241 results on '"T. Walther"'
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2. Iatrogenic Tracheal Rupture After Successful LVAD-Explantation
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F. Emrich and T. Walther
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Pulmonary and Respiratory Medicine ,Transplantation ,Surgery ,Cardiology and Cardiovascular Medicine - Published
- 2022
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3. Bildgebung bei Transkatheter-Aortenklappenimplantation
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T Walther and A. Van Linden
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Durch das Fehlen der direkten intraoperativen Sicht auf die Aortenklappe ist die „Transkatheter-Aortenklappenimplantation“ (TAVI) masgeblich von der standardisierten und prazisen Bildgebung abhangig. Die Echokardiographie dient der eigentlichen Diagnosestellung der Aortenklappenstenose. Zur praoperativen Planung ist die Computertomographie (CT) des Herzens und der gesamten Aorta das standardmasige Verfahren, mit dem sich alle TAVI-relevanten Informationen gewinnen lassen. Das CT ermoglicht die Bestimmungen des Anulusdurchmessers sowie der Abstande der Koronarostien zum Anulus und gibt Aufschluss uber Verkalkungen der Aortenwurzel, einschlieslich der Aortenklappe. Fur die Planung des Zugangsweges werden im CT Femoral- und Iliakalgefase beurteilt. Stenosen, Durchmesser und Kinking mussen berucksichtigt werden, um eine transfemorale TAVI zu planen. Die TAVI-Bildgebung hat sich in den letzten Jahren stark weiterentwickelt, v. a. in Bezug auf Software, die eine teilautomatisierte TAVI-spezifische Analyse von CT-Daten ermoglicht. Am weitesten verbreitet ist die Software 3mensio™ Structural Heart. Ebenfalls im klinischen Einsatz befinden sich HeartNavigator™ und syngo Aortic Valve Guidance™. 3mensio ist unabhangig vom Angiographiesystem und bietet Analysen von Aortenwurzel und Aorta bis in die Femoralarterien. Die beiden anderen Systeme sind mit der Angiographieanlage desselben Herstellers gekoppelt und erlauben die direkte Interaktion (z. B. Overlay). Fur die Mitralklappe werden die ersten kathetergestutzten Prothesen in Zulassungsstudien untersucht; auch hier ist die Bildgebung von enormer Bedeutung, v. a., da die Anatomie der Mitralklappe deutlich komplexer ist als die der Aortenklappe.
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- 2019
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4. Hauptstammstenose: perkutane koronare Intervention vs. chirurgische Koronarrevaskularisation
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T. Walther and M. Arsalan
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Die chirurgische Koronarrevaskularisation galt uber Jahrzehnte als Goldstandard zur Behandlung der Hauptstammstenose. In den letzten Jahren wird jedoch auch diese Koronarpathologie vermehrt mithilfe perkutaner Koronarinterventionen behandelt. Welche der beiden Therapieoptionen fur den individuellen Patienten eingesetzt werden sollte, wurde bereits vielfach diskutiert und ist Gegenstand zahlreicher Studien mit teils widerspruchlichen Ergebnissen. Wahrend einige Studien bei geeigneten Patienten beide Verfahren als gleichwertig beschreiben, zeigen andere einen klaren Vorteil fur die chirurgische Therapie. Der vorliegende CME-Beitrag stellt die aktuellen nationalen und internationalen Leitlinien sowie wesentliche Studien zum Thema vor und zeigt die potenziellen Vor- und Nachteile der jeweiligen Therapieverfahren auf. Des Weiteren wird erlautert, wie durch die Etablierung eines interdisziplinaren Koronar-Heart-Teams die optimale, patientenzentrierte Therapie erfolgen kann.
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- 2018
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5. Indikationsstellung und Patientenselektion für die kathetergestützte Behandlung der Mitralklappeninsuffizienz
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Philipp Kiefer, S. Ensminger, Sabine Bleiziffer, Hendrik Treede, A. Van Linden, Jörg Seeburger, Thilo Noack, S. Sündermann, L. Conradi, T Walther, and David Holzhey
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,Cardiothoracic surgery ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Abstract
Die symptomatische Mitralklappeninsuffizienz (MI) ist die haufigste Herzklappenerkrankung in der westlichen Welt, deren herzchirurgische oder kathetergestutzte Therapie einen multidisziplinaren Behandlungsansatz benotigt. Die MI wird atiologisch in eine primare und eine sekundare MI unterteilt, welche unterschiedlichen Behandlungsstrategien unterliegen. Die Einfuhrung kathetergestutzter Behandlungsverfahren, insbesondere die perkutanen Mitralklappenrekonstruktion mittels MitraClip® (Fa. Abbott Vascular, Santa Clara, CA, USA), haben hierbei zu einer Erweiterung der Behandlungsmoglichkeiten neben der konventionellen Mitralklappenchirurgie gefuhrt. So kann die perkutane Mitralklappenrekonstruktion mittels MitraClip zur Behandlung der primaren und sekundaren MI unter definierten Voraussetzungen bei inoperablen und Hochrisikopatienten Anwendung finden. Hierbei ist es die Aufgabe des Herzchirurgen, den multidisziplinaren Behandlungsprozess aktiv mitzugestalten.
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- 2018
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6. Direct Comparison of Rapid Deployment Valves and Conventional Biological Valves for Treatment of Aortic Stenosis: Insights from the German Aortic Valve Registry
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Timm Bauer, T Walther, Raffi Bekeredjian, Buntaro Fujita, Hugo A. Katus, Christian W. Hamm, Wolfgang Harringer, Sandra Landwehr, Christian Frerker, Andreas Beckmann, Friedrich-Wilhelm Mohr, Stephan Ensminger, Helge Möllmann, and Sabine Bleiziffer
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Pulmonary and Respiratory Medicine ,Aortic valve ,medicine.medical_specialty ,business.industry ,medicine.disease ,language.human_language ,German ,Stenosis ,medicine.anatomical_structure ,Software deployment ,Internal medicine ,language ,medicine ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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7. Prediction of Acute Kidney Injury after TAVI by New Biomarkers
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Won Kim, Christian W. Hamm, Helge Möllmann, M. Renker, Giovanni Filardo, A. Van Linden, Karl J. Lackner, T Walther, Mani Arsalan, Johannes Blumenstein, L. Gaede, and Christoph Liebetrau
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Acute kidney injury ,Surgery ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2018
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8. Conscious Sedation versus General Anesthesia in Transcatheter Aortic Valve Implantation: Insights from the German Aortic Valve Registry
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Christian Frerker, Helge Möllmann, Christian Hengstenberg, Stephan Ensminger, Sabine Bleiziffer, T Walther, Friedrich-Wilhelm Mohr, Raffi Bekeredjian, Buntaro Fujita, Oliver Husser, Andreas Beckmann, and Timm Bauer
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Pulmonary and Respiratory Medicine ,Aortic valve ,medicine.anatomical_structure ,Transcatheter aortic ,business.industry ,Sedation ,Anesthesia ,medicine ,Surgery ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
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9. Prognostic Value of Baseline Hemoglobin on Short- and Mid-Term Clinical Outcomes after Transcatheter Aortic Valve Implantation
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A. Van Linden, Christian W. Hamm, Won-Keun Kim, Annika Arsalan-Werner, Molly C. Mack, Giovanni Filardo, T Walther, Mani Arsalan, John J. Squiers, Benjamin D. Pollock, and Christoph Liebetrau
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,Term (time) ,Internal medicine ,medicine ,Cardiology ,Surgery ,Hemoglobin ,Cardiology and Cardiovascular Medicine ,Baseline (configuration management) ,business ,Value (mathematics) - Published
- 2017
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10. TAVR Risk Scoring Using Established versus New Scoring Systems: Role of the New STS/ACC Model
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Maren Weferling, T Walther, Molly C. Mack, Mani Arsalan, Giovanni Filardo, Mirko Doss, Annika Arsalan-Werner, Christoph Liebetrau, Won-Keun Kim, S. Kalbas, A. Van Linden, Benjamin D. Pollock, Florian Hecker, Christian W. Hamm, and M. Renker
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pediatrics ,business.industry ,Emergency medicine ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2017
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11. Preoperative Exercise Training before Elective Coronary Artery Bypass Graft Surgery: A Prospective Randomized Evaluation on Feasibility and Effects on Operative Outcomes
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H. Baumgarten, C. Borst, C. Steinmetz, C. Walther, and T Walther
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Artery - Published
- 2017
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12. Current Trends in Practice and Outcomes after Surgical Aortic Valve Replacement in Germany: Update of the GARY Registry
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Helge Möllmann, Timm Bauer, K.-H. Kuck, Buntaro Fujita, Stephan Ensminger, Armin Welz, Sandra Landwehr, Friedrich-Wilhelm Mohr, Christian Frerker, Andreas Beckmann, T Walther, and Christian W. Hamm
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Aortic valve replacement ,business.industry ,General surgery ,medicine ,Surgery ,Current (fluid) ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2017
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13. Porcelain Aorta is Associated with Higher Vascular Complication Rates after Transfemoral versus Transapical Transcatheter Aortic Valve Implantation
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T Walther, Mani Arsalan, A. Wöhrle, Mirko Doss, V.L. Arnaud, Won-Keun Kim, and Christoph Liebetrau
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Vascular complication ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Porcelain aorta - Published
- 2017
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14. Minimally Invasive Video-Assisted Mitral Valve Repair in Barlow Disease Using Open Annuloplasty Bands
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Mirko Doss, A. Van Linden, T Walther, Tomas Holubec, Mani Arsalan, S. Van Linden, and M Schönburg
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Pulmonary and Respiratory Medicine ,Mitral valve repair ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Internal medicine ,Cardiology ,Medicine ,Surgery ,Video assisted ,Cardiology and Cardiovascular Medicine ,business - Published
- 2017
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15. Feasibility of a New Automatic Imaging Tool Prototype for Interventional Mitral Valve Therapy
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A. Van Linden, Won-Keun Kim, T Walther, Mani Arsalan, Mirko Doss, Claudia Walther, Christoph Liebetrau, and S. Van Linden
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.anatomical_structure ,Imaging Tool ,business.industry ,Mitral valve ,Medicine ,Surgery ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 2017
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16. One Year Clinical Outcome and Biomarker Levels after Randomized Comparison of Two Supraannular Pericardial Aortic Xenografts
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J. Köhne, Tomas Holubec, Christoph Liebetrau, A. Van Linden, T Walther, Mani Arsalan, Mirko Doss, and Florian Hecker
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Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Biomarker (medicine) ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2017
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17. Outcome after Mitral Valve Replacement (MVR) Using Biological versus Mechanical Valves
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S. Hein, T Walther, Manfred Richter, N. Thaqi, M Schönburg, Z Szalay, W. Skwara, and A. Cetinkaya
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Internal medicine ,Mitral valve replacement ,medicine ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Outcome (game theory) - Published
- 2017
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18. Clinical presentation, aetiology and outcomes of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study
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Habib G., Erba P. A., Iung B., Donal E., Cosyns B., Laroche C., Popescu B. A., Prendergast B., Tornos P., Sadeghpour A., Oliver L., Vaskelyte J. -J., Sow R., Axler O., Maggioni A. P., Lancellotti P, C P Gale, B Beleslin, A Budaj, O Chioncel, N Dagres, N Danchin, J Emberson, D Erlinge, M Glikson, A Gray, M Kayikcioglu, A P Maggioni, V K Nagy, A Nedoshivin, A-S Petronio, J Roos-Hesselink, L Wallentin, U Zeymer, G Habib, P Lancellotti, B Cosyns, E Donal, P Erba, B Iung, B A Popescu, B Prendergast, P Tornos, M Andarala, C Berle, A Brunel-Lebecq, E Fiorucci, C Laroche, V Missiamenou, C Taylor, N N Ali Tatar-Chentir, M Al-Mallah, M Astrom Aneq, G Athanassopoulos, L P Badano, S Benyoussef, E Calderon Aranda, N M Cardim, K-L Chan, I Cruz, T Edvardsen, G Goliasch, A Hagendorff, K Hristova, O Kamp, D-H Kang, W Kong, S Matskeplishvili, M Meshaal, M Mirocevic, A N Neskovic, M Pazdernik, E Plonska-Gosciniak, M Raissouni, R Ronderos, L E Sade, A Sadeghpour, A Sambola, S Sengupta, J Separovic-Hanzevacki, M Takeuchi, E Tucay, A C Tude Rodrigues, A Varga, J Vaskelyte, K Yamagata, K Yiangou, H Zaky, I Granada, M Mahia, S Ressi, F Nacinovich, A Iribarren, P Fernandez Oses, G Avegliano, E Filipini, R Obregon, M Bangher, J Dho, L Cartasegna, M L Plastino, V Novas, C Shigel, G Reyes, M De Santos, N Gastaldello, M Granillo Fernandez, M Potito, G Streitenberger, P Velazco, J H Casabé, C Cortes, E Guevara, F Salmo, M Seijo, F Weidinger, M Heger, R Brooks, C Stöllberger, C-Y Ho, L Perschy, L Puskas, C Binder, R Rosenhek, M Schneider, M-P Winter, E Hoffer, M Melissopoulou, E Lecoq, D Legrand, S Jacquet, M Massoz, L Pierard, S Marchetta, R Dulgheru, C D Emal, C Oury, S Droogmans, D Kerkhove, D Plein, L Soens, C Weytjens, A Motoc, B Roosens, I Lemoine, I Rodrigus, B Paelinck, B Amsel, P Unger, D Konopnicki, C Beauloye, A Pasquet, J L Vanoverschelde, S Pierard, D Vancraeynest, F Sinnaeve, J L Andrade, K Staszko, R Dos Santos Monteiro, M H Miglioranza, D L Shuha, M Alcantara, V Cravo, L Fazzio, A Felix, M Iso, C Musa, A P Siciliano, F Villaca Filho, A Rodrigues, F Vilela, J Braga, R Silva, D Rodrigues, L Silva, S Morhy, C Fischer, M Vieira, T Afonso, J Abreu, S N Falcao, V A Moises, A Gouvea, F J Mancuso, A C Souza, C Y Silva, G João, C S Abboud, R Bellio de Mattos Barretto, A Ramos, R Arnoni, J E Assef, D J Della Togna, D Le Bihan, L Miglioli, A P Romero Oliveira, R Tadeu Magro Kroll, D Cortez, C L Gelape, M D C Peirira Nunes, T C De Abreu Ferrari, K Hay, V Le, M Page, F Poulin, C Sauve, K Serri, C Mercure, J Beaudoin, P Pibarot, I A Sebag, L G Rudski, G Ricafort, B Barsic, V Krajinovic, M Vargovic, D Lovric, V Reskovic-Luksic, J Vincelj, S Jaksic Jurinjak, V Yiannikourides, M Ioannides, C Pofaides, V Masoura, J Pudich, A Linhart, M Siranec, J Marek, K Blechova, M Kamenik, R Pelouch, Z Coufal, M Mikulica, M Griva, E Jancova, M Mikulcova, M Taborsky, J Precek, M Jecmenova, J Latal, J Widimsky, T Butta, S Machacek, R Vancata, J Spinar, M Holicka, F Pow Chon Long, N Anzules, A Bajana Carpio, G Largacha, E Penaherrera, D Moreira, E Mahfouz, E Elsafty, A Soliman, Y Zayed, J Aboulenein, M Abdel-Hay, A Almaghraby, M Abdelnaby, M Ahmed, B Hammad, Y Saleh, H Zahran, O Elgebaly, A Saad, M Ali, A Zeid, R El Sharkawy, A Al Kholy, R Doss, D Osama, H Rizk, A Elmogy, M Mishriky, P Assayag, S El Hatimi, S Hubert, J-P Casalta, F Gouriet, F Arregle, S Cammilleri, L Tessonnier, A Riberi, E Botelho-Nevers, A Gagneux-Brunon, R Pierrard, C Tulane, S Campisi, J-F Fuzellier, M Detoc, T Mehalla, D Boutoille, A S Lecompte, M Lefebvre, S Pattier, O Al Habash, N Asseray-Madani, C Biron, J Brochard, J Caillon, C Cueff, T Le Tourneau, R Lecomte, M M Magali Michel, J Orain, S Delarue, M Le Bras, J-F Faucher, V Aboyans, A Beeharry, H Durox, M Lacoste, J Magne, D Mohty, A David, V Pradel, V Sierra, A Neykova, B Bettayeb, S Elkentaoui, B Tzvetkov, G Landry, C Strady, K Ainine, S Baumard, C Brasselet, C Tassigny, V Valente-Pires, M Lefranc, B Hoen, B Lefevre, E Curlier, C Callier, N Fourcade, Y Jobic, S Ansard, R Le Berre, F Le Ven, M-C Pouliquen, G Prat, P Le Roux, F Bouchart, A Savoure, C Alarcon, C Chapuzet, I Gueit, C Tribouilloy, Y Bohbot, F Peugnet, M Gun, X Duval, X Lescure, E Ilic-Habensus, N Sadoul, C Selton-Suty, F Alla, F Goehringer, O Huttin, E Chevalier, R Garcia, V Le Marcis, P Tattevin, E Flecher, M Revest, C Chirouze, K Bouiller, L Hustache-Mathieu, T Klopfenstein, J Moreau, D Fournier, A-S Brunel, P Lim, L Oliver, J Ternacle, A Moussafeur, P Chavanet, L Piroth, A Salmon-Rousseau, M Buisson, S Mahy, C Martins, S Gohier, O Axler, F Baumann, S Lebras, C Piper, D Guckel, J Börgermann, D Horstkotte, E Winkelmann, B Brockmeier, D Grey, G Nickenig, R Schueler, C Öztürk, E Stöhr, C Hamm, T Walther, R Brandt, A-C Frühauf, C T Hartung, C Hellner, C Wild, M Becker, S Hamada, W Kaestner, K Stangl, F Knebel, G Baldenhofer, A Brecht, H Dreger, C Isner, F Pfafflin, M Stegemann, R Zahn, B Fraiture, C Kilkowski, A-K Karcher, S Klinger, H Tolksdorf, D Tousoulis, C Aggeli, S Sideris, E Venieri, G Sarri, D Tsiapras, I Armenis, A Koutsiari, G Floros, C Grassos, S Dragasis, L Rallidis, C Varlamos, L Michalis, K Naka, A Bechlioulis, A Kotsia, L Lakkas, K Pappas, C Papadopoulos, S Kiokas, A Lioni, S Misailidou, J Barbetseas, M Bonou, C Kapelios, I Tomprou, K Zerva, A Manolis, E Hamodraka, D Athanasiou, G Haralambidis, H Samaras, L Poulimenos, A Nagy, A Bartykowszki, E Gara, K Mungulmare, R Kasliwal, M Bansal, S Ranjan, A Bhan, M Kyavar, M Maleki, F Noohi Bezanjani, A Alizadehasl, S Boudagh, A Ghavidel, P Moradnejad, H R Pasha, B Ghadrdoost, D Gilon, J Strahilevitz, M Wanounou, S Israel, C d'Agostino, P Colonna, L De Michele, F Fumarola, M Stante, N Marchionni, V Scheggi, B Alterini, S Del Pace, P Stefano, C Sparano, N Ruozi, R Tenaglia, D Muraru, U Limbruno, A Cresti, P Baratta, M Solari, C Giannattasio, A Moreo, B De Chiara, B Lopez Montero, F Musca, C A Orcese, F Panzeri, F Spano, C F Russo, O Alfieri, M De Bonis, S Chiappetta, B Del Forno, M Ripa, P Scarpellini, C Tassan Din, B Castiglioni, R Pasciuta, S Carletti, D Ferrara, M Guffanti, G Iaci, E Lapenna, T Nisi, C Oltolini, E Busnardo, U Pajoro, E Agricola, R Meneghin, D Schiavi, F Piscione, R Citro, R M Benvenga, L Greco, L Soriente, I Radano, C Prota, M Bellino, D Di Vece, F Santini, A Salsano, G M Olivieri, F Turrini, R Messora, S Tondi, A Olaru, V Agnoletto, L Grassi, C Leonardi, S Sansoni, S Del Ponte, G M Actis Dato, A De Martino, N Ohte, S Kikuchi, K Wakami, K Aonuma, Y Seo, T Ishizu, T Machino-Ohtsuka, M Yamamoto, N Iida, H Nakajima, Y Nakagawa, C Izumi, M Amano, M Miyake, K Takahashi, I Shiojima, Y Miyasaka, H Maeba, Y Suwa, N Taniguchi, S Tsujimoto, T Kitai, M Ota, S Yuda, S Sasaki, N Hagiwara, K Yamazaki, K Ashihara, K Arai, C Saitou, S Saitou, G Suzuki, Y Shibata, N Watanabe, S Nishino, K Ashikaga, N Kuriyama, K Mahara, T Okubo, H Fujimaki, H Shitan, H Yamamoto, K Abe, M Terada, S Takanashi, M Sata, H Yamada, K Kusunose, Y Saijo, H Seno, O Yuichiro, T Onishi, F Sera, S Nakatani, H Mizuno, K Sengoku, S W Park, K Eun Kyoung, L Ga Yeon, J-W Hwang, C Jin-Oh, S-J Park, L Sang-Chol, C Sung-A, S Y Jang, R Heo, S Lee, J-M Song, E Jung, J Plisiene, A Dambrauskaite, G Gruodyte, R Jonkaitiene, V Mizariene, J Atkocaityte, R Zvirblyte, R Sow, A Codreanu, T Staub, C Michaux, E C L De la Vega, L Jacobs-Orazi, C Mallia Azzopardi, R G Xuereb, T Piscopo, J Farrugia, M Fenech, E Pllaha, C Vella, D Borg, R Casha, L Grib, E Raevschi, A Grejdieru, D Kravcenco, E Prisacari, E Samohvalov, S Samohvalov, N Sceglova, E Panfile, L Cardaniuc, V Corcea, A Feodorovici, V Gaina, L Girbu, P Jimbei, G Balan, I Cardaniuc, I Benesco, V Marian, N Sumarga, B Bozovic, N Bulatovic, P Lakovic, L Music, R Budde, A Wahadat, T Gamela, T Meijers, J P Van Melle, V M Deursen, H J Crijns, S C Bekkers, E C Cheriex, M Gilbers, B L Kietselaer, C Knackstedt, R Lorusso, S Schalla, S A Streukens, S Chamuleau, M-J Cramer, A Teske, T Van der Spoel, A Wind, J Lokhorst, O Liesbek, H Van Heusden, W Tanis, I Van der Bilt, J Vriend, H De Lange-van Bruggen, E Karijodikoro, R Riezebos, E van Dongen, J Schoep, V Stolk, J T Offstad, J O Beitnes, T Helle-Valle, H Skulstad, R Skardal, N Qamar, S Furnaz, B Ahmed, M H Butt, M F Khanzada, T Saghir, A Wahid, T Hryniewiecki, P Szymanski, K Marzec, M Misztal-Ogonowska, W Kosmala, M Przewlocka-Kosmala, A Rojek, K Woznicka, J Zachwyc, A Lisowska, M Kaminska, J D Kasprzak, E Kowalczyk, D F Strzecka, P Wejner-Mik, M Trabulo, P Freitas, S Ranchordas, G Rodrigues, P Pinto, C Queiros, J Azevedo, L Marques, D Seabra, L Branco, M Cruz, A Galrinho, R Moreira, P Rio, A T Timoteo, M Selas, V Carmelo, B Duque Neves, H Pereira, A Guerra, A Marques, I Pintassilgo, M C Tomescu, N-M Trofenciuc, M Andor, A Bordejevic, H S Branea, F Caruntu, L A Velcean, A Mavrea, M F Onel, T Parvanescu, D Pop, A L Pop-Moldovan, M I Puticiu, L Cirin, I M Citu, C A Cotoraci, D Darabantiu, R Farcas, I Marincu, A Ionac, D Cozma, C Mornos, F Goanta, I Popescu, R Beyer, R Mada, R Rancea, R Tomoaia, H Rosianu, C Stanescu, Z Kobalava, J Karaulova, E Kotova, A Milto, A Pisaryuk, N Povalyaev, M Sorokina, J Alrahimi, A Elshiekh, A Jamiel, A Ahmed, N Attia, B Putnikovic, A Dimic, B Ivanovic, S Matic, D Trifunovic, J Petrovic, D Kosevic, I Stojanovic, I Petrovic, P Dabic, P Milojevic, I Srdanovic, S Susak, L Velicki, A Vulin, M Kovacevic, A Redzek, M Stefanovic, T C Yeo, W Kf Kong, K K Poh, I Vilacosta, C Ferrera, C Olmos, M Abd El-Nasser, F Calvo Iglesias, E Blanco-Gonzalez, M Bravo Amaro, E Lopez-Rodriguez, J Lugo Adan, A N Germinas, P Pazos-Lopez, M Pereira Loureiro, M T Perez, S Raposeiras-Roubin, S Rasheed Yas, M-M Suarez-Varela, F Vasallo Vidal, D Garcia-Dorado, N Fernandez-Hidalgo, T Gonzalez-Alujas, J Lozano, O Maisterra, N Pizzi, R Rios, A Bayes-Genis, L Pedro Botet, N Vallejo, C Llibre, L Mateu, R Nunez, D Quesada, E Berastegui, D Bosch Portell, J Aboal Vinas, X Albert Bertran, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, M A Arnau, A Bel, M Blanes, A Osa, M Anguita, F Carrasco, J C Castillo, J L Zamorano, J L Moya Mur, M Alvaro, C Fernandez-Golfin, J M Monteagudo, E Navas Elorza, M C Farinas Alvarez, J Aguero Balbin, J Zarauza, J F Gutierrez-Diez, C Arminanzas, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, R Rodriguez-Alvarez, J Goikoetxea, M Montejo, J M Miro, M Almela, J Ambrosioni, A Moreno, E Quintana, E Sandoval, A Tellez, J M Tolosana, B Vidal, C Falces, D Fuster, C Garcia-de-la-Maria, M Hernandez-Meneses, J Llopis, F Marco, I Ruiz-Zamora, A Bardaji Ruiz, E Sanz Girgas, G Garcia-Pardo, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, L Abid, R Hammami, S Kammoun, M S Mourali, F Mghaieth Zghal, M Ben Hlima, S Boudiche, S Ouali, L Zakhama, S Antit, I Slama, O Gulel, M Sahin, E Karacaglar, S Kucukoglu, O Cetinarslan, U Y Sinan, U Canpolat, B Mutlu, H Atas, R Dervishova, C Ileri, J Alhashmi, J Tahir, P Zarger, F Baslib, S Woldman, L Menezes, C Primus, R Uppal, I Bvekerwa, B Chandrasekaran, A Kopanska, J Chambers, J Hancock, J Klein, R Rajani, M P Ursi, S Cannata, R Dworakowski, A Fife, J Breeze, M Browne-Morgan, M Gunning, S Streather, F M Asch, M Zemedkun, B Alyavi, J Uzokov, G., Habib, P. A., Erba, B., Iung, E., Donal, B., Cosyn, C., Laroche, B. A., Popescu, B., Prendergast, P., Torno, A., Sadeghpour, L., Oliver, J. -J., Vaskelyte, R., Sow, O., Axler, A. P., Maggioni, P, Lancellotti, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, Petronio, A-S, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, P Badano, L, Benyoussef, S, Calderon Aranda, E, M Cardim, N, Chan, K-L, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D-H, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, Ho, C-Y, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M-P, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, Dos Santos Monteiro, R, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, Le Bihan, D, Miglioli, L, P Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, L Gelape, C, C Peirira Nunes, M D, C De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J-P, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J-F, Detoc, M, Mehalla, T, Boutoille, D, S Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, M Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J-F, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M-C, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A-S, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Börgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Öztürk, C, Stöhr, E, Hamm, C, Walther, T, Brandt, R, Frühauf, A-C, T Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A-K, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, R Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, A Orcese, C, Panzeri, F, Spano, F, F Russo, C, Alfieri, O, DE BONIS, Michele, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, M Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, M Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, M Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, W Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J-W, Jin-Oh, C, Park, S-J, Sang-Chol, L, Sung-A, C, Y Jang, S, Heo, R, Lee, S, Song, J-M, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, L De la Vega, E C, Jacobs-Orazi, L, Mallia Azzopardi, C, G Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, P Van Melle, J, M Deursen, V, J Crijns, H, C Bekkers, S, C Cheriex, E, Gilbers, M, L Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, A Streukens, S, Chamuleau, S, Cramer, M-J, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, T Offstad, J, O Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, H Butt, M, F Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, D Kasprzak, J, Kowalczyk, E, F Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, T Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, C Tomescu, M, Trofenciuc, N-M, Andor, M, Bordejevic, A, S Branea, H, Caruntu, F, A Velcean, L, Mavrea, A, F Onel, M, Parvanescu, T, Pop, D, L Pop-Moldovan, A, I Puticiu, M, Cirin, L, M Citu, I, A Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, C Yeo, T, Kf Kong, W, K Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Blanco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, N Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, T Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M-M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tarradellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, A Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, Navas Elorza, E, C Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, Arnaiz de Las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Y Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), University Medical Center Groningen [Groningen] (UMCG), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Université de Médecine Carol Davila, Guy's and St Thomas' Hospital [London], CHU Henri Mondor, Centre Hospitalier Universitaire de Liège (CHU-Liège), AstraZeneca, Bayer, Edwards Lifesciences, Servier, Abbott Vascular Int., Amgen Cardiovascular, Pfizer Alliance, Daiichi Sankyo Europe GmbH, Alliance Daiichi Sankyo Europe GmbH, Gedeon Richter Plc., Menarini Int. Op., Vifor, Boehringer Ingelheim, Boston Scientific Corporation, Bristol-Myers Squibb, Eli Lilly and Company, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service de pathologies cardiovasculaires intensives, UCL - (SLuc) Service de soins intensifs, Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Oxford University Hospitals NHS Trust, University of Oxford [Oxford], Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Bordeaux (UB), Research Center [Associazione Nazionale Medici Cardiologi Ospedalieri] (ANMCO Research Center), Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO), Service de cardiologie [Liège], CHU de Liège-Domaine Universitaire du Sart Tilman, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Exeter, Instituto Nacional de Tecnología Agropecuaria, Pergamino, Argentina, Laboratory of In Vivo Cellular and Molecular Imaging, Vrije Universiteit Brussel (VUB), Centre National de la Recherche Scientifique (CNRS), Division of Engineering and Applied Science, California Institute of Technology, California Institute of Technology (CALTECH), Departamento de Biologia de la Reproduccion, Universidad Autónoma Metropolitana Iztapalapa (UAMI), Universidade Federal de Itajubá, Departamento de Física [Coimbra] (DFC), Universidade de Coimbra [Coimbra], Section of Internal Medicine and Endocrine and Metabolic Sciences, Università degli Studi di Perugia (UNIPG), LIP-Coimbra & Department of Physics of the University of Coimbra, Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Quebec Heart Institute/Laval Hospital, Université Laval [Québec] (ULaval)-Quebec Heart Institute, Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU AMU), CHU Saint-Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service des maladies infectieuses et tropicales [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de bactériologie et hygiène hospitalière [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies infectieuses et tropicales [CHU Limoges], CHU Limoges, Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Centre Hospitalier Universitaire de Reims (CHU Reims), Anesthésie et réanimation en chirurgie cardiaque [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU), Service des maladies infectieuses et tropicales [Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Mécanismes physiologiques et conséquences des calcifications cardiovasculaires: rôle des remodelages cardiovasculaires et osseux, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Cardiology [Ospedali del Tigullio], Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Service des Maladies Infectieuses et Tropicales [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Cardiologie [CHRU Nancy], Service des maladies infectieuses et réanimation médicale, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Service de chirurgie thoracique cardiaque et vasculaire [Rennes], Laboratoire Chrono-environnement - CNRS - UFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), service de maladies infectieuses CHU J Minjoz Besancon, Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Département d'infectiologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Virologie et pathogenèse virale (VPV), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institució Catalana de Recerca i Estudis Avançats (ICREA), Institute for Advanced Studies in Basic Sciences, affiliation inconnue, Dipartamento di Fisica 'E.R. Caianiello', Università degli Studi di Salerno (UNISA), The University of Tokyo, Northern Research Station, Forestry Commission, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Instituto de Plasmas e Fusão Nuclear [Lisboa] (IPFN), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), Instituto de Investigaciones Marinas (CSIC), Faculté des Sciences Pharmaceutiques, EA 4529, Laboratoire de Biochimie, Université Paris-Sud - Paris 11 (UP11), Istituto di Virologia Vegetale, Università degli studi di Torino (UNITO), Universidad Nacional Autónoma de México (UNAM), Service de Chirurgie Cardiovasculaire, University Hospital of Cruces, Geneva University Hospital (HUG), Institut Jean Le Rond d'Alembert (DALEMBERT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Preventive Medicine Unit, University Hospital Joan XXIII, IISPV, Rovira and Virgili University, Popescu, B, Maggioni, A, Gale, C, Nagy, V, Petronio, A, Ali Tatar-Chentir, N, Badano, L, Cardim, N, Chan, K, Kang, D, Neskovic, A, Sade, L, Tude Rodrigues, A, Plastino, M, Casabe, J, Stollberger, C, Ho, C, Winter, M, Emal, C, Vanoverschelde, J, Andrade, J, Miglioranza, M, Shuha, D, Siciliano, A, Falcao, S, Moises, V, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Assef, J, Della Togna, D, Romero Oliveira, A, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Sebag, I, Rudski, L, Casalta, J, Fuzellier, J, Lecompte, A, Magali Michel, M, Faucher, J, Pouliquen, M, Brunel, A, Borgermann, J, Ozturk, C, Stohr, E, Fruhauf, A, Hartung, C, Karcher, A, Pasha, H, Orcese, C, Russo, C, De Bonis, M, Benvenga, R, Olivieri, G, Actis Dato, G, Park, S, Hwang, J, Jang, S, Song, J, De la Vega, E, Xuereb, R, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Kietselaer, B, Streukens, S, Cramer, M, Offstad, J, Beitnes, J, Butt, M, Khanzada, M, Kasprzak, J, Strzecka, D, Timoteo, A, Tomescu, M, Trofenciuc, N, Branea, H, Velcean, L, Onel, M, Pop-Moldovan, A, Puticiu, M, Citu, I, Cotoraci, C, Yeo, T, Poh, K, Germinas, A, Perez, M, Suarez-Varela, M, Arnau, M, Castillo, J, Zamorano, J, Moya Mur, J, Monteagudo, J, Farinas Alvarez, M, Gutierrez-Diez, J, Miro, J, Tolosana, J, Mourali, M, Yasar, U, Ursi, M, Asch, F, Clinical sciences, Cardio-vascular diseases, Cardiology, Medical Imaging, Cardiovascular Centre (CVC), Service de médecine nucléaire [Marseille], Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), MGSOG Scientific staff, MUMC+: MA Cardiologie (9), Cardiologie, RS: Carim - H01 Clinical atrial fibrillation, RS: CARIM - R2.01 - Clinical atrial fibrillation, RS: CARIM - R3.11 - Imaging, Promovendi CD, Fysiologie, MUMC+: MA Med Staf Artsass CTC (9), RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, MUMC+: MA Med Staf Spec Cardiologie (9), RS: Carim - H02 Cardiomyopathy, RS: CARIM - R2.02 - Cardiomyopathy, CTC, MUMC+: MA Med Staf Spec CTC (9), RS: Carim - V04 Surgical intervention, RS: CARIM - R2.12 - Surgical intervention, RS: FdR IC Aansprakelijkheid, Graduate School, ACS - Heart failure & arrhythmias, Radiotherapy, CCA - Imaging and biomarkers, CCA - Cancer Treatment and Quality of Life, and ACS - Atherosclerosis & ischemic syndromes
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Male ,SURGERY ,Embolism ,Infective endocarditi ,Infective endocarditis ,Registry ,Valve disease ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Africa, Northern ,Positron Emission Tomography Computed Tomography ,030212 general & internal medicine ,Hospital Mortality ,Prospective Studies ,Registries ,Prospective cohort study ,Abscess ,Aged, 80 and over ,medicine.diagnostic_test ,Middle Aged ,Staphylococcal Infections ,3. Good health ,Cardiac surgery ,Community-Acquired Infections ,Europe ,Treatment Outcome ,Positron emission tomography ,Echocardiography ,Heart Valve Prosthesis ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Female ,ECHOCARDIOGRAPHY ,Cardiology and Cardiovascular Medicine ,Adult ,medicine.medical_specialty ,Asia ,Prosthesis-Related Infections ,DIAGNOSIS ,03 medical and health sciences ,Fluorodeoxyglucose F18 ,Internal medicine ,Streptococcal Infections ,medicine ,MANAGEMENT ,Journal Article ,Humans ,Aged ,business.industry ,EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY ,Endocarditis, Bacterial ,South America ,medicine.disease ,Heart failure ,Etiology ,Radiopharmaceuticals ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Enterococcus - Abstract
Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
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- 2019
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19. One-Year Outcomes following Transapical Delivery of a Novel, Low-Profile Self-expandable Transcatheter Valve: Results from the ACURATE Neo TA Study
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D. Wünsch, K. Kim, H. Treede, J Kempfert, M. Hilker, U. Schäfer, J. Börgermann, L. Conradi, T Walther, David Holzhey, and Holger Schröfel
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medicine.medical_specialty ,Self expandable ,business.industry ,medicine ,business ,Surgery - Published
- 2019
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20. Deutsches Aortenklappenregister
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D. Holzhey, F.-W. Mohr, Philipp Kiefer, Alexandro Hoyer, T. Walther, Thilo Noack, and J. Seeburger
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Pulmonary and Respiratory Medicine ,Aortic valve ,medicine.medical_specialty ,business.industry ,language.human_language ,German ,medicine.anatomical_structure ,Internal medicine ,medicine ,language ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
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21. Perioperativer Umgang mit moderner Thrombozytenaggregationshemmung
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T. Walther, J. Kempfert, Mani Arsalan, and A. Meyer
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Pulmonary and Respiratory Medicine ,Gynecology ,medicine.medical_specialty ,business.industry ,Cardiothoracic surgery ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Ticagrelor ,medicine.drug - Abstract
In den letzten Jahren sind einige neue Wirkstoffe zur Thrombozytenaggregation zugelassen worden. Das perioperative Management dieser neuen Medikamente stellt die Herzchirurgie vor eine neue Herausforderung. Im Hinblick auf eine duale Thrombozytenhemmung mithilfe der z. T. neuen Wirkstoffe gilt es insbesondere, ein mogliches Blutungsrisiko gegen das potenzielle Risiko ischamischer Komplikationen abzuwagen. Fur die neuen Wirkstoffe besteht v. a. im Rahmen von Notfalleingriffen die Problematik der intraoperativen Hamostase und des Monitorings. Detaillierte Kenntnisse der verfugbaren Therapieoptionen sind hierzu unabdingbar. Aktuell fehlen evidenzbasierte Empfehlungen und spezifische Leitlinien.
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- 2015
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22. Recent Advances in Transcatheter Aortic Valve Implantation: Novel Devices and Potential Shortcomings
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J Kempfert, Helge Moellmann, A. Van Linden, T Walther, Johannes Blumenstein, and Christoph Liebetrau
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Aortic valve ,medicine.medical_specialty ,Cardiac Catheterization ,Transcatheter aortic ,aortic valve stenosis ,Context (language use) ,Prosthesis Design ,Article ,Internal medicine ,Medicine ,Humans ,New device ,transcatheter aortic valve implantation ,Heart Valve Prosthesis Implantation ,Transapical ,business.industry ,Treatment options ,transfemoral ,General Medicine ,Aortic Valve Stenosis ,medicine.disease ,Surgery ,Clinical trial ,Stenosis ,medicine.anatomical_structure ,Treatment Outcome ,Aortic valve stenosis ,Aortic Valve ,Heart Valve Prosthesis ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
During the past years transcatheter aortic valve implantation (TAVI) has evolved to a standard technique for the treatment of high risk patients suffering from severe aortic stenosis. Worldwide the number of TAVI procedures is increasing exponentially. In this context both the transapical antegrade (TA) and the transfemoral retrograde (TF) approach are predominantly used and can be considered as safe and reproducible access sites for TAVI interventions. As a new technology TAVI is in a constant progress regarding the development of new devices. While in the first years only the Edwards SAPIEN(TM) and the Medtronic CoreValve(TM) prostheses were commercial available, recently additional devices obtained CE-mark approval and others have entered initial clinical trials. In addition to enhance the treatment options in general, the main driving factor to further develop new device iterations is to solve the drawbacks of the current TAVI systems: paravalvular leaks, occurrence of AV-blocks and the lack of full repositionability.
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- 2013
23. Prior Hip Surgery Leads to Gender Related Increase in Complication Rates after Transcatheter Aortic Valve Implantation
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Helge Möllmann, Christoph Liebetrau, J. Köhne, Mirko Doss, T Walther, Christian W. Hamm, Won-Keun Kim, and A. Van Linden
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Pulmonary and Respiratory Medicine ,Hip surgery ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,Complication ,Gender related ,business - Published
- 2016
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24. Procedural Outcome of Patients with Bicuspid Aortic Valves Undergoing Transcatheter Aortic Valve Implantation
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A. Van Linden, Won-Keun Kim, T Walther, Mani Arsalan, Christian W. Hamm, Christoph Liebetrau, Mirko Doss, and Helge Moellmann
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,Internal medicine ,medicine ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
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25. Transforming Growth-factor-β is a Potent Inhibitor of FGF23 Secretion from Oncostatin M Stimulated Cardiomyocytes
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Sawa Kostin, A. Skwara, M Schönburg, T. Kubin, Thomas Braun, H.-J. Lautze, R. Maringanti, A. Cetinkaya, Manfred Richter, A. Schneider, and T Walther
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,biology ,business.industry ,Oncostatin M ,Endocrinology ,Internal medicine ,medicine ,biology.protein ,Surgery ,Secretion ,Cardiology and Cardiovascular Medicine ,business ,Transforming growth factor - Published
- 2016
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26. Body Surface Area or Body Mass Index: which is of Greater Prognostic Value for Clinical Outcomes after Transcatheter Aortic Valve Replacement?
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Giovanni Filardo, John J. Squiers, Christoph Liebetrau, T Walther, Mani Arsalan, A. Van Linden, Johannes Blumenstein, Helge Moellmann, Won-Keun Kim, and Benjamin D. Pollock
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Pulmonary and Respiratory Medicine ,Body surface area ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,medicine.medical_treatment ,Surgery ,Valve replacement ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Value (mathematics) - Published
- 2016
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27. Mitral Valve Repair Using Partial versus Complete Annuloplasty Rings
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J. Köhne, Mirko Doss, T Walther, A. Cetinkaya, Manfred Richter, N. Thaqi, Alexander Meyer, A. Ghazari, S. Hamati, A. Van Linden, and Ulrich Fischer-Rasokat
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Pulmonary and Respiratory Medicine ,Mitral valve repair ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Annuloplasty rings ,Repair rate ,Intensive care unit ,law.invention ,Surgery ,medicine.anatomical_structure ,law ,Landing zone ,Mitral incompetence ,Mitral valve ,Internal medicine ,Propensity score matching ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Contemporary mitral valve repair aims at correction of leaflet function and stabilization of the annulus using closed or open annuloplasty rings. Aim of this study was to compare the outcome after OA versus CA mitral valve repair. Methods: 933 patients who received mitral valve surgery between January 2005 and December 2014 were evaluated. Differences in baseline variables were adjusted using propensity score (PS) matching which included logistic regression with 41 preoperative covariates. Mitral valve pathology was degenerative 96.6% (OA) and 95.5% (CA). Results: Cross-clamp time was 82 ± 30 minute (OA) versus 86 ± 32 minute (CA), p = ns. The repair rate was 99.1% in both groups. Postoperative intensive care unit stay was one day in both groups. In hospital mortality was 3.1% (OA) versus 2.3% (CA), p= ns. Postoperative none/trace or mild mitral incompetence at transthoracic echo was diagnosed in 96.9% (OA) versus 97.2% (CA), p = ns Conclusion: Mitral valve surgery leads to good outcomes and a high repair rate using standard techniques including OA and CA. In case of potential future need for repeat intervention CA may provide a better landing zone.
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- 2016
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28. Response to Cardiac Resynchronization with Epicardial versus Transvenous Left Ventricular Leads Assessed by Echocardiography in Time Frame of 5 Years
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Tibor Ziegelhoeffer, G. Göbel, T Walther, and H. Burger
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Ejection fraction ,business.industry ,medicine.medical_treatment ,Cardiac resynchronization therapy ,medicine.disease ,Time frame ,Internal medicine ,Heart failure ,Cardiac resynchronization ,cardiovascular system ,medicine ,Cardiology ,Surgery ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,Lead (electronics) ,Ventricular remodeling ,Ventricular dyssynchrony ,business - Abstract
Objectives: Cardiac resynchronization therapy (CRT) is an inherent part of therapeutic portfolio of advanced heart failure. Resynchronizing of ventricular dyssynchrony may improve the impaired ventricular pump function. Additionally, reverse ventricular remodeling may occur. Unfortunately, up to 20% to 30% of patients do not respond to CRT. A non-optimal left ventricular (LV) lead position may be a potential cause for nonresponse to CRT. As optimal placing of transvenous LV (tLV) leads is dependent on suitable venous anatomy, surgical placement of epicardial LV (eLV) leads usually allows optimal lead positioning. Besides clinical symptomatology, echocardiographic (EG) evaluations provide the most important indicators of CRT success. Methods: Patients with implanted CRT were yearly investigated for clinical symptomatology and EG parameters of ventricular remodeling in a time frame of 5 years. All data were retrospectively analyzed from internal institutional database. Results: 696 patients underwent tLV and 133 eLV implantation. The preoperative characteristics were comparable in both groups. Preoperative ejection fraction (EF) was 24.6 in tLV and 27.9% in eLV group (n.s.). Within 5 years post-implantation the EF remained stable and only marginal changes in both groups were documented. The end-systolic LV diameters were preoperatively 57 in tLV and 54mm in eLV group. The initial reduction was followed by plateau with only small variations during the follow-up. The end-diastolic LV diameters (preoperatively 66 in tLV versus 64mm in eLV group) remained almost unchanged. The NYHA class analysis showed a significant initial drop followed by symptomatic stability thereafter. Conclusions: The long-term observation of EG parameters after CRT implantation confirmed the expected benefit of CRT therapy. This was emphasized by the reduced symptomatology of patients as showed by improvement in NYHA class. No significant differences concerning tLV versus eLV could be demasked.
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- 2016
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29. Durable Mitral Valve Repair with an Adjustable Annuloplasty Ring Two Years after Implantation
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P. Nataf, S. Sündermann, Ottavio Alfieri, J Kempfert, T Walther, Francesco Maisano, Stephan Jacobs, Ehud Raanani, Volkmar Falk, and Markus Czesla
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Mitral valve repair ,business.industry ,medicine.medical_treatment ,Internal medicine ,Cardiology ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Ring (chemistry) - Published
- 2016
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30. Hemodynamic Performance of Self-expandable versus Balloon-expandable Transcatheter Aortic Valve Prosthesis in Patients with a Small Annulus
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Christian W. Hamm, Won Kim, A. Van Linden, D. Serio, N. Zugic, Helge Möllmann, T Walther, H. Baumgarten, and Mirko Doss
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Pulmonary and Respiratory Medicine ,Annulus (mycology) ,medicine.medical_specialty ,Transcatheter aortic ,Self expandable ,business.industry ,Valve prosthesis ,Hemodynamics ,Surgery ,Balloon expandable stent ,Internal medicine ,medicine ,Cardiology ,In patient ,Cardiology and Cardiovascular Medicine ,business - Published
- 2016
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31. Contemporary Conventional Aortic Valve Replacement in All-comer Patients is Associated with Excellent Results
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J. Köhne, T Walther, Mani Arsalan, Z Szalay, D. Serio-Sucec, T Ziegelhöffer, W. Skwara, Mirko Doss, Florian Hecker, and A. Van Linden
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Aortic valve replacement ,business.industry ,Internal medicine ,medicine ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease - Published
- 2016
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32. Echocardiographic and Clinical Outcomes of Minimally Invasive Surgical versus Transcatheter Closure of Atrial Septal Defects
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A. Sprengel, N. Zugic, A. Ceitinkaya, Christoph Liebetrau, D. Serio, Mirko Doss, M. Schönburg, and T Walther
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Medicine ,Surgery ,Closure (psychology) ,Cardiology and Cardiovascular Medicine ,business ,Atrial septal defects - Published
- 2016
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33. Magnetic Resonance Imaging–Compatible Pacemakers in Comparison with Standard Dual-Chamber Pacemakers in 36-Month Follow-up
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T Walther, W. Ehrlich, G. Göbel, Tibor Ziegelhoeffer, and H. Burger
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine ,Surgery ,Magnetic resonance imaging ,Medical physics ,DUAL (cognitive architecture) ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Month follow up - Published
- 2016
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34. Patient Outcomes of Self-expanding versus Balloon Expandable Transcatheter Valves in the Heavily Calcified Aortic Annulus
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Christian W. Hamm, Won-Keun Kim, A. Van Linden, Christoph Liebetrau, Helge Moellmann, T Walther, Mani Arsalan, and Mirko Doss
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Regurgitation (circulation) ,medicine.disease ,Prosthesis ,Surgery ,Balloon expandable stent ,30 day mortality ,Internal medicine ,medicine ,Clinical endpoint ,Cardiology ,Cardiac skeleton ,Major complication ,Cardiology and Cardiovascular Medicine ,business ,Stroke - Abstract
Objective: Aim of this study was to evaluate the performance of different transcatheter aortic valve prostheses in heavily calcified aortic annuli. Methods: Between, January 2011 and May 2015, 1119 patients received transcatheter aortic valve implantations (TAVI) at our institution. 278 of these patients (age 81.8 ± 6.2 years, logistic EuroSCORE 24.2 ± 12.6%) were identified at multi-slice CT (MSCT) screening, of having a heavily calcified aortic annulus. This was defined as a calcium score of greater than the 75% (>3600 AU) on MSCT. 128 patients were treated with self-expanding and 150 patients with balloon expandable TAVI prostheses. Clinical endpoints were procedural complications, device success (VARC II) and 30 day all-cause mortality. Results: 30 day mortality was comparable between the groups (self-expanding 6.3% versus balloon expandable 6.7%, p = 0.89). Residual aortic regurgitation > Grade II was higher in the self-expanding group (16.7% versus 4.7%, p = 0.0001). Procedural failure was also increased in the self-expanding group (25.8% versus 15.3%, p = 0.03). Other major complication rates like annular rupture (1.6% versus 1.3%, p = 0.87), stroke (2.3% versus 4%, p = 0.44), new onset pace maker implantation (12.5% versus 13.3%, p = 0.84) and conversion to conventional surgery (4.7% versus 3.3%, p = 0.56) were comparable between the groups. Conclusion: TAVI in high risk surgical patients, with severely calcified aortic annuli, is feasible with both self-expanding and balloon expandable prosthesis. However, procedural complications and residual aortic regurgitation are lower when using balloon expandable prostheses.
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- 2016
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35. Alternative Treatment of Aortic Prosthesis Infections in High-Risk Patients
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W. Moll, M. Sauerbier, T Walther, Mani Arsalan, and A. Arsalan-Werner
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Aortic prosthesis ,High risk patients ,business.industry ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Alternative treatment - Published
- 2016
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36. Kathetergestützte Aortenklappenimplantation
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H. Nef, T Walther, J. Kempfert, Christian W. Hamm, Helge Möllmann, and C. Liebetrau
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Aortic valve ,medicine.medical_specialty ,Medical treatment ,business.industry ,medicine.medical_treatment ,medicine.disease ,Surgery ,Standard procedure ,medicine.anatomical_structure ,Aortic valve replacement ,Valve replacement ,Aortic valve stenosis ,Concomitant ,Heart team ,Internal Medicine ,medicine ,business - Abstract
Due to increasing life expectancy in the coming decades the number of elderly patients with aortic valve stenosis (AS) and various concomitant diseases will increase. Conventional surgical aortic valve replacement represents the treatment of choice in patients with severe and symptomatic AS. Transfemoral and transapical aortic valve implantation (T-AVI) has evolved as a standard procedure for patients with severe AS who are technically inoperable or at very high risk for surgical valve replacement. The T-AVI approach has been shown to be superior to the standard medical treatment in these high-risk patients. All patients to be considered for T-AVI should be discussed in a consensus conference consisting of cardiac surgeons and cardiologists (heart team).
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- 2012
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37. Die PARTNER-Studie in europäischer Sicht
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F.W. Mohr and T. Walther
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Cardiothoracic surgery ,Medicine ,Surgery ,Vascular surgery ,Cardiology and Cardiovascular Medicine ,business ,Cardiac surgery - Published
- 2012
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38. A TASH experience: post-infarction myocardial oedema necessitating the support of ECMO and occurrence of significant mitral regurgitation
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Sebastian Szardien, Helge Möllmann, T Walther, Andreas Rolf, Christoph Liebetrau, A. Jovanovic, Christian W. Hamm, Holger Nef, Moritz Haas, Adalbert Skwara, Oliver Dörr, D. Basic, and Jürgen Leick
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Mitral regurgitation ,medicine.medical_specialty ,Post infarction ,business.industry ,Internal medicine ,Cardiology ,medicine ,General Medicine ,Cardiology and Cardiovascular Medicine ,business ,Surgery - Published
- 2011
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39. Endurance and Performance of Two Different Concepts for Left Ventricular Stimulation with Bipolar Epicardial Leads in Long-Term Follow-Up
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T Walther, A. Van Linden, Markus Schoenburg, H. Burger, Z. Szalay, J Kempfert, and Tibor Ziegelhoeffer
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Cardiac resynchronization therapy ,Ventricular Function, Left ,Cardiac Resynchronization Therapy ,Germany ,Internal medicine ,Humans ,Medicine ,Cardiac Resynchronization Therapy Devices ,Thoracotomy ,Cardiac Surgical Procedures ,Lead (electronics) ,Aged ,Retrospective Studies ,Heart Failure ,business.industry ,Suture Techniques ,Equipment Design ,Recovery of Function ,Middle Aged ,Sternotomy ,Cardiac surgery ,Treatment Outcome ,Median sternotomy ,Cardiology ,Female ,Surgery ,Implant ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
Background Epicardial left ventricular (LV) leads represent an alternative for CRT therapy if transvenous lead implantation fails. Data on endurance, performance, the impact of the surgical approach (lateral minithoracotomy vs. median sternotomy simultaneously with other cardiac surgery), and the optimal technical concept (screw-in vs. suture-on) is limited. Methods Over a period of 48 months we evaluated 130 consecutive patients with comparable characteristics. A total of 54 screw-in (MyoDex™ 1084T, SJM) and 76 suture-on (Capture Epi 4968, Medtronic) bipolar epicardial steroid-eluting LV leads were implanted either via a left lateral or a median thoracotomy. Sensing, pacing threshold, impedance and NYHA class were recorded at defined time points. Results No surgery-related death or major complication was observed. At the time of implantation, the pacing threshold, sensing and NYHA class did not differ significantly between the two groups. The impedances of screw-in leads were significantly lower compared to those of suture-on leads. Suture-on leads showed a moderate initial drop in their pacing threshold but afterwards remained stable. Screw-in leads were characterized by a moderate but significant increase in the pacing threshold in the first year followed by a continuous decrease thereafter. Twenty-four months post-implantation no differences between both lead types could be detected. Sensing and NYHA class improved in both groups. The surgical approach had no significant impact on lead functionality. Conclusion Our study showed that the implantation of epicardial leads was safe with very low complication rates. There was no superior technical epicardial lead concept (screw-in vs. suture-on leads) and all epicardial leads demonstrated an excellent long-term performance and durability. Therefore, it seems that epicardial leads represent a good alternative to transvenous leads and surgeons should be encouraged to implant epicardial leads during concomitant cardiac surgery when the indications for CRT are present.
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- 2011
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40. Aortenklappenregister
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T. Walther, J. Blumenstein, Christian W. Hamm, and F.W. Mohr
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Pulmonary and Respiratory Medicine ,business.industry ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2011
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41. Left Ventricular Diverticulum Repair in a Newborn
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Friedrich-Wilhelm Mohr, I Daehnert, Martin Kostelka, T Walther, and Ardawan Rastan
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Heart Ventricles ,medicine.medical_treatment ,Internal medicine ,medicine ,Humans ,Cardiac Surgical Procedures ,Left ventricular diverticulum ,Reduction (orthopedic surgery) ,Pericardial patch ,business.industry ,Angiography ,Infant, Newborn ,Dor procedure ,medicine.disease ,Diverticulum ,Heart failure ,cardiovascular system ,Cardiology ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
We report on a male newborn requiring repair of a huge left apical diverticulum leading to progressive heart failure and extensive ventricular arrhythmia. At the age of 11 days, a modified Dor procedure using an autologous endoventricular pericardial patch was performed. Postoperatively, a significant reduction of ventricular extrasystole was evident. One year postoperatively, the infant demonstrates a normal cognitive and somatic development without clinical signs of cardiac failure.
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- 2007
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42. Long-term Rhythm Follow-up in CRT Patients Suffering from Atrial Fibrillation - Evaluation of Efficacy of an Atrial Lead
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X. Ackermann, W. Ehrlich, H. Burger, T Walther, Tibor Ziegelhoeffer, and G. Göbel
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Atrial fibrillation ,medicine.disease ,Atrial Lead ,Term (time) ,Rhythm ,Internal medicine ,Cardiology ,medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Intensive care medicine - Published
- 2015
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43. Comparison of Transfemoral versus Transapical Access in Transcatheter Aortic Valve Implantation Using the Sapien XT Prosthesis- A Propensity Score Matched Analysis
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J Kempfert, Helge Möllmann, Johannes Blumenstein, A. Van Linden, Won-Keun Kim, Christian W. Hamm, T Walther, and Alexander Meyer
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,medicine.medical_treatment ,Prosthesis ,Surgery ,Internal medicine ,Propensity score matching ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
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44. Balloon Post-Dilation for Initial Significant Paravalvular Leakage after Transcatheter Aortic Valve Implantation has No Impact on the Procedure Safety Profile
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A. Ghazari, Helge Möllmann, T Walther, J Kempfert, Alexander Meyer, A. Van Linden, Won-Keun Kim, and Johannes Blumenstein
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Transcatheter aortic ,business.industry ,Balloon ,Surgery ,Safety profile ,Internal medicine ,Paravalvular leakage ,medicine ,Cardiology ,Dilation (morphology) ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
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45. Oncostatin M controls Macrophage Invasion via Release of Chemokines from Cardiomyocytes after Myocardial Damage
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Praveen Gajawada, Sawa Kostin, V. Polyakova, Henning Warnecke, Thomas Braun, Manfred Richter, Holger Lörchner, Yunlong Hou, T Walther, J. Pöling, and T. Kubin
- Subjects
Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Chemokine ,biology ,business.industry ,Macrophage invasion ,Oncostatin M ,biology.protein ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2015
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46. Influence of Epicardial Left Ventricular Pacing Lead on the Response to Cardiac Resynchronization Therapy
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Tibor Ziegelhoeffer, H. Burger, T Walther, and W. Ehrlich
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine.medical_treatment ,medicine ,Cardiology ,Cardiac resynchronization therapy ,Surgery ,Ventricular pacing ,Cardiology and Cardiovascular Medicine ,business ,Lead (electronics) - Published
- 2015
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47. Koronare Notfalleingriffe im Akuten Koronarsyndrom: Beating-heart versus konventionelle Bypasschirurgie
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B. Hentschel, Sven Lehmann, Anne-Kathrin Funkat, Ardawan Rastan, J. I. Eckenstein, J Kempfert, T Walther, and Friedrich-Wilhelm Mohr
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Pulmonary and Respiratory Medicine ,Surgery ,Cardiology and Cardiovascular Medicine - Abstract
Ziel dieser Studie war es, die Ergebnisse der Koronarchirurgie am schlagenden Herzen (BH) mit denen der konventionellen Bypasschirurgie am kardioplegierten Herzen (KA) im Rahmen der Notfallindikation bei Patienten mit akutem Koronarsyndrom (ACS) zu vergleichen. Zwischen 01/2000 und 09/2005 wurden 638 konsekutive Patienten im ACS mit einer Notfall-Indikation zur koronarchirurgischen Versorgung uber eine Sternotomie therapiert. 531 Patienten waren kreislaufstabil, 107 Patienten im kardiogenen Schock. Variablen, welche die Entscheidung beeinflussten, mit KA (n=398) oder BH (n=240) zu operieren, wurden mittels Propensity-Analyse gewichtet. Durch eine Propensity-Score adjustierte Multiregressionsanalyse wurden die Fruh- und Langzeit-Ergebnisse beider Verfahren miteinander verglichen. Die BH-Eingriffe wurden in 116 Fallen mit HLM (Onpump beating heart, OnP-BH) und in 124 Falle ohne HLM (off pump coronary artery bypass, OPCAB) vorgenommen. Patienten im kardiogenen Schock wurden bevorzugt am schlagenden Herzen operiert (multivariate Odds ratio 3,8; p=0,001). Bei kreislaufstabilen Patienten fuhrten folgende Variablen zur Bevorzugung einer BH-Operation: logEuroSCORE>20% (OR 2,05), Kreatinin>1,8mg/dl (OR 4,12), PTCA mit Komplikationen (OR 1,88) und EF
- Published
- 2006
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48. A novel adhesion barrier facilitates reoperations in complex congenital cardiac surgery
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Ingo Dähnert, T Walther, Martin Kostelka, Friedrich-Wilhelm Mohr, S Jakobs, Ardawan Rastan, and Volkmar Falk
- Subjects
Heart Defects, Congenital ,Heart Septal Defects, Ventricular ,Reoperation ,Thorax ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Heart Valve Diseases ,Adhesion (medicine) ,Tissue Adhesions ,Heart Septal Defects, Atrial ,Hypoplastic left heart syndrome ,Germany ,Internal medicine ,Hypoplastic Left Heart Syndrome ,Humans ,Medicine ,Prospective Studies ,Cardiac Surgical Procedures ,Prospective cohort study ,Tetralogy of Fallot ,Heart septal defect ,business.industry ,Aortic Valve Stenosis ,Adhesion barrier ,medicine.disease ,Survival Analysis ,Surgery ,Cardiac surgery ,Treatment Outcome ,Anesthesia ,Cardiology ,business ,Cardiology and Cardiovascular Medicine ,Follow-Up Studies - Abstract
Objective Reoperations are associated with an increased surgical risk due to adhesions. We prospectively evaluated a bioresorbable membrane after surgery for congenital heart defects over a 3.5-year period. Methods The surgical membrane (CV Seprafilm, Genzyme, Cambridge, Mass) was applied in 350 of 1024 patients; 30 of them underwent reoperation and were evaluated in comparison to 10 random reoperated patients. Adhesions were evaluated using a subjective scoring system [1 (lowest tenacity) to 5 (highest tenacity)] and extent in percent at different regions of the heart. Results Patients were operated for atrioventricular septal defect (69), tetralogy of Fallot (65), functional single ventricle (75), valve surgery (48), ventricular septal defect (20), subaortic stenosis (17), hypoplastic left heart syndrome (17), and other diagnoses (39). Application of the surgical membrane was safe in all patients, without any infections. At reoperation patients received Glenn (14), total cavopulmonary connection (6), and others (10). Overall mortality was 2/350 (0.57%). There was a remarkable reduction in tenacity score (3.3 vs 4.3) and in the extent of adhesions (77.7% vs 86%). Duration of reoperation was significantly reduced. Conclusions A bioresorbable surgical membrane leads to a significant reduction in the tenacity and amount of adhesions. It is recommended for general use whenever repeat operation is anticipated in congenital as well as in adult cardiac surgery.
- Published
- 2005
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49. Epicardial Treatment of Atrial Fibrillation Using Cryoablation in an Acute Off-pump Sheep Model
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T Walther, Patrick Kornherr, Stefan Dhein, Heike Aupperle, C. Ullmann, Ardawan Rastan, K. Schneider, Heinz-Adolf Schoon, Friedrich-Wilhelm Mohr, A. M. Fabricius, Bob Kiaii, and Nicolas Doll
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Vena Cava, Superior ,medicine.medical_treatment ,Cryosurgery ,medicine.artery ,Internal medicine ,Atrial Fibrillation ,Ascending aorta ,medicine ,Animals ,Humans ,Atrial Appendage ,Thoracotomy ,Esophagus ,Sheep ,business.industry ,Cryoablation ,Atrial fibrillation ,Blood flow ,Ablation ,medicine.disease ,Treatment Outcome ,medicine.anatomical_structure ,Pulmonary Veins ,Descending aorta ,Models, Animal ,cardiovascular system ,Cardiology ,Feasibility Studies ,Surgery ,Cardiology and Cardiovascular Medicine ,business ,Pericardium - Abstract
Background The purpose of this study was to test the feasibility and effectiveness of cryoablation therapy (SurgiFrost trade mark CryoCath, Endocare Inc., Irvine, California, USA) for linear epicardial treatment of atrial fibrillation in an acute off-pump sheep model. Methods After thoracotomy, we performed epicardial cryoablation (2 min intervals at -160 degrees C) with pacing electrodes positioned at the left atrial appendage (LAA), the pulmonary veins (PVs), the right atrial appendage (RAA), and the vena cava cranialis (VCC) in 8 sheep. Circular epicardial ablations were performed with online temperature measurement in the ascending aorta and in the esophagus. The sheep were sacrificed two hours after ablation procedure, and heart, lungs, and esophagus were retrieved for histological examination. Out of all 8 sheep, histo-pathological analysis was performed on the RAA and VCC in 6 sheep and on the CAA and PV in all 8 sheep. Results Thin-walled structures such as PVs and VCC showed electrical isolation. No significant changes in temperature in the descending aorta and the esophagus were observed. There was evidence of extensive transmural alteration including vascular lesions, myocardial degeneration and necrosis as well as epi- and endocardial necrosis in the left atria in three of 8 cases, in the right atria in 5 of 6 cases, in the VCC in 6 of 6 cases, and in the PV in 5 of 8 cases. Mild lesions of the muscular layer of the esophagus were found in 7 of 8 cases. Conclusions Epicardial cryoablation is not effective on thicker tissues like LAA and RAA due to the rewarming of the current blood flow. However, thin tissues like VCC and PV can be isolated. Further chronic studies are necessary to evaluate the potential for regeneration of adjacent structures.
- Published
- 2003
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50. Transapikale Aortenklappenimplantation
- Author
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T. Walther
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Medicine ,Surgery ,Cardiology and Cardiovascular Medicine ,business - Published
- 2012
- Full Text
- View/download PDF
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