1. Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging.
- Author
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Mansour N, Nekolla SG, Reyes E, Angelidis G, Georgoulias P, Anagnostopoulos C, Bravo P, Bruno I, Flotats A, Fuentes-Ocampo F, Sciagrà R, Keng F, Kessler L, Papathanasiou M, Soman P, and Rischpler C
- Subjects
- Reproducibility of Results, Coronary Artery Disease diagnostic imaging, Humans, Retrospective Studies, Male, Female, Middle Aged, Aged, Myocardial Perfusion Imaging methods, Tomography, Emission-Computed, Single-Photon
- Abstract
Background: Cadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI., Methods: 83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity., Results: Image quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0.05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87.5% vs. 62.5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0.54 vs. conv. 0.49, P < 0.05)., Conclusions: Higher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems., (© 2022. The Author(s).)
- Published
- 2023
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