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Background: The severe forms of influenza infection requiring intensive care unit (ICU) admission remain a medical challenge due to its high mortality. New H1N1 strains were hypothesized to increase mortality. The studies below represent a large series focusing on ICU-admitted influenza patients over the last decade with an emphasis on factors related to death., Methods: A retrospective study of patients admitted in ICU for influenza infection over the 2010-2019 period in Réunion Island (a French overseas territory) was conducted. Demographic data, underlying conditions, and therapeutic management were recorded. A univariate analysis was performed to assess factors related to ICU mortality., Results: Three hundred and fifty adult patients were analyzed. Overall mortality was 25.1%. Factors related to higher mortality were found to be patient age >65, cancer history, need for intubation, early intubation within 48 h after admission, invasive mechanical ventilation (MV), acute respiratory distress syndrome (ARDS), vaso-support drugs, extracorporal oxygenation by membrane (ECMO), dialysis, bacterial coinfection, leucopenia, anemia, and thrombopenia. History of asthma and oseltamivir therapy were correlated with a lower mortality. H1N1 did not impact mortality., Conclusion: Patient's underlying conditions influence hospital admission and secondary ICU admission but were not found to impact ICU mortality except in patients age >65, history of cancer, and bacterial coinfections. Pulmonary involvement was often present, required MV, and often evolved toward ARDS. ICU mortality was strongly related to ARDS severity. We recommend rapid ICU admission of patients with influenza-related pneumonia, management of bacterial coinfection, and early administration of oseltamivir., Competing Interests: All the authors declare that they have no conflict of interest., (© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)

Introduction: Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. The objective of our study was to study risk factors and complications associated with severe preeclampsia requiring intensive care unit (ICU) admission., Methods: Retrospective comparative study over a period from 1st of January 2015 to 1st of January 2019 in the University's maternity unit of South Reunion (Indian Ocean). Our sampling included all preeclamptic patients who delivered in the Southern part of the island. Patients admitted to intensive care unit (ICU) and those who remained in the maternity unit (controls) were reviewed., Results: Out of 482 preeclampsia cases, 94 women (19.5%) needed a transfer in ICU, of which only 21 (4.3%) needed invasive intensive care. Mean length of stay was 2.4 ± 2.1 days. ICU admission was associated with HELLP syndrome (OR 8.5 [4.9-14.9], p <.001), severe post-partum hemorrhage (OR 5.86 [1.29-26.70], p =.01) and early onset of preeclampsia (<34 weeks gestation), 2.97 [1.9-4.7], p <.001), leading to higher rate of C-section (OR 2.83 [1.67-4.78], p <.001). There were three patients with a history of eclampsia and no case of maternal death was reported. Fetal prognosis was much poorer in maternal ICU admissions than in controls, with outcomes including lower birth weight (1776 vs. 2304 g, p <.001) and higher perinatal morbidity (infant respiratory distress syndrome 3.70 [1.94-7.05], p <.001) and mortality (<.001)., Conclusions: Women needing invasive ICU represented 4.3% of preeclampsia cases. This experience is of interest for lower resource settings such as in countries like Madagascar where very intensive ICU means are very poor, but simpler ICU surveillance is possible. Fetal prognosis was poor though no maternal death was reported. Thus, a multidisciplinary approach of patients with preeclampsia should be encouraged; admission into ICU should be facilitated, as soon as any sign of severity and complications appears.

Introduction: The 2009 pandemic influenza A (H1N1) virus has emerged to cause the first pandemic of the 21st century. On July 3, 2009, novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in Reunion Island, French overseas department located in the southern hemisphere. The present study describes the characteristics and the impact of the epidemic on the activity of an emergency department (ED) from July 3 to August 31, 2009., Method: Patients consulting the ED with a discharge diagnosis of influenza-like illness were analyzed., Results: The ED activity in 2009, compared to 2008, increased by 0.5% in July and 9.7% in August. In July and August, respectively 7.1 and 20.0% cases of S-OIV infection were hospitalized. For the 394 patients studied (186 males, 36.2+/-18.5 years), 199 (50.5%) were reported to have comorbidity or risk factor (RF) for complications. Complications occurred in 112 patients (28.4%). The most common complications were bronchospasme (52.7%), pneumonia (32.1%), decompensation caused by comorbidity (17.9%). Seventy-three patients (18.5%) required hospitalization. Patients aged 65 and over accounted for 10.9% of all patients, 31.5% of hospitalized patients and 21.4% of complicated S-OIV infection. Regardless of age, comorbidity and / or RF was reported in 80.2% of complicated S-OIV infection and 86.3% of hospitalized patients. The circuit of patients with S-OIV infection was initially focused on "consultation S-OIV" localized in ED. This organization mobilized several health professionals, disorganized the various medical departments involved, and was unsuitable for the childcare or patient's monitoring with signs of poor tolerance. This organization, even identifying S-OIV patients at their arrival, referred patients to different areas of the hospital and various consultation rooms in ED., Conclusion: Recommendations for surveillance, prevention and policy for persons with RF, particularly respiratory disease, are justified. This feedback can raise questions about the patient's circulation in hospital and adjust plans for the organization., (Copyright 2010 Elsevier Masson SAS. All rights reserved.)