1. The role of CT brain findings in the early diagnosis of infantile encephalitic beriberi.
- Author
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Wani, Nisar A., Malik, Ishaq, Tariq, Syed, Bhat, Abdus Sami, and Qureshi, Umar Amin
- Subjects
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WERNICKE'S encephalopathy , *BRAIN , *COMPUTED tomography , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *HOSPITAL care of newborn infants , *GAS chromatography , *MASS spectrometry , *RURAL conditions , *EARLY diagnosis , *BASAL ganglia diseases , *AMMONIA , *DISEASE complications , *CHILDREN ,DEVELOPING countries - Abstract
Background: Thiamine deficiency disease may occur in infants from thiamine-deficient mothers in developing countries, as well as in infants fed solely with soy-based formula. Thiamine deficiency in infants may present with acute neurological manifestations of infantile encephalitic beriberi. Objective: To review the role of noncontrast CT brain findings in infantile encephalitic beriberi in early diagnosis. Materials and methods: A retrospective review of noncontrast CT scans of the brain in 21 infants with acute-onset infantile encephalitic beriberi was carried out. Results: On noncontrast-enhanced CT brain, hypodense lesions were seen symmetrically in the putamen in all the babies; symmetric hypodensities were seen in the caudate nuclei in 14/21 (67%), in dorsomedial thalami/hypothalamic/subthalamic area in 4/21 (19%), and in the globi pallidi in 2/21 (9.5%) of the infants. Conclusion: Recognition of symmetrical hypodense lesions in the basal ganglia and medial thalami/hypothalamic/subthalamic area on noncontrast CT scan of the brain are important early features to recognize in encephalitic beriberi in at-risk infants. Advances in knowledge: IEBB is a cause of hypodense bilateral basal ganglia and may be identified by this finding in the appropriate clinical settings. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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