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1. Acute renal failure due to visceral leishmaniasis by Leishmania infantum successfully treated with a single high dose of liposomal amphotericin B.

Author

Beltrame A, Arzese A, Camporese A, Rorato G, Crapis M, Tarabini-Castellani G, Boscutti G, Pizzolitto S, Calianno G, Matteelli A, Di Muccio T, Gramiccia M, and Viale P

Subjects
Adult, Angola, Animals, Dose-Response Relationship, Drug, Glomerulonephritis drug therapy, Glomerulonephritis microbiology, Humans, Italy, Leishmania infantum isolation & purification, Leishmaniasis, Visceral complications, Male, Treatment Outcome, Acute Kidney Injury drug therapy, Acute Kidney Injury microbiology, Amphotericin B administration & dosage, Antiprotozoal Agents administration & dosage, Leishmaniasis, Visceral diagnosis, Leishmaniasis, Visceral drug therapy, Travel
Abstract

We report a visceral leishmaniasis case in an immunocompetent immigrant with acute renal failure. Parasites were demonstrated in bone marrow, peripheral blood, and kidney samples. A collapsing focal segmental glomerulosclerosis was documented, which was successfully treated with a single infusion of 10 mg/kg liposomal amphotericin B.

Published
2008
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