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Assessing the Burden of COVID-19 among Children Aged 6-14 Years in Karnataka, India: A Cross-sectional Survey.
- Source :
-
Indian Journal of Community Medicine . Jan/Feb2024, Vol. 49 Issue 1, p110-104. 5p. - Publication Year :
- 2024
-
Abstract
- Background: India experienced three coronavirus disease (COVID-19) waves, with the third attributed to the highly contagious Omicron variant. Before the national vaccination rollout for children above 6, understanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) positivity in the pediatric population was essential. This study aims to assess the burden of Covid-19 infection and to estimate the seroprevalence in children aged 6 to 14 years in the state of Karnataka. Material and Methods: We surveyed 5,358 children aged 6-14 across Karnataka using 232 health facilities, from June 6 to 14, 2022. We determined the sample size using the PPS (Population Proportional to Size) technique and employed cluster sampling. We tested all participants for SARS-CoV-2 IgG with an enzyme-linked immunosorbent assay (ELISA) kit and SARS-CoV-2 RNA with reverse transcription-polymerase chain reaction (RT-PCR). We sequenced samples with a cycle threshold (CT) value below 25 using whole genomic sequencing (WGS). Result: We found an adjusted seroprevalence of IgG at 75.38% statewide, and we found 0.04% of children RT-PCR positive for COVID-19. We determined a case-to-infection ratio of 1:37 and identified the SARS-CoV-2 strains as Omicron, BA.5, and BA.2.10. Conclusion: The study showed a high seroprevalence of IgG among children with low active infection. Omicron, BA. 5, and BA. 2.10 variants were detected through WGS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RESEARCH
*SEROPREVALENCE
*CLUSTER sampling
*REVERSE transcriptase polymerase chain reaction
*COVID-19
*SAMPLE size (Statistics)
*SEQUENCE analysis
*GENETIC mutation
*COVID-19 vaccines
*CROSS-sectional method
*REINFECTION
*SEVERITY of illness index
*SURVEYS
*GENOME-wide association studies
*GENOMICS
*ENZYME-linked immunosorbent assay
*IMMUNOENZYME technique
*DESCRIPTIVE statistics
*RESEARCH funding
*MICROBIAL virulence
*DATA analysis software
*DISEASE risk factors
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 09700218
- Volume :
- 49
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Indian Journal of Community Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 175597814
- Full Text :
- https://doi.org/10.4103/ijcm.ijcm_60_23