1. N-terminal pro-B-type natriuretic peptide and long-term mortality in non-ischaemic cardiomyopathy.
- Author
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Krackhardt F, Düngen HD, Trippel TD, Inkrot S, Tscholl V, Schlattmann P, Kehrt K, and Haverkamp W
- Subjects
- Biomarkers blood, Cardiomyopathies diagnosis, Comorbidity, Female, Germany epidemiology, Humans, Male, Middle Aged, Myocardial Ischemia blood, Myocardial Ischemia diagnosis, Myocardial Ischemia mortality, Prevalence, Reproducibility of Results, Risk Assessment methods, Risk Factors, Sensitivity and Specificity, Survival Analysis, Survival Rate, Ventricular Dysfunction, Left diagnosis, Cardiomyopathies blood, Cardiomyopathies mortality, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Ventricular Dysfunction, Left blood, Ventricular Dysfunction, Left mortality
- Abstract
Aim: The inactive N-terminal fragment of B-type natriuretic peptide is a strong predictor of mortality among patients with acute and chronic heart failure secondary to ischaemic heart disease. Its prognostic utility in patients with non-ischaemic heart disease is not well established. We therefore assessed the relationship of N-terminal proBNP levels and long-term mortality in patients with non-ischaemic cardiomyopathy., Methods: N-terminal proBNP was measured in serum samples of 156 patients who presented to a single academic centre with worsening heart failure secondary to non-ischaemic cardiomyopathy. The rate of death from all causes was determined after a mean follow-up of 8.9 years., Results: Multivariate analyses, using Cox proportional hazards models, established NT-proBNP and left ventricular diastolic diameter as predictors for cardiac mortality with estimated hazard ratios of 2.76 (95% confidence interval: 1.53, 4.98) and 1.06 (95% confidence interval: 1.02, 1.10), respectively., Conclusion: This to date longest-term analysis of N-terminal proBNP and mortality in patients with proven non-ischaemic cardiomyopathy confirms this cardiac-specific biomarker as powerful, independent risk predictor. It is a superior prognostic determinant to New York Heart Association functional class and left ventricular ejection fraction.
- Published
- 2011
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