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During the COVID-19 public health emergency, an increasing number of studies reported the occurrence of SARS-CoV-2 in wastewaters worldwide, but little is known about the presence of the virus in surface freshwaters. The aim of the current study was to develop and validate an appropriate and scalable methodological approach for the concentration and detection of SARS-CoV-2 from surface freshwater samples, collected within the Milan rural network subjected to flood spillways activity. Overall, both surface water and distilled water samples spiked with inactivated SARS-CoV-2 were used to validate the concentration method for pathogens determination. Two pre-filtration systems, filter paper and Sartolab® P20 (Sartorius, Germany) and two concentration methods, two-phase (PEG-dextran method) separation and tangential flow ultrafiltration (UF), were compared. The effects of pre-filtration and concentration on viral nucleic acid recovery were assessed through real time RT-PCR targeting SARS-CoV-2 and the internal viral control PMMoV (Pepper Mild Mottle Virus). Our results showed that UF is more sensitive than the PEG-dextran method in viral acid nucleic recovery from surface water samples. Better results were obtained pre-filtering samples with Sartolab® P20 and extracting the nucleic acids with undiluted silica, rather than diluted as required by the standard protocol. The proposed method will be used for the monitoring of surface waters in the Milan area. [ABSTRACT FROM AUTHOR]

Aimac), Rome, Italy; 6Alleanza Contro il Cancro, Rome, Italy; 7SC Haematology, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy; 8Rehabilitation Medicine Unit, Strategic Health Services Department, Istituto Nazionale Tumori-IRCCS Fondazione G. Pascale, Naples, Italy; 9Department of Oncology and Molecular Medicine, Italian National Institute of Health (ISS), Rome, Italy; 10Evaluative Epidemiology Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy; 11DOPO Clinic, Department of Pediatric Haematology/Oncology, IRCCS Istituto Giannina Gaslini, Genoa, Italy; 12Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy; 13Applied Research Division for Cognitive and Psychological Science, IEO European Institute of Oncology IRCCS, Milan, Italy; 14Psychology Unit, IRCCS Regina Elena Cancer Institute, Rome, Italy; 15Medical Oncology Unit, Umberto I Hospital, Department of Oncology, RAO, Siracusa, ItalyCorrespondence: Luigino Dal Maso, Epidemiologia Oncologica, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Via Franco Gallini 2, Aviano (PN), 33081, Italy, Tel +39 0434 659354, Email [email protected] Paolo Tralongo, Medical Oncology Unit, Umberto I Hospital, Department of Oncology, RAO, Via Giuseppe Testaferrata 1, Siracusa, 96100, Italy, Tel +39 0931 724 464, Email [email protected] A multidisciplinary panel of experts and cancer patients developed a position paper to highlight recent evidence on "cancer cure" (ie, the possibility of achieving the same life expectancy as the general population) and discuss the consequences of this concept on follow-up and rehabilitation strategies. The aim is to inform clinicians, patients, and health-care policy makers about strategies of survivorship care for cured cancer patients and consequences impacting patient lives, spurring public health authorities and research organizations to implement resources to the purpose. Two identifiable, measurable, and reproducible indicators of cancer cure are presented. Cure fraction (CF) is > 60% for breast and prostate cancer patients, > 50% for colorectal cancer patients, and > 70% for patients with melanoma, Hodgkin lymphoma, and cancers of corpus uteri, testis (> 90%), and thyroid. CF was > 65% for patients diagnosed at ages 15– 44 years and 30% for those aged 65– 74 years. Time-to-cure was consistently < 1 year for thyroid and testicular cancer patients and < 10 years for patients with colorectal and cervical cancers, melanoma, and Hodgkin lymphoma. The working group agrees that the evidence allows risk stratification of cancer patients and implementation of personalized care models for timely diagnosis, as well as treatment of possible cancer relapses or related long-term complications, and preventive measures aimed at maintaining health status of cured patients. These aspects should be integrated to produce an appropriate follow-up program and survivorship care plan(s), avoiding stigma and supporting return to work, to a reproductive life, and full rehabilitation. The "right to be forgotten" law, adopted to date only in a few European countries, may contribute to these efforts for cured patients. [ABSTRACT FROM AUTHOR]

This special issue presents a selection of extended and thoroughly revised papers resulting from the 10th (IMC) International Masonry Conference, which took place at the Technical University of Milan (Politecnico di Milano) in Milan, Italy from 9 to 11 July 2019. [ABSTRACT FROM AUTHOR]

GRAPH For the first time in the history of the International Color Association, the AIC congress held every 4 years, will be organized in Italy by Associazione Italiana Colore. Color and Psychology: phenomenology of colors, color harmonies, color and form, perceptive, emotional, esthetic, and diagnostic aspects. [Extracted from the article]

The article highlights the poetry of experimental 20th-century poet Emilio Villa. Topics covered include an image showing Villa's signature digitized by communication designer Alessandro Segalini in 2014, the selected poetry of Villa from 1914 to 2003 published by Contra Mundum Press in 2014, and Villa's book titled "The Selected Poetry of Emilio Villa."

This paper discusses three case studies of early science museum-related websites in the 1990s and early 2000s, when web technology was still relatively new and evolving. The Virtual Museum of Computing (VMoC) was a completely virtual museum, originally produced in 1995 as part of the Virtual Library museums pages (VLmp), an international online museum directory within the WWW Virtual Library, adopted by the International Council of Museums (ICOM). The Science Museum in London was one of the first museums in the United Kingdom to have its own web server. The museum hosted an early meeting on web service provision by and for museums, concurrently with an exhibition on the Information Superhighway at the museum in 1995. Exhiblets were launched online in 1998. Ingenious was a multi-site digital collections transformation project, launched as a website in 2003. Virtual Leonardo and Leonardo's Ideal City were two experiments conducted by the digital team of the Science and Technology Museum of Milan, between 1999 and 2001. The experiment consisted of the creation of a shared online 3D world, namely a reconstruction of the real museum in the first case and a completely imaginary world in the second case. This paper describes the above three case studies from the early World Wide Web and then draws some conclusions, from first-hand experience of developments at the time. We cover both the advantages and the challenges encountered by the various projects and illustrate why they did not necessarily become established, despite promising early results. [ABSTRACT FROM AUTHOR]

Analytical performance specifications (APS) based on outcomes refer to how 'good' the analytical performance of a test needs to be to do more good than harm to the patient. Analytical performance of a measurand affects its clinical performance. Without first setting clinical performance requirements, it is difficult to define how good analytically the test needs to be to meet medical needs. As testing is indirectly linked to health outcomes through clinical decisions on patient management, often simulation-based studies are used to assess the impact of analytical performance on the probability of clinical outcomes which is then translated to Model 1b APS according to the Milan consensus. This paper discusses the related key definitions, concepts and considerations that should assist in finding the most appropriate methods for deriving Model 1b APS. We review the advantages and limitations of published methods and discuss the criteria for transferability of Model 1b APS to different settings. We consider that the definition of the clinically acceptable misclassification rate is central to Model 1b APS. We provide some examples and guidance on a more systematic approach for first defining the clinical performance requirements for tests and we also highlight a few ideas to tackle the future challenges associated with providing outcome-based APS for laboratory testing. [ABSTRACT FROM AUTHOR]

In several Western European countries, a significant share of social rental housing stock has been sold since the 1980s as part of government policies aimed at promoting homeownership societies. Research has shown that tenure conversion has contributed to increasing socio-spatial segregation of lower-income groups, with diverging spatial patterns of homeownership among immigrants. This paper examines the impact of recent public housing privatization schemes in Milan in relation to micro-segregation and peripheralization processes of foreign populations, which represent distinctive features of immigrant residential distribution in this city. By employing name analysis, an unconventional approach in segregation studies, I inferred the geographical origins of homebuyers and mapped their distribution across the city. The findings reveal divergent purchasing behaviors, whereby Italians predominantly acquire properties in semi-central areas currently undergoing urban regeneration. In contrast, immigrants tend to concentrate their acquisitions in peripheral post-war public housing neighborhoods or in areas predominantly inhabited by residents with similar geographical origins. This paper contributes to the existing literature on ethnic residential segregation in Southern European cities by shedding light on the underexplored role of public housing privatization policies in shaping specific residential patterns and housing outcomes among different groups. [ABSTRACT FROM AUTHOR]

Background: Accurately predicting mobile network traffic can help mobile network operators allocate resources more rationally and can facilitate stable and fast network services to users. However, due to burstiness and uncertainty, it is difficult to accurately predict network traffic. Methodology: Considering the spatio-temporal correlation of network traffic, we proposed a deep-learning model, Convolutional Block Attention Module (CBAM) Spatio-Temporal Convolution Network-Transformer, for time-series prediction based on a CBAM attention mechanism, a Temporal Convolutional Network (TCN), and Transformer with a sparse self-attention mechanism. The model can be used to extract the spatio-temporal features of network traffic for prediction. First, we used the improved TCN for spatial information and added the CBAM attention mechanism, which we named CSTCN. This model dealt with important temporal and spatial features in network traffic. Second, Transformer was used to extract spatio-temporal features based on the sparse self-attention mechanism. The experiments in comparison with the baseline showed that the above work helped significantly to improve the prediction accuracy. We conducted experiments on a real network traffic dataset in the city of Milan. Results: The results showed that CSTCN-Transformer reduced the mean square error and the mean average error of prediction results by 65.16%, 64.97%, and 60.26%, and by 51.36%, 53.10%, and 38.24%, respectively, compared to CSTCN, a Long Short-Term Memory network, and Transformer on test sets, which justified the model design in this paper. [ABSTRACT FROM AUTHOR]

The article presents the discussion on 48th Annual Conference of the European Finance Association (EFA) taking place virtually from 25th August until 27th August 2021. Topics include EFA 2021 meeting according to the respective number of accepted manuscripts and the corresponding downloads; and making use of machine learning approaches to forecast future price developments on the basis of past ones for US stocks from 1993 to 2019.

Introduction: To date, there are no known studies that have investigated the new need for volunteer services among cancer patients during the Covid-19 pandemic. However, it is essential for volunteer associations to heighten such knowledge to best guide their offer in this challenging period. Aim: The present study aims to provide a mapping of the cancer patients' needs for volunteer services followed at Istituto Nazionale dei Tumori in Milan (Italy) during the Covid-19 pandemic. Since there are no specific questionnaires for this purpose, we created an ad hoc tool for which we report the preliminary result. Method: We used a mixed-method multiphase approach. Phase I: in April-May 2020 40 ad hoc paper questionnaires were distributed at the entrance of the aforementioned hospital, with the aim of investigating patients' needs through two open-ended questions then analyzed through thematic analysis. Phase II: the contents that emerged from Phase I were transformed into items and submitted to the judgment of a small group of "peers" (patients) and "experts" (professionals) in November-December 2020 to evaluate their comprehensiveness, representativeness and intrusiveness. Phase III: in January-February 2021 paper questionnaires, containing the items reviewed in Phase II, were distributed within the hospital to a representative sample of cancer patients. We applied descriptive statistics, Exploratory Factor Analysis (EFA) and Cronbach's Alpha. Results: 32 patients completed Phase I, 3 "peers" and 9 "experts" participated in Phase II, 214 patients completed the questionnaire in Phase III. EFA highlights five kinds of needs during the Covid-19 pandemic, in order of priority: (1) need to be supported at the hospital; (2) need for emotional support; (3) need for daily errands; (4) need for practical support to family members; (5) need to share free time. Preliminary results on the tool are encouraging, although further studies are needed. These results will allow local volunteer associations to adapt their services during the pandemic. [ABSTRACT FROM AUTHOR]

The paper is rooted in the results of the Resilience Practices Observatory (RPO) project, which engaged more than one hundred community-led practices to improve local resilience capacities and about fifty applied research and institutional-led initiatives. The article in retracing the complex and articulated RPO research-action project aims to stimulate the disciplinary debate on the contribution and role of resilience practices in a renewed landscape planning framework process. In particular, the paper focuses on the resilience practices acting on ecological landscape enhancement, assuming nature-based solutions as an umbrella concept under numerous approaches, models, and theoretical frameworks supporting the integration of ecological values in the territorial and urban transformation towards their conservation and improvement. The selected cases are placed in the Milano metropolitan area, aiming to safeguard, improve, and valorize urban and periurban landscapes. The cases are used to explore three emerging phenomena: (1) the alliances and the role of community in orienting landscape planning; (2) the role of practices in solution co-design and planning implementation; (3) the role of community in micro-intervention for urban biodiversity and landscape functionality. The final section emphasizes the potential role of community-led initiatives in implementing the NBS European policy and landscape planning guidelines. In the meantime, final remarks underline perspectives in overcoming the existing criticalities towards renovated and adaptive governance process, enabling a more collaborative arena supporting the engagement of differentiated actors along the whole process, from decision making to the implementation and management of landscape planning. [ABSTRACT FROM AUTHOR]

The authors are to be congratulated on a valuable and thought-provoking contribution on the analysis of geo-referenced high-dimensional data describing the use over time of the mobile-phone network in the urban area of Milan, Italy. This is a timely and world-wide problem that opens wide avenues for new methodological contributions. The authors develop a Bagging Voronoi Treelet Analysis which is a non-parametric method for the analysis of spatially dependent functional data. This approach integrates the treelet decomposition with a proper treatment of spatial dependence, obtained through a Bagging Voronoi strategy. In our discussion, we focus on the following points: (i) a mobre general form of the spatio-temporal model proposed in Secchi et al. (Stat Methods Appl, ), (ii) alternative methods to approach the smooth temporal functions, (iii) additional methods to reduce the problem of dimension for spatial dependence data, and (iv) comments on the pros and cons of the proposed pre-processing methodology. [ABSTRACT FROM AUTHOR]

The increasing use of electromedical equipment in hospital care services necessitates effective management of complex devices often unsupported by existing control systems. This paper focuses on developing a pool of evaluation indices for the Clinical Engineering Department (CED) of the ASST Grande Ospedale Metropolitano Niguarda in Milano (Italy), aiming to enhance awareness of the economic value, assess operational units, and optimize maintenance processes. Leveraging business intelligence, this study identifies 18 key performance indicators (KPIs) across logistics, technical, and equipment management categories. An interactive dashboard, implemented using Power BI, facilitates dynamic analysis and visualization of these KPIs, providing insights into the maintenance efficiency and obsolescence of medical devices. It offers a comprehensive framework for ongoing monitoring and decision-making. The results showcase the potential of the developed KPIs and dashboard to enhance operational insights and guide improvements in the healthcare facility's maintenance processes. [ABSTRACT FROM AUTHOR]

The increases in both the elderly population and urbanization present new problems for planning new cities and managing old cities. To solve this challenge, innovative ideas/proposals that encourage walkability and reduce fossil energy motor transport are needed, in line with the actions advocated by Sustainable Development Goal #11 (SDG11), Sustainable Cities and Communities. Opening passages that cross blocks, creating connections between the streets, is the proposal discussed in this paper, as seen in cities like Paris, Prague, Milan, and Juíz de Fora, which have passages in their urban fabric. These can be implemented in a building's rehabilitation or when a new building replaces it. New architectural project designs should have several characteristics that promote walkability in the city, including passages and galleries. Although previous research has obtained promising results, extending the research to different urban fabrics and block sizes is needed. Using space syntax and data analysis, we simulated and quantitatively assessed the walkability of three neighborhoods in Lisbon, Portugal. The comparison of all simulations and the discussion of the results show that the passages improve walkability. It is also noticeable that there is higher walkability in orthogonal urban fabrics than in non-orthogonal fabrics. The results for block size are inconclusive. [ABSTRACT FROM AUTHOR]

Introduces a selection of papers presented at the 60th Congress of the International Institute of Public Finance, held in Milan, Italy in August 2004

Universal Time (UT) variations in many magnetospheric state indicators and indices have recently been reviewed by Lockwood and Milan (2023, https://doi.org/10.3389/fspas.2023.1139295). Key effects are introduced into magnetospheric dynamics by the eccentric nature of Earth's magnetic field, features that cannot be reproduced by a geocentric field model. This paper studies the UT variation in the occurrence of substorm onsets and uses a simple Monte‐Carlo model to show how it can arise for an eccentric field model from the effect of the diurnal motions of Earth's poles on the part of the geomagnetic tail where substorms are initiated. These motions are in any reference frame that has an X axis that points from the center of the Earth to the center of the Sun and are caused by Earth's rotation. The premise behind the model is shown to be valid using a super‐posed epoch study of the conditions leading up to onset. These studies also show the surprising degree of preconditioning ahead of the growth phase that is required, on average, for onset to occur. A key factor is the extent to which pole motions caused by Earth's rotation influence the near‐Earth tail at the relevant X coordinate. Numerical simulations by a global MHD model of the magnetosphere reveal the effect required to generate the observed UT variations and with right order of amplitude, albeit too small by a factor of about one third. Reasons why this discrepancy may have arisen for the simulations used are discussed. Plain Language Summary: Earth's magnetic field is eccentric in that the main magnetic (dipole) axis does not pass through the center of the Earth. This introduces a wobble into many aspect of near‐Earth space (the "magnetosphere") as Earth rotates. Many consequences of this have been noted in previous papers. This paper investigates the effect of the eccentricity on the phenomenon of magnetospheric substorms. It is shown that the explosive releases of energy stored in the tail of the magnetosphere are more likely to start ("onset") at some Universal Times (and therefore geographic longitudes) than others and an explanation of why is provided. Key Points: Universal Time (UT) effects in the magnetosphere are caused by the eccentric nature of Earth's intrinsic magnetic fieldThere is a UT dependence of the open flux (and hence also the integrated magnetopause reconnection voltage) needed to trigger substorm onsetGrowth phases that lead to substorm onset show considerable preconditioning by prior reconnection [ABSTRACT FROM AUTHOR]

Based on in-depth qualitative research, this paper compares and contrasts two different policy approaches to Preventing and Countering Violent Extremism (P/CVE) within the European context. On the one hand, the Dutch case relies on a holistic and integrated approach in which a national framework underlies a targeted multi-stakeholder approach to preventing and countering manifestations of violent extremism. On the other hand, while lacking an overarching national policy framework, the Italian case study presents a range of mechanisms and projects aimed at combating violent extremism at the local level. The paper traces the different histories of terrorism and radicalization in the two countries to assess the emergence of these divergent approaches. Subsequently, regional case studies of the Delft and Milan areas are explored in-depth to illustrate how the respective policies are put into action, and to highlight the strengths and weaknesses of each approach. The research is based on expert interviews and institutional research involving municipalities, education, social work, and civil society actors. [ABSTRACT FROM AUTHOR]

The sedimentary cycle of Fengcheng Formation in Junggar Basin changes rapidly and is difficult to identify. The low classification accuracy of high-frequency fine-grained sedimentary cycles restricts the exploration of unconventional shale oil and gas. Full-interval coring of well Maye 1 provides a solid foundation for small-layer research. In this paper, the high-frequency sedimentary cycle of Milan kovitch in Fengcheng Formation is studied by means of spectral analysis and wavelet transform, and the shale sweet spot is identified. The long period of eccentricity of 405ka, short period of eccentricity of 100ka and long period of axis slope of 42736a can be used as semi-quantitative basis for the classification of the fourth, fifth and sixth sequences. The Fengcheng Formation can be divided into 2 quaternary sequence cycles, 9 quaternary sequence cycles and 16 quaternary sequence cycles. A long period of eccentricity of 405ka can identify large-scale lake recessional and recessional, and there is a maximum lake flooding surface in the middle of the second Fengcheng Formation, which corresponds to high abundance of organic matter and high hydrocarbon generation potential. The 100ka short period eccentricity can identify the sweet spot layer, and there are 8 sweet spots in the well Maye 1, which is consistent with the results of nuclear magnetic interpretation. The research results provide a semi-quantitative basis for the classification of high-frequency sedimentary cycles and the identification of sweet spots of Fengcheng Formation in Mahu Sag, Junggar Basin. [ABSTRACT FROM AUTHOR]

The emergence of antibiotic resistance poses a significant threat to public health worldwide, affecting various medical fields, including ophthalmology. Eye infections, ranging from conjunctivitis to more severe conditions like keratitis, are commonly treated with antibiotics. However, the misuse and overuse of these drugs have led to the development of resistant strains of bacteria, allowing traditional treatments ineffective. This paper aims to examine the current situation of antibiotic resistance in eye infections globally, with a specific focus on a large group of hospitals located in Milan (Italy) with considerable experience in cataract and cornea surgery as well as in retinopathy. The results of the study show the prevalence of Gram-positives in the tested samples and a low resistance of fluoroquinolones and glycopeptides. The results also highlight the need to implement sample collection methods for ocular infections, as the quantity of positive samples is rather low compared to the total number of samples. In conclusion, the study, although with limited data, shows that resistance to aminoglycosides and cephalosporins is a situation to be monitored. These data also show the critical need to improve and guide the biological sample collection modalities in order to make the diagnosis more reliable. [ABSTRACT FROM AUTHOR]

This paper suggests a "neoclassical" reading of Ernan McMullin's thought on science and theology. McMullin's Augustinian convictions on God and the God–world relation coincide with those of some prominent scholars from two renowned schools of neo-scholastic philosophy of the twentieth century in Louvain and Milan. The school of Milan, thanks to the work of some disciples of its leading figure, Amato Masnovo, developed a neoclassical version of neo-scholasticism, articulating a fundamental theory of knowledge, as well as an essential, rigorous path to God. We recall the main tenets of a neoclassical path to God, and we interpret this path as a possible contribution to the science–theology dialogue, in line with McMullin's Augustinism. A neoclassical approach to science and theology, with its rediscovery and reactualization of some ideas of classic philosophy in an interdisciplinary context, grounds the intelligibility of the universe and safeguards its mystery. [ABSTRACT FROM AUTHOR]

This study conducted an extensive literature review spanning from 1950 to 2023, exploring the methodologies in urban geomorphology and urban geoheritage assessment, and the possibility of applying Nature-Based Solutions (NbSs) in order to enhance geomorphological maps. The methodology proposed here is based on a two-step approach: (i) a bibliographic review and methodological investigation and (ii) methodological proposal in order to enhance the traditional geomorphological and geoheritage maps with NbS to reduce the geomorphological risk in urban areas. This paper aims to introduce a methodological framework and illustrated its practical application to provide researchers and practitioners with a clear understanding of its implementation in real-world scenarios. The proposed methodology was applied in the north and northeastern parts of Milan, Italy. The implementation of the proposed methodology demonstrated its effectiveness in urban contexts and its potential for further modification and extension to various urban environments in the future. [ABSTRACT FROM AUTHOR]

The concept of social mix has been thoroughly examined in the housing literature. Research to date finds little evidence of encounters between socially diverse residents living in mixed settings. This paper provides comparative insights into new, socially mixed housing initiatives in Milan and Paris that have been conceived to promote encounters among diverse residents. Both initiatives, implemented by not-for-profit organizations, provide affordable housing for university students or young professionals in low-income social housing neighborhoods in exchange for their commitment to organize solidarity activities with and for their social housing neighbors. The paper examines how frameworks provided by housing practitioners for "intentional" encounters between motivated youth and low-income residents shape these encounters and considers the receptivity of the youth population to intentionally engage in common projects across diversity. It distils some core conditions within these programs that promote encounters among diverse residents. [ABSTRACT FROM AUTHOR]

Mega-events imply several city transformations at different scales that could be challenging to be identified and documented. The impacts of such events like Universal Exhibitions are difficult to be identified and tracked in space and over a long period of time. This paper discusses the use of open-source geospatial technologies as innovative tools in support of urban planning and management of digital cities, analysing in particular the case of an international exhibition in the urban landscape. A GIS-based approach is used to design a spatially enabled database, which is essential for implementing advanced analytics in modern smart cities. The pilot project proposes the design and implementation of such georeferenced database for monitoring the urban transformations of the area used for Expo 2015 Milano (Italy). The potential of GIS environment in the consultation process, which allows to obtain different interactive views and to make selections and queries of the data, is explored. The paper also discusses the possibility of publishing such prototype on a shared platform, allowing a larger non-technical audience to follow the urban evolution of the area in a diachronic perspective. [ABSTRACT FROM AUTHOR]

Three-dimensional digitization has been widely used for the documentation of built heritage. This paper presents two different approaches to the three-dimensional documentation of historic buildings using active 3D Terrestrial Laser Scanning (TLS) devices and data integration from other heterogeneous sources. Both methods aim to produce accurate and complete 3D surveys by integrating data from other sources, such as historical photographs, conservation reports, and traditional drawings, to enable a geometric analysis of the buildings. The first approach aims for completeness and redundancy of geometric information. The second method focuses on rapidness and is suitable for situations where the building is not easily accessible. The two approaches are applied to the case studies of Diotti Palace in Milan and Uzbekistan Hotel in Tashkent, demonstrating the efficiency of the two different datasets for analyzing the built heritage. The paper compares these two approaches and highlights their advantages and drawbacks in terms of the reliability of the resulting data. The study shows how two different methodologies can be adopted in different scenarios to obtain a comprehensive database for reliable and in-depth analysis of historic buildings. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to investigate the effects of corporate governance mechanisms, namely, board of directors and auditors, on tax aggressiveness in Italian companies listed on the Milan Stock Exchange. Design/methodology/approach: This study used a population of 168 Italian non-financial firms listed on the Milan Stock Exchange, holding shares in at least one foreign subsidiary in countries other than Italy in fiscal year 2018. Data on corporate boards and auditors were collected through the evaluation of companies' annual reports over the period 2011–2018. Five panel data analyses with fixed effects were performed for each tax aggressiveness index, yielding 1,176 observations to test the research hypothesis. Findings: This paper finds that corporate board characteristics, such as size, gender diversity and CEO duality, and auditors' features, such as external audit quality, increase corporate tax aggressiveness. Practical implications: This study provides investors with an understanding of corporate boards' and auditors' roles in preventing agency conflicts and evaluating a company's tax approach. Furthermore, the findings are useful for international political bodies in regulating corporate board composition and managerial monitoring. Originality/value: Almost all studies focusing primarily on corporate governance mechanisms' effects on tax aggressiveness are within the US context. Empirical evidence on the topic in the European contexts is limited. The legislative discrepancy between countries is reflected in the computation of indices measuring tax aggressiveness, affecting US studies' generalizability across nations. This paper extends the literature on the topic by investigating other unexplored corporate governance mechanisms. Five indices were used to measure corporate tax aggressiveness and to assess analysis reliability and data robustness. Moreover, to the best of the authors' knowledge, this study is the first attempt to investigate the link between corporate governance mechanisms and tax aggressiveness in Italy. [ABSTRACT FROM AUTHOR]

European peripheries and suburbs are generally seen by scholars and policy experts as part of a polycentric urban-regional network. This conceptually 'cityist' and methodologically 'urbano-centric' narrative often neglects the dynamics that may emanate from and within the periphery itself instead of cities alone. This paper engages with the history, possibilities, and transformative potential of European urban peripheries in their own right. It does this by employing the idea of 'postsuburbia'. On the one hand, the concept of 'post-suburbia' is relatively open and flexible, thus helpful in disclosing novel peripheral conditions and contexts. On the other hand, it captures the relevant places and dynamics of metropolitan integration and the consolidation of regional networks in metropolitan space. First, the paper demonstrates how post-World War II European suburbanization has culminated in diverse, uneven post-suburban landscapes in the urban regions of Milan and Amsterdam, and specifically in Pioltello and Almere respectively. Second, the paper shows the nuances of socio-spatial transformations that have emerged in these two suburban peripheries, as an outcome of suburbanization. This twofold reflection enables post-suburbia as a valuable perspective that can unpack the diversities and complexities of urban regions under constant transformation by accounting for processes of diversification resulting in suburban 'blendscapes'. [ABSTRACT FROM AUTHOR]

The present paper proposes a three‐axis method for identifying metropolitan regions in a European context that was developed from a public policy perspective within the field of regional geography. Drawing on a harmonised definition of functional urban area and a case‐specific literature review, the proposed method can be applied to urban regions characterised by multiple territorial development patterns. This paper focuses on the metropolitan node of Milan within the urban network of northern Italy. First, the concept of functional territorial scale is used to assess the city‐regional scale of Milan. Then, based on available geographical descriptions of metropolitan Milan, the metropolitan region is defined as a set of labour market areas, rather than as a single metropolitan area. Finally, some demographic and employment trends that have characterised the Milan metropolitan region and its emerging territorial imbalances over time are highlighted. Having identified a metropolitan territorial unit of Milan, the paper outlines some linkages between city‐regional development and metropolitan institutional policy. [ABSTRACT FROM AUTHOR]

Migrant community-based organizations (MCBOs) are key mediating structures between immigrants and host societies. However, when implementing this role in host societies, MCBOs often face a number of challenges that reduce their chances to be effective in promoting social justice. This paper aims to analyze the challenges that MCBOs settled in Milan (Northern Italy) experience and the coping strategies that they use in order to provide some guidelines on how to support them. In-depth interviews, observations and document analysis with 15 MCBOs were conducted. Based on a situational analysis, we present the main challenges perceived by MCBOs at three levels: internal (i.e., surviving), inter-organizational (i.e., collaborating) and community (i.e., being recognized as mediating actors). We provide specific guidelines for action on how to address such challenges and thus foster the role of MCBOs as mediating structures in receiving societies. [ABSTRACT FROM AUTHOR]

The genetic causes of epilepsies and developmental and epileptic encephalopathies (DEE) with onset in early childhood are increasingly recognized. Their outcomes vary from benign to severe disability. In this paper, we wished to retrospectively review the clinical, genetic, EEG, neuroimaging, and outcome data of patients experiencing the onset of epilepsy in the first three years of life, diagnosed and followed up in four Italian epilepsy centres (Epilepsy Centre of San Paolo University Hospital in Milan, Child Neurology and Psychiatry Unit of AUSL-IRCCS di Reggio Emilia, Pediatric Neurology Unit of Vittore Buzzi Children's Hospital, Milan, and Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia). We included 168 patients (104 with monogenic conditions, 45 with copy number variations (CNVs) or chromosomal abnormalities, and 19 with variants of unknown significance), who had been followed up for a mean of 14.75 years. We found a high occurrence of generalized seizures at onset, drug resistance, abnormal neurological examination, global developmental delay and intellectual disability, and behavioural and psychiatric comorbidities. We also documented differing presentations between monogenic issues versus CNVs and chromosomal conditions, as well as atypical/rare phenotypes. Genetic early-childhood-onset epilepsies and DEE show a very wide phenotypic and genotypic spectrum, with a high risk of complex neurological and neuropsychiatric phenotypes. [ABSTRACT FROM AUTHOR]

The application of artificial intelligence (AI) techniques may lead to significant improvements in different aspects of rail sector. Considering asset management and maintenance, AI can improve data analysis and asset status forecasting and decision-making processes, fostering predictive and prescriptive maintenance strategies. A prescriptive approach should be able to predict future scenarios as well as to suggest a course of actions. Nevertheless, the decision-making in rail asset management is often based on the classical asset-oriented approach, concentrating on the function of the asset itself as a main key performance indicator (KPI), whereas a user-oriented approach could lead to improved performance in terms of level of service. This paper is aimed at integrating the passengers' perspective in the decision-making process for asset management to mitigate the impact that service interruptions may have on the final users. A data-driven prioritisation framework is developed to prioritise maintenance interventions taking into account asset status and criticality. In particular, a three-step approach is proposed, which focuses on the analysis of passenger data to evaluate the failure impact on the service, the analysis of alarms and anomalies to evaluate the asset status, and the suggestion of maintenance interventions. The proposed approach is applied to the maintenance of the metro line M5 in the Italian city of Milan. Results show the usefulness of the proposed approach to support infrastructure managers and maintenance operators in making decisions regarding the priority of maintenance activities, reducing the risk of critical failures and service interruptions. [ABSTRACT FROM AUTHOR]

Most victims of physical violence sooner or later will access a hospital or medical cabinet because of that violence, and in particular emergency departments (EDs). This paper aims to analyze the performance of emergency ward clinicians in the forensic management of such victims by examining the activities carried out and the data reported. A total of 991 medical records were extrapolated from the database of the ED of the Policlinico of Milan in an average pre-pandemic 1-year activity. For each medical record, 16 parameters were analyzed in-depth including epidemiological data, information on the type of violent actions, injuries, and time between the infliction of the lesion and access to the ED. In the vast majority of cases, all the actions with medicolegal implications had been neglected by health professionals causing loss of data not only for the justice system but especially for correctly interpreting what happened and taking appropriate measures to protect the patient/victim. Hence, given that clinicians in EDs are busy with non-forensic clinical tasks (and rightly so), it should be ensured that there be specific forensic clinical personnel. However, it is crucial that when unfortunately there can be no forensic staff, at least the clinicians who work in the ED are properly trained to correctly apply essential medicolegal measures. Overall, timely and informed medical and forensic intervention is possible and necessary for the improvement and maintenance of the mental and physical health of victims of violence. [ABSTRACT FROM AUTHOR]

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The paper discusses the current practices in the regeneration of public spaces starting from research that compares case studies from Milan (I) and Copenhagen (DK) developed by the authors, trying to exceed the rhetoric of the 15-min city, that nowadays is mainstream. The aim of the paper is identifying potential approaches for designers and planners, when they intervene on daily, public spaces that have lost their meaning and identities. Testing existing proposals, the study explores a set of issues that affect the physical, social, economic condition of places and that should be took in account in the process of reactivation. Discussing the results, the study proposes a set of tools and recommendations that can support the work of the urban designers and could foster the social and physical impacts of their work. The conclusions open a perspective on the role of this type of intervention in the construction of the future city. [ABSTRACT FROM AUTHOR]

Broadband Coherent Anti-Stokes Raman Scattering (BCARS) is a valuable spectroscopic imaging tool for visualizing cellular structures and lipid distributions in biomedical applications. However, the inevitable biological changes in the samples (cells/tissues/lipids) introduce spectral variations in BCARS data and make analysis challenging. In this work, we conducted a systematic study to estimate the biological variance in BCARS data of two commonly used cell lines (HEK293 and HepG2) in biomedical research. The BCARS data were acquired from two different experimental setups (Leibniz Institute of Photonics Technology (IPHT) in Jena and Politecnico di Milano (POLIMI) in Milano) to evaluate the reproducibility of results. Also, spontaneous Raman data were independently acquired at POLIMI to validate those results. First, Kramers–Kronig (KK) algorithm was utilized to retrieve Raman-like signals from the BCARS data, and a pre-processing pipeline was subsequently used to standardize the data. Principal component analysis – Linear discriminant analysis (PCA-LDA) was performed using two cross-validation (CV) methods: batch-out CV and 10-fold CV. Additionally, the analysis was repeated, considering different spectral regions of the data as input to the PCA-LDA. Finally, the classification accuracies of the two BCARS datasets were compared with the results of spontaneous Raman data. The results demonstrated that the CH band region (2770–3070 cm−1) and spectral data in the 1500–1800 cm−1 region have significantly contributed to the classification. A maximum of 100% balanced accuracies were obtained for the 10-fold CV for both BCARS setups. However, in the case of batch-out CV, it is 92.4% for the IPHT dataset and 98.8% for the POLIMI dataset. This study offers a comprehensive overview for estimating biological variance in biomedical applications. The insights gained from this analysis hold promise for improving the reliability of BCARS measurements in biomedical applications, paving the way for more accurate and meaningful spectroscopic analyses in the study of biological systems. [ABSTRACT FROM AUTHOR]

Despite the proposed 'certainty' in a city or region hosting a mega-event, there has long been issues of uncertainty surrounding the planning and implementation of what have until now essentially been mega-projects. Large events have found a variety of ways to adapt and respond to unforeseen circumstances due to political conflicts, planning of oversize venues, limited time of implementation, and legacies that are difficult to manage. Considering the further increased uncertainty surrounding the planning of mega-events as a result of the COVID-19 pandemic, this paper examines how an accompanying cultural component—e.g., the Cultural Olympiad—may help cities that plan for events like the Olympics transition toward diversified drivers and long-term legacy. In particular, the case of cultural offering in Milan between the two mega-events of Expo 2015 and the upcoming 2026 Milano-Cortina Olympic Games shows how host cities can address growing uncertainty through the expanded role of a cultural programme combined with the rescaling of traditional mega-event formats. With this purpose, 2012 London Cultural Olympiad has been selected as an antecedent example—with positive and negative outcomes—to critically review the relationships between the Olympics and the Cultural Olympiad, as well as their widespread spatial strategy and public engagement. In addition, the paper offers more general conclusions regarding learning potentials of jointly studying mega-events and cultural policy. [ABSTRACT FROM AUTHOR]

Creative and cultural workers (CCWs) concentrate in large cities due to the livelihood opportunities they facilitate. Synchronously, cities have experienced the highest rate of Covid-19 infections. Focusing on the case study of Milan, the paper explores the criticalities of the sector and the impact of the pandemic using qualitative interviews and digital ethnography. It highlights how C-19 has exacerbated the effects of neoliberalism on CCWs, illuminating their precarious working conditions but paradoxically providing time and focus for workers to collectively organise. This paper captures CCWs use of the city to make their precarious working conditions visible in response to the unsustainable demands of neoliberalism. It also engages with the need for re-futuring contemporary understanding of the creative city, questioning the value of agglomeration economies and creative city policies, especially if workers' rights and livelihoods do not become central to the future local policy agenda. [ABSTRACT FROM AUTHOR]

This paper investigates the changes in neighbourhood attractiveness during the Covid-19 pandemic (2020) compared to the year before in 2019 in the city of Milan. Central neighbourhoods recorded a drop in users from -63% to -47%, while the peripheral areas showed a relatively steady presence during the day. Indeed, remote working and the fear of public transport led to rethinking commuting and re-value working close to home. Semi-peripheral and peripheral neighbourhoods have gained a renewed role in attracting remote workers, and coworking spaces represent a valuable alternative for those willing to improve work-life balance through near working. Within this context, the paper aims to:(i) measure the presence of remote workers at the neighbourhood level; (ii) explore the accessibility to coworking spaces within 15 minutes of walking and cycling distance; (iii) focus on three peripheral neighbourhoods which show the lowest number of city users loss, do not host CSs, and present different levels of essential services and access to subway stations. The three cases are explored to understand whether they are considered feasible locations for hosting a neighbourhood coworking space. The change of the city users' presence in the Milan neighbourhoods in 2019-2020 is analysed using «TIM Big Data -- Data Visual Insight», which includes the presence and mobility of the TIM mobile network's users. [ABSTRACT FROM AUTHOR]

The paper is an overview of the musicological research project „Towards a global history of music", which was carried out between 2013 and 2017 on the basis of a Balzan Prize for Musicology (2012), with the assistance of international music research institutes and their specialists. A main outcome of the project are three collective volumes of papers, published in 2018, 2019 and 2021, respectively. The project has viewed the variety of musical experiences around the world as a historical unfolding, to be explored via a „long path" through both geography and history. It has queried the enlightenment idea of a fundamental unity of all music (universalism), and the often fragile status of musical-cultural identities on the regional or national levels. It has sought to join methodologies of ethnomusicology and historical research, and has observed that the concepts of music and historiography themselves are less than universal. To the discourses of globalisation and modernisation, the project has added the alternative of transculturality, allowing for more neutral or participatory interpretations of cultural encounter. Summarising this research, tensions between nation and migration, regionalism and adaptation, ‚radial' and ‚imposed' globality are shown. The paper proposes to expand such studies into non-scientific practice and to find new institutional bases, which would benefit further global understanding and sharing. [ABSTRACT FROM AUTHOR]

This paper examines the enactment of relational welfare in Milan through a focus on how new welfare professionals operating in deprived neighborhoods in Milan work to stimulate participation and relational energies among migrant and low-income parents. The paper introduces the notion of the "intimate public," a spatial and relational milieu for activating an increasingly diverse public in the absence of traditional welfare resources. Through the lens of the intimate public, a number of effects come into view: First, the incitement to participate recasts the private as simultaneously a source of new forms of solidarity and a potential obstacle to social cohesion and integration. Second, assumptions about the organic and sustainable nature of citizen-based solidarity effectively erase the affective labor required to produce and sustain it, especially in marginalized neighborhoods. Finally, the intense relationality that characterizes the intimate public produces uncertainty and entanglements that bind professionals and participants in compelling ways. [ABSTRACT FROM AUTHOR]

In the last years, interactive exhibitions based on digital technologies have become widely common, thanks to their flexibility and effectiveness in engaging visitors and creating memorable experiences. One of the topics in which digital technologies can be particularly effective is the communication of abstract concepts that are difficult for the human mind to imagine. An emblematic example is the astronomy discipline, which requires us to imagine and understand phenomena far away from our everyday life. In this paper, the authors present a research project, MARSS, in which digital technologies are used effectively to enhance the Users' Experience of the Museo Astronomico di Brera located in Milan. Specifically, the MARSS project aims at designing and developing a new digital journey inside the museum to allow different categories of visitors to enjoy the exhibition in an engaging and interactive way. The paper presents the design and development phases of the experience and its evaluation with users. The results of the evaluation indicate that the digital interactive experience is appreciated by users and is successful in translating the content of high scientific value into more engaging and easily understandable elements. [ABSTRACT FROM AUTHOR]