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According to the Social Cognitive Theory and the perspectives of parental differential treatment, the current research proposed and verified a moderated mediation model to explore the mediating role of teacher support and the moderating role of only-child (OC) /non-only-child (NOC) status in the relationship between hardiness and college student learning adaptation. A questionnaire survey of 1138 Chinese college students was conducted using the hardiness scale, the learning adaptation scale, and the student perception of teacher supportive behavior questionnaire. The results revealed a significant positive effect of hardiness on college student learning adaptation. The mediation model analysis showed that teacher support had a complementary partial mediating role in the relationship between hardiness and college students' learning adaptation. Furthermore, the moderated mediation model analysis suggested that OC/NOC status moderated the second half of this mediating relationship and indicated that teacher support had a stronger effect on the learning adaptation of college students with OC status than NOC status. The research results not only enrich our understanding of the internal influence mechanism of the relationship between hardiness and college students' learning adaptation, but also broaden the research on the identity difference between OC/NOC status. Practical discussions and suggestions are proposed based on the results.

In this study, the teacher support scale, the hardiness scale and the learning adaptation scale were used in a kindergarten teacher's college in Changde. A survey was conducted among 1148 college students to analyze the relationship between teacher support, hardiness and learning adaptation, and to explore whether hardiness plays a role in the moderation between teacher support and learning adaptation. The result is that: (1) Teacher support can significantly predict students' learning adaptation; (2) Hardiness can also be significant predication of students' learning adaptation; (3) Hardiness can play a moderator role in teacher support and learning adaptation. I conclude by acknowledging the limitations of this study and recommending further research.

Background. Because of the similarity of intestinal tuberculosis and Crohn's disease in disease phenotype, differential diagnosis has always been a clinical problem. Arachidonic acid metabolites play an important role in the inflammatory response of intestinal tuberculosis and Crohn's disease. Recent studies have shown that the polymorphism locus in the promoter region of LTA4H gene affects LTB4 expression level and the susceptibility to extrapulmonary tuberculosis. Thus, we identified a total of 148 patients with intestinal tuberculosis, 145 with Crohn's disease, and 700 normal controls in this study. Methods. All the study participants were local Han people from Jiangxi Province in the past eleven years. DNA was extracted from the paraffin-embedded specimens or the whole blood. The LTA4H promoter SNP (rs17525495) was genotyped with TaqMan assay. Results. The T-alleles frequency was not significantly increased in patients with intestinal tuberculosis compared with healthy control group (p=0.630; OR=1.07; 95%CI=0.81-1.41), while patients with Crohn's disease have significantly increased T allele frequency compared with healthy population (p=0.032; OR=1.34; 95%CI=1.03-1.75). During treatment, the presence of the T allele significantly increased the proportion of Crohn's patients requiring glucocorticoids (p<0.05). Conclusions. The T allele of LTA4H gene SNP (rs17525495) is a risk factor for Crohn's disease instead of intestinal tuberculosis. More importantly, there may be a potential association of the different genotypes of rs17525495 with the treatment efficacy of 5-ASA and glucocorticoids in patients with Crohn's disease. The association between LTA4H polymorphism and drugs therapeutic effects might contribute to the practice of precision medicine and the prediction of clinical outcomes. [ABSTRACT FROM AUTHOR]

Legionellosis caused by Legionella longbeachae is diagnosed mainly by PCR. We report a case of L. longbeachae infection in mainland China, which was diagnosed by metagenomic next-generation sequencing, in a man who developed an epileptic seizure after using moxifloxacin. Metagenomic next-generation sequencing may be a useful tool to detect Legionella spp.