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A recent study conducted by researchers at Yale University focused on the career choices of graduates from combined medicine-pediatrics residency programs. The study found that over 8000 physicians have completed dual training in this field since its establishment in 1967. The research, supported by the Medicine Pediatrics Program Directors Association, revealed that graduates pursued diverse career paths, with the top four reported fields being internal medicine fellowship, private ambulatory/outpatient practice, medicine-pediatrics hospitalist, and academic practice. This study highlights the important contributions that medicine-pediatrics physicians make to the healthcare workforce. [Extracted from the article]

A recent study from Yale University provides an update on the use of botulinum toxin treatment for painful diabetic neuropathy, post-traumatic neuralgia, postherpetic neuralgia, and occipital neuralgia. The research reviews the efficacy of botulinum therapy for these conditions, highlighting the need for further controlled and blinded studies with larger patient cohorts. The study discusses the potential advantages of botulinum therapy over current treatment methods for these pain disorders. For more information, readers can refer to the original article published in Toxicon. [Extracted from the article]

A recent study conducted at Yale University School of Medicine focused on the development of a radiotracer, [F-18]TZ4877, for imaging the sphingosine-1-phosphate receptor-1 (S1PR(1)) in nonhuman primates. The research aimed to evaluate the pharmacokinetic properties of the radiotracer for potential use in clinical settings. The findings suggest that [F-18]TZ4877 exhibits reversible kinetic properties, but its low plasma free fraction (f(P)) may limit its reproducible quantification. The study concludes that S1PR(1) is a promising target for PET imaging, encouraging further exploration of alternative F-18 labeled radiotracers for future human studies. [Extracted from the article]

A recent report from Yale University School of Medicine discusses the use of large language models (LLMs) to detect gastrointestinal bleeding (GIB) in electronic health records (EHR). The study focused on identifying recurrent bleeding and improving reimbursement coding for patients with GIB. The LLM-based pipeline accurately detected various types of bleeding and resulted in increased per-patient reimbursement. This research highlights the potential of LLMs in aiding quality improvement and appropriate reimbursement in the field of gastroenterology. [Extracted from the article]

Researchers at Yale University School of Medicine conducted a study to evaluate spike ripples as a potential biomarker for the epileptogenic zone. The study involved analyzing intracranial EEG recordings from subjects who underwent surgical resection for epilepsy. Results showed that spike ripples were more effectively removed in subjects with positive outcomes compared to other interictal biomarkers, suggesting that spike ripples may be a promising indicator for localizing epileptogenic tissue. The research has been peer-reviewed and provides valuable insights into epilepsy diagnostics and treatment. [Extracted from the article]

A recent study conducted by Yale University explores the use of wearable technology and artificial intelligence to characterize psychiatric disorders and identify genetic associations. The research highlights the potential of wearable sensors in providing quantitative and unbiased data on human behavior, leading to more accurate classification of adolescents with psychiatric disorders. By analyzing wearable and genetic data, the study identifies significant genetic loci and psychiatric-associated genes, such as ELFN1 and ADORA3, showcasing the power of continuous, wearable-derived features in genome-wide association studies. This research underscores the role of wearable technology in uncovering new connections between behavior and genetics in the field of mental health. [Extracted from the article]

A recent study from Yale University School of Medicine discusses the challenges and management strategies for radio-recurrent prostate cancer. The research emphasizes the importance of personalized treatment approaches, including androgen deprivation therapy and second-line antiandrogen therapies. Various local salvage therapies, such as salvage radical prostatectomy and salvage radiation therapy, are also explored as potential options for localized recurrences. The study concludes by highlighting the need for continued exploration of new treatment avenues and personalized strategies for improved outcomes in managing radio-recurrent prostate cancer. [Extracted from the article]

A recent study from Yale University sheds light on Acid Sphingomyelinase Deficiency (ASMD) and Gaucher disease, rare inherited disorders with liver and lipid abnormalities. The research highlights the importance of early diagnosis to prevent irreversible complications. The study found that low HDL cholesterol levels could serve as a potential biomarker for disease activity in these conditions. For more information, readers can refer to the original article in Hepatology Communications. [Extracted from the article]

Researchers from Yale University School of Medicine have conducted a study on stem cell research, specifically focusing on metabolic rewiring in skin epidermis that drives tolerance to oncogenic mutations. The study found that different strategies of epithelial tolerance are invoked by oncogenes, with wild-type cells outcompeting beta-catenin-gain-of-function cells, and HrasG12V cells outcompeting wild-type cells. The research also discovered that treatment with metformin, a modifier of cytosolic redox, can inhibit downstream mutant phenotypes and reverse cell-competition outcomes in both mutant models. This peer-reviewed study provides valuable insights into the metabolic changes that occur when wild-type stem cells interact with mutant cells in the skin epidermis. [Extracted from the article]

Researchers from Yale University have identified a phospho-regulatory module involving the PPP2R3C and MAP3K1 proteins that controls centrosome function. This discovery sheds light on disorders of gonadal development and highlights the importance of balanced activities of these proteins. The study utilized a systems genetics approach to uncover previously unrecognized gene functions related to centrosome regulation. The research was funded by various organizations including the National Institutes of Health (NIH) and the National Science Foundation (NSF). [Extracted from the article]

A study conducted by Yale University School of Medicine focused on the impact of rare variants in the melanocortin 4 receptor gene (MC4R) on abdominal fat distribution and insulin resistance in youth with obesity. The research involved 877 participants aged 6-21 years with overweight/obesity, and found that those with pathogenic variants in MC4R exhibited higher glucose and insulin levels, lower insulin sensitivity, and increased visceral adipose tissue and intrahepatic fat content compared to those without pathogenic variants. The study concluded that pathogenic variants in MC4R are associated with increased visceral adipose tissue, intrahepatic fat content, and insulin resistance in youth, independent of the degree of obesity. [Extracted from the article]

Researchers from Yale University conducted a study to assess if patient sex influences physician decision-making for postintubation sedation strategies in emergency departments and intensive care units. The study involved a survey of physicians at three academic medical centers, revealing that sex had the lowest weight in affecting decisions for sedation strategies. Despite evidence of sex-related differences in medication metabolism, physicians reported that patient sex rarely influenced their choice of sedation strategies. The research concluded that further investigation is needed to identify ideal sedation strategies that consider patient sex. [Extracted from the article]

A recent study from Yale University explores the role of Adamts1 in cyst expansion in polycystic kidney disease. The research suggests that preventing Adamts1 upregulation after the loss of tubular Pkd1 can effectively reduce cyst growth and preserve kidney function. This study was supported by the United States Department of Defense and has been peer-reviewed, offering valuable insights into potential treatments for this genetic condition. [Extracted from the article]

Researchers at Yale University Child Study Center conducted a study on patients with opioid use disorder (OUD) and chronic pain (CP), finding that cognitive behavioral therapy (CBT) reduced nonmedical opioid use compared to treatment-as-usual (TAU). The study aims to test the effectiveness of a Stepped Care for Patients to Optimize Whole Recovery (SC-POWR) model, which includes CBT, exercise, and stress reduction, in reducing nonmedical opioid use and pain intensity. The research, funded by the National Institutes of Health, will follow 316 patients for 24 weeks to evaluate the impact on various outcomes such as illicit opioid use, pain, anxiety, depression, and retention in OUD medications. [Extracted from the article]

Researchers at Yale University conducted a study to assess the reproducibility of quantitative analyses of Technetium-99m pyrophosphate (Tc-99m PYP) uptake from cardiac planar and SPECT images using a new method. The study included 95 subjects referred for Tc-99m PYP imaging for transthyretin cardiac amyloidosis suspicion. The findings showed excellent intra- and inter-observer reproducibility for quantitative assessments of Tc-99m PYP uptake, with the conclusion that the mean SUV assessment of myocardial PYP uptake via Tc-99m SPECT imaging using the new method is highly reproducible. [Extracted from the article]

A study conducted by investigators from Yale University School of Medicine aimed to compare maternal characteristics and pregnancy outcomes in term patients evaluated for decreased fetal movement (DFM) who were either delivered or expectantly managed. The study found significant sociodemographic and clinical variations between groups, with factors such as noncommercial insurance, hypertension in pregnancy, and high body mass index associated with reduced odds of immediate delivery. However, there were no differences in delivery or neonatal outcomes among the groups. This research, published in the American Journal of Perinatology, highlights the importance of understanding the factors influencing management decisions for patients with DFM at term. [Extracted from the article]

A recent study from Yale University School of Medicine focused on the validation of criteria for identifying carriers of the CDH1 pathogenic variant, which is associated with diffuse gastric and lobular breast cancer syndrome. The study found that the NCCN/Yale criteria had a significantly higher sensitivity in detecting CDH1 pathogenic variants compared to other criteria. This research, supported by the C Richard Boland Fund, addresses practical challenges in cancer genetics and has been peer-reviewed. For more information, readers can refer to the Journal of Medical Genetics. [Extracted from the article]

A recent study from Yale University examined the impact of right-wing media rhetoric on social media platforms, specifically YouTube. The research found that user comments often diverged significantly from the original video transcripts, introducing emotionally charged rhetoric and conspiracy theories. The study challenges the idea that media attributes can be transferred directly to the public agenda, suggesting a need to synthesize different approaches in future research. This peer-reviewed research was supported by the John S. and James L. Knight Foundation and provides valuable insights into the dynamics of media influence in the U.S. cultural landscape. [Extracted from the article]

A recent study conducted at Yale University in New Haven, Connecticut, explored the role of parathyroid hormone (PTH) in stabilizing RANKL mRNA, which is associated with increased phosphorylation of the Kh-type splicing regulatory protein. The research found that PTH treatment led to elevated RANKL mRNA expression and increased phosphorylation of KSRP, suggesting a potential role for phosphoKSRP in stabilizing the RANKL transcript. This peer-reviewed study provides valuable insights into the molecular mechanisms controlling mRNA abundance in bone formation and osteoclastogenesis. For more information, readers can refer to the original article published in Molecular and Cellular Endocrinology. [Extracted from the article]

Researchers at Yale University School of Medicine conducted a study on cannabis use among youth who vape nicotine and are motivated to quit. The study found that cannabis use is common among these youth, which may interfere with nicotine cessation efforts. Most participants reported using cannabis, with smoking and vaping being prevalent methods of consumption. The research highlights the importance of understanding cannabis and nicotine co-use for targeting treatment for both substances. [Extracted from the article]

Researchers at Yale University School of Medicine have conducted a study on managing edema and reducing flap compression in postoperative nursing care following trauma to the lower extremity. Techniques such as rope suspension, mini water mattresses, and pillow or blanket stacking were identified as effective measures to reduce edema and compression in patients recovering from lower extremity trauma. The research provides valuable insights for orthopaedic nurses in acute care settings and has been peer-reviewed for accuracy and reliability. For more information, readers can refer to the article "Methods To Manage Edema and Reduce Flap Compression In Postoperative Nursing Care Following Trauma To the Lower Extremity" published in Orthopaedic Nursing. [Extracted from the article]

Researchers at Yale University School of Medicine have conducted a study on the use of Intravenous Contrast-Enhanced Ultrasound (CEUS) in both adult and pediatric populations. The study highlights the potential of CEUS in enhancing diagnostic applications, therapeutic use, and interventional procedures, particularly in the field of interventional oncology. While CEUS shows promise in identifying systemic pathologies without radiation-intensive scans, there are challenges such as operator dependence, limited field of view, and a lack of trained personnel for widespread use. The research emphasizes the need for further exploration of CEUS applications in healthcare. [Extracted from the article]

A recent study conducted at Yale University explored the impact of maternal childhood trauma on child cognitive development in the context of drug addiction. The research involved 71 mother-child dyads affected by substance use disorder and found that while maternal caregiving behavior was associated with child cognitive development, maternal childhood trauma did not have a significant impact. The study highlights the importance of interventions that promote sensitive caregiving behaviors to support child cognitive development in the face of maternal substance use disorder and childhood trauma. [Extracted from the article]

Researchers at Yale University School of Public Health have documented a case of Rickettsia parkeri rickettsiosis in a patient in Connecticut, USA, following a bite from a Gulf Coast tick (Amblyomma maculatum). The study used PCR to amplify R. parkeri DNA from the tick and found that the patient showed a 4-fold rise in IgG reactive with R. parkeri antigens. This research sheds light on the establishment of Amblyomma maculatum ticks and Rickettsia parkeri in the northeastern United States. [Extracted from the article]

Researchers at Yale University have reported new findings on the role of Angiopoietin-like 4 (ANGPTL4) in diabetic kidney disease. The study highlights the importance of ANGPTL4 in accelerating fibrosis in diabetic kidneys and suggests that targeted pharmacologic therapy inhibiting ANGPTL4 gene expression could protect against proteinuria and fibrosis. The research emphasizes the fibrogenic role of podocyte- and tubule-derived ANGPTL4 in diabetic kidneys, offering insights into potential therapeutic interventions for this condition. The study was supported by various organizations including the National Institutes of Health (NIH) and Japan Society for the Promotion of Science. [Extracted from the article]

Researchers from Yale University have published a study on the mechanisms involved in licensing human replication origins, specifically focusing on the loading of replicative helicases onto DNA. The research highlights differences in the human MCM2-7 replicative helicase loading pathway compared to yeast systems, which may enhance resilience against challenges faced by multicellular organisms during DNA replication. The study utilized biochemical reconstitution and electron microscopy to reconstruct the human MCM loading pathway, shedding light on the complex process of DNA replication initiation in humans. This research has been peer-reviewed and provides valuable insights into the fundamental mechanisms of DNA replication. [Extracted from the article]

A report from Yale University discusses the findings on fibrotic diseases, particularly focusing on myeloid cell populations in various tissues. The research proposes a unified nomenclature for myeloid cells across fibrotic tissues, highlighting the enrichment of DC3 dendritic cells in fibrotic skin, lung, and liver, and SPP1 macrophages in fibrotic lung, heart, and kidney. The study emphasizes the importance of understanding the signaling mechanisms of these cells across different organs for future investigations. [Extracted from the article]

A recent study conducted at Yale University School of Medicine focused on developing a curriculum for chief residents to increase psychological safety in the clinical learning environment. The curriculum aimed to provide chief residents with tools to promote psychological safety and improve responses to workplace mistreatment or bias. The study involved 66 chief residents from 25 residency programs and showed significant improvements in self-reported efficacy and behavior change. Further assessment of the curriculum's impact on individual programs and institutional climate is planned. [Extracted from the article]

Research conducted at Yale University School of Medicine has provided new information about pudendal neuralgia, a chronic pelvic pain condition associated with the pudendal nerve. The study systematically assessed various interventions for pudendal neuralgia, including surgery, injections, and pulse radiofrequency treatments, to evaluate their impact on pain relief. The research found that all interventions improved pain to a similar extent, with no treatment clearly superior for pain relief, highlighting the need for further investigation due to the heterogeneous patient populations and non-standardized treatments in existing studies. [Extracted from the article]

Researchers at Yale University School of Medicine have reported new data on autologous hematopoietic stem cell transplant for systemic sclerosis associated interstitial lung disease, a leading cause of death in systemic sclerosis. Studies have shown that this treatment leads to stabilization and potential improvement of lung function, with better long-term outcomes compared to conventional therapies for diffuse cutaneous systemic sclerosis. Future research is needed to refine patient selection, conditioning regimens, and the role of maintenance immunosuppression in treating interstitial lung disease. [Extracted from the article]

Researchers at Yale University School of Medicine conducted a study to evaluate the utility of factor VIII levels and the International Society on Thrombosis and Hemostasis (ISTH) DIC score in distinguishing disseminated intravascular coagulation (DIC) from the coagulopathy of liver disease. The study found that factor VIII levels did not differ significantly between patients with DIC, liver disease, or both, and ISTH scores were lower in patients with DIC. The addition of various laboratory parameters to the ISTH score improved the ability to distinguish DIC in liver disease patients. This research has been peer-reviewed and may aid in identifying DIC in patients with liver disease. [Extracted from the article]

A study conducted at Yale University School of Medicine focused on the treatment of iron-deficiency anemia (IDA) during pregnancy, a condition affecting over 40% of pregnant individuals globally. The research aimed to determine if intravenous iron (IVI) supplementation reduced maternal morbidity in pregnant patients with IDA. The study found that patients who received IVI had higher odds of experiencing maternal morbidity, although this effect was attenuated after adjusting for potential confounders and was not significant among patients who completed a full treatment course. This research has been peer-reviewed and provides valuable insights into the management of IDA during pregnancy. [Extracted from the article]

A recent report from Yale University discusses findings on congenital perineal hernias, focusing on diagnostic methods, treatment approaches, and outcomes. The study reviewed 12 documented cases and presented two cases of congenital perineal hernia in siblings. The research emphasizes the importance of considering congenital perineal hernias when encountering a reducible swelling in the buttock area, highlighting the need for individualized care based on case-specific attributes. The study underscores the complexity of congenital perineal hernias and the importance of tailored treatment approaches. [Extracted from the article]

The article discusses a study conducted at Yale University School of Medicine on anal cancer screening in men who have sex with men with HIV. The research evaluated the uptake of screening, detection rates of high-grade lesions, and the effectiveness of anal cytology as a triage test for referral. The study found poor uptake of screening over time, particularly in older age groups, and concluded that anal cytology performed poorly in detecting high-grade lesions. The research was peer-reviewed and provides valuable insights into anal cancer screening programs for this population. [Extracted from the article]

A recent study conducted at Yale University School of Medicine focused on the impact of chronic kidney disease (CKD) on arteriovenous fistulae (AVF) remodeling in mice. The research found that CKD accelerates transforming growth factor (TGF)-beta activation, promoting endothelial-to-mesenchymal transition (EndMT) and reducing AVF patency. Inhibition of TGF-beta signaling, particularly in endothelial cells, was shown to attenuate EndMT and improve AVF patency, suggesting that targeting EndMT could be a therapeutic approach to enhance AVF function in CKD patients. [Extracted from the article]

A recent report from Yale University School of Medicine discusses the global epidemic of metabolic dysfunction-associated steatotic liver disease (MASLD) and its severe subgroup metabolic dysfunction-associated steatohepatitis (MASH), driven by chronic overnutrition and genetic factors. The research highlights the first approved therapeutic for MASLD and MASH, resmetirom, and explores the potential for other therapeutic approaches such as thyroid hormone receptor-beta agonists and incretin analogues. The study emphasizes the need for further clinical research to understand optimal treatment strategies for patients with these conditions. [Extracted from the article]

Researchers at Yale University have reported new findings on lung diseases and conditions, focusing on unsupervised domain adaptation for intubation prediction. The study explores the use of transformer-based models and prior knowledge to improve generalization and interpretation in medical image analysis tasks. The proposed method, Prior Knowledge-guided Vision-transformer-based Unsupervised Domain Adaptation (PUDA), shows effectiveness in predicting intubation status in patients with lung diseases. The research has been peer-reviewed and offers valuable insights into improving clinical outcome predictions in respiratory medicine. [Extracted from the article]

Researchers at Yale University have developed a new method called Patho-DBiT to spatially explore RNA biology in formalin-fixed paraffin-embedded tissues, which could revolutionize histopathology research. This technique allows for the profiling of gene expression, RNA processing, splicing isoforms, and transcriptomic mapping in clinically archived samples. The study, funded by the National Institutes of Health, Packard Fellowship for Science and Engineering, and others, highlights the potential of Patho-DBiT in unraveling rich RNA biology in FFPE tissues for clinical pathology evaluation. [Extracted from the article]

A recent study conducted by Yale University examined the impact of rising temperatures on crime and violence. The research found that higher temperatures were significantly associated with an increase in crime and violence, particularly for violent crimes. The study recommended future research to focus on larger spatial/temporal scales, consistent definitions of crime and violence, and different populations and locations. This systematic review and meta-analysis was supported by the United States Environmental Protection Agency and the National Institute on Minority Health and Health Disparities. [Extracted from the article]

Researchers at Yale University School of Medicine have found that CCR2-positive monocytes are not essential for resolving acute pulmonary Pseudomonas aeruginosa infections in both normal and cystic fibrosis mice. This study challenges the assumption that monocytes are crucial for eradicating infections like P. aeruginosa in cystic fibrosis patients. The findings suggest that targeting monocyte recruitment could potentially be a therapeutic strategy to reduce lung tissue damage in cystic fibrosis. The research was supported by the National Institutes of Health and the Yale Cooperative Center of Excellence in Hematology. [Extracted from the article]

A recent study from Yale University explores the role of cholesterol in promoting IFNG mRNA expression in CD4+ effector/memory cells by activating SGK1. The research suggests that the CNS milieu rich in lipids influences metabolic conditions leading to IFN gamma-secreting brain CD4 T cells. These findings offer potential avenues for further research targeting lipid pathways to modulate inflammatory conditions, highlighting the importance of environmental factors in inducing effector responses in CD4+ cells. [Extracted from the article]

A recent study conducted at Yale University School of Medicine explored the impact of glucagon on hepatic mitochondrial oxidation and pyruvate carboxylase flux in individuals with fatty liver disease. The research found that rates of hepatic mitochondrial oxidation were not significantly altered in individuals with metabolic-dysfunction-associated steatotic liver (MASL) and steatohepatitis (MASLD), but glucagon increased these rates by 50%-75%. This study sheds light on the role of glucagon in promoting increased hepatic mitochondrial oxidation in individuals with fatty liver disease. [Extracted from the article]

A recent study conducted by Yale University School of Medicine focused on utilizing natural language processing (NLP) to extract functional status assessments from clinical documentation of patients with heart failure. The study involved 34,070 patients seeking outpatient care for heart failure in Connecticut and successfully developed NLP models to detect New York Heart Association (NYHA) classification and heart failure symptoms. The NLP approach accurately extracted patient data from clinical notes, enhancing care delivery tracking and identifying patients eligible for clinical trials. This research provides valuable insights into improving heart failure management and patient selection for clinical trials. [Extracted from the article]

A recent study from Yale University School of Medicine explores the generalizability of brain-phenotype associations across diverse real-world data sets in cognitive neuroscience. The research highlights the importance of predictive modeling in neuroimaging and demonstrates the potential for reproducible and generalizable brain-behavior associations despite significant inter-dataset variability. This work lays a critical foundation for future evaluations of brain-phenotype associations in real-world and clinical settings, emphasizing the importance of training on diverse data to improve predictions in specific cases. [Extracted from the article]

A recent study from Yale University School of Medicine highlights the importance of using measurable residual disease (MRD) as a biomarker for prognostication and therapeutic decision-making in Acute Myeloid Leukemia (AML). The research emphasizes that targeting MRD with innovative treatment strategies can lead to improved patient outcomes. This peer-reviewed study underscores the significance of preemptive interventions based on MRD status in AML, particularly in guiding therapeutic decisions post-intensive chemotherapy and pre-allogeneic hematopoietic cell transplantation. [Extracted from the article]

A recent study conducted at Smilow Cancer Hospital in New Haven, Connecticut, compared the real-world effectiveness and safety of filgrastim and filgrastim-sndz in patients with chemotherapy-induced neutropenia. The study aimed to address concerns about biosimilars and their acceptance among clinicians. Results showed that filgrastim-sndz was more cost-effective and had similar effects on absolute neutrophil count, fever, and febrile neutropenia compared to reference filgrastim. This research, which has been peer-reviewed, provides valuable insights into healthcare resource costs and clinical outcomes in diverse patient populations. [Extracted from the article]

A recent study conducted at Yale-New Haven Hospital focused on high-grade transformation and carcinosarcoma in the salivary gland, highlighting the rarity of this phenomenon and its impact on treatment and prognosis. The research reviewed existing literature, described histologic features, and emphasized the diagnostic criteria for high-grade transformation in salivary gland carcinomas. Carcinosarcoma is found to predominantly arise in pleomorphic adenomas, following an adenoma-carcinoma-sarcoma pathway. This peer-reviewed study provides valuable insights into the advanced progression of these conditions. [Extracted from the article]

A recent report from Yale University School of Medicine highlights the challenges faced by small island developing states in the Eastern Caribbean, which are dealing with both climate-related disasters and noncommunicable diseases (NCDs). The Eastern Caribbean Health Outcomes Research Network (ECHORN) is conducting a longitudinal cohort study to understand the impact of repeated disaster exposure on NCD management in the region. The study aims to inform disaster-resilient NCD management and policy development in the face of increasing NCDs and disasters in the Caribbean. [Extracted from the article]

The article from Hepatitis Weekly discusses a study conducted by Yale University School of Medicine on the histopathology and clinical correlation of liver biopsies in patients with treated autoimmune hepatitis (AIH). The research found that certain histologic features of AIH persisted even after treatment, suggesting categorization into direct and indirect hepatocytic injuries. Direct hepatocytic injury features correlated significantly with transaminase levels and responded well to treatment, while indirect features showed weaker correlation and relative treatment resistance. The study provides valuable insights into the diagnosis and treatment of AIH. [Extracted from the article]

Researchers at Yale University School of Medicine have developed an electronic health record-based machine learning model to assess the risk of gastrointestinal bleeding (GIB) in patients presenting with symptoms. The model outperformed current clinical risk scores, such as the Glasgow-Blatchford Score and Oakland Score, in identifying very-low-risk patients who could be discharged from the emergency department. This study, supported by the National Institutes of Health, highlights the potential of machine learning technology to improve risk assessment and patient care in GIB cases. [Extracted from the article]