1. Whole genome and phylogenetic analysis of two SARS-CoV-2 strains isolated in Italy in January and February 2020: additional clues on multiple introductions and further circulation in Europe.
- Author
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Stefanelli P, Faggioni G, Lo Presti A, Fiore S, Marchi A, Benedetti E, Fabiani C, Anselmo A, Ciammaruconi A, Fortunato A, De Santis R, Fillo S, Capobianchi MR, Gismondo MR, Ciervo A, Rezza G, Castrucci MR, and Lista F
- Subjects
- Betacoronavirus isolation & purification, COVID-19, China, Coronavirus classification, Coronavirus isolation & purification, Coronavirus Infections epidemiology, Coronavirus Infections transmission, Germany, Humans, Italy, Molecular Epidemiology, Pandemics, Phylogeny, Pneumonia, Viral epidemiology, Pneumonia, Viral transmission, Point Mutation, RNA, Viral isolation & purification, SARS-CoV-2, Severe Acute Respiratory Syndrome virology, Betacoronavirus genetics, Coronavirus genetics, Coronavirus Infections diagnosis, Genome, Viral genetics, Pneumonia, Viral diagnosis, RNA, Viral genetics, Severe Acute Respiratory Syndrome diagnosis, Travel, Whole Genome Sequencing methods
- Abstract
Whole genome sequences of SARS-CoV-2 obtained from two patients, a Chinese tourist visiting Rome and an Italian, were compared with sequences from Europe and elsewhere. In a phylogenetic tree, the Italian patient's sequence clustered with sequences from Germany while the tourist's sequence clustered with other European sequences. Some additional European sequences in the tree segregated outside the two clusters containing the patients' sequences. This suggests multiple SARS-CoV-2 introductions in Europe or virus evolution during circulation.
- Published
- 2020
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