1. Constituents from the Roots of Actinidia chinensis and Their Cytochrome P450 Enzyme Inhibitory Activities.
- Author
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Xu YX, Xiang ZB, Jin YS, Xu W, Sun LN, Chen WS, and Chen HS
- Subjects
- Cytochrome P-450 Enzyme Inhibitors chemistry, Cytochrome P-450 Enzyme Inhibitors isolation & purification, Dose-Response Relationship, Drug, Molecular Structure, Structure-Activity Relationship, Triterpenes chemistry, Triterpenes isolation & purification, Actinidia chemistry, Cytochrome P-450 Enzyme Inhibitors pharmacology, Cytochrome P-450 Enzyme System metabolism, Plant Roots chemistry, Triterpenes pharmacology
- Abstract
A newly discovered triterpenoid, (2α,3β)-2,3,23-trihydroxyurs-13(18)-en-28-oic acid (1), along with twelve known compounds (2 - 13), were isolated from the roots of Actinidia chinensis Planch (Actinidiaceae). Their chemical structures were determined by 1D- and 2D-NMR spectra and mass spectrometry (MS). The crude extracts and six main constituents (8 - 13) were tested for cytochrome P450 (CYPs) enzyme inhibitory activity. The results showed that, except for compound 8, compounds 9 - 13 had different inhibitory effects on the cytochrome P450 (CYPs) enzyme, and compound 9 significantly inhibited the catalytic activities of CYP3A4 to < 10% of its control activities., (© 2016 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2016
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