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Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. [ABSTRACT FROM PUBLISHER]

Rheumatic diseases reach across continents with some similarities as well as unique challenges. The intersection between genetic factors, environmental exposures and socioeconomic factors, as well as challenges, with delays in access to subspecialty care and medications, manifest in different ways. By understanding both the challenges and successes in different countries, while also recognizing the significant diversity both within and across continents, unified strategies to improve rheumatic disease outcomes and decrease disparities among the most vulnerable groups can be developed and disseminated., Competing Interests: Disclosure The writers have no competing or conflict of interest to report. This article is based on work presented at the 13th Annual Lupus Conference (Lupus 2019) in April 2019 and the authors would like to acknowledge the conference organizer, Dr. Lindsey Criswell, for raising this important topic. Dr. Candace Feldman incorporated the continent-specific sections into a single article. There was no funding for this article., (Copyright © 2020 Elsevier Inc. All rights reserved.)