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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Treatment using oncolytic virus as a new tumor immunologic agent has made continuous breakthroughs in basic and clinical research of tumor in recent years, and it is expected to play an important role in cancer immunotherapy in the future. At present, there are 4 oncolytic viruses approved for marketing in the world, among which recombinant human type-5 adenovirus (H101) is the only oncolytic virus approved in China. To further standardize the clinical research practice of oncolytic virus in tumor and improve the clinical application of cancer immunotherapy, this consensus is established based on the "Shanghai expert consensus on clinical application of oncolytic virus in the treatment of malignant tumors (2021 edition)" and guided by evidencebased methodology, focusing on the application scope of oncolytic virus approved for marketing at home and abroad, and the clinical studies of oncolytic virus with high level of evidence but not approved at present, looking forward to the future research and development trend of oncolytic virus, clarifying the specific use method of oncolytic virus (mainly recombinant oncolytic adenovirus), and exploring the new modes of follow-up, efficacy evaluation and other aspects. On the basis of literature retrieval, quality evaluation and evidence summary were carried out, and specific issues and hot topics such as the application scope, combination with antiviral drugs, gene detection and other common concerns in the clinical application of recombinant oncolytic adenovirus in cancer were discussed and investigated through multidisciplinary expert meetings, Delphi methods and other forms. The "Chinese expert consensus on clinical application of recombinant oncolytic adenovirus in treatment for malignant tumors (2022 edition)" was completed by the investigation and summarization of the opinions of 86 experts from more than 12 different cities and 58 hospitals for 4 times, relying on the Expert Committee on Immunotherapy of China Society of Clinical Oncology and the Professional Committee on Tumor Biotherapy of Shanghai Anti-cancer Association, with a view to providing evidence reference and normative basis for future clinical and basic research exploration of oncolytic viruses, clinical practice of frontline medical personnel in cancer treatment, medical administration management at all levels for tumor immunotherapy, and laying a foundation for subsequent development of relevant industry guidelines. [ABSTRACT FROM AUTHOR]

Sperm morphology analysis has always been the focus and difficulty in the field of reproductive testing, with some problems such as strong subjectivity, difficulty in quality control and poor mutual recognition of the results among laboratories. In order to further standardize the process of sperm morphology analysis and improve the accuracy of analysis results, the Reproductive Testing Branch of China Sexology Association initiated and organized the experts in the field of sperm morphology analysis to jointly discuss and formulate this consensus based on the 5th and 6th editions of WHO Laboratory Manual for the Examination and Processing of Human Semen, in combination with the relevant literature published in recent years and clinical practice of China. This consensus covers the contents, methods and procedures of sperm morphology analysis, criteria for normal and abnormal sperm morphology, specific sperm deformities, evaluation process of sperm morphology, and the quality control, report contents, existing problems and prospects of sperm morphology analysis, and is intended to provide reference for medical personnel engaged in reproductive medicine, andrology and reproductive testing. [ABSTRACT FROM AUTHOR]

Sjögren syndrome, a systemic autoimmune disease that is characterized by dry mouth and eyes, on which treatment decision remain challenging, while traditional Chinese medicine ( TCM) has advantages and is widely used in China. However, the lack of consensus on standardized TCM patterns diagnosis and treatment based on evidence-based evidence, limits the further improvement of clinical efficacy and scientific research level. Rheumatology Branch, Chinese Academy of Chinese Medicine organized more than 50 experts from 48 hospitals across the country to form Expert Consensus for TCM Patterns of Sjögren Syndrome: (ⅰ) pattern of yin deficiency and depletion of fluid; (ⅱ) pattern of deficiency of both qi and yin; (ⅲ) pattern of endogenous heat due to yin deficiency ( pattern of yin deficiency and heat-poison, included); (ⅳ) pattern of intermingled dryness and blood stasis; (ⅴ) pattern of intermingled dryness and dampness. According to the patterns, principles of treatment and prescriptions are also on the same page. The formation and promotion of this consensus is of importance in the TCM course of diagnosis and treatment of Sjögren syndrome. [ABSTRACT FROM AUTHOR]

Lung cancer is the most common malignant tumor in China, and chemotherapy is still one of the main treatment methods. Due to diverse pathology and tumor stages, the purpose and mode of chemotherapy are different, and their roles are also distinct, such as neoadjuvant chemotherapy, adjuvant chemotherapy, radical chemotherapy and palliative chemotherapy. On the basis of a large number of evidence-based medical evidence, the members of the Chemotherapy Expert Group of Cancer Branch, Chongqing Medical Association, referring to relevant domestic and foreign guidelines and literature reports, formed the Expert Consensus on the Chemotherapy Principles of Lung Cancer after repeated discussion and revision, and the consensus elaborated the standard treatment mode of lung cancer chemotherapy according to the disease type and stage, providing a reference for oncologists to scientifically standardize the clinical practice of lung cancer chemotherapy. [ABSTRACT FROM AUTHOR]

The prevalence of breast cancer currently ranks first among Chinese women with malignant tumors, occurring during premenopausal childbearing age in more than 60% of patients. With the increasing age of women at childbirth, the wide application of assisted reproductive technology (ART) and the rejuvenation of tumor patients, the prevalence of breast cancer occurring during pregnancy (PrBC) is gradually increasing. There are many domestic and foreign expert consensus articles and guidelines on fertility preservation for children and patients of childbearing age with malignant tumors, but there is a lack of expert consensus or guidelines on fertility preservation for patients with PrBC. Considering the uniqueness of PrBC patients, there is an urgent need for a standardized suggestion regarding their fertility preservation. The Committee of Fertility Protection and Preservation of China Association for the Promotion of Health Science and Technology together with the Chinese Society of Gynecological Endocrinology affiliated with the International Society of Gynecological Endocrinology (CSGE-ISGE) organized relevant experts from different disciplines to formulate this consensus to guide fertility preservation of PrBC patients. [ABSTRACT FROM AUTHOR]

With the new trend of oncoplastic surgery and breast reconstruction in China and the emergence of new evidencebased medical data, expert of Chinese Anti-Cancer Association, Committee of Breast Cancer Society convened domestic clinical experts in the field of breast cancer treatment, including breast surgeons, plastic surgeons, oncologist, radiologist and pathologist, who jointly discussed and formulated the “expert consensus on oncoplastic surgery of breast tumor and breast reconstruction (2022 edition)” on the basis of the 2018 edition. In the 2022 version, endoscopic breast reconstruction, prepectoral breast reconstruction and case management of breast reconstruction were added. Besides, the original nipple-sparing mastectomy chapter was replaced by conservative mastectomy. The consensus also elaborated the prepectoral breast reconstruction and deep inferior epigastric artery perforator flap (DIEP) surgery. It is believed that this update will help hospitals at all levels to improve the ability of oncoplastic surgery and breast reconstruction, improve the standardization of treatment, optimize the treatment outcome, and ultimately improve patient satisfaction. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To establish the “ Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” based on the Delphi method, so as to provide methodological basis for further studies on drug risk assessment in pregnancy. METHODS: By referring to the literature related to drug risk assessment in pregnancy, the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China ” was established, and the expert consultation questionnaire was designed. Fifty-one experts from Beijing, Shanghai and other provinces and cities were selected to apply the Delphi method for two rounds of expert consultation to revise the content of the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China”. RESULTS: The recovery rates of the two rounds of questionnaire were 100%. The expert authority coefficient(Cr) was 0. 80±0. 10, the coefficient of variation(CV) of expert opinion was 0. 15±0. 04 in the first round and 0. 13±0. 03 in the second round, and the coordination coefficient of expert opinion (Kendall-W) was 0. 170 in the first round and 0. 493 in the second round. In both rounds, Chi-square test showed statistically significant differences ( P < 0. 001). Finally, the “ Expert Consensus on Risk Assessment of Drugs in Pregnancy in China” was determined. CONCLUSIONS: The Delphi method is used to establish the “Expert Consensus on Risk Assessment of Drugs in Pregnancy in China”, which provides methodological basis for the risk assessment of drugs during pregnancy in China. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Tacrolimus has been accepted as the first-line drug of immunosuppressive therapy after solid organ transplantation, with the macrolide chemical structure, which is mainly used for prophylaxis of rejection in liver, kidney, heart, lung or bone marrow transplantation treatment. Based on the characteristics of narrow therapeutic window, large inter-and intra-individual variances, multiple influencing factors of drug exposure, drug monitoring is widely recommended for tacrolimus in drug instructions, clinical guidelines and literature. Drug therapy is a patient-centered and clinical-dominated multidisciplinary technical work. The information in tacrolimus drug instructions cannot cover all the issues in clinical practice. As important supplements to medical documents, clinical guidelines and expert consensus are conducive to solving clinical problems and benefiting patients. "Expert Consensus on Individual Treatment of Tacrolimusin Solid Organ Transplantation"（ hereinafter referred to as"the consensus"） drafting expert group analyzed 54 tacrolimus-related guidelines and expert consensus before 2020, and concluded that it is necessary for medical multidisciplinary cooperation to comprehensively, systematically and in-depth explain the role of tacrolimus in solid organ transplantation. The expert group not only put forward urgently needed technical support and thoroughly resolved treatment issues from clinical perspective, but clarify the drug treatment elements of concern and the pharmacist responsibility list of pharmaceutical care from pharmacological perspective, so as to strengthen the rational use of tacrolimus and improve the benefits of patients. The consensus was jointly drafted by clinical clinicians and pharmacists. The main text includes four parts: preface, clinical application, drug monitoring and clinical pharmacists, covering immunosuppressive therapy for liver, kidney, heart and lung transplantation, including clinical therapeutic targets, plasma concentration monitoring, gene polymorphism determination and drug interactions. The active participation of clinical pharmacists is helpful for individualized tacrolimus treatment. According to the experience of many organ transplantation centers in China, the consensus put forward suggestions for clinical pharmacists in organ transplantation, so as to improve the quality of pharmaceutical care and optimize the individualized tacrolimus treatment. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of West China Journal of Stomatology is the property of Sichuan University, West China College of Stomatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective :To establish a high-alert medication catalogue , management system，operational regulations and uniform labels for those high-alert medications ,in accordance with drug utilization features in maternal and child hospitals .Methods ：The existing high-alert medication catalogues，management systems，operational regulations and uniform labels for those high-alert medications were collected from 16 maternal and child hospitals in China .Relevant experts were called up to establish drug se¬lection standards using the Delphi method by the Pharmaceutical Management Committee of China Maternal and Child Health Care Association .Then,classifications and summaries were made specifically and a uniform and high-alert medication catalogue was compiled ,and at the same time the management system ,operational regulations and uniform labels for those high-alert medications were established .Results and Conclusion ： Through consensus of the experts ,the catalogue of those high-alert medi¬cations was established ,and the management system ,operational regulations and uniform labels for those high-alert medications suitable for use in maternal and child hospitals were drafted in the end .With it，the management of high-alert medications could be intensified from various aspects，drug management in maternal and child hospitals would be more suitable to the reality of hospitals .Therefore，it would help to lower medication risks and reduce drug-induced injuries in maternal and child hospitals. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Physical Education Institute / Shanghai Tiyu Xueyuan Xuebao is the property of Shanghai Physical Education Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)