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Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections.

Authors :
Carneiro, Victor Alves
dos Santos, Hélcio Silva
Sousa Arruda, Francisco Vassiliepe
Bandeira, Paulo Nogueira
Albuquerque, Maria Rose Jane Ribeiro
Pereira, Maria Olívia
Henriques, Mariana
Cavada, Benildo Sousa
Teixeira, Edson Holanda
Source :
Molecules; Jan2011, Vol. 16 Issue 1, p190-201, 12p, 1 Diagram, 2 Graphs
Publication Year :
2011

Abstract

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 μg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
16
Issue :
1
Database :
Complementary Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
67676518
Full Text :
https://doi.org/10.3390/molecules16010190