Investigators from Yale University Target Biology (A Disease-associated Ppp2r3c-map3k1 Phospho-regulatory Module Controls Centrosome Function).

Researchers from Yale University have identified a phospho-regulatory module involving the PPP2R3C and MAP3K1 proteins that controls centrosome function. This discovery sheds light on disorders of gonadal development and highlights the importance of balanced activities of these proteins. The study utilized a systems genetics approach to uncover previously unrecognized gene functions related to centrosome regulation. The research was funded by various organizations including the National Institutes of Health (NIH) and the National Science Foundation (NSF). [Extracted from the article]