1. Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery.
- Author
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Morales-Burgos AM, Carvajal-Millan E, Sotelo-Cruz N, Rascón-Chu A, Lizardi-Mendoza J, López-Franco YL, Martínez-Porchas M, and Canett-Romero R
- Subjects
- Administration, Oral, Animals, Colon metabolism, Colon microbiology, Diabetes Mellitus, Experimental chemically induced, Diabetes Mellitus, Experimental drug therapy, Diabetes Mellitus, Experimental microbiology, Diabetes Mellitus, Type 1 chemically induced, Diabetes Mellitus, Type 1 microbiology, Diabetes Mellitus, Type 2 chemically induced, Diabetes Mellitus, Type 2 microbiology, Humans, Insulin pharmacokinetics, Intestinal Mucosa metabolism, Intestinal Mucosa microbiology, Male, Microspheres, Rats, Streptozocin administration & dosage, Streptozocin toxicity, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 2 drug therapy, Drug Carriers metabolism, Gastrointestinal Microbiome, Insulin administration & dosage, Xylans metabolism
- Abstract
In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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