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Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery
- Source :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 163
- Publication Year :
- 2020
-
Abstract
- In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.
- Subjects :
- Male
Colon
medicine.medical_treatment
Pharmaceutical Science
Administration, Oral
02 engineering and technology
Pharmacology
030226 pharmacology & pharmacy
Streptozocin
Microsphere
Diabetes Mellitus, Experimental
03 medical and health sciences
0302 clinical medicine
Polyuria
In vivo
Diabetes mellitus
medicine
Animals
Humans
Insulin
Intestinal Mucosa
Bifidobacterium
Drug Carriers
biology
Chemistry
General Medicine
021001 nanoscience & nanotechnology
biology.organism_classification
medicine.disease
Microspheres
Gastrointestinal Microbiome
Rats
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Drug delivery
Xylans
Bacteroides
medicine.symptom
0210 nano-technology
Biotechnology
Subjects
Details
- ISSN :
- 18733441
- Volume :
- 163
- Database :
- OpenAIRE
- Journal :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- Accession number :
- edsair.doi.dedup.....8be5faa6f618f644a709c02832fec88d