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N-terminal pro-B-type natriuretic peptide and long-term mortality in non-ischaemic cardiomyopathy.
- Source :
-
Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2011 Dec; Vol. 123 (23-24), pp. 738-42. Date of Electronic Publication: 2011 Nov 23. - Publication Year :
- 2011
-
Abstract
- Aim: The inactive N-terminal fragment of B-type natriuretic peptide is a strong predictor of mortality among patients with acute and chronic heart failure secondary to ischaemic heart disease. Its prognostic utility in patients with non-ischaemic heart disease is not well established. We therefore assessed the relationship of N-terminal proBNP levels and long-term mortality in patients with non-ischaemic cardiomyopathy.<br />Methods: N-terminal proBNP was measured in serum samples of 156 patients who presented to a single academic centre with worsening heart failure secondary to non-ischaemic cardiomyopathy. The rate of death from all causes was determined after a mean follow-up of 8.9 years.<br />Results: Multivariate analyses, using Cox proportional hazards models, established NT-proBNP and left ventricular diastolic diameter as predictors for cardiac mortality with estimated hazard ratios of 2.76 (95% confidence interval: 1.53, 4.98) and 1.06 (95% confidence interval: 1.02, 1.10), respectively.<br />Conclusion: This to date longest-term analysis of N-terminal proBNP and mortality in patients with proven non-ischaemic cardiomyopathy confirms this cardiac-specific biomarker as powerful, independent risk predictor. It is a superior prognostic determinant to New York Heart Association functional class and left ventricular ejection fraction.
- Subjects :
- Biomarkers blood
Cardiomyopathies diagnosis
Comorbidity
Female
Germany epidemiology
Humans
Male
Middle Aged
Myocardial Ischemia blood
Myocardial Ischemia diagnosis
Myocardial Ischemia mortality
Prevalence
Reproducibility of Results
Risk Assessment methods
Risk Factors
Sensitivity and Specificity
Survival Analysis
Survival Rate
Ventricular Dysfunction, Left diagnosis
Cardiomyopathies blood
Cardiomyopathies mortality
Natriuretic Peptide, Brain blood
Peptide Fragments blood
Ventricular Dysfunction, Left blood
Ventricular Dysfunction, Left mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1613-7671
- Volume :
- 123
- Issue :
- 23-24
- Database :
- MEDLINE
- Journal :
- Wiener klinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 22105112
- Full Text :
- https://doi.org/10.1007/s00508-011-0092-y