1. Candidemia in the Neonatal Intensive Care Unit: A Retrospective, Observational Survey and Analysis of Literature Data.
- Author
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Caggiano, Giuseppina, Lovero, Grazia, De Giglio, Osvalda, Barbuti, Giovanna, Montagna, Osvaldo, Laforgia, Nicola, and Montagna, Maria Teresa
- Subjects
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INFECTION , *ACADEMIC medical centers , *ANTIFUNGAL agents , *BIRTH weight , *LOW birth weight , *BLOOD testing , *BLOODBORNE infections , *CANDIDA albicans , *CELL culture , *CHI-squared test , *DATABASES , *ETHICS , *FISHER exact test , *GESTATIONAL age , *HOSPITAL care , *LENGTH of stay in hospitals , *INFORMED consent (Medical law) , *MEDLINE , *NEONATAL intensive care , *PATHOGENIC microorganisms , *POLYMERASE chain reaction , *SURVEYS , *LITERATURE reviews , *NEONATAL intensive care units , *HUMAN research subjects , *RETROSPECTIVE studies , *DATA analysis software , *DESCRIPTIVE statistics , *CANDIDEMIA , *MANN Whitney U Test , *DIAGNOSIS - Abstract
We evaluated the epidemiology of Candida bloodstream infections in the neonatal intensive care unit (NICU) of an Italian university hospital during a 9-year period as a means of quantifying the burden of infection and identifying emerging trends. Clinical data were searched for in the microbiological laboratory database. For comparative purposes, we performed a review of NICU candidemia. Forty-one candidemia cases were reviewed (overall incidence, 3.0 per 100 admissions). Candida parapsilosis sensu stricto (58.5%) and C. albicans (34.1%) were the most common species recovered. A variable drift through years was observed; in 2015, 75% of the cases were caused by non-albicans species. The duration of NICU hospitalization of patients with non-albicans was significantly longer than in those with C. albicans (median days, 10 versus 12). Patients with non-albicans species were more likely to have parenteral nutrition than those with C. albicans (96.3% versus 71.4%). Candida albicans was the dominant species in Europe and America (median, 55% and 60%; resp.); non-albicans species predominate in Asia (75%). Significant geographic variation is evident among cases of candidemia in different parts of the world, recognizing the importance of epidemiological data to facilitate the treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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