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Heracleifolinosides A-F, new triterpene glycosides from Cimicifuga heracleifolia, and their inhibitory activities against hypoxia and reoxygenation.
- Source :
-
Planta medica [Planta Med] 2013 Mar; Vol. 79 (3-4), pp. 301-7. Date of Electronic Publication: 2013 Jan 30. - Publication Year :
- 2013
-
Abstract
- Six new 9,19-cycloartane triterpene glycosides, heracleifolinosides A-F (1-6), and one new chromone, norkhelloside (7), were isolated from the rhizome of Cimicifuga heracleifolia, together with 15 known compounds (8-22). The structures of the new compounds were elucidated by means of spectroscopic methods including 2D NMR and mass spectrometry. The extracts of C. heracleifolia and all the isolated compounds were tested for activities against hypoxia and reoxygenation injury in human umbilical vein endothelial cells. Heracleifolinoside B (2) is effectively resistant to hypoxia and reoxygenation-induced human umbilical vein endothelial cell injury, with cell viabilities of 61.95 ± 2.04 %, 77.04 ± 4.44 %, and 83.65 ± 3.29 % at concentrations of 1, 10, and 100 µM, respectively.<br /> (Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Cell Survival drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical methods
Glycosides pharmacology
Human Umbilical Vein Endothelial Cells drug effects
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Plant Extracts chemistry
Plant Extracts pharmacology
Rhizome chemistry
Saponins chemistry
Saponins pharmacology
Cell Hypoxia drug effects
Cimicifuga chemistry
Glycosides chemistry
Triterpenes chemistry
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-0221
- Volume :
- 79
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Planta medica
- Publication Type :
- Academic Journal
- Accession number :
- 23364886
- Full Text :
- https://doi.org/10.1055/s-0032-1328174