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Traditional Chinese medicine for smoking cessation: An umbrella review of systematic reviews and meta-analysis of randomized controlled trials.

Authors :
Chun-Li Lu
Xin-Yan Jin
Qian-Yun Wang
Xiao-Ying Chen
Ruo-Xiang Zheng
Chao-Jie Wang
Jing-Jing Jiang
Shu-Yu Qiao
Si-Hong Yang
Wei-Han Zhang
Si-Yi Chen
Jia-Xuan Li
Xue-Han Liu
Yu-Si Suo
Jian-Hua Wang
Xue Xue
Li-Rong Liang
Robinson, Nicola
Jian-Ping Liu
Source :
Tobacco Induced Diseases; Nov2023, Vol. 21, p1-11, 11p
Publication Year :
2023

Abstract

INTRODUCTION Traditional Chinese medicine (TCM) may have special advantages in facilitating smoking cessation, but consensus on effectiveness is lacking. We aim to comprehensively review, update, and refine current evidence on TCM effectiveness and safety. METHODS Nine databases were searched from their inception up to 28 February 2023. Systematic reviews (SRs) and meta-analysis of TCM for smoking cessation were identified and retrieved. Additional databases and hand searches of RCTs from included SRs were performed for data pooling. Cochrane ROB tools and AMSTAR-2 were used to evaluate the methodological quality of RCTs and SRs, respectively. RCT data are presented as relative risks (RR) or mean differences (MD) with 95% confidence intervals (CI) using RevMan 5.4. RESULTS Thirteen SRs involving 265 studies with 33081 participants were included. Among these 265 studies, 157 were duplicates (58.36%) and 52 were non-RCTs (19.62%). Combined with the remaining 56 RCTs identified through hand searches, 88 RCTs involving 12434 participants were finally included for data synthesis. All the SRs focused on acupoint stimulation, and the majority were of low or very low quality. The methodological quality of RCTs was either unclear or high risk. For continuous abstinence rate, TCM external interventions were better than placebo in 6 months to 1 year (RR=1.60; 95% CI: 1.14-2.25; I²=27%; n=5533 participants). Compared with placebo, TCM external application was effective in reducing nicotine withdrawal symptoms, and the effect was gradually stable and obvious in the fourth week (MD= -4.46; 95% CI: -5.43 -- -3.49; n=165 participants). Twelve RCTs reported adverse events as outcome indicators for safety evaluation, and no serious adverse events occurred. CONCLUSIONS Despite the methodological limitations of the original studies, our review suggests that TCM intervention shows potential effectiveness on the continuous abstinence rate. Extending the intervention time can enhance the effect of TCM on nicotine withdrawal symptoms. Referred to adverse events, more data for safety evaluation are required. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20707266
Volume :
21
Database :
Complementary Index
Journal :
Tobacco Induced Diseases
Publication Type :
Academic Journal
Accession number :
174155122
Full Text :
https://doi.org/10.18332/tid/174090