1. Analysis of schizophrenia-associated genetic markers in the HLA region as risk factors for tardive dyskinesia.
- Author
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Wang R, Lu JY, Herbert D, Lieberman JA, Meltzer HY, Tiwari AK, Remington G, Kennedy JL, and Zai CC
- Subjects
- Humans, Female, Male, Adult, Middle Aged, Risk Factors, Genetic Markers, Severity of Illness Index, Genotype, Genetic Predisposition to Disease, Canada, Antipsychotic Agents adverse effects, Schizophrenia genetics, Tardive Dyskinesia genetics, Polymorphism, Single Nucleotide
- Abstract
Objectives: The pathology of Tardive Dyskinesia (TD) has yet to be fully understood, but there have been proposed hypotheses for the cause of this condition. Our team previously reported a possible association of TD with the Complement Component C4 gene in the HLA region. In this study, we explored the HLA region further by examining two previously identified schizophrenia-associated HLA-region single-nucleotide polymorphisms (SNPs), namely rs13194504 and rs210133., Methods: The SNPs rs13194504 and rs210133 were tested for association with the occurrence and severity of TD in a sample of 172 schizophrenia patients who were recruited for four studies from three different clinical sites in Canada and USA., Results: The rs13194504 AA genotype was associated with decreased severity for TD as measured by Abnormal Involuntary Movement Scale (AIMS) scores (p = 0.047) but not for TD occurrence. SNP rs210133 was not significantly associated with either TD occurrence or AIMS scores., Conclusion: Our findings suggest that the rs13194504 AA genotype may play a role in TD severity, while SNP rs210133 may not have a major role in the risk or severity of TD., (© 2024 The Authors. Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd.)
- Published
- 2024
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