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Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases.

Authors :
Maiti, Amit K.
Kim-Howard, Xana
Viswanathan, Parvathi
Guillén, Laura
Qian, Xiaoxia
Rojas-Villarraga, Adriana
Sun, Celi
Cañas, Carlos
Tobón, Gabriel J.
Matsuda, Koichi
Shen, Nan
Cherñavsky, Alejandra C.
Anaya, Juan-Manuel
Nath, Swapan K.
Source :
Rheumatology; Jul2010, Vol. 49 Issue 7, p1239-1244, 6p, 2 Charts
Publication Year :
2010

Abstract

Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. [ABSTRACT FROM PUBLISHER]

Subjects

Subjects :
AUTOIMMUNITY
GENETIC polymorphisms

Details

Language :
English
ISSN :
14620324
Volume :
49
Issue :
7
Database :
Complementary Index
Journal :
Rheumatology
Publication Type :
Academic Journal
Accession number :
51648315
Full Text :
https://doi.org/10.1093/rheumatology/kep470