Back to Search
Start Over
Genetic susceptibility to tardive dyskinesia in chronic schizophrenia subjects: III. Lack of association of CYP3A4 and CYP2D6 gene polymorphisms
- Source :
-
Schizophrenia Research . Jun2005, Vol. 75 Issue 1, p21-26. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n=335) from north India. Tardive dyskinesia was diagnosed in ∼29% (96/335) of these patients. No significant association of either of the two SNPs with TD (CYP3A4*1B χ2=0. 308, df=1, p=0.579; CYP2D6*4 χ2=0.006, df=1, p=0.935) was observed. However a trend towards increased severity of TD in patients heterozygous for the CYP2D6*4 mutation was observed. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 75
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 16934333
- Full Text :
- https://doi.org/10.1016/j.schres.2004.12.011