1. Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections.
- Author
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Carneiro, Victor Alves, dos Santos, Hélcio Silva, Sousa Arruda, Francisco Vassiliepe, Bandeira, Paulo Nogueira, Albuquerque, Maria Rose Jane Ribeiro, Pereira, Maria Olívia, Henriques, Mariana, Cavada, Benildo Sousa, and Teixeira, Edson Holanda
- Subjects
THERAPEUTIC use of plant extracts ,ETHANOL ,PLANT metabolites ,ANTI-infective agents ,BIOFILMS ,THERAPEUTICS - Abstract
Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 μg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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