10 results on '"Jones-Engel, Lisa"'
Search Results
2. A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.
- Author
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Matsen FA 4th, Small CT, Soliven K, Engel GA, Feeroz MM, Wang X, Craig KL, Hasan MK, Emerman M, Linial ML, and Jones-Engel L
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- APOBEC Deaminases, APOBEC-3G Deaminase, Animals, Bangladesh, Bayes Theorem, Codon, Terminator, Computational Biology, Cytidine Deaminase genetics, Host-Pathogen Interactions genetics, Humans, Macaca genetics, Macaca virology, Models, Genetic, RNA, Viral genetics, Simian foamy virus pathogenicity, Simian foamy virus physiology, Species Specificity, Virus Replication, Cytosine Deaminase genetics, Mutation, Retroviridae Infections genetics, Retroviridae Infections transmission, Simian foamy virus genetics, Zoonoses genetics, Zoonoses transmission
- Abstract
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.
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- 2014
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3. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia.
- Author
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Jones-Engel L, May CC, Engel GA, Steinkraus KA, Schillaci MA, Fuentes A, Rompis A, Chalise MK, Aggimarangsee N, Feeroz MM, Grant R, Allan JS, Putra A, Wandia IN, Watanabe R, Kuller L, Thongsawat S, Chaiwarith R, Kyes RC, and Linial ML
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- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Ape Diseases transmission, Ape Diseases virology, Asia epidemiology, DNA, Viral genetics, Female, Humans, Male, Middle Aged, Occupational Exposure, Phylogeny, Retroviridae Infections epidemiology, Retroviridae Infections transmission, Simian foamy virus, Zoonoses transmission
- Abstract
In Asia, contact between persons and nonhuman primates is widespread in multiple occupational and nonoccupational contexts. Simian foamy viruses (SFVs) are retroviruses that are prevalent in all species of nonhuman primates. To determine SFV prevalence in humans, we tested 305 persons who lived or worked around nonhuman primates in several South and Southeast Asian countries; 8 (2.6%) were confirmed SFV positive by Western blot and, for some, by PCR. The interspecies interactions that likely resulted in virus transmission were diverse; 5 macaque taxa were implicated as a potential source of infection. Phylogenetic analysis showed that SFV from 3 infected persons was similar to that from the nonhuman primate populations with which the infected persons reported contact. Thus, SFV infections are likely to be prevalent among persons who live or work near nonhuman primates in Asia.
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- 2008
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4. Exposure to human respiratory viruses among urban performing monkeys in Indonesia.
- Author
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Schillaci MA, Jones-Engel L, Engel GA, and Kyes RC
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- Animals, Animals, Domestic, Antibodies, Viral blood, Enzyme-Linked Immunosorbent Assay, Female, Humans, Indonesia, Male, Measles immunology, Measles transmission, Measles virus immunology, Monkey Diseases immunology, Parainfluenza Virus 2, Human immunology, Parainfluenza Virus 3, Human immunology, Paramyxoviridae Infections immunology, Respirovirus Infections immunology, Respirovirus Infections transmission, Rubella immunology, Rubella virus immunology, Urban Health, Macaca fascicularis, Monkey Diseases transmission, Paramyxoviridae Infections transmission, Rubella transmission, Zoonoses transmission
- Abstract
Performing monkeys, a common phenomena in Asia, occupy a unique urban niche that comprises a number of factors influencing the likelihood of cross-species transmission of pathogens. Here we present the first documented evidence of exposure to measles, rubella, and parainfluenza in a population of performing monkeys. Evidence of exposure to these endemic human respiratory viruses in the performing monkeys confirms human-to-primate transmission and suggests the possibility of primate-to-human transmission. Urban animal markets, the likely source of these performing monkeys, may represent an environment conducive to the mixing of animals and pathogens, making these monkeys a potential conduit for infectious agents passing from a variety of animals found in animal markets to humans. The potential significance of these results to human public health and the unique contexts of disease transmission associated with the urban ecology of the performance monkeys are discussed. Given the level of overseas travel, this potential threat is not confined solely to Asia.
- Published
- 2006
5. Considering human-primate transmission of measles virus through the prism of risk analysis.
- Author
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Jones-Engel L, Engel GA, Schillaci MA, Lee B, Heidrich J, Chalise M, and Kyes RC
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- Animals, Antibodies, Viral blood, Disease Transmission, Infectious veterinary, Female, Humans, Male, Measles epidemiology, Measles virology, Monkey Diseases epidemiology, Monkey Diseases transmission, Nepal epidemiology, Risk Assessment, Seroepidemiologic Studies, Singapore epidemiology, Zoonoses epidemiology, Macaca fascicularis, Macaca mulatta, Measles transmission, Measles veterinary, Measles virus isolation & purification, Monkey Diseases virology, Zoonoses transmission, Zoonoses virology
- Abstract
Measles is a respiratory virus that is endemic to humans. Human-nonhuman primate (NHP) transmission of the measles virus has been shown to cause significant morbidity and mortality in NHP populations. We investigated serological evidence of exposure to measles virus in two free-ranging populations of macaques at the Bukit Timah (BTNR) and Central Catchment Nature (CCNR) reserves in Singapore and the Swoyambhu Temple in Katmandu, Nepal. At BTNR/CCNR none of the 38 macaques (Macaca fascicularis) sampled were seropositive for antibodies to measles virus. In contrast, at Swoyambhu 100% (n = 39) of the macaques (M. mulatta) sampled were seropositive for antibodies to the measles virus. Here the contrasting seroprevalences of the two sites are analyzed using risk analysis. These case studies show how risk analysis can be used to approach the phenomenon of cross-species pathogen transmission., (Copyright 2006 Wiley-Liss, Inc.)
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- 2006
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6. Temple monkeys and health implications of commensalism, Kathmandu, Nepal.
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Jones-Engel L, Engel GA, Heidrich J, Chalise M, Poudel N, Viscidi R, Barry PA, Allan JS, Grant R, and Kyes R
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- Animals, Antibodies, Viral blood, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections virology, Female, Herpesviridae Infections epidemiology, Herpesviridae Infections virology, Humans, Lentivirus Infections epidemiology, Lentivirus Infections veterinary, Lentivirus Infections virology, Male, Monkey Diseases epidemiology, Nepal epidemiology, Polyomavirus Infections epidemiology, Polyomavirus Infections virology, Public Health, Seroepidemiologic Studies, Zoonoses epidemiology, Cytomegalovirus Infections veterinary, Herpesviridae Infections veterinary, Macaca mulatta, Monkey Diseases virology, Polyomavirus Infections veterinary, Zoonoses virology
- Abstract
The threat of zoonotic transmission of infectious agents at monkey temples highlights the necessity of investigating the prevalence of enzootic infectious agents in these primate populations. Biological samples were collected from 39 rhesus macaques at the Swoyambhu Temple and tested by enzyme-linked immunosorbent assay, Western blot, polymerase chain reaction, or combination of these tests for evidence of infection with rhesus cytomegalovirus (RhCMV), Cercopithecine herpesvirus 1 (CHV-1), simian virus 40 (SV40), simian retrovirus (SRV), simian T-cell lymphotropic virus (STLV), simian immunodeficiency virus (SIV), and simian foamy virus (SFV). Antibody seroprevalence was 94.9% to RhCMV (37/39), 89.7% to SV40 (35/39), 64.1% to CHV-1 (25/39), and 97.4% to SFV (38/39). Humans who come into contact with macaques at Swoyambhu risk exposure to enzootic primateborne viruses. We discuss implications for public health and primate management strategies that would reduce contact between humans and primates.
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- 2006
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7. Replication Capacity of Avian Influenza A(H9N2) Virus in Pet Birds and Mammals, Bangladesh.
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Lenny, Brian J, Shanmuganatham, Karthik, Sonnberg, Stephanie, Feeroz, Mohammed M, Alam, S. M. Rabiu, Hasan, M. Kamru, Jones-Engel, Lisa, McKenzie, Pamela, Krauss, Scott, Webster, Robert G, Jones, Jeremy C, Alam, S M Rabiul, and Hasan, M Kamrul
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CAGE bird diseases ,ANIMAL diseases ,PETS ,INFLUENZA A virus ,VIRAL replication ,INFLUENZA transmission ,ANIMAL experimentation ,AVIAN influenza ,BIRDS ,EPIDEMICS ,BIOLOGICAL evolution ,INFLUENZA ,MAMMALS ,POULTRY ,RESEARCH funding ,SWINE ,INFECTIOUS disease transmission - Abstract
Avian influenza A(H9N2) is an agricultural and public health threat. We characterized an H9N2 virus from a pet market in Bangladesh and demonstrated replication in samples from pet birds, swine tissues, human airway and ocular cells, and ferrets. Results implicated pet birds in the potential dissemination and zoonotic transmission of this virus. [ABSTRACT FROM AUTHOR]
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- 2015
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8. Characterizing human–macaque interactions in Singapore.
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Fuentes, Agustín, Gettler, Lee, Kalchik, Stephanie, Kwiatt, Anne, Konecki, McKenna, and Jones-Engel, Lisa
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HUMAN-animal relationships ,MACAQUES ,ZOONOSES ,HABITATS ,KRA - Abstract
Previous studies have noted substantial human–macaque interactions involving physical contact in Bali, Indonesia; Gibraltar; and Mt. Emei, China [Fuentes, American Journal of Primatology 68:880–896, 2006; Zhao, Tibetan macaques, visitors, and local people at Mt. Emei: problems and countermeasures. In: Paterson and Wallis, editor. Commensalism and conflict: the human–primate interface. Norman, OK: American Society of Primatologists. p 376–399, 2005]. The aim of this study was to conduct preliminary observations in order to begin to characterize interaction patterns between humans and long-tailed macaques (Macaca fascicularis) in Singapore. Unlike Bali, Gibraltar, and Mt. Emei, Singapore occasionally enforces fines and penalties and engages in an education campaign in an effort to minimize physical contact between humans and macaques. Observers stationed at two sites in Singapore conducted 92 5 hr of observation that included 730 human–macaque interactions over 16 days. Data recorded include interaction characteristics, demographic and behavioral variables, presence of feeding by humans, and presence of automobiles. Although feeding by humans was relatively infrequent overall, it generally occurred most often by individuals in cars and when human children were present. Data analysis suggests that interactions involving physical contact between macaques and humans are rare in Singapore, in contrast to the findings from Bali, Gibraltar, and Mt. Emei. This low level of physical contact suggests a low risk of macaque–human pathogen transmission in Singapore. Am. J. Primatol. 70:879–883, 2008. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
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9. Human exposure to herpesvirus B-seropositive macaques, Bali, Indonesia.
- Author
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Engel, Gregory A., Engel, Lisa Jones, Schillaci, Michael S., Suaryana, Komang Gde, Putra, Artha, Fuentes, Agustin, Henkel, Richard, Jones-Engel, Lisa, and Schillaci, Michael A
- Subjects
MENINGOENCEPHALITIS ,CENTRAL nervous system diseases ,TREATMENT for bites & stings ,ANIMAL experimentation ,BITES & stings ,CARRIER state (Communicable diseases) ,COMPARATIVE studies ,ENZYME-linked immunosorbent assay ,EPIDEMIOLOGICAL research ,HERPESVIRUS diseases ,HERPESVIRUSES ,RESEARCH methodology ,MEDICAL cooperation ,PRIMATES ,PUBLIC health ,RESEARCH ,VIRAL antibodies ,EVALUATION research ,ZOONOSES ,INFECTIOUS disease transmission - Abstract
Herpesvirus B (Cercopithecine herpesvirus 1) has been implicated as the cause of approximately 40 cases of meningoencephalitis affecting persons in direct or indirect contact with laboratory macaques. However, the threat of herpesvirus B in nonlaboratory settings worldwide remains to be addressed. We investigated the potential for exposure to herpesvirus B in workers at a "monkey forest" (a temple that has become a tourist attraction because of its monkeys) in Bali, Indonesia. In July 2000, 105 workers at the Sangeh Monkey Forest in Central Bali were surveyed about contact with macaques (Macaca fascicularis). Nearly half of those interviewed had either been bitten or scratched by a macaque. Prevalence of injury was higher in those who fed macaques. Serum from 31 of 38 Sangeh macaques contained antibodies to herpesvirus B. We conclude that workers coming into contact with macaques at the Sangeh Monkey Forest are at risk for exposure to herpesvirus B. [ABSTRACT FROM AUTHOR]
- Published
- 2002
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10. Sensitive Assays for Simian Foamy Viruses Reveal a High Prevalence of Infection in Commensal, Free-Ranging Asian Monkeys.
- Author
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Jones-Engel, Lisa, Steinkraus, Katherine A., Murray, Shannon M., Engel, Gregory A., Grant, Richard, Aggimarangsee, Nantiya, Lee, Benjamin P. Y.-H., May, Cynthia, Schillaci, Michael A., Somgird, Chaleamchat, Sutthipat, Tulyawat, Vojtech, Lucia, Jian Yuan Zhao, and Linial, Maxine L.
- Subjects
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SIMIAN viruses , *RETROVIRUSES , *MONKEY diseases , *RETROVIRUS diseases , *ZOONOSES , *ENZYME-linked immunosorbent assay , *WESTERN immunoblotting , *INFECTIOUS disease transmission - Abstract
Foamy viruses (FV) are retroviruses that naturally infect many hosts, including most nonhuman primates (NHPs). Zoonotic infection by primate FV has been documented in people in Asia who reported contact with free-ranging macaques. FV transmission in Asia is a concern, given abundant human-NHP contact, particularly at monkey temples and in urban settings. We have developed three assays capable of detecting the presence of FV in Asian NHP species that are commensal with humans: enzyme-linked immunosorbent assay (ELISA), Western blot assays using recombinant viral Gag protein, and an indicator cell line that can detect macaque FV. The recombinant ELISA correlates very well with the presence of FV sequences detected by PCR. We have used these assays to demonstrate both that FV is highly prevalent among free-ranging NHPs and that seroconversion occurs at a young age in these animals. These assays should also prove useful for large-scale analysis of the prevalence of FV infections in human populations in Asia that are commensal with free-ranging NHPs. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
- View/download PDF
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