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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans.
- Source :
-
Journal of dental research [J Dent Res] 2010 Nov; Vol. 89 (11), pp. 1203-7. Date of Electronic Publication: 2010 Aug 25. - Publication Year :
- 2010
-
Abstract
- Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19~197.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05~0.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03~13.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism.
- Subjects :
- Adenine
Adult
Cartilage Oligomeric Matrix Protein
Case-Control Studies
Cytosine
Exons genetics
Female
Gene Frequency genetics
Genetic Linkage genetics
Genetic Markers genetics
Genetic Predisposition to Disease genetics
Genotype
Guanine
Haplotypes genetics
Humans
Korea
Male
Matrilin Proteins
Prognathism genetics
Promoter Regions, Genetic genetics
Risk Factors
Thymine
Young Adult
Extracellular Matrix Proteins genetics
Glycoproteins genetics
Polymorphism, Single Nucleotide genetics
Prognathism etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1544-0591
- Volume :
- 89
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of dental research
- Publication Type :
- Academic Journal
- Accession number :
- 20739701
- Full Text :
- https://doi.org/10.1177/0022034510375962