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This study addresses a gap in resilience interventions for rural preschoolers by validating a 14-week play-based picture-book reading program involving 80 Chinese preschoolers aged 4-5 years. Participants were randomly assigned to non-intervention (NI), play intervention (PI), picture-book reading intervention (PRI), or play-based picture-book reading intervention (PPRI) groups. Kindergarten teachers and parents reported children's resilience with the Chinese version of Devereux Early Childhood Assessment for Preschoolers at pretest, post-test, and follow-up. Results revealed that intervention groups (PI, PRI, PPRI) exhibited higher resilience gain scores than the NI group. Notably, the PPRI group demonstrated greater resilience gains compared to the PRI and PI groups. Furthermore, the intervention effects of the PPRI group were maintained for two months following the intervention. Those findings suggest that PPRI may be a valuable intervention for enhancing resilience in preschoolers, with potential applications in kindergarten classrooms.

This study examined the effect of dialogic reading intervention on improving the theory of mind of rural Chinese children. A 12-week-randomized controlled trial design with two intervention groups, i.e. school practice intervention (SPI), parent-involved intervention (PII), and one control group with traditional reading intervention (TRI) that provided data at pre-, mid-, post-test, and follow-up tests, was adopted. Seventy-five children participated in the study, with twenty-five participants in each group. Results indicated the gain scores of ToM score from pre to mid-tests and pre- to post-tests of the two intervention groups were higher than the control group. The PII group showed higher gain scores in the mid- and post-test than the SPI group. The intervention effects were well maintained in the SPI and PII groups during the two-month follow-up assessment. The findings indicated school-based dialogic reading can effectively promote ToM development and has a maintenance effect, especially when parents are engaged.

Backgrounds: Prunus mume in the Rosaceae and commonly referred to as mei or Chinese plum is widely used as a traditional ornamental flowering plant and fruit tree in China. Although some population and genetic analyses have been conducted for this species, no extensive comparisons of genetic variation from plastomes have yet been investigated. Methods: We de novo assembled a total of 322 complete P. mume plastomes in this study and did a series of comparative analyses to better resolve pan-plastomic patterns of P.mume. To determine the phylogeny and domestication history of this species, we reconstructed the phylogenetic tree of Prunus genus, and resolved the population structure of P. mume. We also examined the nucleotide variation of P. mume to find potential DNA barcodes. Results: The assembled plastomes exhibited a typical quadripartite structure and ranged from 157,871 bp to 158,213 bp in total size with a GC content ranging from 36.73 to 36.75%. A total of 112 unique genes were identified. Single nucleotide variants (SNVs) were the most common variants found among the plastomes, followed by nucleotide insertions/deletions (InDels), and block substitutions with the intergenic spacer (IGS) regions containing the greatest number of variants. From the pan-plastome data six well-supported genetic clusters were resolved using multiple different population structure analyses. The different cultivars were unevenly distributed among multiple clades. We also reconstructed a phylogeny for multiple species of Prunus to better understand genus level diversity and history from which a complex introgressive relationship between mei and other apricots/plums was resolved. Conclusion: This study constructed the pan-plastome of P. mume, which indicated the domestication of P. mume involved multiple genetic origins and possible matrilineal introgression from other species. The phylogenetic analysis in Prunus and the population structure of P. mume provide an important maternal history for Prunus and the groundwork for future studies on intergenomic sequence transfers, cytonuclear incompatibility, and conservation genetics. [ABSTRACT FROM AUTHOR]

BACKGROUND Stress hyperglycemia ratio (SHR) could provide accurate information on the acute status of hyperglycemia. The relationship between SHR and acute coronary syndrome (ACS) prognosis remains unclear. This study was conducted to identity the association between SHR and in-hospital outcomes in patients with ACS. METHODS A total of 12,010 patients were eventually enrolled in the study. The relationship between SHR and in-hospital major adverse cardiovascular events (MACEs) was then modeled by restricted cubic spline (RCS) curves, and all patients were divided into three groups according to the results. The multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes, described as odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses were also performed on different diseases. RESULTS The median age of this cohort was 63 (54, 71) years old, and 8942 (74.5%) were male. Group 1 was defined as SHR < 0.6 (n = 426), Group 2 was defined as SHR between 0.6 and 1 (n = 5821), and Group 3 was defined as SHR > 1 (n = 5763). Compared with Group 2, Group 1 (OR = 1.891, 95% CI: 1.028-3.479, P < 0.001) and Group 3 (OR = 1.868, 95% CI: 1.434-2.434, P < 0.001) had higher risks of suffering from in-hospital MACEs. SHR was associated with higher risks of in-hospital MACEs in the subgroups of DM [OR = 2.282, 95% CI: 1.477-3.524). CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital MACEs. Young males with DM, hypertension, and decreased renal function had much higher risks of suffering from SHR-correlated MACEs. [ABSTRACT FROM AUTHOR]

With the appearance of potential risks and benefits brought about by environmental, social, and governance factors, various industries are aware of the importance of sustainable investment. Undeniably, sustainable investing has become an important force for change in different industries, especially in financial markets. However, the current state of research in this field remains unexplored, with the specific research focus and the role of countries in economic globalization and sustainable development remaining undocumented. To address this issue, this article presents a bibliometric analysis of sustainable investments in financial markets using data extracted from the Scopus database. The study explores the current state of research on sustainable investing in financial markets and identifies potential directions for future research by analysing a total of 1,794 academic articles published in leading finance and sustainability journals between 1982 and April 2023. This analysis further examines the relationship between national academic collaboration and key research themes. Analysis of the results shows that the United States, China and the United Kingdom rank among the top three in the number of publications in the field of sustainable investment research. Developing countries such as China and India are also gradually increasing their attention in this field and gradually assuming corresponding responsibilities. The keyword co-occurrence analysis further highlights the vital role of the core concepts of “Investment”, “Commerce”, “Costs” and “Climate Change” and “Energy policy” in sustainable investment research and practice. The findings of this quantitative bibliographic analysis will be of significant value to researchers, policymakers and practitioners interested in sustainable investing and its role in shaping the future of finance. [ABSTRACT FROM AUTHOR]

Background/Aims:Functional dyspepsia (FD) overlapping with other gastrointestinal disorders are quite common. The characteristics of FD overlap in Chinese population with latest Rome IV criteria were unclear. This large-scale outpatient-based study assessed the characteristics of FD overlap in South China. Methods:Consecutive FD patients visited the Gastroenterology Clinic at 2 tertiary medical centers in Hangzhou, China who fulfilled the Rome IV criteria were enrolled. Complete questionnaires related to the gastrointestinal symptoms (Rome IV criteria), Reflux Disease Questionnaire, anxiety and depression, quality of sleep and life, and demographic information were collected. Results: Among the total of 3281 FD patients, 50.69% overlapped with gastroesophageal reflux disease, 21.46% overlapped with irritable bowel syndrome, 6.03% overlapped with functional constipation. FD overlap had higher proportion of single/divorced/widowed rate, high education level, being employed, drinking, night shift, unhealthy dietary habit than FD only (P < 0.05). They had higher frequency of consultation and economic burden, as well as lower scores in quality of life (P < 0.001). Multivariate logistic regression showed that increasing age, female, low body mass index, history of gastroenteritis, anxiety, depression, and poor sleep quality were independent risk factors for FD overlap. Conclusions:FD overlap was quite common in China with high economic burden and poor quality of life, FD patients with history of gastroenteritis, anxiety, depression, and poor sleep quality were more likely to have overlap disorders. Awareness of the physical and psychosocial stressors in overlapping condition would help optimize the management of FD overlap in clinical practice. [ABSTRACT FROM AUTHOR]

Background: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a critical gap in the early and non-invasive detection of PD. Current diagnostic methods are often invasive, expensive, or late in identifying the disease, leading to missed opportunities for early intervention. Objective: The goal of this study is to explore the efficiency and accuracy of combining fNIRS technology with machine learning algorithms in diagnosing early-stage PD patients and to evaluate the feasibility of this approach in clinical practice. Methods: Using an ETG-4000 type near-infrared brain function imaging instrument, data was collected from 120 PD patients and 60 healthy controls. This cross-sectional study employed a multi-channel mode to monitor cerebral blood oxygen changes. The collected data were processed using a general linear model and β values were extracted. Subsequently, four types of machine learning models were developed for analysis: Support vector machine (SVM), K-nearest neighbors (K-NN), random forest (RF), and logistic regression (LR). Additionally, SHapley Additive exPlanations (SHAP) technology was applied to enhance model interpretability. Results: The SVM model demonstrated higher accuracy in differentiating between PD patients and control group (accuracy of 85%, f1 score of 0.85, and an area under the ROC curve of 0.95). SHAP analysis identified the four most contributory channels (CH) as CH01, CH04, CH05, and CH08. Conclusion: The model based on the SVM algorithm exhibited good diagnostic performance in the early detection of PD patients. Future early diagnosis of PD should focus on the Frontopolar Cortex (FPC) region. [ABSTRACT FROM AUTHOR]

This study investigates the clinical effects of the novel Traditional Chinese Medicine (TCM) topical wash used in combination with negative pressure irrigation and tadalafil for the treatment of vascular erectile dysfunction. Eighty-seven patients with vascular erectile dysfunction were divided into an observation group and a control group. The observation group was administered negative pressure irrigation (TCM) in combination with oral tadalafil for four weeks, and the control group was administered oral tadalafil for four weeks. The observation group included 21 patients with arterial erectile dysfunction and 22 with intravenous erectile dysfunction. After treatment, IIEF-5, EHS, GAD scores, PSV, EDV and RI in observation group were improved compared with those before treatment (P = 0.000, 0.000, 0.000, L0.000/R0.000, L0.000/R0.000, L0.003/R0.000). Erectile function (IIEF-5, EHS) was significantly improved compared with the control group (P = 0.008, 0.002). In the observation group, there were 21 cases of arterial erectile dysfunction and 22 cases of intravenous erectile dysfunction. After treatment, PSV of arterial ED improved significantly (P = L0.000/R0.000), but EDV did not decrease significantly (P = L0.084/R 0.098). In patients with venous ED, PSV increased (P = L0.026/R0.032) and EDV decreased significantly (P = L0.000/R0.000). These findings suggest that TCM negative pressure lavage combined with tadalafil improves the blood supply of the penile artery, relaxes smooth muscle, and improves the closing mechanism of venous vessels in patients with vascular erectile dysfunction, ultimately improving the erectile function. [ABSTRACT FROM AUTHOR]

Background: In the era of immunotherapy, the optimal combination of immune checkpoint inhibitors (ICIs) and chemoradiotherapy (CRT) for stage III non-small cell lung cancer (NSCLC) is not defined. The current study investigated the efficacy and safety of definitive CRT(dCRT) plus consolidation ICIs with or without induction ICIs in stage III NSCLC. Methods: 123 consecutive patients treated with dCRT followed by consolidation ICIs at our institution from 2018 to 2022 were retrospectively reviewed. Failure patterns, survival outcomes, and toxicity profiles were analyzed. Results: The 1- and 2- year PFS rates were 75.3% and 56.9%, respectively, and median PFS was 30.83 months from the start of treatment. In-field failure (18.7%) was the most common failure pattern. The most common adverse event (AE) was pneumonitis caused by ICIs or RT. The incidence of Grade 3-4 and Grade 5 pneumonitis was 5.7% and 1.6%, respectively. Further analysis showed that the induction plus consolidation ICIs group has significantly lower cumulative incidence of distant metastasis rates (HR: 0.30, 95%CI: 0.09-1.00, p=0.043) and higher incidence of pneumonitis (p=0.039) compared with patients in the consolidation ICIs group.Conclusions: Combined CRT and consolidation ICIs achieved encouraging efficacy and manageable toxicity in patients with stage III NSCLC in China. Induction plus consolidation ICIs might reduce distant metastasis and deserve further investigation. [ABSTRACT FROM AUTHOR]

This research contributes to an understanding of the 'intertwined destiny' of China's twin initiatives, the BRI and the CSD. We find that the security implications of the twin initiatives drive different patterns of responses among ASEAN states. The dynamism emanates from diversifying preferences of ASEAN states amid complex interdependence. The BRI does a better job of projecting China's material and soft power, as it aligns closely with ASEAN states' comprehensive national interests. The CSD fares less well because it seeks to impose Beijing's hegemonic claims on the SCS, thereby posing a security challenge to claimant states in the region. The nuances suggest that the charm of the BRI cannot be readily converted into a passport for the CSD. For some ASEAN states, power asymmetry inherent in their relations with China requires a security commitment from this giant northern neighbour, which Beijing is still reluctant to provide. [ABSTRACT FROM AUTHOR]

Background: The genus Illiesonemoura Baumann, 1975 (Plecoptera, Nemouridae) is a small-sized stonefly with slender and curved embranous cerci. Currently, 18 species of the genus are known worldwide, mainly distributed in the Palaearctic and Oriental Regions, with a total of two species known to China. New information: Three new species of Illiesonemoura Baumann, 1975, I. bituberculata Wang & Du, sp. nov., I. motuoensis Du & Ji, sp. nov. and I. weii Du & Ji, sp. nov. are described and illustrated, based on male adults from China. Illiesonemoura bituberculata is characterised by two pairs of tubercles arising posteromedially from tergum 10 and by two rows of spinules outlining the lateral edge of the ventral sclerite of the epiproct. Illiesonemoura motuoensis is characterised by the heart-shaped epiproct with a thin and slightly sclerotised protrusion between the sclerotised bands. Illiesonemoura weii is characterised by a pair of small knobs on tergum 10, outer lobes of paraprocts basally broad, then slender towards apices with a pointed tip and the epiproct with lateral spinules. [ABSTRACT FROM AUTHOR]

INTRODUCTION Traditional Chinese medicine (TCM) may have special advantages in facilitating smoking cessation, but consensus on effectiveness is lacking. We aim to comprehensively review, update, and refine current evidence on TCM effectiveness and safety. METHODS Nine databases were searched from their inception up to 28 February 2023. Systematic reviews (SRs) and meta-analysis of TCM for smoking cessation were identified and retrieved. Additional databases and hand searches of RCTs from included SRs were performed for data pooling. Cochrane ROB tools and AMSTAR-2 were used to evaluate the methodological quality of RCTs and SRs, respectively. RCT data are presented as relative risks (RR) or mean differences (MD) with 95% confidence intervals (CI) using RevMan 5.4. RESULTS Thirteen SRs involving 265 studies with 33081 participants were included. Among these 265 studies, 157 were duplicates (58.36%) and 52 were non-RCTs (19.62%). Combined with the remaining 56 RCTs identified through hand searches, 88 RCTs involving 12434 participants were finally included for data synthesis. All the SRs focused on acupoint stimulation, and the majority were of low or very low quality. The methodological quality of RCTs was either unclear or high risk. For continuous abstinence rate, TCM external interventions were better than placebo in 6 months to 1 year (RR=1.60; 95% CI: 1.14-2.25; I²=27%; n=5533 participants). Compared with placebo, TCM external application was effective in reducing nicotine withdrawal symptoms, and the effect was gradually stable and obvious in the fourth week (MD= -4.46; 95% CI: -5.43 -- -3.49; n=165 participants). Twelve RCTs reported adverse events as outcome indicators for safety evaluation, and no serious adverse events occurred. CONCLUSIONS Despite the methodological limitations of the original studies, our review suggests that TCM intervention shows potential effectiveness on the continuous abstinence rate. Extending the intervention time can enhance the effect of TCM on nicotine withdrawal symptoms. Referred to adverse events, more data for safety evaluation are required. [ABSTRACT FROM AUTHOR]

We report the clonal spread and evolution of high-risk Pseudomonas aeruginosa sequence type 463 co-producing KPC-2 and AFM-1 carbapenemases isolated from hospital patients in China during 2020–2022. Those strains pose a substantial public health threat and surveillance and stricter infection-control measures are essential to prevent further infections. [ABSTRACT FROM AUTHOR]

Background: Allergic rhinitis is prevalent among children and can cause nasal itching, fatigue, and even hinder growth and development. The main discomfort symptom of allergic rhinitis is nasal itching. Clinical reports suggest that Chinese herbal medicine (CHM) is effective in allergy rhinitis treatment. Therefore, we evaluate the clinical efficacy of Chinese herbal medicine in treating nasal itching caused by allergic rhinitis in children. Methods: Nine databases, including PubMed, Embase, The Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wan Fang Data, CQVIP, Chinese Biological Medicine, and ClinicalTrials.gov, were systematically searched from their inception until March 2023. Randomized controlled trials (RCTs) comparing the efficacy of Chinese herbal medicine, either alone or in combination with Western medicine, to Western medicine treatment or placebo intervention for treating allergic rhinitis in children were eligible for inclusion. The effectiveness of Chinese herbal medicines for nasal itching was mainly evaluated. The Risk of Bias tool 2.0 assessed the risk of bias. Statistical analysis using RevMan 5.3 and Stata/SE 12. The quality of evidence was evaluated by GRADEpro 3.6. Risk ratios (RR) with corresponding 95% confidence intervals (CI) were utilized to evaluate and present dichotomous data, while mean difference (MD) and standardized mean difference (SMD) were employed for continuous data. A fixed-effects model was applied in cases where the data exhibited homogeneity (p > 0.1, I2 < 50%), whereas a random-effects model was utilized for heterogeneous data. Statistical significance was determined by a p-value <0.05. This study was conducted by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and its review protocol was registered on the International Platform for Registered Systematic Reviews and Meta-Analysis Programs (INPLASY202340076). Results: The review incorporated 23 studies. The meta-analysis indicated that herbal medicine was significantly related to the reduction of nasal itching (MD = -0.59, 95% CI: -0.94-0.24) and the increase of interleukin 10 level (SMD = 1.47, 95% CI: 0.90-2.05). Compared to Western medicine, the combining herbs and Western medicine showed better efficacy in relieving nasal itching, inhibiting immunoglobulin E, interleukin 4 and 33, enhancing interleukin 10, improving therapeutic efficiency, andreducing recurrent. Oral herbal medicine was more effective in treating nasal itching (MD = -0.45, 95% CI: -0.62-0.29). Combining oral and external herbal medicines was more efficient in treating nasal itching (MD = -0.44, 95% CI: -0.54-0.33), inhibiting immunoglobulin E, interleukin 4 (SMD = -0.87, 95% CI: -1.24-0.50) and 33 (SMD = -1.16, 95% CI: -1.54-0.77), and improving therapeutic efficiency. External herbal medicine did not show differences compared to Westernmedicines. Regarding safety, herbal medicine alone exhibited fewer adverse events than Western medicine; combining herbal and Western medicine showed no significant variation in adverse event incidence. Conclusion: Chinese herbal medicine (CHM) holds great potential in alleviating symptoms, modulating immune factors levels, and reducing relapse in pediatric rhinitis. Meanwhile, CHM is relatively safe. However, the efficacy and safety of CHM in treating pediatric rhinitis still need to be confirmed due to the inclusion of studies with low methodological quality, small sample sizes, and potential heterogeneity. More high-quality research is necessary to provide reliable evidence for the clinical application of CHM. [ABSTRACT FROM AUTHOR]

Background: Escherichia coli is one of the most common pathogens causing neonatal infections. Recently, the incidence and drug resistance of E. coli have increased, posing a major threat to neonatal health. The aim of this study was to describe and analyze the antibiotic resistance and multilocus sequence typing (MLST) characteristics of E. coli derived from infants admitted to neonatal intensive care units (NICUs) across China. Methods: In this study, 370 strains of E. coli from neonates were collected. E. coli isolated from these specimens were subjected to antimicrobial susceptibility testing (by broth microdilution method) and MLST. Results: The overall resistance rate was 82.68%, with the highest rate of methicillin/sulfamethoxazole (55.68%) followed by cefotaxime (46.22%). Multiple resistance rate was 36.74%, 132 strains (35.68%) had extended-spectrum β-lactamase (ESBL) phenotype and 5 strains (1.35%) had insensitivity to the tested carbapenem antibiotics. The resistance of E. coli isolated from different pathogenicity and different sites of infections varied, strains derived from sputum were significantly more resistant to β-lactams and tetracyclines. Currently, the prevalence spectrum in NICUs was dominated by ST1193, ST95, ST73, ST69 and ST131 across China. And the multidrug resistance of ST410 was the most severe. ST410 had the highest resistance rate to cefotaxime (86.67%), and its most common multidrug resistance pattern was β-lactams + aminoglycosides + quinolones + tetracyclines + sulfonamides. Conclusions: Substantial proportions of neonatal E. coli isolates were severely resistant to commonly administered antibiotics. MLST results can suggest the prevalent characteristics of antibiotic resistance in E. coli with different ST types. [ABSTRACT FROM AUTHOR]

Background: The significant association between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD) is well documented. In this report, we tested the hypothesis that SUA might improve the widely studied fatty liver index (FLI) to predict NAFLD. Methods: A cross-sectional study was performed in a community of Nanjing, China. The population data on sociodemographics, physical examinations, and biochemical tests were collected from July to September 2018. The associations of SUA and FLI with NAFLD were analyzed using linear correlation, multiple linear regressions, binary logistic analyses, and area under receiver-operating characteristic curve (AUROC). Results: A total of 3,499 people were included in this study, of which 36.9% had NAFLD. The prevalence of NAFLD increased with the increase of SUA levels (all P <.05). Logistic regression analyses revealed that SUA was significantly associated with an increased risk of NAFLD (all P <.001). The NAFLD predictive value after combining SUA with FLI was superior to FLI, especially in females (AUROCSUA + FLI = 0.911 vs. AUROCFLI = 0.903, P <.05). The reclassification of NAFLD also significantly improved, based on net reclassification improvement (0.053, 95% confidence interval [CI]: 0.022--0.085, P <.001) and integrated discrimination improvement (0.096, 95% CI: 0.090--0.102, P <.001). A regression formula of this combined algorithm was proposed as: The novel formula = 0.032* waist circumference + 0.303* body mass index + 1.301* natural logarithm of triglyceride + 0.478* natural logarithm of glutamyl transpeptidase + 0.002* SUA- 18.823. At the cutoff value of 13.3, the sensitivity and specificity of this model were 89.2% and 78.4%, respectively. Conclusions: SUA level was positively associated with NAFLD prevalence. A new formula combining SUA with FLI may serve as a better indicator to predict NAFLD compared to FLI, especially in females. [ABSTRACT FROM AUTHOR]

A large number of mines are closed or abandoned every year in China. Geothermal utilization is one of the important ways to efficiently reuse underground resources in abandoned mines. How to calculate the volume and distribution of underground water storage space is the key to accurately evaluate the sustainable geothermal production in abandoned mines. In this paper, according to the multi-scale characteristics of the underground space in abandoned mine, the flow and heat transfer equations in the multi-scale space are sorted out systematically, and the calculation methods of different secondary space volumes are derived in detail. Taking Jiahe abandoned mine as the background, the volume and distribution of underground secondary space are calculated, and three heat storage evaluation models considering different water storage spaces are established by using COMSOL. The simulation results show that there are great differences among different models, and the results of the equivalent porous media model considering the multi-scale space are most consistent with the reality. Sensitivity analyses of key parameters model results indicated that the heat production is closely related to not only the recharge flow rate but also the recharge temperature and operating time. Furthermore, the energy saving and emission reduction benefits of geothermal utilization in abandoned mines are calculated, the results show that geothermal utilization of abandoned mines can effectively reduce energy consumption and CO2 emissions, and it has great economic benefits. [ABSTRACT FROM AUTHOR]

Corona virus disease 2019 (COVID-19) infection has become a major public health issue affecting human health. The main goal of epidemic prevention and control at the current stage in China is to "protect people's health and prevent severe cases". Patients with lung cancer who receive antitumor therapy have low immunity, and the risk of severe illness and death once infected is much higher than healthy people, so they are vulnerable to COVID-19 infection. At present, less attention has been paid to the prevention and treatment of COVID-19 infection in patients with lung cancer in domestic guidelines and consensus. Based on the published data in China and abroad, we proposed recommendations and formed expert consensus on the vaccination of COVID-19, the use of neutralizing antibodies and small molecule antiviral drugs for patients with lung cancer, for physician's reference. [ABSTRACT FROM AUTHOR]

A rapid identification method for flue-cured tobacco quality was proposed based on Raman spectroscopy. Considering the critical quality factors of flue-cured tobacco-like oil content, softness, and glossiness, four statistical methods, random forest, K-nearest neighbor, logistic regression, and partial least squares, can effectively improve the accuracy of quality identification. We randomly collected 149 flue-cured tobacco samples from multiple producing areas in China. After Raman spectroscopy analysis, Savitzky–Golay convolution smoothing and multi-scatter correction were done. The functional groups were analyzed to select characteristic peaks as features for discriminant analysis. The results show that the Raman spectroscopic information can distinguish the quality of flue-cured tobacco with an accuracy greater than 95%, whereas the partial least-squares approach delivers an accuracy of 100%. We conclude that Raman spectroscopy can be considered a vital avenue for identifying the quality of flue-cured tobacco. [ABSTRACT FROM AUTHOR]

Background: Tuberculosis (TB) is a serious public health problem to human health, but the pathogenesis of TB remains elusive. Methods: To identify novel candidate genes associated with TB susceptibility, we performed a population-based case control study to genotype 41SNPs spanning 21 genes in 435 pulmonary TB patients and 375 health donors from China. Results: We found Notch4 gene rs206018 and rs422951 polymorphisms were associated with susceptibility to pulmonary tuberculosis. The association was validated in another independent cohort including 790 TB patients and 1,190 healthy controls. Moreover, we identified that the rs206018 C allele was associated with higher level of Notch4 in PBMCs from pulmonary TB patients. Furthermore, Notch4 expression increased in TB patients and higher Notch4 expression correlated with the severer pulmonary TB. Finally, we explored the origin and signaling pathways involved in the regulation of Notch4 expression in response to Mycobacterium tuberculosis (Mtb) infection. We determine that Mtb induced Notch4 and its ligand Jagged1expression in macrophages, and Notch4 through TLR2/P38 signaling pathway and Jagged1 through TLR2/ERK signaling pathway. Conclusion: Our work further strengthens that Notch4 underlay an increased risk of TB in humans and is involved in the occurrence and development of TB, which could serve as a novel target for the host-targeted therapy of TB. [ABSTRACT FROM AUTHOR]

Background: For multiple myeloma (MM), the proportions of patients reaching the subsequent line of therapy (LOT) decline gradually and real-world data describing the attrition rates of LOT in Chinese MM were limited. Herein, we investigated the attrition rates by subsequent LOTs and their relevant risk factors in MM patients in China. Methods: MM patients who had been hospitalized and received at least one LOT from January 2008 to August 2019 in West China Hospital Sichuan University were retrospectively recruited. Demographic and clinical characteristic data were obtained from the "HemaTank" Chinese Multiple Myeloma Database. The Cox proportional hazards regression model was applied to analyze the risk factors of frontline treatment attrition. Results: A total of 1,255 newly diagnosedMMwere enrolled, with 573 (45.7%) patients receiving only one LOT and 682 (54.3%) patients receiving more than one LOT. Thalidomide with dexamethasone/prednisone was the most common frontline treatment before 2017, while bortezomib-based regimens constituted the majority of frontline treatment in 2017 and beyond. The attrition rates from the first to the fifth LOT exhibited a gradual upward trend (45.7%, 48.7%, 58.9% and 62.5%, respectively). Meanwhile, 54.3%, 27.9%, 11.5%, and 4.3% of all the enrolled MM patients received a second, third, fourth and fifth LOT. MM who underwent autologous stem cell transplantation (ASCT) showed lower attrition rates across all LOTs (range 12%-56.8%) than MM without ASCT (range 49.1%-64.5%). The multivariate Cox regression model revealed that ISS stage III (HR 2.07, p < .001), elevated LDH (HR 1.47, p = .006), and comorbidities such as amyloidosis (HR 1.63, p = 0 .01), hepatic disease (HR 1.36, p = .022), pulmonary disease (HR 1.38, p = .022), and cardiac disease (HR 1.62, p = .004) were independent risk factors for MM patients attritted from the frontline treatment. Conclusion: In this study, the attrition rates were generally high and increased gradually across all LOTs. Nearly half of MM patients received only one LOT, and higher tumor burden and more comorbidities may be associated with fewer subsequent LOTs. The high attrition rates highlight the importance of applying the most optimal frontline treatment regimen rather than salvaging subsequent LOTs. [ABSTRACT FROM AUTHOR]

Medical research is important to scientific progress and medical education. Institutions worldwide have sought to increase student involvement in research such as clinician–scientists training programs, while little is known about how medical undergraduates perceive research. A cross‐sectional study was conducted in Chongqing Medical University, Chongqing, China, with first–fourth year undergraduates. An online, anonymous, and self‐rating 5‐point Likert questionnaire was conducted to investigate medical undergraduates' demographic characteristics and assess motivation, self‐efficacy, perception, curiosity, and barriers regarding medical research. Content validity was checked with experts and face validity was checked for clarity and understanding of the questionnaire. The Cronbach's alpha coefficient of the questions ranged from 0.813 to 0.879. A total of 3273 medical undergraduates were surveyed, and 86.62% (2835) participants (male 962, female 1873) were identified as effective. Males scored higher than females on self‐efficacy (p < 0.001), perception (p = 0.017), and curiosity (p < 0.001), and lower on barriers (p < 0.001). The second year students are at the peak of their perception (p = 0.006) and lowest barrier scores (p = 0.003). Students with scientific research experience scored higher in motivation (p = 0.002), self‐efficacy (p < 0.001), perception (p < 0.001), and curiosity (p < 0.001). Lack of proper mentoring opportunity (86.2%) and knowledge (84.5%) were the main barriers in conducting research. Even though they have a positive perspective, only a few undergraduates enrolled in research. Medical universities should encourage faculties to supervise and guide undergraduates' projects, and provide feasible solutions for students to learn scientific knowledge and skills. It is vital to build a research‐oriented environment and academic atmosphere. [ABSTRACT FROM AUTHOR]

Ice storms, as important sources of frequent and injurious disturbances, drive forest dynamics in the Northern Hemisphere. However, stand-level differential vulnerability to ice storms and the associated factors that predispose forest stands remain unclear. This is particularly concerning in the subtropics where the frequency of ice storms is predicted to increase with global warming. Here we assessed how the impact on three forest stands (early and late secondary-growth forests, and old-growth forests) differed after an extreme ice storm during 20-21 March 2022, and identified the abiotic and biotic factors that determine the damage intensity in the Shennongjia World Natural Heritage Site, a biodiversity conservation hotspot in central China. We found a stand-specific 'middomain effect' where the late secondary-growth forest sustained the most severe damage, the early secondarygrowth forest sustained the least, and the old-growth forest suffered an intermediate amount. 'Crown broken' was the most severe damage type across all three forest stands, although the proportion of 'branch broken' was also high in the old-growth forest. Topography played a significant role in determining the vulnerability of the early secondary-growth forest to severe ice storms whereas the forest structure and composition were important factors in explaining the damage rates in the old-growth forest, although they differed among the damage categories. In contrast, topography, forest structure and composition generally explain the intensity of damage in the late secondary-growth forests. Our results highlight that, in subtropical forests, the intensity of damage caused by severe ice storms and related determining factors are stand-level dependent. We also suggest exploring potential management strategies (e.g., slow-growing hardwood species that can resist storms should be the main species for reforestation in early secondary-growth forests) to mitigate the risk of future severe ice storms, as well as other wind-related climatic extremes. [ABSTRACT FROM AUTHOR]

The concentration of heavy metals (HMs) in soil-plant systems was an important indicator of soil heavy metal pollution, and the migration and transportation abilities of HMs from soil to plants were of great significance for evaluating food safety and reducing health risks. This study was conducted to investigate the contamination and translocation of HMs in the soil-Paeonia lactiflora system in Bozhou, Anhui Province, China. The soil pollution was assessed by calculating the Geoaccumulation index (Igeo), Potential ecological risk index (RI), and Pollution load index (PLI). The transfer ability of HMs was evaluated by using the bioconcentration factor (BCF) and translocation factor (TF). The results showed that Fe, Mn, Cr, and As were the priority pollutants in soil. Paeonia lactiflora presented high potential to translocate Zn, Cu, and Fe from soil to roots, and had strong ability to translocate HMs except for Cd from roots to stems and leaves [ABSTRACT FROM AUTHOR]

Background Suboptimal health status (SHS) is a non-clinical or pre-disease state between optimal/ideal health and disease. While its etiology remains unclear, lifestyle is considered one of the most important risk factors. We aimed to examine the effects of lifestyles on SHS through a nationwide survey in China. Methods We conducted a cross-sectional survey in 148 cities across China between 20 June and 31 August 2022, on 30505 participants from rural and urban communities gathered through stratified quota sampling. We measured SHS with the Short-Form Suboptimal Health Status Questionnaire (SHSQ-SF). We gathered information on participants' lifestyles (ie, smoking, alcohol consumption, breakfast habits, weekly food delivery frequency, intermittent fasting, sleep duration and physical activities) through face-to-face interview. We determined the relationship between lifestyle and SHS logistic regression analysis by based on odds ratios (ORs) and 95% confidence intervals (CIs). Results We included 22897 participants (female: 13056, male: 9841), 12 108 (52.88%) of whom reported exposure to SHS. After adjusting for demographic characteristics, individuals who currently smoked (OR = 1.165; 95% CI = 1.058-1.283) and those who drank alcohol (OR = 1.483; 95% CI = 1.377.1.596) were at a higher risk of SHS than those who have never done either. In a dose-response way, takeaway food consumption was associated with a higher risk of SHS, while increased frequency of breakfast and mild-intensity exercise conversely reduced said risk. Individuals with shorter sleep duration had a higher risk of SHS when compared to those who slept for more than seven hours per day. Conclusions We observed a relatively high prevalence of SHS across China, highlighting the importance of lifestyle in health promotion. Specifically, adopting healthy dietary habits, engaging in regular physical activity, and ensuring high-quality sleep are key in preventing SHS. [ABSTRACT FROM AUTHOR]

Ginseng (Panax ginseng C.A.Mey.) is the dry root and rhizome of the Araliaceae ginseng plant. It has always been used as a tonic in China for strengthening the body. Cardiovascular disease is still the main cause of death in the world. Some studies have shown that the functional components of ginseng can regulate the pathological process of various cardiovascular diseases through different mechanisms, and its formulation also plays an irreplaceable role in the clinical treatment of cardiovascular diseases. Therefore, this paper elaborates the current pharmacological effects of ginseng functional components in treating cardiovascular diseases, summarizes the adverse reactions of ginseng, and sorts out the Chinese patent medicines containing ginseng formula which can treat cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Improvements of the happiness of the rural population are an essential sign of the effectiveness of relative poverty governance. In the context of today's digital economy, assessing the relationship between digital literacy and the subjective happiness of rural low-income groups is of great practicality. Based on data from China Family Panel Studies, the effect of digital literacy on the subjective well-being of rural low-income groups was empirically tested. A significant happiness effect of digital literacy on rural low-income groups was found. Digital literacy promotes the subjective happiness of rural low-income groups through income increase and consumption growth effects. The observed happiness effect is heterogeneous among different characteristic groups, and digital literacy significantly positively impacts the subjective happiness of rural low-income groups. Decomposition of subjective happiness into life satisfaction and job satisfaction shows that digital literacy significantly positively affects the job and life satisfaction of rural low-income groups. This paper demonstrates that digital literacy induces a practical happiness effect. To further strengthen the subjective welfare effect of digital literacy in the construction of digital villages, the government should focus on cultivating digital literacy among low-income groups from the demand side. The construction of digital infrastructure should be actively promoted from the supply side. [ABSTRACT FROM AUTHOR]

The COVID-19 has seriously impacted various aspects of the society on a global scale. However, it is still unclear how perceived risk influences epidemic information-avoidance behavior which generally helps us understand public information avoidance. This study aimed to assess the relationship between the perceived epidemic risk and information-avoidance behavior and the mediating role of fear and powerlessness during the COVID-19 pandemic in China. A total of 557 Chinese respondents with COVID-19 treated in modular hospitals ranging from 16 to 72 years old were recruited and completed questionnaires in the face-to-face manner containing scales of the perceived epidemic risk of COVID-19, fear, powerlessness, and information-avoidance behavior. To test the conceptual model, we adopted structural equation modeling (SEM) with the perceived risk of the COVID-19 pandemic as a predictor, fear and powerlessness as mediating variables, and informationavoidance behavior as the outcome. The results indicated a significant and positive association between the perceived epidemic risk of COVID-19 and information-avoidance behavior. Powerlessness acted as the mediator between the perceived epidemic risk of COVID-19 and information-avoidance behavior. The perceived epidemic risk of COVID-19 influenced informationavoidance behavior through fear and powerlessness in turn. Findings from this study implied that public health managers should consider the mediating roles of negative emotions such as fear and powerlessness for coping with behaviors in public health emergencies, especially the information avoidance behaviors related to risk perception. [ABSTRACT FROM AUTHOR]

Given the influence of controlling shareholders on the company, it is important to analyze how independent directors can protect minority shareholders' interests using the information and resources obtained from social networks. This paper studies the impact of director networks on controlling shareholders' tunneling behavior in China over the period 2002-2020. Using social network analysis, this paper finds that controlling shareholders' appropriation to minority shareholders is mitigated in companies with wellconnected independent directors. These results remain consistent after a series of robustness and endogeneity tests. This study also reveals that internal controls play a mediating role between director networks and tunneling behavior. In addition, the study indicates that the restraining effect of director networks on controlling shareholders' tunneling behavior is more pronounced in companies with weaker audit monitoring and poorer transparency. In conclusion, the results reveal that well-connected independent directors play an important role in protecting minority shareholders' interests. [ABSTRACT FROM AUTHOR]

Confucian doctors are representative of traditional Chinese medicine (TCM) practitioners with excellent moral character and medical knowledge, they are not hidden in the depths of ancient documents but are a guiding inspiration for professional medical personnel today. Confucian doctors are representative group of benevolence in Confucian philosophy and demonstrate the scientific and humanistic spirit of Confucian philosophy and demonstrate the scientific and humanistic spirit of Confucianism in their medical practice. They are also leading medical practitioners who uphold professional ethics in their pursuits of scientific research, clinical diagnosis & treatment, and scholarship. Both TCM and Confucian doctors played important roles during the outbreak of the coronavirus disease 2019 (COVID-19) pandemic in China. By virtue of the superb medical skills of Confucian doctors, integrated Chinese and Western medicine can quickly alleviate patients' symptoms, increase cure rates, reduce mortality rates, thus saving lives. Following the results of extensive clinical trials, this integrated therapy is now understood to be a beneficial treatment for COVID-19. The combination of TCM and Western medicine is a major feature of COVID-19 prevention and control in China. In particular, TCM plays a significant role in the fight against the COVID-19 pandemic with its unique advantages. [ABSTRACT FROM AUTHOR]

The holistic characterization and quality control of all the medicinal herbs of proprietary Chinese medicines (PCMs) are of great significance to ensure their safety, efficacy, and consistency. Thin-layer chromatography (TLC), a simple and classic approach for qualitatively characterizing and examining quality markers of natural products, has been widely used in the characterization and quality control of traditional Chinese medicines. Zaoren Anshen (ZRAS) capsule, prepared from three medicinal herbs of fried Ziziphi Spinosae Semen, Salvia Miltiorrhiza Radix et Rhizoma, and vinegar-processed Schisandrae Chinensis Fructus, is a famous PCM in China for the treatment of insomnia, amnesia, and dizziness in clinical practice. However, no effective method is available so far for simultaneous identification and examination of all the three medicinal herbs of ZRAS capsule. In the present study, we developed a TLC method via twice-development and visualization by UV light or chromogenic agent, which could be used for simultaneous qualitative identification of all the three medicinal herbs of ZRAS capsule in one plate. Moreover, the sample preparation method was optimized. The developed TLC method was rapid, simple, low-cost, and effective, and thus it could be used for quality control of ZRAS capsule. [ABSTRACT FROM AUTHOR]

Based on the principle of bionics, this paper combines the design of flexible bionic antenna with Chinese culture and proposes a dual-material bionic antenna with Electromagnetic Band Gap (EBG) structure. The antenna uses a polyimide flexible substrate. Radiation patch of this antenna is shaped like a \pear flower", and the \CHINA" shaped slot is etched on the ground to form a Logo mark. In order to reduce the impact of antenna radiation on human body, the introduction of an EBG structure made of Polydimethylsiloxane (PDMS) material makes the front-to-back ratio of the antenna radiation significantly increased. The antenna was bent in different ways and placed on human body model for simulation and testing. The results showed that the antenna achieved an impedance bandwidth of 18.8% (2.22{2.46 GHz), peak gain of 4.02 dBi, and the antenna was low sensitive to deformation, which makes it suitable for modern flexible electronic equipment. From the perspective of bionics, the antenna has good radiation and wearable type, and the beautiful pattern improves the viewing ability of the antenna and people's willingness to wear the wearable antenna, which provides a new design idea for the future design of wearable devices. [ABSTRACT FROM AUTHOR]

OBJECTIVE To explore the relationship between Lactobacillus and prognosis of acute myocardial infarction (AMI) patients treated by percutaneous coronary intervention (PCI) and its correlation with clinical parameters. METHODS Consecutive patients with AMI in the coronary care unit of Tianjin Chest Hospital in China who received emergency PCI between July 2017 and December 2018 were enrolled. Subjects' fecal 16S rDNA gene sequencing data were analyzed and subjects were categorized into low, medium and high level groups according to stool Lactobacillus measurements. The primary endpoints were major adverse cardiac events. Cox regression analysis was used to analyze the relationship between Lactobacillus and prognosis. Spearman correlation analysis and trend tests were used to assess the relationship between Lactobacillus and the clinical indicators. RESULTS The data of 254 patients were included in the analysis. Mean age was 65.90 ± 11.56 years, and 152 patients (59.84%) were male. Follow-up time was 652 (548.25-753.00) days. Multivariate Cox regression analysis showed a significantly lower risk of major adverse cardiac events in patients with Lactobacillus > 7.1 copies/g [adjusted hazard ratio (HR) = 0.216, 95% CI: 0.094-0.493, P < 0.001] compared to patients with Lactobacillus = 3.6 copies/g. Statistically significant differences were shown in ST-segment elevation myocardial infarction (STEMI) (HR = 0.217, 95% CI: 0.085-0.551, P = 0.001). Lactobacillus was a protective factor for male smokers aged over 60 years whose brain natriuretic peptide was over 1,000 pg/mL. Spearman correlation analysis showed that Lactobacillus correlated negatively with white blood cells, neutrophils, high-sensitivity C-reactive protein, TroponinT, creatine kinase, creatine kinase-MB and brain natriuretic peptide (downward trend), and correlated positively with left ventricular ejection fraction (upward trend). CONCLUSIONS This study is the first to reveal the correlation between Lactobacillus and inflammation and myocardial damage after STEMI. STEMI patients, especially male smokers aged over 60 years with severe impairment of cardiac function, have better outcomes with high levels of Lactobacillus, suggesting new therapeutic strategies for improving the prognosis and quality of life of AMI patients. [ABSTRACT FROM AUTHOR]

Background: Shuxuan cattle is a crossed cattle breed in southwest of China, by crossing the indigenous Bashan cattle with two exotic breeds. The objective of this study was to estimate allele frequencies of the g.88925365A>C in TYW5 gene in Shuxuan cattle and to evaluate association between this polymorphism and meat quality traits. Methods: The SNP g.88925365A>C was genotyped in 151 Shuxuan cattle and subjected to association analysis with the 17 amino acid content and total amino acid. Result: The AC was the main genotype with 41.06% and C was the predominant allele with 50.99% at this locus. The allele diversity based on the He (0.4998), Ne (1.9992) and PIC (0.3749) revealed moderate genetic variation within Shuxuan cattle population. Significant association (P<0.05) was observed between the polymorphism and six amino acid content (Glu, Asp, Val, Ile, Ser and Cys). These results provided a potential genetic marker for the genetic improvement of meat quality in Shuxuan cattle. [ABSTRACT FROM AUTHOR]

We evaluated 24-h control forecast products from The International GrandGlobal Ensemble center over the 10 first-class water resource regions of Mainland China in 2013-18 from the perspective of precipitation processes (continuous) and precipitation events (discrete). We evaluated the forecasts from the China Meteorological Administration (CMA), the Centro de Previsão de Tempo e Estudos Climáticos (CPTEC), the Canadian Meteorological Centre (CMC), the European Centre for Medium-Range Weather Forecasts (ECMWF), the Japan Meteorological Agency (JMA), the Korea Meteorological Administration (KMA), the United Kingdom Met Office (UKMO), and the National Centers for Environmental Prediction (NCEP). We analyzed the differences among the numerical weather prediction (NWP) models in predicting various types of precipitation events and showed the spatial variations in the quantitative precipitation forecast efficiency of the NWP models over Mainland China. Meanwhile, we also combined four hydrological models to conductmeteo-hydrological runoff forecasting in three typical basins and used the Bayesian model averaging (BMA) method to perform the ensemble forecast of different scenarios. Our results showed that the models generally underestimate and overestimate precipitation in northwestern China and southwestern China, respectively. This tendency became increasingly clear as the lead time rose. Each model has a high reliability for the forecast of no-rain and light rain in the next 10 days, whereas the NWP model only has high reliability on the next day for moderate and heavy rain events. In general, each model showed different capabilities of capturing various precipitation events. For example, the CMA and CMC forecasts had a better prediction performance for heavy rain but greater errors for other events. The CPTEC forecast performed well for long lead times for no-rain and light rain but had poor predictability for moderate and heavy rains. The KMA, UKMO, and NCEP forecasts performed better for no-rain and light rain. However, their forecasting ability was average formoderate and heavy rain. Although the JMA model performed better in terms of errors and accuracy, it seriously underestimated heavy rain events. The extreme rainstorm and flood forecast results of the coupled JMA model should be treated with caution. Overall, the ECMWF had the most robust performance. Discrepancies in the forecasting effects of various models on different precipitation events vary with the lead time and region. When coupled with hydrological models, NWP models not only control the accuracy of runoff prediction directly but also increase the difference among the prediction results of different hydrological models with the increase in NWP error significantly. Among all the single models, ECMWF, JMA, and NCEP have better effects than the other models. Moreover, the ensemble forecast based onBMA is more robust than the single model, which can improve the quality of runoff prediction in terms of accuracy and reliability. [ABSTRACT FROM AUTHOR]

Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer. The systemic antitumor therapy of advanced NSCLC has undergone renovations of chemotherapy, targeted therapy and immunotherapy, which results in greatly improved survival for patients with advanced NSCLC. Immune checkpoint inhibitors (ICIs), especially targeting programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1), has changed the treatment paradigm of NSCLC. ICIs have become the standard treatment for advanced NSCLC without epidermal growth factor receptor(EGFR) mutation or anaplastic lymphomakinase(ALK) translocation in the first- or second-line setting, and for locally advanced NSCLC following concurrent radiotherapy and chemotherapy. ICIs are also promising in adjuvant/neoadjuvant therapy. More and more ICIs have been approved domestically for the treatment of NSCLC. Led by the NSCLC expert committee of Chinese Society of Clinical Oncology (CSCO), this consensus was developed and updated based on thoroughly reviewing domestic and foreign literatures, clinical trial data, systematic reviews, experts' discussion and the consensus(2019 version). This consensus will aid domestic clinicians in the treatment of NSCLC with ICIs. [ABSTRACT FROM AUTHOR]

Artificial adjustment and urbanization are key factors of global change and have significant influences on hydrological processes. This study focuses on the effects of urban land-use patterns on flood regimes in a typical urbanized basin in eastern China. Comprehensive assessments of urban land-use patterns were implemented on three levels: total imperviousness area (TIA) magnitude, landscape configuration and relative location in the basin. Hydrologic Engineering Center's Modeling System (HEC-HMS) was calibrated and validated using four groups of parameters associated with land-use conditions. Fourteen flood events were simulated based on 10 land-use scenarios with different land-use patterns. The results indicate that floods are closely associated with three landscape pattern indicators. First, over the past 20 years, the impermeability rate has increased from 3.92 to 17.48%, with the landscape pattern converted from extension growth form to fill-up growth form after 2003. Second, the average flood peak discharge increased by 80% due to impermeable surfaces expansion, with minor floods more sensitive to the expansion than major floods. Third, the contribution of imperviousness expansion to peak discharge in the inner basin is more remarkable than downstream of the river basin, with the landscape pattern metrics of TIA, arable land and forest land displaying strong correlations with flood characteristics. [ABSTRACT FROM AUTHOR]

Lung cancer has the highest incidence and mortality rates of all cancers in China. Immune-related genes and immune infiltrating lymphocytes are involved in tumor growth, and in the past decade, immunotherapy has become increasingly important in the treatment of lung cancer. Using the edgeR package, differentially expressed genes and immune-related genes (DEIRGs) were identified in patients with lung adenocarcinoma (LUAD). Functional enrichment analysis of DEIRGs was performed using Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Survival-associated immune-related genes (IRGs) were selected using univariate Cox regression analysis and the prognostic model was assessed using multivariate Cox regression analysis. Overall, 273 DEIRGs were identified in LUAD, and KEGG pathway analysis of IRGs showed that 'cytokine-cytokine receptor interaction' was the most significantly enriched pathway. Furthermore, six survival associated IRGs were screened to establish a prognostic model; patients in the high risk score group had less favorable survival times, and the prognostic model was negatively associated with B cell infiltration. The present study established a prognostic model using analysis of survival-related immune-related genes, which were associated with B cell infiltration. [ABSTRACT FROM AUTHOR]

Zinc (Zn) deficiency is common worldwide and is a major limiting factor in the cultivation of Platycodon grandiflorum because most P. grandiflorum is cultivated on soils with slight or severe levels of Zn deficiency in China. To investigate the effects of soil Zn fertilization on P. grandiflorum and its residual effects on soil characteristics, a randomized complete block design was conducted at the experimental station of Shandong Agricultural University China in 2016–2018. In 2016, ZnSO4 · 7H2O was used as Zn fertilizer. The fertilizer levels of Zn fertilizer were designed as 0, 4, 6, 8 and 10 kg ha−1 and were denoted as CK, Zn4, Zn6, Zn8 and Zn10. No Zn fertilizer was used in 2017 and 2018. The results showed that soil Zn fertilization increased the quantity of soil bacteria, and actinobacteria, Zn8 and Zn10 treatments increased the soil fungal quantity in 2017, whereas the effect was observed only in the Z10 treatment in 2018. Soil Zn fertilization enhanced the activity of polyphenol oxidase, decreased that of phosphatase, and did not influence the invertase activity in both 2017 and 2018. Both the yield and the quality of P. grandiflorum in the succeeding three years increased due to the soil Zn fertilization in 2016. Overall, soil Zn application is a suitable approach to the cultivation of P. grandiflorum, and the residual effects of a one-time soil Zn fertilization could last at least two years. [ABSTRACT FROM AUTHOR]

Non-small cell lung cancer (NSCLC) is the most common pathological type of lung cancer, most NSCLC patients are at advanced stage at the time of diagnosis. For patients without sensitive driven-oncogene mutations, chemotherapy is still the main treatment at present, the overall prognosis is poor. Improving outcomes and obtaining longterm survival are the most urgent needs of patients with advanced NSCLC. In recent years, immunotherapy has developed rapidly. Immune checkpoint inhibitors (ICIs), especially targeting programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1), have made a breakthrough in the treatment of NSCLC, beneficial to patients' survival and changed the treatment pattern for NSCLC. It shows more and more important role in the treatment of NSCLC. Led by NSCLC expert committee of Chinese society of clinical oncology (CSCO), relevant experts in this field were organized. On the basis of referring to domestic and foreign literature, systematically evaluating the results of Chinese and foreign clinical trials, and combining the experiences of the experts, the experts group reached an agreement to develop this consensus. It will guide domestic counterparts for better application of ICIs to treat NSCLC. [ABSTRACT FROM AUTHOR]

Purpose: The study aims to investigate, using anodal transcranial direct current stimulation (A-tDCS), over which site, the left lip region of primary motor cortex (M1) or the Broca's area, there would be better recovery from apraxia of speech (AoS) in patients with poststroke aphasia and to examine for altered activation in speech-related areas after tDCS with nonlinear electroencephalography (EEG). Method: Fifty-two patients with AoS were randomized into A-tDCS over the left M1 (A-tDCS-M1), Broca's area, and sham tDCS groups who underwent 10 sessions of tDCS and speech treatment for 5 days. The EEG nonlinear index of approximate entropy was calculated for 6 subjects in each group before and after treatment. Results: After treatment, the change in speech-language performance improved more significantly in the A-tDCS-M1 group than the other 2 groups (p < .05). EEG approximate entropy indicated that both A-tDCS groups could activate the stimulated sites; the improvement in the A-tDCS-M1 group was correlated with high activation in the dorsal lateral prefrontal cortex and Broca's areas of the left hemisphere in addition to the stimulated site. Conclusion: A-tDCS over the left M1 can improve the speech function in patients with poststroke aphasia and severe AoS and excite and recruit more areas in the motor speech network. [ABSTRACT FROM AUTHOR]

Liver cancer is a common malignant tumor, which is one of the most common causes of cancer related deaths worldwide, specially, in China. Piper longum Linn. is a traditional Chinese medicine that is used to treat and prevent diseases in clinical practice, however, the active ingredients and potential targets of its action against liver cancer remain unclear. In this study, network pharmacology approach was used to identify active ingredients and the major targets of Piper longum against liver cancer. In addition, the key pathways were also predicted on the network pharmacology level, which might be beneficial to the chemical basis and pharmacological studies of this plant. [ABSTRACT FROM AUTHOR]

Background. Pregnancy with an adnexal mass is one of the most common complications during pregnancy and clinicians are sometimes caught in a dilemma concerning the decision to be made regarding clinical management. Objectives. The objective of this study was to outline and discuss the clinical features, management and outcomes of adnexal masses that were encountered during a cesarean section (CS) at a university-affiliated hospital in China. Material and methods. The medical records of the patients with an adnexal mass observed during a CS were retrospectively collected at Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China, from January 1991 to December 2011. Results. The incidence of adnexal masses was 16.40 per 1000 CSs. The most common pathologic diagnosis was benign ovarian tumor, the 2nd was ovarian endometrioma and the 3rd was theca lutein cyst. Thirteen cases of ovarian malignancies were diagnosed during a CS. Only 388 cases (29.78%) were detected using an ultrasonography (USG) examination before a CS. Eight cases required emergency CS due to abdominal pain; all other patients were clinically asymptomatic. The reasons for abdominal pain included torsion (n = 5), rupture (n = 2) and ovarian enlargement (n = 1). In 13 cases with ovarian endometrioma, cysts ruptured during a CS without any clinical manifestation. No maternal and fetal complications related to surgery were observed. Conclusions. Preconception care and routine prenatal care, including USG examination, may optimize the detection and management of an adnexal mass. The presumptive ovarian endometrioma detected before pregnancy could be the indication for surgery due to the possibility of spontaneous hemoperitoneum. Theca lutein cysts might be huge and exist throughout the whole pregnancy period. Expectant management is reasonable for an adnexal mass that emerged during pregnancy without suspicion of malignancy. Abdominal pain might be a clue for cyst torsion or rupture. [ABSTRACT FROM AUTHOR]

Land cover (LC) is an important terrestrial variable and key information for understanding the interaction between human activities and global change. As the cause and result of global environmental change, land cover change (LCC) influences the global energy balance and biogeochemical cycles. Continuous and dynamic monitoring of global LC is urgently needed. Effective monitoring and comprehensive analysis of LCC at the global scale is rare. Using the latest version of GLASS (The Global Land Surface Satellite) CDRs (Climate Data Records) from 1982 to 2015, we built the first set of CDRs to record the annual dynamics of global land cover (GLASS-GLC) at 5 km resolution using the Google Earth Engine (GEE) platform. Compared to earlier global LC products, GLASS-GLC is characterized by high consistency, more detailed classes, and longer temporal coverage. The average overall accuracy is 85 %. We implemented a systematic uncertainty analysis at the global scale. In addition, we carried out a comprehensive spatiotemporal pattern analysis. Significant changes and patterns at various scales were found, including deforestation and agricultural land expansion in the tropics, afforestation and forest expansion in northern high latitudes, land degradation in Asian grassland and reclamation in northeast China, etc. A global quantitative analysis of human factors showed that the average human impact level in areas with significant LCC was about 25.49 %. The anthropogenic influence has a strong correlation with the noticeable Earth greening. Based on GLASS-GLC, we can conduct long-term LCC analysis, improve our understanding of global environmental change, and mitigate its negative impact. GLASS-GLC will be further applied in Earth system modeling in order to facilitate research on global carbon and water cycling, vegetation dynamics and climate change. The data set presented in this article is published in the Tagged Image File Format (TIFF) at https://doi.org/10.1594/PANGAEA.898096. The data set includes 34 TIFF files and one instruction doc file. [ABSTRACT FROM AUTHOR]

The purpose of this study was to determine whether limited occurrence data for highly threatened species can provide useful spatial information to inform conservation. The study was conducted across central and southern China. We developed a habitat suitability model for the Critically Endangered Chinese giant salamander (Andrias davidianus) based on one biotic and three abiotic parameters from single-site locality records, which represent the only relevant environmental data available for this species. We then validated model quality by testing whether increased percentage of predicted suitable habitat at the county level correlated with independent data on giant salamander presence. We randomly selected 48 counties containing historical records which were distinct from, and independent of, the single-site records used to develop the model, and 47 additional counties containing >50% predicted suitable habitat. We interviewed 2,812 respondents near potential giant salamander habitat across these counties and tested for differences in respondent giant salamander reports between counties selected using each method. Our model predicts that suitable giant salamander habitat is found widely across central and southern China, with counties containing =50% predicted suitable habitat distributed in 13 provinces. Counties with historical records contain significantly more predicted suitable habitat than counties without historical records. There are no statistical differences in any patterns of respondent giant salamander reports in surveyed counties selected from our model compared with the areas of known historical giant salamander distribution. A Chinese giant salamander habitat suitability model with strong predictive power can be derived from the restricted range of environmental variables associated with limited available presence-only occurrence records, constituting a cost-effective strategy to guide spatial allocation of conservation planning. Few reported sightings were recent, however, with most being over 20 years old, so that identification of areas of suitable habitat does not necessarily indicate continued survival of the species at these locations. [ABSTRACT FROM AUTHOR]

A new species of the genus Synechococcus C. Nägeli was described from extreme environment (high salinity) of the Yuncheng salt lake, North China. Morphological characteristics observed by light microscopy (LM) and transmission electron microscopy (TEM) were described. DNA barcodes (16S rRNA+ITS-1, cpcBA-IGS) were used to evaluate its taxonomic status. This species was identified as Synechococcus salsus H. Lv et S. Xie. It is characterized by unicellular, without common mucilage, cells with several dispersed or solitary polyhedral bodies, widely coccoid, sometimes curved or sigmoid, rounded at the ends, thylakoids localized along cells walls. Molecular analyses further support its systematic position as an independent branch. The new species Synechococcus salsus is closely allied to S. elongatus, C. Nägeli, but differs from it by having shorter cell with length 1.0-1.5 times of width. [ABSTRACT FROM AUTHOR]

Global climate change is causing widespread glacier retreat, with many small glaciers disappearing from the world's mountain ranges. We obtained the annual mass balance of a small glacier (the Ningchan No.1 Glacier) located on the northeastern Tibetan Plateau, from the years 2010 to 2015 using glaciological and geodetic methods. We also measured the glacier's thickness in 2014 using ground-penetrating radar. Employing topographical maps and ZY-3 images, we obtained Digital Elevation Models for 1972 and 2014. Our results showed that the mean annual mass balance from 2010 to 2015 was~-0.9 ± 0.5 m w.e. The mean equilibrium line altitude was ~4680 m in the period 2010-15, which exceeds the maximum elevation of the glacier. The glacier has lost area and mass across its elevation range. The mean ice thickness was 24.0 ± 2.5 m in 2014. From 1972 to 2014, the glacier's area shrank from 0.77 ± 0.05 to 0.39 ± 0.04 km², and the ice volume decreased by (14.96 ± 0.97) × 106 m³, equivalent to (12.72 ± 0.82) × 106 t w.e. over the same period. [ABSTRACT FROM AUTHOR]

BACKGROUND: Organizational citizenship behavior (OCB) is important to the development of an organization. Research into factors that foster OCB and the underlying processes are therefore substantially crucial. OBJECTIVE: The current study aimed to test the association between trait self-control and OCB and the mediating role of consideration for future consequence. METHOD: Four hundred and ninety-four Chinese employees (275 men, 219 women) took part in the study. Participants completed a battery of self-report measures online that assessed trait self-control, tendencies of consideration of future consequence, and organizational citizenship behavior. Path analysis was conducted and bootstrapping technique (N= 5000), a resampling method that is asymptotically more accurate than the standard intervals using sample variance and assumptions of normality, was used to judge the significance of the mediation. RESULTS: Results of path analysis showed that trait self-control was positively related to OCB. More importantly, the "trait self-control-OCB" link was mediated by consideration of future consequence-future, but not by consideration of future consequence-immediate. CONCLUSIONS: Employees with high trait self-control engage in more organizational citizenship behavior and this link can be partly explained by consideration of future consequence-future. [ABSTRACT FROM AUTHOR]