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Value co-creation unfolds as a system of interactions in which the user and service provider play an active role in collaboratively creating values that go beyond economical and financial worth. Value co-creation is a growing trend in museums; however, little is known about how it can enhance educational activities, especially concerning digital technologies. This study analyzes the role of digital technology in the value co-creation process by addressing the following research questions: (1) how can museums, and schools implement actions to enhance co-creation activities? and (2) how does digital technology contribute to the generation of a value co-creation approach, engaging a young target audience in history education? The research adopts a single case study methodology, which is based on WORld Wars Toward Heritage for Youth (WORTHY), an educational European project that involves cultural and educational institutions from Germany, Poland, Croatia, England, and Italy. WORTHY creates a virtual collaborative museum through a digital platform. The paper's findings make clear that digital technologies play a role in value co-creation through two main experiences: learning and sharing. In the learning experience, digital co-creation is grounded in artifacts and contents, while during the sharing experience, digital technologies play a role relatively to people and content.

The list of standard abbreviations for JDS is available at adsa.org/jds-abbreviations-24. Nonstandard abbreviations are available in the Notes. Following a comparison of nutrient total-tract digestibility estimates in lactating buffaloes using single-point undigestible NDF (uNDF) or acid-insoluble ash (AIA) as internal markers, the potential of fecal near-infrared spectroscopy (NIRS) to provide calibration equations for the assessment of the chemical composition of feces and nutrient total-tract digestibility estimated with internal markers was explored. Chemical analyses were performed on 147 fecal samples from lactating buffaloes reared on 5 farms in central Italy (Naples). Each farm fed a silage-based TMR to the buffaloes, and the TMR was sampled in the 2 d before the fecal collection. The TMR and individual fecal samples were collected and analyzed for DM, OM, ash, AIA, ether extract (EE), starch, fiber fractions (amylase-treated NDF without residual ash [aNDFom], amylase-treated NDF inclusive of residual ash [aNDF], ADF without residual ash [ADFom], ADF, hemicellulose, cellulose, ADL, uNDF), N, CP and CP bound to aNDF (NDICP) and to ADF (ADICP). The uNDF content was determined through a 240-h in vitro fermentation and employed, together with AIA as markers, to estimate the total-tract apparent digestibility and total-tract digestibility of DM, OM, ash, N, CP, EE, aNDFom, aNDF, NDIP, ADFom, and ADF, ADIN, ADL, hemicellulose, cellulose, starch, NFC, and the B3 fraction of N (NB3). No correlation was found between DM and OM digestibility estimated with AIA and uNDF as internal markers. Weak correlations were detected for all the other nutients digestibilities, and strong correlations were observed for EE, ADFom, hemicellulose, NDIN, ADIN, NB3, NFC, and starch. The sample set (n = 147) was divided in a calibration set (n = 111) and a validation set (n = 36) to "train" and "validate" the fecal NIRS curve through an external validation process. An estimation usable for preliminary or initial evaluation was obtained for N, CP, and aNDF fecal content. An excellent prediction was obtained for total tract digestibility of ADIN (R2 = 0.90) when estimated with uNDF as the internal marker. The NIRS technology was not able to accurately predict all the other traits and the estimated nutrient digestibility of lactating buffalo diets from fecal spectra. [ABSTRACT FROM AUTHOR]

Coronavirus Disease 2019 (COVID-19) became a significant challenge for the work and personal experience of physiotherapists (PTs) To investigate how the work activities of PTs in a region in Italy have changed, describe the reasons for change, perceived competence, and effectiveness of professional education, and explore their personal experience We adopted a monocentric convergent mixed-methods light–questionnaire variant study. The questionnaire contains both closed-ended and open-ended questions. Quantitative and qualitative data were combined to interpret the results Among 78 respondents (response rate 24.4%), 87.2% worked during the pandemic, 52.9% treated patients with COVID-19, and 45.6% changed their working activities. Professional competence was perceived as low in intensive and sub-intensive care settings. The major critical aspect of professional education was respiratory rehabilitation. Life-learning education was judged as effective, even if mainly focused on safety. Nine themes emerged from the analysis of the PTs' experiences: 1) Physiotherapy during COVID-19; 2) Fear and negative feelings; 3) Positive aspects; 4) Organization and management; 5) Prevention measures; 6) Patients; 7) Change; 8) Information; and 9) Professional education PTs who have direct experience with patients with COVID-19 showed great resilience. They overcame the first phase of disorientation and fear, despite a specific lack of competence in the respiratory field. [ABSTRACT FROM AUTHOR]

Aim: The study was designed to generate real‐world evidence on IDegLira in the Italian clinical practice in two groups of patients with type 2 diabetes (T2D), switching to IDegLira either from a basal only (basal group) or basal‐bolus insulin regimen (BB group). Materials and Methods: This was a non‐interventional, multicentre, single‐cohort, prospective study assessing the long‐term glycaemic control in patients with T2D, who switched to IDegLira from a basal insulin ± glucose‐lowering medication regimen with or without a bolus insulin component for approximately 18 months, conducted in 28 Italian diabetes centres. The primary endpoint was the change in glycated haemoglobin (HbA1c) levels from baseline to 6 months after IDegLira initiation. Results: The study included 358 patients with a mean age 67.2 years and diabetes duration of 15.7 years. HbA1c significantly decreased from IDegLira start to all study time points in the overall population (basal group −1.19%; BB group −0.60% at the end of observation). Patients achieving HbA1c <7% levels increased from 12.9% (n = 43) to 40.3% (n = 110) at 18 months. Fasting blood glucose and body weight also significantly decreased in both groups, although more in the BB group. Overall, 14.3% of completed patients had an intensification of treatment (mainly in the basal group) and 48.6% had a simplification of treatment (mainly in the BB group). Conclusions: Switching to IDegLira in a real‐world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories. [ABSTRACT FROM AUTHOR]

Tomato fruit blotch virus (ToFBV) (Blunervirus solani, family Kitaviridae) was firstly identified in Italy in 2018 in tomato plants that showed the uneven, blotchy ripening and dimpling of fruits. Subsequent High-Throughput Sequencing (HTS) analysis allowed ToFBV to be identified in samples collected in Australia, Brazil, and several European countries, and its presence in tomato crops was dated back to 2012. In 2023, the virus was found to be associated with two outbreaks in Italy and Belgium, and it was included in the EPPO Alert list as a potential new threat for tomato fruit production. Many epidemiologic features of ToFBV need to be still clarified, including transmission. Aculops lycopersici Massee (Acariformes: Eriophyoidea), the tomato russet mite (TRM), is a likely candidate vector, since high population densities were found in most of the ToFBV-infected tomato cultivations worldwide. Real-time RT-PCR tests for ToFBV detection and TRM identification were developed, also as a duplex assay. The optimized tests were then transferred to an RT-ddPCR assay and validated according to the EPPO Standard PM 7/98 (5). Such sensitive, reliable, and validated tests provide an important diagnostic tool in view of the probable threat posed by this virus–vector system to solanaceous crops worldwide and can contribute to epidemiological studies by simplifying the efficiency of research. To our knowledge, these are the first molecular methods developed for the simultaneous detection and identification of ToFBV and TRM. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the occurrence of vancomycin-variable enterococci (VVE) in a hospital in central Italy. Methods: vanA positive but vancomycin-susceptible Enterococcus faecium isolates (VVE-S) were characterized by antibiotic susceptibility tests, molecular typing (PFGE and MLST), and WGS approach. The reversion of VVE-S to a resistant phenotype was assessed by exposure to increasing vancomycin concentrations, and the revertant isolates were used in filter mating experiments. qPCR was used to analyze the plasmid copy number. Results: Eleven putative VVE-S were selected. WGS revealed two categories of vanA cluster plasmid located: the first type showed the lack of vanR, the deletion of vanS, and an intact vanH/vanA/vanX cluster; the second type was devoid of both vanR and vanS and showed a deletion of 544-bp at the 5′-end of the vanH. Strains (n = 7) carrying the first type of vanA cluster were considered VVE-S and were able to regain a resistance phenotype (VVE-R) in the presence of vancomycin, due to a 44-bp deletion in the promoter region of vanH/vanA/vanX, causing its constitutive expression. VVE-R strains were not able to transfer resistance by conjugation, and the resistance phenotype was unstable: after 11 days of growth without selective pressure, the revertants were still resistant but showed a lower vancomycin MIC. A higher plasmid copy number in the revertant strains was probably related to the resistance phenotype. Conclusion: We highlight the importance of VVE transition to VRE under vancomycin therapy resulting in a potential failure treatment. We also report the first-time identification of VVE-S isolates pstS-null belonging to ST1478. [ABSTRACT FROM AUTHOR]

The family Tenuipalpidae includes agricultural pests that have garnered extensive attention from the global research community. Despite the economic importance of tenuipalpids, due to their ecology and global trade of the infested plants, there has not been any corresponding and comprehensive research on these mites in Italy in recent decades. This study aimed to determine the species composition of tenuipalpid mites in Italy, update the Italian checklist for the taxon, and include new records and host plant associations of the genera Brevipalpus Donnadieu and Cenopalpus Pritchard and Baker worldwide. The study found several new records of tenuipalpid species in Italy, including four Cenopalpus and two Brevipalpus species. Additionally, one new species Cenopalpus ulmifolius De Giosa, Ochoa et de Lillo was added to the list. The research also incorporated new records of Cenopalpus species in different countries and several new host plant associations and the description of novel taxonomic characters were present for the Cenopalpus species studied during this work, since they were the most abundant tenuipalpid collected in the sampled areas. The study's findings are crucial for developing effective management for tenuipalpid mites, understanding the fauna composition, and constructing preparedness strategies for quarantine purposes. [ABSTRACT FROM AUTHOR]

The presence of carbapenem–resistant bacteria and carbapenem resistance genes (CRGs) in livestock is increasing. To evaluate the presence of carbapenemase-producing Enterobacteriaceae (CPE) and the main CRGs along swine food chains of the Marche Region (Central Italy), samples of faeces, feed, and animal-food derived products were collected from seven small/medium, medium, and large-scale pig farms. A total of 191 samples were analysed using a culture-dependent method, with the aim of isolating CPE. Isolates were analysed for their resistance to carbapenems using a modified Hodge test and the microdilution method for the minimum inhibitory concentration (MIC) determination. Moreover, the extraction of microbial DNA from each sample was performed to directly detect selected CRGs via qPCR. Among the 164 presumptive resistant isolates, only one strain from a liver sample, identified as Aeromonas veronii, had an ertapenem MIC of 256 μg/mL and carried a carbapenemase- (cphA) and a β-lactamase- (blaOXA-12) encoding genes. A low incidence of CRGs was found; only nine and four faecal samples tested positive for blaNDM-1 and blaOXA-48, respectively. Overall, the importance of monitoring CPE and CRGs in livestock and their food chains should be stressed to control all potential non-human CPE and CRGs reservoirs and to determine safety levels for human health. [ABSTRACT FROM AUTHOR]

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Objectives To investigate the optrA -carrying genetic elements and their transferability in two linezolid-resistant Streptococcus dysgalactiae subsp. equisimilis (SDSE) strains of swine origin. Methods SDSE strains (V220 and V1524) were phenotypically and genotypically characterized. Transferability of oxazolidinone resistance genes (filter mating), genetic elements and relatedness between isolates (WGS) were analysed. Excision of the genetic elements was assayed by inverse PCR. Results SDSE isolates were resistant to chloramphenicol, florfenicol and linezolid, but susceptible to tedizolid and both carried the optrA gene. In SDSE V220 optrA was located on a 72.9-kb ICE Sdy V220 inserted in the 3′ end of the chromosomal rum gene. It was 94%–96% identical (coverage, from 31% to 61%) to other optrA -carrying ICEs. In-depth ICE Sdy V220 sequence analysis revealed that optrA was carried by an IME Sdy V220 (17.9 kb), also containing the tet (O/W/32/O) gene. Inverse PCR assays excluded the ICE Sdy V220 mobility. In SDSE V1524, optrA was carried by the Φ Sdy V1524 prophage, integrated near the 5′ end of the chromosomal had gene, showing a genetic organization similar to that of other streptococcal phage. Conjugation and transduction assays failed to demonstrate the optrA transferability to streptococcal recipients. V220 and V1524 belonged to two novel sequence types (ST704 and ST634, respectively). Conclusions To the best of our knowledge, this is the first identification of the optrA gene on a prophage and an ICE in SDSE isolates from swine brain. These findings are consistent with the current belief in the key role of bacteriophages and ICEs in the streptococcal evolution and adaptation. [ABSTRACT FROM AUTHOR]

Purpose: Literature on board interlocks agrees that these inter-organizational ties are effective channels to exchange information and share knowledge. However, studies that consider the nature and the amount of knowledge that firms exchange are still relatively absent. Filling this gap, this paper aims to identify four types of mechanisms that can be recognised as drivers of interlocks' creation. The first two types deal more strictly with the nature of the knowledge that directors sitting on the board of other firms possess. The other two respond to the willingness of firms to increase their exposure to different sources of knowledge. Design/methodology/approach: Through a statistical analysis the authors study the relationship between the presence of board interlocks and the type of knowledge embedded in these inter-organizational ties. To test the hypotheses the authors conduct a longitudinal analysis of the whole population of Italian listed firms covering the period from 1998 to 2006. Findings: It is shown that interlocking directorates are mainly associated with an exchange of knowledge in the usual domains of the firm while they are rare in the case of new knowledge. That is, ties among firms of the same industry proliferate while interlocks with organizations of different sectors are infrequent. The only exceptions are links between manufacturing and financial firms driven by the need to share sensible information typical in a borrower-lender relationship. Originality/value: The paper introduces and tests a knowledge exchange perspective in analysing interlocking directorates. Differently from previous studies it argues that interlocks can be seen as means to link, through shared directors, different knowledge domains. Thus the paper contributes to the understanding of formation and deletion of these kinds of inter-organizational ties. (Contains 1 figure and 4 tables.)

UnReinforced Masonry (URM) buildings constitute the majority of the Italian building stock and represent one of the most vulnerable construction typologies, as emerged during the seismic events occurred in the last decades. The objective of the present work is the proposal of a methodology for the seismic vulnerability and fragility assessment of different typologies of URM buildings. Through the statistical analysis of post-earthquake damage survey forms and of census data, the most prevalent structural typologies were identified in the Emilia Romagna region (Italy), leading to the definition of two reference masonry buildings, built at the beginning of the XX century and representative of the building stock of the study area. These buildings were modeled according to the equivalent frame method and their seismic performance was studied by means of nonlinear static analyses, considering uncertainties on the mechanical properties of masonry, on the intensity of the seismic action and on the displacement demand calculation method. Through the definition of Response Surfaces, analytical fragility curves relative to the investigated structural typologies were determined for the different damage states. [ABSTRACT FROM AUTHOR]

Simple Summary: In consideration of poor survival and rising incidence of pancreatic cancer (PC), the impact of microscopic diagnosis of PC (MiDPC) turns out to be crucial in therapeutic choice. Clinical and oncological data regarding all cases of PC in the Veneto region (Italy) from 1987 were extracted from the Veneto cancer registry. The percentage of MiDPC was 60% in 2018. MiDPC was higher among patients <75 years old (84.4%) compared to those ≥75 years old (38.9%). Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Considering the evidence regarding the impact of histopathological parameters on PC patient selection and tailored treatment approaches, 41% of PCs in the Veneto region are still not histologically proven, with a consequent impact on the choice of the correct treatment strategy and, thus, survival. In light of the increasing incidence of the disease, its mortality, and its heterogeneity, all efforts should be aimed to optimize diagnostic–therapeutic pathways, encouraging MiDPC. Background: Incidence of pancreatic cancer (PC) is increasing worldwide and is set to become the second leading cause of cancer-related death in 2040 with a poor 5-year overall survival (OS). The aim of this study was to analyze the impact of microscopic diagnosis of PC (MiDPC) on diagnostic–therapeutic management and outcome. Methods: The Veneto region (north-eastern Italy) has been covered by a cancer registry (CR) since 1987. Clinical and oncological data about all cases of PC in the Veneto region from 1987 were extracted from the Veneto CR database. Results: In 2018, 1340 incident cases of PC in the Veneto population were registered (4.1% of all malignant tumors), with an increasing trend in females and stable incidence in males. Five-year OS in patients with PC was 8%. The percentage of MiDPC increased from 44% in 2010 to 60% in 2018 (p = 0.001). MiDPC was higher among patients aged < 75 years old (84.4%) compared to those aged ≥75 years old (38.9%), p = 0.001. Between 2010 and 2018, a significant increase in biopsy on the primary neoplasm (24.9% vs. 13%, p < 0.001) was reported. Patients with MiDPC had higher 5-year survival than patients with no MiDPC (12.9% vs. 1.2%, p < 0.001). Conclusions: The implementation of MiDPC was essential to improve diagnostic–therapeutic pathways and consequently the survival of PC patients. [ABSTRACT FROM AUTHOR]

Introduction: IDegLira was shown to maintain glycemic control while reducing risk of hypoglycemia and body weight gain. The REX study was designed to generate real-world evidence on the use of IDegLira in Italian clinical practice in two different subgroups of patients, those switching to IDegLira from a basal insulin-supported oral therapy (BOT group) and those from a basal plus bolus insulin regimen (BB group). Methods: Adult patients with T2D diagnosed for at least 12 months and having started IDegLira 2–3 months prior to enrolment, coming from a BOT or BB regimen, were enrolled in this multicenter observational prospective cohort study conducted in 28 Italian centers. This paper presents the methodological framework of the REX study and provides the interim analysis results describing the patients' baseline characteristics and the clinical reasons for IDegLira treatment initiation. Results: Of the 360 patients enrolled in the REX study, 331 were considered eligible for this interim analysis, 76.4% in the BOT and 23.6% in the BB group. Mean (SD) HbA1c was 8.5% (1.4) in the BOT and 8.2% (1.7) in the BB group. The most common T2D complications were diabetic macroangiopathy and diabetic nephropathy in both groups. The median (interquartile range) insulin daily dose before IDegLira was 15.0 (10.0–20.0) units in the BOT group and 42 (30.0–52.0) in the BB group. Oral antidiabetics were taken by 98% and 51.3% of patients, respectively. The main reason for switching to IDegLira was the inadequate glycemic control in the BOT group (86% of patients), and the intent to simplify the treatment in the BB group (66.7%). Conclusions: IdegLira is initiated after BOT in inadequately controlled patients to improve glycemic control, whereas in BB patients it is used to simplify the therapeutic regimen. Final results of the REX study will shed light on patients' outcomes after IdegLira treatment under routine clinical care. [ABSTRACT FROM AUTHOR]

Objectives: To investigate the genetic elements and the transferability of linezolid resistance genes in three enterococci co-carrying cfr(D) and poxtA2 isolates from manure of a swine farm in central Italy.Methods: Two Enterococcus faecalis isolates and one Enterococcus casseliflavus isolate carrying both cfr(D) and poxtA genes were tested for their susceptibility to florfenicol, chloramphenicol, linezolid, tedizolid, tetracycline and vancomycin. Linezolid resistance genes transfer (filter mating), localization (S1-PFGE/hybridization), genetic elements and relatedness between isolates (WGS) were analysed.Results: Two E. faecalis isolates and one E. casseliflavus isolate carried the cfr(D) gene and the recently described poxtA2 variant. In the three enterococci, cfr(D) and poxtA2 were co-located on a 33 480 bp plasmid, pV386, 95%-100% identical (coverage 84%) to the Tn6349 transposon of Staphylococcus aureus AOUC-0915. In all isolates, both genes also showed a chromosomal location. Same sequence identities were found from the comparison with currently known poxtA2 genetic elements. In the plasmid pV386, poxtA2 gene was not bounded by two IS1216, as described in pIB-BOL, but closely associated to the cfr(D) and fexA genes. pV386 was always transferred by filter mating to Enterococcus faecium 64/3 recipient.Conclusions: The occurrence of the pV386 plasmid in E. faecalis and E. casseliflavus from swine manure is of great concern and highlights the need for control measures to contain its spread to other enterococcal species. [ABSTRACT FROM AUTHOR]

Olive (Olea europaea L.) is a traditional crop of great socioeconomic importance in the Mediterranean Basin. In 2021, a survey was performed in an Italian nursery located in Central Italy where unusual symptoms and widespread dieback had been observed on young potted olive trees. Twigs and branches of all plants affected by dryness showed the presence of the alien bark beetle Xylosandrus compactus. Woody tissues colonized by X. compactus were transferred into the laboratory and several fungi such as Cladosporium perangustum and Neofusicoccum parvum were then identified. In addition to these species, Geosmithia pallida was also reported for the first time in Italy on this plant. Studies on this bark beetle and its associated fungi are currently in progress to further evaluate potential risks for olive cultivation. [ABSTRACT FROM AUTHOR]

Background: The worldwide spread of the SARS‐CoV‐2 infection has profoundly affected all aspects of human life, with tangible consequences in several contexts, including reproduction. However, evidences on the inter‐relation between psychological distress and reproductive medicine are still conflicting. Methods: The national lockdown imposed in Italy in March‐May 2020 and the consequent assisted reproductive techniques (ART) activity blockage allowed to evaluate the conception ability of couples who suffered the postponement of ART cycles. In particular, we collected anamnestic, anthropometrical and demographic data of those women attending ART straddling the lockdown period attending to the Fertility Centre of Reggio Emilia. Results: Among the 431 couples recalled to reschedule ART cycles, 34 couples (7.9%) obtained a spontaneous pregnancy during the lockdown. Comparing spontaneously pregnant to non‐pregnant women, the pregnant group resulted younger (P = 0.009) and with a shorter infertility history (P = 0.029). Interestingly, the sexual activity frequency was significantly higher in pregnant women compared to non‐pregnant ones (P < 0.001). In a multivariate logistic analysis, number of sexual intercourses per week and the infertility history duration were significantly related to pregnancy (P < 0.001 and P = 0.030, respectively). In addition, the application of neural network technology including data about women age, body mass index, infertility duration, weekly sexual intercourses and infertility causes allowed to correctly classify pregnant women with an accuracy of 92.7%. Conclusion: The high pregnancy rate observed in a very short time‐frame interval probably revealed an under‐explored cause of idiopathic infertility, that is the frequency of sexual intercourses, resulting the best predictive variable on achieving a spontaneous pregnancy. This factor is commonly under‐investigated during the anamnestic workup of infertile couples. Clinicians involved in ART should better investigate the sexual habits of infertile couples, with the aim to correctly apply ART to those couples who really need it, avoiding unnecessary over‐treatment for those couples able to conceive spontaneously. [ABSTRACT FROM AUTHOR]

Landslides are widespread geological features in Italy's Northern Apennines, with slow-moving earthflows among the most common types. They develop in fine-grained rocks and are subject to periodic rainfall-induced reactivations alternating to phases of dormancy. In this paper, we use radar interferometry (InSAR) and information about landslide activity to investigate deformation signals on an areal basis and to assess the dynamics of recently reactivated earthflows. We use traditional two-pass interferometry by taking advantage of the short revisit time of the Sentinel 1 satellite to characterize 4 years of slope deformations over the 60 km2 study area, where 186 landslides are mapped. Our results show that most intense and sustained deformation signals are associated with phenomena on the verge of reactivation, indicating that radar interferometry may have a potential for early warning purposes. By focusing on three specific earthflow reactivations, we analyze their dynamics through the years that preceded their failure. Despite inherent uncertainties, it was possible to retrieve the deformation signal's temporal evolution, which displayed seasonally recurring accelerations, peaking during the major precipitation episodes in the area. [ABSTRACT FROM AUTHOR]

Eriophyoid mites are represented worldwide by a multitude of extremely specialized species, with feeding habits largely restricted to a single host plant species. Hemp has been used for fiber, food, and medicine for thousands of years and it is still being used nowadays. One eriophyoid mite, Aculops cannabicola (Farkas, 1960) (Acari: Eriophyoidea), appears to be very difficult to control and it constitutes a real menace to world hemp cultivation. In May 2021, severe damages were found in a greenhouse of therapeutic Cannabis sativa L. near Greve in Chianti (Florence); these damages were caused by A. cannabicola, the "hemp russet mite": this is the first record of the agricultural pest in Italy. [ABSTRACT FROM AUTHOR]

Ooencyrtus gonoceri Viggiani (Hymenoptera Encyrtidae) is a poorly known egg parasitoid species with an apparently rare occurrence in the Mediterranean basin. It was originally identified in southern Italy emerging from Gonocerus acuteangulatus (Goeze) eggs and successively recorded also from Spain. Recently O. gonoceri emerged from sentinel egg batches of Halyomorpha halys (Stal) (Hemiptera Pentatomidae) in central Italy. Due to the scanty data on this species, biological and demographic parameters of O. gonoceri were investigated under laboratory conditions on the alternative host Graphosoma italicum italicum (Muller) (Hemiptera Pentatomidae). Estimated fecundity was over 200 eggs/female and the mean progeny production per female was high (173.76 specimens). At the standard rearing condition (26 °C) the development time of both sexes was similar and adults emerged after two weeks. Moreover O. gonoceri females lived much longer than males and the host feeding behaviour resulted irrelevant for the parasitoid longevity. The main biological parameters of O. gonoceri were similar to those reported for other cogeneric species. However, this species appeared to be a very effective egg parasitoid if compared with Ooencyrtus telenomicida (Vassiliev) reared on the same host. [ABSTRACT FROM AUTHOR]

The economic decline of Italy between the mid-1990s and the outset of the financial crisis is a critical case in European political economy because its model of capitalism was deeply reformed at the time when its decline commenced. This paper argues that the Italian economic stagnation cannot be attributed to the lack of market-friendly reforms in a globalized economic context, as argued by previous literature. Instead, Italian economic decline is a consequence of institutional change which on the one hand has destroyed previous institutional complementarities, and on the other hand has led to an incoherent, or 'hybrid,' capitalist setting. Under the lenses of the Varieties of Capitalism approach, this paper reviews the main reforms in the fields of corporate governance and finance as well as in the labor market. It shows that such reforms established new institutions alternatively apt to support both strategic coordination and market coordination, resulting in institutional incoherence, and mixed incentives. In the short-run, incoherent reforms have reduced the availability of capital to SMEs; in the longer-run, they failed to give actors incentives to pursue innovation. This paper contributes theories of economic growth/decline focused on the supply-side of the economy and it is compatible with other – non-rival – explanations focused on the demand-side. [ABSTRACT FROM AUTHOR]

The implications of the severe lockdown regime introduced in Italy in the context of the Covid-19 emergency can be correctly understood only through a broader look at how the text of the provisions adopted by the government is transformed by media reporting and law enforcement practice. From such a perspective, it appears clearly that we are witnessing nothing more than the most recent segment of a populist approach to the use of legal tools, the history of which starts well before the pandemic. [ABSTRACT FROM AUTHOR]

Debris flow events, generated by surface runoff, occur with great frequency in the Dolomites (Northeastern Italian Alps) during the summer season. Summer thunderstorms, which are common in the region, can quickly generate runoff at the base of rocky cliffs, which then entrains and propagates downstream the underlying unconsolidated material. In the past, the main atmospheric feature considered in evaluating the initiation of debris flow events was rainfall. Observations led to the development of rainfall intensity–duration thresholds for sediment mobilization, which compared incoming severe rainfalls with the potential for triggering debris flows. This study works toward the examination of another characteristic of the atmosphere, the atmospheric electric field. In particular, the behavior of the electric field prior to convective rainfall is investigated as an indicator of rainfall intensities capable of triggering debris flows, in a basin near Cortina d'Ampezzo (Italy). Results suggest that prior to bursts of intense rainfall, the electric field derivative frequency distribution exhibits a recurrent pattern roughly half the time. When it occurs, the amplitude of derivative frequency distribution intersects the zero axis twice before rainfall reaches maximum intensity. A regression model is designed which considers the amplitude maximum and the difference in time between the crossings of the zero axis. The validation of this model suggests a mild relationship between electric field and rainfall intensity in an alpine environment. [ABSTRACT FROM AUTHOR]

Background: Female sex has been reported as an independent predictor of severe post-liver transplantation (LT) chronic kidney disease. We performed a by sex post-hoc analysis of the SURF study, that investigated the prevalence of renal impairment following LT, aimed at exploring possible differences between sexes in the prevalence and course of post-LT renal damage.Methods: All patients enrolled in the SURF study were considered evaluable for this sex-based analysis, whose primary objective was to evaluate by sex the proportion of patients with estimated Glomerular Filtration Rate (eGFR) < 60 ml/min/1.73m2 at inclusion and follow-up visit.Results: Seven hundred thirty-eight patients were included in our analysis, 76% males. The proportion of patients with eGFR < 60 mL/min/1.73 m2 was significantly higher in females at initial study visit (33.3 vs 22.8%; p = 0.005), but also before, at time of transplantation (22.9 vs 14.7%; p = 0.0159), as analyzed retrospectively. At follow-up, such proportion increased more in males than in females (33.9 vs 26.0%, p = 0.04). Mean eGFR values decreased over the study in both sexes, with no significant differences. Statistically significant M/F differences in patient distribution by O'Riordan eGFR levels were observed at time of transplant and study initial visit (p = 0.0005 and 0.0299 respectively), but not at follow-up.Conclusions: Though the limitation of being performed post-hoc, this analysis suggests potential sex differences in the prevalence of renal impairment before and after LT, encouraging further clinical research to explore such differences more in depth. [ABSTRACT FROM AUTHOR]

Introduction: Communication can be affected by age related cognitive decline and mental deterioration. The second edition of the Communication Activities of the Daily Living (CADL 2) appears as an interesting ecological assessment tool of cognitive functions in old age.Objective: The aim of this work is to (1) develop an Italian version of CADL 2, (2) to test its psychometric properties in terms of reliability and validity, and (3) to measure CADL 2 discriminative capacity between cognitively healthy and cognitively impaired older subjects.Method: One hundred and eleven subjects were enrolled (36 M; 75 F, age 80, 80.85 ± 7 years, education 9.3 ± 4.7 years). The CADL 2 was administered together with a standard neuropsychological battery.Results: The CADL 2 showed good reliability and correlates with all the cognitive evaluation tests. The CADL 2's area under the curve was equal to 0.80, index of good diagnostic accuracy.Conclusions: The CADL 2 is an appropriate assessment tool for communication skills in aging. [ABSTRACT FROM AUTHOR]

Slow moving landslides are widespread geomorphological features in the Northern Apennines of Italy where they represent one of the main landscape forming processes. The lithology of the Northern Apennines fold and thrust belt is characterized by alternations of sandstone, siltstone and clayshales, also known as flysch, and clay shales with a chaotic block in matrix fabric, which are often interpreted as tectonic or sedimentary mélanges. While flysch rocks with a high pelitic fraction host earthslides that occasionally evolve into flow like movements, earthflows are the dominant landslide type in chaotic clay shales. In the present work, we document the kinematic response to rainfall of landslides in these different lithologies using radar interferometry. The study area includes three river catchments in the Northern Apennines. Here, the Mediterranean climate is characterized by two wet seasons during autumn and spring respectively, separated by dry summers and winters with moderate precipitation. We use SAR imagery from the X-band satellite COSMO SkyMed and from the C-band satellite Sentinel 1 to retrieve spatial displacement measurements between 2009 and 2016 for 25 landslides in our area of interest. We also document detailed temporal and spatial deformation signals for eight representative landslides, although the InSAR derived deformation signal is only well constrained by our dataset during the years 2013 and 2015. In spring 2013, long enduring rainfalls struck the study area and numerous landslide reactivations were documented by the regional authorities. During 2013, we measured higher displacement rates on the landslides in pelitic flysch formations compared to the earthflows in the clay shales. Slower mean velocities were measured on most landslides during 2015. We analyse the temporal deformation signal of our eight representative landslides and compare the temporal response to precipitation. We show that earthslides in pelitic flysch formations accelerate faster than earthflows in chaotic clay shales and reach higher velocities, while the kinematic behaviour of the earthflows can be described as rather steady with only minor accelerations. Although we have no detailed pore pressure measurements for the period of interest, the observed behaviour can be explained in our view by the morphological and hydrological characteristics of the different landslide types. On the one hand landslide material and bedrock in the pelitic flysch rocks are more resistant, which is why slope angles are higher in this lithology. On the other hand, landslides in the pelitic flysch formations have often deeper slip surfaces and landslide material is more permeable. This is why long persistent rainfall is necessary to saturate the landslide material and induce pore pressures that are high enough to trigger displacement. [ABSTRACT FROM AUTHOR]

Synthetic Aperture Radar (SAR) interferometry (InSAR) is used to make measurements of small surface displacements in different situations including ground-settlement, landslides and excavations. We document the deformation history of four dormant deep-seated landslides in the Northern Apennines of Italy that were reactivated by the excavation of a double road tunnel. The tunnel is part of a larger infrastructure project that involves the improvement of the A1 highway which connects Bologna and Florence. The excavation of the tunnel under the landslides' basal shear surfaces started in 2011, and with the advance of the tunnel front, deformation began to occur, causing damages to homes and infrastructures. The tunnel passes under the small villages of Ripoli and Santa Maria Maddalena. The deformation slowed down after the tunnel was completed in November 2014, and low surface displacement rates were registered for the period between October 2014 and June 2016. We show the results of an InSAR analysis designed to measure surface movements between 2003 and 2016. The InSAR displacements are derived from the Envisat, COSMO SkyMed, and Sentinel 1 datasets and cover the main construction phase of the tunnel (2011–2015). A detailed geological and geomorphological mapping of the slope is developed based on the field evidence and on the spatial pattern of surface deformation provided by our InSAR analysis. Together with the map, a new conceptual geological model of the slope in tectonically sheared and weathered flysch is presented. The satellite InSAR data show good agreement with available ground based monitoring data that include inclinometer and GPS-measurements, while small differences occur with respect to deformation time series obtained from a ground-based InSAR instrument. In particular, the InSAR results for the X-Band data of COSMO SkyMed demonstrate the close relationship between the position of the excavation front and the displacement rates of previously dormant landslide deposits. Conversely, the concurrent rainfall does not appear to significantly influence the observed behavior and, if any, had only a minor influence on the displacement history of the investigated landslides. [ABSTRACT FROM AUTHOR]

The literature about the care givers of patients with Disorders of Consciousness (DOCs) has highlighted the impact on both mental and physical dimensions of quality of life. This study aimed to: (1) describe emotional burden, quality of life, and coping styles in care givers of hospitalized patients with DOCs, compared to Italian normative data; (2) explore the relationships between these variables and their associations with socio-demographic features; and (3) describe their changes over time.Fifteen care givers of patients with DOCs, mostly middle-aged women, were assessed using the Family Strain Questionnaire, the SF-36 Health Survey, and the Coping Orientation to Problems Experienced – Nuova Versione Italiana. Eleven subjects were also assessed after 6 and 12 months. Data were analysed through descriptive statistics, correlations, and nonparametric tests of group differences.Compared to the Italian normative data, our sample showed a worse outcome in mental health, social functioning, global mental component, and emotional role functioning. Furthermore, subjects with high emotional burden had more thoughts of death compared to subjects with low emotional burden. Follow-up analyses revealed no variables changed over time.These results highlight the need for psychological interventions and support, since care givers represent an important part of an all-embracing support and care network for patients with DOCs. [ABSTRACT FROM AUTHOR]

Background: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.Methods: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).Results: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).Conclusions: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome. [ABSTRACT FROM AUTHOR]

To investigate the occurrence of oxazolidinone resistance genes, 18 florfenicol-resistant enterococci were isolated from 66 fecal samples collected from several cattle farms in central Italy. The PCR screening indicated that only a bovine florfenicol-resistant isolate, Enterococcus faecium 249031-C, was positive for the presence of optrA and poxtA genes. The strain was tested for its susceptibility to florfenicol, chloramphenicol, linezolid, tedizolid, tetracycline, erythromycin, and vancomycin. Whole Genome Sequencing analysis showed that E. faecium 249031-C, belonging to the ST22 lineage, harbored two plasmids: the optrA-carrying p249031-S (179 kb) and the poxtA-carrying p1818-c (23 kb). p249031-S, containing a new optrA-carrying Tn7695 transposon, was closely related to the plasmid pF88_1 of E. faecium F88, whereas p1818-c had already been detected in a human E. faecium, both enterococci were from Switzerland. The linezolid resistance genes were cotransferred to the E. faecium 64/3 recipient. Circular forms from both optrA- and poxtA-carrying genetic contexts were obtained. The occurrence of oxazolidinone resistance genes in a bovine E. faecium isolate and their localization on conjugative and mobilizable plasmids pose a risk for public health. [ABSTRACT FROM AUTHOR]

This mixed methods study aimed to explore perceptions/attitudes, to evaluate knowledge/ skills, to investigate clinical behaviours of undergraduate physiotherapy students exposed to a composite education curriculum on evidence-based practice (EBP). Students' knowledge and skills were assessed before and after integrated learning activities, using the Adapted Fresno test, whereas their behaviour in EBP was evaluated by examining their internship documentation. Students' perceptions and attitudes were explored through four focus groups. Sixty-two students agreed to participate in the study. The within group mean differences (A-Fresno test) were 34.2 (95% CI 24.4 to 43.9) in the first year and 35.1 (95% CI 23.2 to 47.1) in the second year; no statistically significant change was observed in the third year. Seventy-six percent of the second year and 88% of the third year students reached the pass score. Internship documentation gave evidence of PICOs and database searches (95-100%), critical appraisal of internal validity (25-75%) but not of external validity (5-15%). The correct application of these items ranged from 30 to 100%. Qualitative analysis of the focus groups indicated students valued EBP, but perceived many barriers, with clinicians being both an obstacle and a model. Key elements for changing students' behaviours seem to be internship environment and possibility of continuous practice and feedback. [ABSTRACT FROM AUTHOR]

Stable isotope ratios (SIRs) of C, N, H and O have been exensively used in fruit juices quality control (ENV and AOAC methods) to detect added sugar and the watering down of concentrated juice, practices prohibited by European legislation (EU Directive 2012/12). The European Fruit Juice Association (AIJN) set some reference guidelines in order to allow the judging of the genuiness of a juice. Moreover, various studies have been carried out to determine the natural variability of SIRs in fruit juices, but none of these has investigated SIRs extensively in authentic citrus juices from Italy. In this work, about 500 citrus juice samples were officially collected in Italy by the Italian Ministry of Agricultural and Forestry Policies from 1998 onwards. (D/H)I and (D/H)II in ethanol and δ13Cethanol, δ13Cpulp, δ13Csugars, δ18Ovegetalwater, δ15Npulp, and δ18Opulp were determined using Site-Specific Natural Isotope Fractionation-Nuclear Magnetic Resonance and Isotope Ratio Mass Spectrometry, respectively. The characteristic ranges of variability in SIRs in genuine Italian citrus juice samples are here presented as well as their relationships and compliance with the limits indicated by the AIJN and others proposed in the literature. In particular, the Italian range of values was found to be not completely in agreement with AIJN guidelines, with the risk that genuine juices could be judged as not genuine. Variety seems not to influence SIRs, whereas harvest year and region of origin have some influence on the different ratios, although their data distribution shows overlapping when principal component analysis is applied. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Abstract: Landscape evolution in active mountain chains can be dominated by gravitational slope movements. This is observed in a large portion of the Reno river catchment, Apennines, Italy, where weak rocks, such as clayshales, are subject to earthflows that control hillslope morphology and supply sediments to the channel network. In this paper, we evaluate the sediment flux generated by earthflows and compare it with Holocene-averaged deposition rates to assess the contribution of mass movements to landscape evolution. Present-day hillslope sediment flux is estimated by combining measured displacement rates (72 inclinometers) and spatial attributes of earthflows and historical frequency of reactivations. Averaged sediment yield (~1.6x103 t/km2/yr) compares well with similar studies on earthflow-dominated landscapes, despite notable differences in methodology. In the study area, the connectivity between hillslopes and the stream network is well developed and no significant sediment sinks influence the sediment transport processes. We document best estimates of regional sediment fluxes and related uncertainties, based on available data. Coarse limestone fragments, present in the clayshales, are used as a natural sediment tracer to allow a comparison with sedimentation rates taking place at the mouth of the intramontane catchment. Here, available borehole logs, 14C datings and stratigraphic correlations of the alluvial fan are used to obtain an estimate of the deposition that took place during Holocene times. Taking also into account the role of solute transport, sedimentation rates are compared to earthflow sediment production rates. Results show a good agreement and demonstrate that earthflows are the primary mass wasting process in these weak rock lithologies. We document best estimates of regional sediment fluxes and related uncertainties. Present earthflow sediment production outpaces Holocene-averaged sedimentation rates by a factor of two. The gap between sediment production and deposition can be partly justified by uncertainties associated with our estimates and by time-scale differences. With this respect, the dynamic equilibrium between erosion and deposition, is likely affected by intra-Holocene oscillations at a short time scale (10 to 1ky) attributable to climate variability. Terraced deposits documenting sedimentary episodes would also support such interpretation. [Copyright &y& Elsevier]

Purpose |!|#8211; The prevalent literature considers interlocking directorates as a mechanisms of cooperation among companies, but if the same director seats on the boards of two companies that are in competition, interlocking directorates, matching cooperation with competition, become a coopetition mechanism. This article aims to argue that the analysis of both the structure and the evolution of interlocking directorates provides some relevant insights on the driving forces behind the coopetition among firms.Design/methodology/approach |!|#8211; Through a longitudinal study the authors analyzed relations among Italian listed firms belonging to financial or manufacturing sectors and traced the evolution networks of interlocking directorates among them. They then analyzed the coopetitive nature of interlocking directorates among firms acting in the same sector that are in direct competition and their impact on M|!|#38;A processes.Findings |!|#8211; It was evidenced that interlocking directorates among firms belonged to the same industry could be considered a coopetitive mechanism if they facilitate formation of deeper relations among competitors such as their integration through M|!|#38;A.Originality/value |!|#8211; This article offers a new perspective of analysis in interlocking directorates|!|#39; field of research. [ABSTRACT FROM AUTHOR]

Clay-shales largely outcrop in the Northern Apennines of Italy, where they are associated with frequent and widespread landslide activity. The paper presents the results of monitoring activities carried out in two field-sites and focused on the hydrology of clay-shales prone to landsliding. In the monitored slopes, the water table is close to the ground surface throughout the year, with seasonal fluctuations of tens of centimetres to a couple of metres. Shallow weathered soils, or clay cover, and unaltered material exhibit a much different behaviour. Although responses to single rainfalls are clearly identifiable as pressure pulses in the clay cover, they are never observed in the underlying parental clay-shales where downward gradients indicate recharge and only long-term seasonal fluctuations are recorded. Short-term variations of pressure head in the clay cover are ruled by downward propagation of a pressure wave in saturated conditions. More than 400 pore-pressure responses collected in the two sites are analysed in terms of lag time, rate and amount of pressure increase and timing of pressure peaking. It emerges that the linear diffusion theory can satisfactorily explain the observed behaviour. In deeper unaltered material, the barometric effect influences the measures similarly to what is observed in confined aquifers. After its removal, the corrected data exhibit regular seasonal fluctuations which are used to estimate the diffusivity of the material based on phase-lag and attenuation of the downward propagating long-term periodic pulse. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Objectives: The study investigated the effect of whole-body vibration (WBV) alone and in association with localized radiofrequency on fat deposits in young nonobese subjects. Methods: Forty-four (44) healthy, nonobese women aged 25.3±5.26 years, body-mass index (BMI) 21.7±2.47 kg/m2 were randomly assigned to an 8-week trial of WBV (2 sessions per week) or WBV plus localized radiofrequency (WBV+RF) in the abdominal, buttock, and thigh region. Anthropometry, body composition (dual-energy x-ray absorptiometry, DXA), and motor performance were assessed before and after the trial. Data were analyzed by one-way analysis of variance (ANOVA) or ANOVA for repeated measures (group×time). Results: Valid data were obtained for 36 women (WBV, n=18; WBV+RF, n=18). Body mass and BMI did not change after trial. Body circumferences were unchanged or slightly reduced, with no difference between groups. Skinfold thickness was significantly reduced at several sites in the whole study population ( n=36), reduction being higher at the thigh site in the WBV+RF group. According to DXA analysis, total body lean mass increased ( p=0.009) and total body fat mass decreased ( p=0.036) in the whole study population after trial with no significant difference between the WBV and WBV+RF group in spite of larger absolute changes in the latter. Standing long jump improved after trial with no change in flamingo balance test. Conclusions: An 8-week WBV training is effective in inducing positive body composition changes as well as increased muscle strength in women; it could be recommended as an alternative/complementary tool in physical activity or fitness programs as it is well tolerated. The current data give limited support to the association of localized RF treatment and WBV training as synergistic in inducing body fat mass loss; such a beneficial effect should be further investigated in subject with larger subcutaneous fat deposits (i.e., overweight or obese). [ABSTRACT FROM AUTHOR]

Abstract: Empirical mobility relationships can be used for delineating debris flow inundated areas. A database of documented events in alpine mountain catchments of northeastern Italy is used to test the model DFlowz (). We back-analyzed 25 DF events, ranging in volume from 3000 to 350,000m3, with the support of high resolution topographic information derived from LiDAR. The analysis makes use of an objective methodology for evaluating the accuracy of the predictions and involves the calibration of the model based on factors describing the uncertainty associated with the empirical relationships. Results indicate that the model is capable of reproducing the observed behavior with a maximum uncertainty of a factor of 3. The most relevant source of error lies in the estimation of the deposited volumes which affects the results of back-calculation and is mainly responsible also for the scatter associated with the empirical mobility relationships. On the contrary, the influence of different flow properties on the depositional process appears to play a minor role as the mutual relations between the three main scaling parameters (volume, inundated area, and cross-sectional area) are respected in the vast majority of cases and calibrated mobility coefficients show no significant relationship with the angle of reach of the deposit. [Copyright &y& Elsevier]

Background: Over the past decade inspiratory capacity (IC) has received increasing attention, especially in studies on chronic obstructive pulmonary disease. Though a few recent studies provide reference values for IC, still little is known on the distribution of its values in healthy subjects. Objective: To estimate percentiles of IC in a sample of healthy nonsmokers by applying quantile regression. Methods: We applied quantile regression to estimate seven percentiles of IC from 5 to 95% for a given age, height and body mass index, separately in males and females, in a sample of 411 healthy nonsmokers, aged 8-73 years, drawn from the general population in Northern Italy. Results: The magnitude and statistical significance of the effect of age, height and body mass on IC varied across percentiles and between genders. When the 50th percentile of IC was compared with the predicted values of several studies, including those published by the European Community for Coal and Steel, the differences were as large as 0.86 liters in males and 0.90 liters in females. The possible advantage of the 5th percentile predicted from quantile regression over the 'traditional 5th percentile' as lower limit of normal was also illustrated. Conclusions: Inference on percentiles, rather than just the mean, of IC and other lung function measures may help in the future to better understand the effect of various risk factors, model growth curves and derive more accurate reference values. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Background Group B streptococcus (GBS) is a leading cause of severe infections in newborns. Intrapartum antibiotic chemoprophylaxis (IAP) reduces the rate of early-onset disease. The aim of this study is to determine the degree of clinicians' compliance with the suggested protocol for GBS prevention in Emilia-Romagna (Italy). Methods Characteristics of each delivery were prospectively recorded in the period between October 2005 to December 2005. Standardized pro-forma were used to collect data. Results Among 5118 babies, 7.2% (369) were preterm and 92.3% were born at term (4749). Antenatal screening was performed in 86.6% of women who delivered at term, of which 18.1% were GBS culture-positive. Information regarding culture site was available in 93.2% of women screened and recto-vaginal cultures were documented in 42.7%. IAP was administered to 28.7% of 3937 women at term who had either spontaneous delivery or emergency caesarean section. In this cohort, 15.9% were diagnosed GBS culture-positive, of which 92.6% received IAP. Prophylaxis was also administered to 8.4% (331) of women for no apparent reason. Compared with tertiary level hospitals, women delivering in primary/secondary hospitals were more likely to be both GBS screened (P < 0.0001; OR 3.04; CI 2.33-3.97) and to receive prophylaxis ≥4 hours before delivery (P = 0.0025; OR 1.57; CI 1.17-2.12). Conclusions GBS screening was performed in >85% of women and >90% of culture-positive women received prophylaxis. However, there is a need to educate clinicians about protocol adherence, as most cultures were suboptimal and cases of unnecessary IAP were administered. The screening was more effective in hospitals with fewer deliveries. [ABSTRACT FROM AUTHOR]

This article contributes to the political economic literature regarding the effects of industrial relations institutions on national economic outcomes. Based on an econometric analysis of the determinants of wage moderation in sixteen industrialized countries between 1974 and 2000, it argues that the organizational characteristics of trade unions have a significant impact on wage dynamics. Controlling for a number of institutional and economic factors, the countries in which trade union confederations directly involve workers in the process of collective bargaining ratification have on average lower wage growth relative to productivity than others. The authors also find that collective bargaining coordination and contract ratification magnify each other's wage-dampening effect. through case studies of Ireland and Italy, the article examines the causal mechanisms underlying the uncovered statistical regularities and concludes that, particularly at a time in which classic political exchange is waning, worker involvement in contract ratification allows confederation leaders to resolve conflicting claims inside their organizations at lower wage levels than are achieved by a less participatory governance process. [ABSTRACT FROM AUTHOR]

The article presents a research that attempts to evaluate the effect of urban residence on bronchial hyperresponsiveness. It examines two general population samples enrolled in two cross-sectional epidemiological studies performed in Italy. The study demonstrates that living in urban area is a risk factor for the increase of bronchial responsiveness.

According to the European Directive 2009/128/EC and the subsequent provisions activated in member states, conventional pesticides should be progressively replaced by "non-chemical tools and/or measures". The identification of reliable alternatives to pesticides is crucial to achieve this objective. A European project (PURE) was funded to investigate this topic with reference to annual and perennial crops. In this framework, a number of natural insecticides, in particular microbial and botanical ones (Bacillus thuringiensis ssp. kurstaki, Beauveria bassiana, azadirachtin, pyrethrins and spinosad) were selected to test their effectiveness against grape berry moths, the key pests in most European vineyards. Trials were conducted in 2011 and 2012 in two experimental vineyards located in Italy (Tuscany and Veneto regions), following a randomized block design. Additional investigations were carried out in the Veneto region during 2013. Trial results stressed the high performance of spinosad and B. thuringiensis in controlling berry moth densities and the related damage. The use of B. bassiana mixed with B. thuringiensis did not significantly improve the impact of B. thuringiensis alone. Azadirachtin, and especially pyrethrins, proved to be less effective on berry moths than previous insecticides. The use of selected insecticides caused side-effects on a number of secondary pests, in particular leafhoppers. In 2011, densities of Empoasca vitis were higher in spinosad-treated plots probably because of a reduced egg parasitization rate. One year later, the population density of Zygina rhamni was higher in the plots treated with spinosad or pyrethrins. This trend was confirmed on spinosad-treated plots in the last experimental year. At the same time, spinosad and pyrethrins significantly reduced the predatory mite populations compared to other treatments. The use of these insecticides in viticulture is discussed in the framework of organic viticulture and Integrated Pest Management (IPM). [ABSTRACT FROM AUTHOR]

This paper aims to demonstrate that capillary effects and structural collapse can not be ruled out as significant factors in the development of subsidence occurring above gas fields. These phenomena provide sound explanations for continuing surface settlements when reservoir pore pressures stabilize and for additional settlements occurring even after the end of gas production. Conventional subsidence models fail to simulate this settlement behavior. Capillary effects also explain the lower rock compressibilities observed in gas-bearing strata as compared to the values obtained in the laboratory from fully saturated samples. Taking into account these aspects, the observed subsidence above a reservoir in the North Adriatic basin, Italy, is studied in detail. [ABSTRACT FROM AUTHOR]

This paper provides some empirical evidence on organizational characteristics and strategies of firms in the Italian gold and fashion industries. The analysis is based on a data set of three SME clusters in Arezzo (a city and province in Tuscany, Italy, southeast of Florence) which led us to the identification of two main alternative strategies which can be implemented when facing the new global competition: a firm-centered brand strategy and an outsourcing strategy (a supply alliance with co-branding possibilities with one or more large Italian firms). We analyzed the resources and competencies of firms that adopted different export marketing strategies and further explored the relationship between strategic choices and performance of participating firms (measured in terms of growth, innovation, and export capabilities). The results show that the choice of a strategy is strongly influenced by the ability of SMEs to respond to changes in consumer behavior and competition, and that some variables significantly affect performance. Both strategies can be effective, and in some cases it is suggested to follow the middle of the road competitive approach: combining the two strategies, exporting own brand directly to the end markets and collaborating with a large firm in order to achieve a sustainable and significant competitive advantage. [ABSTRACT FROM AUTHOR]

This article discusses the use of a combined hydrological-geotechnical model to predict landslides in an alpine watershed in the Friuli region of Italy. The model uses field surveys, geotechnical characteristics, and soil moisture measurements together with the depth of available sediments to characterize the hydraulic properties of the area. A probabilistic approach is used to compute the safety factor related to the variability of the natural slope stability. The GEOtop-FS model was validated to map future failure probabilities and calibrated by reproducing historical rainfall events.

Objective Our objectives were to determine the prevalence of psychological distress in a large sample of Italian patients with psoriasis; to establish whether disease severity and psychological distress are associated; to identify the strategies employed to cope with psoriasis; to evaluate the coping strategies employed by dermatologists; and to identify potential predictors of psychological distress. Design Cross-sectional. Setting Thirty-nine Italian dermatology centres. Subjects One thousand five hundred and eighty (1580) patients with psoriasis. Methods Minor psychological distress was evaluated using the General Health Questionnaire-12 (GHQ-12) and major psychopathological distress using the Brief Symptom Inventory (BSI); coping strategies were evaluated using the Brief COPE questionnaire; disease severity was evaluated using the body surface area index. Results Patients were aged 44 ± 13 years (mean ± SD) and were mainly men (57%). Minor psychological distress was present in 46% of patients and major psychopathological distress in 11% of them. Both minor (54% vs. 40%, P < 0.0001) and major (17% vs. 7%, P < 0.0001) distress were more frequent in women than in men. The psychological status of women was worse than that of men independently from the extension of psoriasis. There was no association between the presence of distress and the treatment prescribed by dermatologists. Planning and active coping were the strategies most commonly employed by patients to cope with psoriasis, but there were between-gender differences. Most dermatologists employed a ‘problem-orientated’ attitude in caring for patients. Conclusions (i) Psychological distress was relatively frequent in our patients with psoriasis; (ii) female gender was the most important predictive factor for psychological distress; (iii) there was no association between psoriasis severity and psychological distress; (iv) planning and active coping were the coping strategies most frequently employed by patients; and (v) most dermatologists employed a problem-orientated attitude in caring for patients. [ABSTRACT FROM AUTHOR]

The presence of endocrine-disrupting compounds in influent and effluent water samples from four waste water treatment plants located in Italy was studied. The estrogen-like activity of the water samples was measured using a chemiluminescent recombinant yeast assay which is based on genetically engineered yeast cells that express the human estrogen receptor. This receptor, once activated, elicits the expression of the reporter gene lac-Z and, consequently, the production of β-galactosidase, which is then measured by chemiluminescence. To control and minimize sample matrix effects, an external control based on a modified yeast strain stably expressing β-galactosidase was developed and also used in the assay. Rapid and sensitive chemiluminescent enzyme immunoassays were also developed and validated for the quantification of 17β-estradiol, estrone, and estriol in waste water samples. Results from both methods were compared with a reference high-performance liquid chromatography and electrospray ionization tandem mass spectrometry (HPLC ESI-MS-MS) method developed for the quantification of natural estrogens. The recombinant yeast assay revealed a significant estrogenic activity in the influent samples, ranging from 80 to 400 pmol/L 17β-estradiol equivalents (EEQ), which was reduced by 70–95 % in the effluent samples. The yeast assay also showed a systematic 20–30 % overestimation of estrogenic activity relative to the HPLC ESI-MS-MS method, suggesting the presence of other compounds in the samples with estrogenic activity. The chemiluminescent enzyme immunoassays showed the presence of estrogens in the influent samples (mean concentrations: 350–450 pmol/L for estrone, 5–100 pmol/L for 17β-estradiol, 25–300 pmol/L for estriol), with significantly lower concentrations detected in the respective effluent samples. The waste water treatment was able to reduce natural estrogen concentrations by 40–95 %, although a high variability was observed. The enzyme immunoassay data correlated well with data obtained by the HPLC ESI-MS-MS method. Although the recombinant yeast assay represents a useful tool for a first-level screening of estrogenic activity due to its simplicity and high analytical throughput, sample matrix effects observed in waste water of industrial origin were found to strongly affect the yeast cells response, even when properly corrected for using the external control, thereby limiting its use to urban waste water. Its integration with chemiluminescent enzyme immunoassays would improve its performance by reducing false negative results, thereby enabling its use in extensive studies monitoring for the presence of endocrine-disrupting compounds in urban treatment plant effluents. [ABSTRACT FROM AUTHOR]

OBJECTIVE To validate the Italian version of two questionnaires for lower urinary tract symptoms (LUTS), i.e. the long (LF) and the short form (SF) of the International Consultation on Incontinence Questionnaire (ICIQ). METHODS Two native Italian speakers and a native English speaker collaborated with clinical investigators through a multistep process to obtain a consensus version of the questionnaires. The resulting Italian versions were then pre-tested during a pilot study on 16 women for the LF and 10 for the SF. The final versions of the ICIQ-LF and ICIQ-SF were administered to two samples of consecutive female patients, aged ≥ 18 years, who had been having LUTS for ≥ 3 months, with respectively 82 and 50 women. Internal consistency and test-retest reliability were then assessed; to evaluate the latter, a subset of patients (25 for the ICIQ-LF and 42 for ICIQ-SF) was re-rated. To test the capacity of the questionnaires to discriminate women with or without LUTS (respectively cases and controls), a sample of healthy women was also enrolled and assessed. RESULTS Both scales showed good psychometric properties overall. The correlation coefficient between ratings was > 0.75 in both questionnaires, and the discriminant power between cases and controls was confirmed for both scales. The ICIQ-SF showed good internal consistency for the total score (Cronbach's α 0.90). The sections of the ICIQ-LF ‘impact of incontinence on everyday life’, ‘emotional aspects’, ‘urinary symptoms’ and the degree of bother seemed to be internally consistent (Cronbach's α > 0.70); there was a weak relationship for items related to ‘sexual matters’ (Cronbach's α 0.38). CONCLUSION The Italian version of both questionnaires is a valid and robust instrument which can now be used reliably both in daily practice and in clinical research. [ABSTRACT FROM AUTHOR]