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A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.

Authors :
Matsen FA 4th
Small CT
Soliven K
Engel GA
Feeroz MM
Wang X
Craig KL
Hasan MK
Emerman M
Linial ML
Jones-Engel L
Source :
PLoS computational biology [PLoS Comput Biol] 2014 Feb 27; Vol. 10 (2), pp. e1003493. Date of Electronic Publication: 2014 Feb 27 (Print Publication: 2014).
Publication Year :
2014

Abstract

Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.

Details

Language :
English
ISSN :
1553-7358
Volume :
10
Issue :
2
Database :
MEDLINE
Journal :
PLoS computational biology
Publication Type :
Academic Journal
Accession number :
24586139
Full Text :
https://doi.org/10.1371/journal.pcbi.1003493