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1. Anatomical confirmation of computed tomography-based diagnosis of the atherosclerosis discovered in 17th century Korean mummy.

Author

Kim MJ, Kim YS, Oh CS, Go JH, Lee IS, Park WK, Cho SM, Kim SK, and Shin DH

Subjects
Abdominal Cavity diagnostic imaging, Abdominal Cavity pathology, Adult, Aorta, Abdominal diagnostic imaging, Aorta, Abdominal pathology, Coronary Vessels diagnostic imaging, Coronary Vessels pathology, Female, Heart diagnostic imaging, Humans, Middle Aged, Asian People, Atherosclerosis diagnostic imaging, Atherosclerosis pathology, Mummies diagnostic imaging, Mummies pathology, Tomography, X-Ray Computed
Abstract

In the present study on a newly discovered 17th century Korean mummy, computed tomography (CT) revealed multiple aortic calcifications within the aortic wall that were indicative of ancient atherosclerosis. The CT-based findings were confirmed by our subsequent post-factum dissection, which exhibited possible signs of the disease including ulcerated plaques, ruptured hemorrhages, and intimal thickening where the necrotic core was covered by the fibrous cap. These findings are strong indicators that the mummy suffered from aortic atherosclerosis during her lifetime. The present study is a good example of how CT images of vascular calcifications can be a useful diagnostic tool in forming at least preliminary diagnoses of ancient atherosclerosis.

Published
2015
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2. Antenatal manifestation of congenital pancreatoblastoma in a fetus with Beckwith-Wiedemann syndrome

Author

G. P. e. l. i. z. z. o., . G. Conoscenti, Vesce, Fortunato, Guerrini, . P., Cavazzini AUTHOR CORRECTIONS: Two of the author names in the above paper, . L., published in the April issue of Prenatal Diagnosis, The correct names are Fortunato Vesce, were supplied e. r. r. o. n. e. o. u. s. l. y., and The authors would like to apologise for any inconvenience caused, Pietro G. u. e. r. r. i. n. i.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Pathology, Pancreatic disease, Beckwith-Wiedemann Syndrome, Pregnancy, High-Risk, Pancreatoblastoma, Beckwith–Wiedemann syndrome, Prenatal diagnosis, Ultrasonography, Prenatal, Pregnancy, Neoplasms, medicine, complications/pathology/ultrasonography, Humans, Prenatal, Cyst, Tomography, Genetics (clinical), Ultrasonography, Fetus, business.industry, Infant, Newborn, Obstetrics and Gynecology, Infant, complications/surgery/ultrasonography, Neoplasms, Germ Cell and Embryonal, Middle Aged, medicine.disease, complications/pathology/ultrasonography, Female, Humans, Infant, Newborn, Maternal Age, Middle Aged, Neoplasms, Germ Cell and Embryonal, complications/surgery/ultrasonography, Pancreatic Neoplasms, complications/surgery/ultrasonography, Pregnancy, Pregnancy, High-Risk, Tomography, X-Ray Computed, Treatment Outcome, Ultrasonography, Newborn, Uniparental disomy, X-Ray Computed, Pancreatic Neoplasms, medicine.anatomical_structure, Treatment Outcome, Female, High-Risk, Pancreas, business, Tomography, X-Ray Computed, Maternal Age
Abstract

Antenatal detection of an isolated abdominal cyst was found to be a pancreatoblastoma in a female fetus with Beckwith-Wiedemann syndrome. Prenatal and post-natal features and management of this very rare tumour are discussed. Molecular investigation disclosed a mosaic paternal 11p15 uniparental disomy in the tumoral cells. The prognosis of a congenital pancreatoblastoma is good if complete surgical excision is achieved. However, the association with Beckwith-Wiedemann syndrome requires a prolonged follow-up because of the increased risk of developing malignant tumours.

Published
2003