-139.[2] Ruiz-Ortiz et al. (2016). Sci. Dril. 21, 41-46.[3] Menegatti et al. (1998). Paleoceanography 13, 530-545.[4] Bralower et al. (1999). J. Foram. Res. 29, 418-437. [ABSTRACT FROM AUTHOR]

Background: The representation of wildlife-livestock interface (WLI) at an accurate spatial resolution poses several challenges. Furthermore, there is a lack of published material providing detailed descriptions of geospatial techniques for the purpose of producing visual results that are interpretable and contrastable for epidemiological analysis., Objectives: Our aim is to develop a standardized, applicable, and scalable methodological framework for describing and characterizing the WLI across a large spatial extent. Subsequently, we aim to employ this framework to depict specific WLI based on different epidemiological scenarios determined by the abundance of wild boar (Sus scrofa) and domestic ungulates as an illustrative case, specifically focusing on mainland Spain., Methods: To establish a methodological framework, we merged data from both wild and domestic sources into a hexagonal grid. We utilized data on wild boar hunting and the locations of pig, cattle, sheep, and goat farms in mainland Spain. New variables were derived from this combined dataset to illustrate the overlapping abundance between wild boar and domestic species. Finally, a cluster analysis of the generated variables was carried out, with the aim of distinguishing and characterizing various scenarios of the wild boar-domestic ungulate interface in mainland Spain., Results: The hexagonal grid proved appropriate to represent and evaluate the WLI at fine spatial resolution over such broad extent. Despite the inability to ascribe a dominant livestock type and production system to a specific region, we were able to identify fifteen main areas of interest in terms of overlap. As for extensive livestock, normally at the highest risk of interaction with wild boar, the primary regions in Spain were those with dehesa agroecosystem and the Atlantic areas. Certain scenarios were particularly relevant in terms of risk for interaction and subsequent transmission of disease, namely, the case of extensive pig production in south western Spain (dehesa agroecosystem), which is especially concerned about the potential introduction of African Swine fever (ASF) in the Country. DISCUSSION AND CONCLUSIONS: We provide a basis for visualizing and understanding of different WLI scenarios, which is extensible to other regions and interfaces, and automatable where precise source of data from wildlife and livestock are available. This spatial statistics framework enables the utilization of high-resolution data, ensuring consistency on uniform grids. This aligns with the needs of high-resolution disease dissemination models based on wildlife behaviour. Such aspects are crucial for developing risk assessment and improving strategies for the prevention, control, and eradication of shared priority emerging diseases at national and international levels, such as ASF., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Tick abundance is an essential demographic parameter to infer tick-borne pathogen transmission risks. Spatiotemporal patterns of tick abundance are heterogeneous, so its determinants at small spatial scales need to be understood to reduce their negative effects on hosts. Current knowledge of these determinants is scarce, especially in Mediterranean environments, limiting the possibilities for designing efficient tick control strategies. With the goal of unravelling tick abundance determinants and informing new tick management strategies, we estimated tick burdens on 1965 wild ungulates in Doñana National Park, Spain, annually between 2010 and 2020. Under the hypothesis of a predominant host influence on tick abundance, we modelled the burdens of Rhipicephalus annulatus, Hyalomma lusitanicum, and Ixodes ricinus with relevant predictors grouped into four factors: i) environment; ii) host population; iii) host individual; and iv) land-use. Generalized linear mixed models with a zero-inflated negative binomial distribution were built. Additionally, we analysed the differential contribution to abundance of each factor by deviance partitioning. We finally estimated the similarity in the environmental space of tick species by analysing their niche overlap with the environmental principal component analysis method. Our work hypothesis was confirmed for R. annulatus and H. lusitanicum, but we found that tick abundance at a fine spatial scale is jointly driven by multiple drivers, including all four factors considered in this study. This result points out that understanding the demography of ticks is a complex multifactorial issue, even at small spatial scales. We found no niche differences between the three tick species at the study spatial scale, thus showing similar host and environmental dependencies. Overall results identify that host aggregation areas displaying environmentally favourable traits for ticks are relevant tick and vector-borne pathogen transmission hotspots. Our findings will facilitate the design of new strategies to reduce the negative effects of tick parasitism., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)

Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018., Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation., Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001)., Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population., (© 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.)

Objectives: ANA are the most extensively used test for the diagnosis of systemic autoimmune diseases. However, testing by indirect immunofluorescence assays (IIFAs) on HEp-2 cells, the gold standard test, is time-consuming and needs expertise. Thus there is a trend to replace it with other automated solid-phase assays directed against specific ANA. Nonetheless, the Hep-2 cell is an autoantigen array and ANA have been classified into 29 types, some of them with no clear association with a specificity to be detected. It is especially in these uncommon patterns where no clinical relationship is found and no antigenic specificity is detected. Here we retrospectively collected clinical data from patients with confirmed uncommon HEp-2 IIFA patterns to search for an associated clinical condition., Methods: We conducted an observational retrospective study including 608 patients with organ-specific and non-organ-specific autoimmune diseases (OSADs and NOSADs, respectively) with a confirmed rare pattern of ANA detected by IIFA on HEp-2 cells in the routine practice of the Spanish European Autoantibodies Standardization Initiative laboratories. Inclusion criteria are the existence of a minimum follow-up of 2 years and the availability of clinical data., Results: Nuclear patterns were more frequent in SLE (P = 0.001) and SS (P = 0.001), whereas the cytoplasmic ones were significantly higher in SSc (P = 0.022) and inflammatory myositis (P = 0.016). Mitotic patterns did not show any preferences for a specific disease and 62.7% of them corresponded to the nuclear mitotic apparatus pattern (AC-26). The most frequent NOSADs in patients with the AC-26 pattern were SLE (28.6%), SS (11.9%) and RA (11.9%). The cytoplasmic HEp-2 IIFA patterns were equally distributed in both groups of patients. In the OSAD patients there was no predominant pattern, except for AC-6 in primary biliary cholangitis due to Sp-100 antibodies (P < 0.001)., Conclusion: Detection of infrequent ANA might be a unique finding with no disease-associated specificities and could lead to the suspicion of an autoimmune disease., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60-81 years) and 3656 (58.3%; 95% confidence interval 57.1-59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients' profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition., (Copyright © 2021 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.)

BackgroundRecent and reliable estimates on the prevalence of coinfection with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in Europe are lacking.AimLeveraged on a study designed to assess HIV/HCV coinfection prevalence, we assessed the prevalence of HIV/HBV coinfection in Spain in 2018 and compared the results with five similar studies performed since 2002.MethodsThis cross-sectional prevalence study was carried out in 43 centres, and patients were selected using simple random sampling. The reference population comprised 40,322 patients and the sample size were 1,690 patients.ResultsThe prevalence of HIV/HBV coinfection in Spain at the end of 2018 was 3.2%. The prevalence in 2002, 2009, 2015, 2016 and 2017 was 4.9%, 3.4%, 3%, 3.9% and 3%, respectively. Among the HIV/HBV-coinfected patients identified in 2018, 16.7% had cirrhosis according to transient elastography and 26.3% tested positive for antibodies against hepatitis D virus. All HIV/HBV-coinfected patients were receiving drugs with activity against HBV, and 97% of those tested for HBV DNA had an HBV DNA load < 80 IU/mL.ConclusionsThe prevalence of HIV/HBV coinfection in Spain remained stable at around 3% for a decade. Our data could facilitate the design of national programmes to control HBV infection and help identify areas of patient management that need improvement.