1. Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans.
- Author
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Jang JY, Park EK, Ryoo HM, Shin HI, Kim TH, Jang JS, Park HS, Choi JY, and Kwon TG
- Subjects
- Adenine, Adult, Cartilage Oligomeric Matrix Protein, Case-Control Studies, Cytosine, Exons genetics, Female, Gene Frequency genetics, Genetic Linkage genetics, Genetic Markers genetics, Genetic Predisposition to Disease genetics, Genotype, Guanine, Haplotypes genetics, Humans, Korea, Male, Matrilin Proteins, Prognathism genetics, Promoter Regions, Genetic genetics, Risk Factors, Thymine, Young Adult, Extracellular Matrix Proteins genetics, Glycoproteins genetics, Polymorphism, Single Nucleotide genetics, Prognathism etiology
- Abstract
Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19~197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05~0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03~13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism.
- Published
- 2010
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