1. Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children.
- Author
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Kuntz M, Kohlfürst DS, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J, Otto EM, Rose MA, Schneider C, Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, and Henneke P
- Subjects
- Adolescent, Age Factors, Austria epidemiology, Child, Child, Preschool, Female, Germany epidemiology, Humans, Infant, Infant, Newborn, Lymphadenitis microbiology, Male, Mycobacterium Infections, Nontuberculous microbiology, Registries, Retrospective Studies, Risk Factors, Seasons, Sex Factors, Lymphadenitis epidemiology, Mycobacterium Infections, Nontuberculous epidemiology, Nontuberculous Mycobacteria isolation & purification
- Abstract
Nontuberculous mycobacteria (NTM) are an emerging cause of infections, including chronic lymphadenitis in children. To identify risk factors for NTM lymphadenitis, particularly complicated disease, we collected epidemiologic, clinical, and microbiological data on 138 cases of NTM lymphadenitis in children across 13 centers in Germany and Austria. We assessed lifestyle factors but did not identify specific risk behaviors. We noted that more cases of NTM lymphadenitis occurred during cold months than during warm months. Moreover, we noted female sex and age <5.5 years as potential risk factors. Complete extirpation of the affected lymph node appeared to be the best therapeutic measure. We integrated the study data to develop a simple risk score to predict unfavorable clinical outcomes for NTM lymphadenitis.
- Published
- 2020
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