30 results on '"Mauricio Lynn"'
Search Results
2. Hemoglobin-Based Oxygen Carrier Rescues Double-Transplant Patient From Life-Threatening Anemia
- Author
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M. F. Gomez, O. Aljure, Gaetano Ciancio, and Mauricio Lynn
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Transplantation ,medicine.medical_specialty ,Anemia ,business.industry ,030208 emergency & critical care medicine ,Heparin ,030204 cardiovascular system & hematology ,Hemoglobin levels ,medicine.disease ,Institutional review board ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Immunology and Allergy ,Pharmacology (medical) ,Transplant patient ,In patient ,Hemoglobin ,Solid organ transplantation ,business ,medicine.drug - Abstract
This case describes a 46-year-old male recipient of a kidney-pancreas transplant who is Jehovah's Witness. Early in the postoperative period, he was found to have splenic vein thrombosis requiring heparin infusion. Two days later, he developed severe symptomatic anemia (hemoglobin
- Published
- 2017
3. Disasters and Mass Casualty Incidents : The Nuts and Bolts of Preparedness and Response to Protracted and Sudden Onset Emergencies
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Mauricio Lynn, Howard Lieberman, Lior Lynn, Gerd Daniel Pust, Kenneth Stahl, Daniel Dante Yeh, Tanya Zakrison, Mauricio Lynn, Howard Lieberman, Lior Lynn, Gerd Daniel Pust, Kenneth Stahl, Daniel Dante Yeh, and Tanya Zakrison
- Subjects
- Surgery, Disaster medicine--Handbooks, manuals, etc, Emergency medicine--Handbooks, manuals, etc, Emergency management--Handbooks, manuals, etc
- Abstract
Mass Casualty events may occur as a result of natural or human-caused disasters or after an act of terrorism. The planning and response to disasters and catastrophes needs to take into consideration the distinction between progressive and sudden events. Insidious or slowly progressive disasters produce a large number of victims but over a prolonged time period, with different peaks in the severity of patients presenting to the hospital. For example, radiation events will produce a large number of victims who will present days, weeks, months, or years after exposure, depending on the dose of radiation received. The spread of a biological agent or a pandemic will produce an extremely high number of victims who will present to hospitals during days to weeks after the initial event, depending on the agent and progression of symptoms.On the other hand, in a sudden disaster, there is an abrupt surge of victims resulting from an event such as anexplosion or a chemical release. After the sarin gas attack in a Tokyo subway in 1995, a total of 5500 victims were injured and required medical attention at local hospitals immediately after the attack. The car bomb that exploded near the American Embassy in Nairobi, Kenya, killed 213 people and simultaneously produced 4044 injured patients, many requiring medical care at local hospitals. The Madrid train bombing in March 2004 produced more than 2000 injured victims in minutes, overwhelming the city's healthcare facilities. More than 500 injured patients were treated at local hospital after the mass shooting in Las Vegas. Finally, earthquakes may produce a large number of victims in areas in which the medical facilities are partially or completely destroyed. Sudden events bring an immediate operational challenge to community healthcare systems, many of which are already operating at or above capacity.The pre-hospital as well as hospital planning and responseto sudden mass casualty incidents (SMCI's) is extremely challenging and requires a standard and protocol driven approach. Many textbooks have been published on Disaster Medicine; although they may serve as an excellent reference, they do not provide a rapid, practical approach for management of SMCI's. The first edition of “Mass Casualty Incidents: The Nuts and Bolts of Preparedness and Response for Acute Disasters” dealt exclusively with sudden mass casualty incidents. The second edition will expand its focus and include planning and response for insidious and protracted disasters as well. This new book is designed to provide a practical and operational approach to planning, response and medical management of sudden as well as slow progressive events. The target audience of the second edition will be health care professionals and institutions, as well as allied organizations, which respond to disasters and mass casualty incidents. Parts I and II are essentially the first edition of the book and consist of planning of personnel, logistic support, transport of patients and equipment and response algorithms. These 2 parts will be revised and updated and include lessons learned from major mass shootings that occurred recently in the United States and other parts of the world Part III will describe the planning process for progressive disasters and include response algorithms and checklists.Part IV will handle humanitarian and mental health problems commonly encountered in disaster areas.Part V will deal with team work and communication both critical topics when handling catastrophes and mass casualty incidents. This new book will be a comprehensive tool for healthcare professionals and managers and should
- Published
- 2019
4. Management of Crush Injuries and Crush Syndrome
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Mauricio Lynn
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medicine.medical_specialty ,integumentary system ,business.industry ,musculoskeletal, neural, and ocular physiology ,medicine.medical_treatment ,Limb amputation ,medicine.disease ,Fasciotomy ,Surgery ,body regions ,surgical procedures, operative ,nervous system ,Crush injury ,Medicine ,business ,Crush syndrome ,Compartment (pharmacokinetics) - Abstract
Crush injury – Occurs as a result of pressure applied to any part of the body, usually extremities, for a prolonged period of time. It may be associated or not with limb fractures. Complications of a crush injury are crush syndrome and compartment syndrome.
- Published
- 2018
5. Is there an optimal time for laparoscopic cholecystectomy in acute cholecystitis?
- Author
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Carl I. Schulman, Mauricio Lynn, Mark G. McKenney, Fahim Habib, Dror Soffer, Lorne H. Blackbourne, Peter P. Lopez, Stephen M. Cohn, Robert Benjamin, and M. Goldman
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Cholecystitis, Acute ,Cohort Studies ,Internal medicine ,medicine ,Acute cholecystitis ,Humans ,Prospective Studies ,Registries ,Aged ,business.industry ,Gallbladder ,General surgery ,Length of Stay ,Middle Aged ,Hepatology ,medicine.disease ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Cholecystectomy, Laparoscopic ,Cohort ,Cholecystitis ,Female ,Cholecystectomy ,Complication ,business ,Abdominal surgery - Abstract
Laparoscopic cholecystectomy (LC) is safe in acute cholecystitis, but the exact timing remains ill-defined. This study evaluated the effect of timing of LC in patients with acute cholecystitis.Prospective data from the hospital registry were reviewed. All patients admitted with acute cholecystitis from June 1994 to January 2004 were included in the cohort.Laparoscopic cholecystectomy was attempted in 1,967 patients during the study period; 80% were women, mean patient age was 44 years (range, 20-73 years). Of the 1,967 LC procedures, 1,675 were successful, and 292 were converted to an open procedure (14%). Mean operating time for LC was 1 h 44 min (SD +/- 50 min), versus 3 h 5 min (SD +/- 79 min) when converted to an open procedure. Average postoperative length of stay was 1.89 days (+/- 2.47 days) for the laparoscopic group and 4.3 days (+/- 2.2 days) for the conversion group. No clinically relevant differences regarding conversion rates, operative times, or postoperative length of stay were found between patients who were operated on within 48 h compared to those patients who were operated on post-admission days 3-7.The timing of laparoscopic cholecystectomy in patients with acute cholecystitis has no clinically relevant effect on conversion rates, operative times, or length of stay.
- Published
- 2006
6. Database Predictors of Transfusion and Mortality
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Richard P. Dutton, Mauricio Lynn, and Rolf Lefering
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Adult ,Male ,medicine.medical_specialty ,business.industry ,Trauma center ,Trauma registry ,Length of Stay ,Critical Care and Intensive Care Medicine ,Trauma care ,Injury Severity Score ,Treatment Outcome ,Risk Factors ,Germany ,Baltimore ,Emergency medicine ,Florida ,Humans ,Wounds and Injuries ,Medicine ,Blood Transfusion ,Female ,Surgery ,Registries ,business - Abstract
Transfusion is a cornerstone of early trauma care, but little is known regarding the consistency of transfusion practice in different regions of the world. We examined data available in the German Trauma Registry, the University of Miami Trauma Registry, and the Registry of the Shock Trauma Center in Baltimore to learn more regarding this question. We sought to identify the rate of transfusion of trauma patients during the resuscitative phase, the volume of transfusion administered, and the correlation of various levels of transfusion with clinical outcomes such as mortality, hospital length of stay, and the incidence of organ system failure. Mortality associated with transfusion was remarkably similar in all three systems, making it clear that the volume of blood received during early resuscitation is a strong predictor of outcome for patients presenting in hemorrhagic shock.
- Published
- 2006
7. What Does Ultrasonography Miss in Blunt Trauma Patients With A Low Glasgow Coma Score (GCS)?
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Carl I. Schulman, Dror Soffer, Mark G. McKenney, Mauricio Lynn, Stephen M. Cohn, Nicolas Alvarez Renaud, and Nicholas Namias
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Adult ,Male ,medicine.medical_specialty ,Abdominal Injuries ,Neurological disorder ,Wounds, Nonpenetrating ,Critical Care and Intensive Care Medicine ,Sensitivity and Specificity ,Blunt ,Predictive Value of Tests ,medicine ,Humans ,Glasgow Coma Scale ,Prospective Studies ,Diagnostic Errors ,Ultrasonography ,Coma ,business.industry ,Trauma center ,Ultrasound ,medicine.disease ,Surgery ,Abdominal trauma ,Blunt trauma ,Female ,medicine.symptom ,business - Abstract
Background: The role of ultrasound (US) as a screening tool for the evaluation of blunt abdominal trauma is still controversial. Determining the types of missed injuries and the accuracy of US in patients with a low GCS will improve the evaluation of these blunt trauma patients. Methods: Prospectively collected data from the trauma registry of a Level I trauma center was reviewed. Results: 7,952 patients were included in the study. US examination had an accuracy of 89%, sensitivity of 77%, specificity of 97%, positive predictive value (PPV) of 78%, and negative predictive value (NPV) of 98%. GCS correlated with ISS and base deficit levels. US examination had a significantly lower accuracy in patients with a low GCS and in women. Conclusion: The sensitivity and specificity of US examination is similar in those with normal and low GCS. Therefore ultrasonographic examination may be considered a good screening tool for the evaluation of patients with blunt abdominal trauma, but its accuracy is diminished in patients with a low GCS. Further imaging may be warranted in these patients.
- Published
- 2006
8. A Prospective Evaluation of Ultrasonography for the Diagnosis of Penetrating Torso Injury
- Author
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Nicholas Namias, Carl I. Schulman, Mark G. McKenney, Mauricio Lynn, Raquel Garcia-Roca, Stephen M. Cohn, Dror Soffer, and Peter P. Lopez
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Thoracic Injuries ,Exploratory laparotomy ,medicine.medical_treatment ,Wounds, Penetrating ,Critical Care and Intensive Care Medicine ,Sensitivity and Specificity ,Age Distribution ,Blunt ,Trauma Centers ,Laparotomy ,Outcome Assessment, Health Care ,Preoperative Care ,medicine ,Humans ,False Positive Reactions ,Prospective Studies ,Thoracotomy ,Child ,Prospective cohort study ,False Negative Reactions ,Aged ,Ultrasonography ,business.industry ,Patient Selection ,Trauma center ,Middle Aged ,medicine.disease ,Surgery ,body regions ,Abdominal trauma ,Florida ,Female ,Radiology ,business ,Needs Assessment ,Penetrating trauma - Abstract
Background: Ultrasound (US) is commonly used for the diagnosis of hemo-peritoneum after blunt abdominal trauma, but the value of US as an aid for identification of operative lesions after penetrating trauma is not well documented. The purpose of this investigation was to determine the accuracy of US for the evaluation of penetrating torso trauma and to assess the impact of this information on patient management. Methods: We conducted a prospective cohort observational study of consecutive penetrating torso patients at a Level I trauma center. Results: During the 6-month trial period, 177 victims of penetrating torso trauma were assessed by our trauma teams. Ninety-two patients had stab wounds, 84 patients had gunshot wounds, and 1 patient had a puncture wound. All 28 patients with positive US examination had an exploratory laparotomy or thoracotomy (one patient had more than one procedure), resulting in 26 therapeutic operations. There were 149 negative US examinations, but in this group, 36 patients underwent laparotomy or thoracotomy, and 28 had therapeutic operations. The overall accuracy of the US examination was therefore 85%, the sensitivity was 48%, and the specificity was 98%. There were only three patients who had their initial management altered by a positive US examination. Conclusion: The US examination lacks sensitivity to be used alone in determining operative intervention after gunshot or stab wounds. Rarely does US information contribute to the management of patients with penetrating abdominal injuries.
- Published
- 2004
9. The Resident Experience on Trauma: Declining Surgical Opportunities and Career Incentives? Analysis of Data from a Large Multi-institutional Study
- Author
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Ajai K. Malhotra, Antoinette Kanne, Lawrence Lottenberg, Michael F. Rotondo, Richard A. Pomerantz, Andrew B. Peitzman, Scott G. Sagraves, Pascal Udekwu, Juan L. Peschiera, Jennifer L. Sarafin, David J. Dries, Thomas M. Scalea, Gary W. Welch, Kwang I. Suh, Juan A. Asensio, Michael Oswanshi, Farouck N. Obeid, Ronald G. Albuquerque, Victor L. Landry, Hans Joseph Schmidt, Deborah Baker, Dorraine D. Watts, Raymond Talucci, Scott B. Frame, John B. Holcomb, Lewis J. Kaplan, Dennis Wang, S. M. Siram, Grace S. Rozycki, Russell Dumire, Benjamin D. Mosher, Eliza Enriquez, Terrence H. Liu, Samir M. Fakhry, Anne Kuzas, F.Barry Knotts, Sherry M. Melton, John F. Bilello, George M. Testerman, Blaine L. Enderson, James S. Gregory, Dennis W. Ashley, Patrick A. Dietz, Karlene E. Sinclair, Diane Higgins, Ivan Puente, Barbara Esposito, Stuart J.D. Chow, William F. Pfeifer, Daniel C. Cullinane, Judith Phillips, James K. Lukan, Michael Moncure, John L. Hunt, John R. Hall, Susan Schrage, Pauline Park, Faran Bokhari, Jeffery Rosen, Kathleen A. LaVorgna, Gerard J. Fulda, Monica Newton, Macram M. Ayoub, Leanne Adams, Mark L. Gestring, Thomas A. Santora, Paul R. Kemmeter, Joan L. Huffman, William Marx, Mitchell S. Farber, Karyn L. Butler, Collin E.M. Brathwaite, Jon Walsh, Jeffrey P. Salomone, John D. Josephs, Timothy C. Fabian, Frederick A. Moore, Murray J. Cohen, Paul E. Bankey, Wayne E. Vander Kolk, Dan A. Galvan, John Bonadies, Walter Forno, James M. Cross, Nirav Patel, Pam Nichols, Carnell Cooper, Michael Haraschak, Judith A. O'connor, Daniel Powers, Mary B. Myers, Kathleen P. O’hara, A. Jay Raimonde, Hani Seoudi, Juan B. Grau, Imtiaz A. Munshi, Kimberly K. Nagy, Peter Rhee, Eddy H. Carrillo, Sharon Buchro, Mary Jo Wright, Lisa A. Patterson, Dennis B. Dove, C. M. Buechler, Wendy L. Wahl, Wendy Sue Shreve, Thomas H. Cogbill, Robert A. Cherry, Scott H. Norwood, J. Martin Perez, Bernard R. Boulanger, J. P. Dineen, John E. Sutton, Arthur B. Dalton, Scott Monk, Carl P. Valenziano, Christopher D. Wohltmann, Michael Schurr, Robert A. Jubelelirer, William J. Mileski, Tiffany K. Bee, Kathy Coon, Fred A. Luchette, April Settell, Arthur L. Ney, Jonathan Kohn, Mary E. Fallat, Sheila Staib, Dennis C. Gore, Van L. Vallina, Jose A. Acosta, David Kam, Jeff Strickler, Eileen Corcoran, Leon H. Pachter, Anne O'Neill, Lonnie W. Frei, Larry M. Jones, David G. Jacobs, Om P. Sharma, Curt S. Koontz, Christopher P. Michetti, Michael D. Pasquale, Raymond P. Bynoe, Pablo Rodriguez, Robert Marburger, Michael C. Chang, Karla S. Ahrns, Michael D. McGonigal, Paula Griner, Gustavo Roldán, Leonard J. Weireter, Sharon S. Cohen, Andrew J. Kerwin, L. F. Diamelio, Mauricio Lynn, Donald H. Jenkins, John P. Hunt, W. Michael Johnson, Robert Holtzman, Brian J. Daley, Paul Dabrowski, Jeffrey J. Morken, Vicki J. Bennett-Shipman, Stanley Kurek, Charles J. Yowler, Christopher Salvino, Dale Oller, Brian J. Norkiewicz, Vicki Hardwick-Barnes, Don Fishman, Frederic J. Cole, John C. Layke, Frederick B. Rogers, James Davis, Keith D. Clancy, Emily M. Sposato, Judith Johnson, Charles E. Wiles, Uretz J. Oliphant, and James V. Yuschak
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medicine.medical_specialty ,Attitude of Health Personnel ,medicine.medical_treatment ,Specialty ,Traumatology ,Critical Care and Intensive Care Medicine ,Patient Admission ,Diagnostic peritoneal lavage ,Blunt ,Trauma Centers ,Surveys and Questionnaires ,Laparotomy ,medicine ,Humans ,Focused assessment with sonography for trauma ,Peritoneal Lavage ,Ultrasonography ,Motivation ,Career Choice ,medicine.diagnostic_test ,business.industry ,General surgery ,Trauma center ,Internship and Residency ,United States ,Education, Medical, Graduate ,Blunt trauma ,Case-Control Studies ,Workforce ,Physical therapy ,Wounds and Injuries ,Surgery ,Clinical Competence ,business - Abstract
Purpose: The surgical resident experience with trauma has changed. Many residents are exposed to predominantly nonoperative patient care experiences while on trauma rotations. Data from a large multicenter study were analyzed to estimate surgical resident exposure to trauma laparotomy, diagnostic peritoneal lavage (DPL), and focused abdominal sonography for trauma (U/S). Methods: Centers completed a self-report questionnaire on their institutional demographics, admissions, and procedure for a 2-year period (1998-1999). Results: A total of 82 trauma centers that provide resident teaching were included. The included centers represent over 247,000 trauma admissions. The majority of trauma centers (65.9%) had > 80% blunt injury. Although all centers performed laparotomies, other results were more variable. For U/S, 24.2% performed none at all and 47.0% performed fewer than two U/S examinations per month. For DPLs, 3.8% performed none and 66.7% performed fewer than two per month. Assuming 1 night of 4 on call, the average surgical resident training at a trauma center performing > 80% blunt trauma has the potential to participate in only 15 trauma laparotomies, 6 diagnostic peritoneal lavages, and 45 ultrasound examinations per year. In addition, the resident will care for an average of 500 blunt trauma patients before performing a splenectomy or liver repair. Conclusion: Surgical resident experience on most trauma services is heavily weighted to nonoperative management, with a relatively low number of procedures, little experience with DPL, and highly variable experience with ultrasound. These data have serious implications for resident training and recruitment into the specialty.
- Published
- 2003
10. Updates in the management of severe coagulopathy in trauma patients
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Yoram Klein, Uri Martinowitz, Igor Jeroukhimov, and Mauricio Lynn
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medicine.medical_specialty ,Resuscitation ,Blood Loss, Surgical ,Hemorrhage ,Factor VIIa ,Critical Care and Intensive Care Medicine ,chemistry.chemical_compound ,Anesthesiology ,medicine ,Coagulopathy ,Humans ,Intensive care medicine ,Hemostasis ,Factor VII ,business.industry ,Metabolic acidosis ,Hypothermia ,medicine.disease ,Recombinant Proteins ,Surgery ,chemistry ,Damage control surgery ,Wounds and Injuries ,medicine.symptom ,business - Abstract
Coagulopathy is the major cause of bleeding-related mortality in patients who survive the operating room. Its association with hypothermia and metabolic acidosis is common and constitutes a vicious cycle. Usually, post-traumatic coagulopathy is an early event and may be present during surgery. The pathogenesis of severe post-traumatic coagulopathy is complex and multifactorial. Virtually every aspect of the normal coagulation cascade is affected in the cold, acidotic, exsanguinating trauma patient. In the last decade many surgeons have emphasized the role of prevention or early treatment of this vicious cycle. Damage control surgery with planned re-operations has demonstrated superiority over the traditional approach in cases where the patients' condition is deteriorating. Early control of surgical bleeding and significant contamination, together with vigorous correction of hypothermia and continuous resuscitation, has improved the survival of these patients. Recently, a new adjunct to the treatment of coagulopathy in trauma patients has been reported and is undergoing controlled animal trials. Recombinant activated factor VII (rFVIIa) was originally developed as a pro-hemostatic agent for the treatment of bleeding episodes in hemophilia patients. rFVIIa has been successfully used in moribund trauma patients in whom standard procedures had failed to correct bleeding. Preliminary preclinical and clinical studies are under way.
- Published
- 2002
11. Does prehospital fluid administration impact core body temperature and coagulation functions in combat casualties?
- Author
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Nickolai Turchin, Arieh Eldad, Uri Farkash, Alon Scope, R. Maor, Borris Sverdlik, and Mauricio Lynn
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Emergency Medical Services ,Warfare ,Resuscitation ,medicine.medical_specialty ,Body Temperature ,Injury Severity Score ,medicine ,Coagulopathy ,Humans ,Prospective Studies ,Israel ,Prospective cohort study ,Blood Coagulation ,General Environmental Science ,Prothrombin time ,Core (anatomy) ,medicine.diagnostic_test ,business.industry ,Hypothermia ,medicine.disease ,Surgery ,Military Personnel ,Anesthesia ,Prothrombin Time ,Fluid Therapy ,Wounds and Injuries ,General Earth and Planetary Sciences ,Partial Thromboplastin Time ,medicine.symptom ,business ,Partial thromboplastin time - Abstract
Background: Administration of large amounts of fluids to trauma patients, in the absence of surgical control, may increase bleeding, cause hypothermia and coagulopathy which may worsen the bleeding and increase morbidity and mortality. The purpose of our study is to examine the impact of prehospital fluid administration to military combat casualties on core body temperature and coagulation functions. Methods: Prospective data were collected on all cases of moderately (9≤ISS≤14) and severely (ISS≥16) injured victims wounded in South Lebanon, treated by Israeli military physicians and evacuated to hospitals in Israel, over a two-year period. Data regarding prehospital phase of injury (timetables, amount of fluids) and upon hospital arrival (initial core body temperature, prothrombin time [PT], partial thromboplastin time [PTT]) were examined for monotonic relation using Spearman's non-parametric test. Results: Fifty-three moderately injured and 31 severely injured patients were included in the study. The average evacuation time for the moderately injured group was 109.3±44.8 min, and for the severely injured 100.3±38.4 min (P value=NS). The mean volume of fluids administered was 2.39±1.52 and 2.49±1.47 l, respectively (P=NS). No statistical correlation was found between core body temperature, PT or PTT, measured upon hospital arrival, and prehospital fluid treatment. In addition, no correlation was found between core body temperature on hospital arrival and prehospital time, or between prehospital fluid volumes and prehospital time. The mean core body temperature of the moderately injured patients was 36.8 °C, and that of severely injured was 35.8 °C (P=0.026). Conclusions: With proper control of blood loss and avoidance of excessive fluid administration, moderately and severely injured combat casualties in ‘low intensity conflict’ in South Lebanon can be resuscitated with fluid volumes that do not result in a coagulation deficit or hypothermia. The core body temperature on arrival at the hospital is related to the severity of the injury.
- Published
- 2002
12. Recombinant Activated Factor VII for Adjunctive Hemorrhage Control in Trauma
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Gili Kenet, Mauricio Lynn, Eran Segal, Jørgen Ingerslev, Uri Martinowitz, Aharon Lubetsky, and J. Luboshitz
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Hemorrhage ,Factor VIIa ,Critical Care and Intensive Care Medicine ,chemistry.chemical_compound ,medicine ,Humans ,Immunology and Allergy ,Contraindication ,Aged ,Prothrombin time ,Disseminated intravascular coagulation ,Hemostasis ,medicine.diagnostic_test ,Factor VII ,business.industry ,Hematology ,Middle Aged ,Bleed ,medicine.disease ,Recombinant Proteins ,Surgery ,Clinical trial ,Medical–Surgical Nursing ,Anesthesiology and Pain Medicine ,Coagulation ,chemistry ,Anesthesia ,Prothrombin Time ,Wounds and Injuries ,Female ,Partial Thromboplastin Time ,business ,Partial thromboplastin time - Abstract
SUMMARY Background: Recombinant activated factor VII (rFVIIa) was approved for treatment of hemorrhages in patients with hemophilia who develop inhibitors to factors VIII or IX. Conditions with increased thromboembolic risk, including trauma with or without disseminated intravascular coagulation, were considered a contraindication for the drug. The mechanism of action of rFVIIa suggests enhancement of hemostasis limited to the site of injury without systemic activation of the coagulation cascade. Therefore, use of the drug in trauma patients suffering uncontrolled hemorrhage appears to be rational. Methods: Seven massively bleeding, multitransfused (median, 40 units [range, 25–49 units] of packed cells), coagulopathic trauma patients were treated with rFVIIa (median, 120 μg/kg [range, 120–212 μg/kg]) after failure of conventional measures to achieve hemostasis. Results: Administration of rFVIIa resulted in cessation of the diffuse bleed, with significant decrease of blood requirements to 2 units (range, 1–2 units) of packed cells (p < 0.05); shortening of prothrombin time and activated partial thromboplastin time from 24 seconds (range, 20–31.8 seconds) to 10.1 seconds (range, 8–12 seconds) (p < 0.005) and 79 seconds (range, 46–110 seconds) to 41 seconds (range, 28–46 seconds) (p < 0.05), respectively; and an increase of FVII level from 0.7 IU/mL (range,0.7-0.92 IU/mL) to 23.7 IU/mL (range, 18–44 IU/mL) (p < 0.05). Three of the seven patients died of reasons other than bleeding or thromboembolism. Conclusion: The results of this report suggest that in trauma patients rFVIIa may play a role as an adjunctive hemostatic measure, in addition to surgical hemostatic techniques, and provides the motivation for controlled animal and clinical trials.
- Published
- 2001
13. Coronary Artery Stenting for Occlusive Dissection after Blunt Chest Trauma
- Author
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Jim Dygert, Manuel Mayor, Edwardo Parra-Davila, Mauricio Lynn, Enrique Ginzburg, and Jose Almeida
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Adult ,Male ,Thorax ,medicine.medical_specialty ,Arterial disease ,Myocardial Infarction ,Dissection (medical) ,Electrocardiography ,Blunt ,medicine ,Humans ,medicine.diagnostic_test ,Multiple Trauma ,Vascular disease ,business.industry ,Occlusive ,medicine.disease ,Coronary Vessels ,Surgery ,medicine.anatomical_structure ,Heart Injuries ,Stents ,Radiology ,business ,Artery - Published
- 1998
14. Diaphragmatic rupture secondary to blunt thoracic trauma
- Author
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Vanitha Vasudevan, Daniel Aronovich, Loredana Roman, Alexander J. Scumpia, Mauricio Lynn, and Ryan M Shadis
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medicine.medical_specialty ,medicine.medical_treatment ,Splenectomy ,Diaphragmatic breathing ,lcsh:Medicine ,Diagnostic Acumen ,Images in Emergency Medicine ,blunt thoracic trauma ,Blunt ,hemothorax ,emergency medicine ,Laparotomy ,medicine ,Diaphragmatic hernia ,Diaphragmatic rupture ,medicine.diagnostic_test ,business.industry ,diaphragmatic hernia ,lcsh:R ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,General Medicine ,lcsh:RC86-88.9 ,medicine.disease ,Hemothorax ,rib fractures ,Surgery ,business ,Chest radiograph - Abstract
We present a case of a 71-year-old male that was involved in a high-speed motor vehicle collision, as an unrestrained back seat passenger. On primary survey, decreased breath sounds and bowel sounds were auscultated in the left thorax. Secondary survey was positive for left anterior chest wall tenderness. Chest radiograph demonstrated multiple rib fractures, hemothorax, and diaphragmatic rupture with herniation of bowel loops into the chest cavity (Figure 1). Upon insertion of a nasogastric tube, repeat radiograph demonstrated the nasogastric tube to be in the left upper abdomen (Figure 2). The patient underwent emergency laparotomy for repair of his injury. Incidentally, a splenic laceration was identified intraoperatively. Successful repair of the diaphragmatic injury as well as splenectomy was achieved.
- Published
- 2013
15. Management of conventional mass casualty incidents: ten commandments for hospital planning
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Jennifer Kaliff, Daniel Gurr, Abdul Memon, and Mauricio Lynn
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Standardization ,Poison control ,Disaster Planning ,Occupational safety and health ,Clinical Protocols ,Health care ,Forensic engineering ,medicine ,Humans ,Family ,Health Workforce ,Israel ,Equipment and Supplies, Hospital ,Protocol (science) ,Emergency management ,business.industry ,Communication ,Rehabilitation ,Hospital Distribution Systems ,medicine.disease ,United States ,Mass-casualty incident ,Hospital Bed Capacity ,Preparedness ,Emergency Medicine ,Surgery ,Medical emergency ,Triage ,business - Abstract
The successful management of mass casualty incidents (MCIs) requires standardization of planning, training, and deployment of response. Recent events in the United States, most importantly the Hurricane season in 2005, demonstrated a lack of a unified response plan at local, regional, state, and federal levels. A standard Israeli protocol for hospital preparedness for conventional MCIs, produced by the Office of Emergency Preparedness of the Israeli Ministry of Health, has been reviewed, modified, adapted, and tested in both drills and actual events at a large university medical center in the United States. Lessons learned from this process are herein presented as the10 most important steps (ie, Commandments) to follow when preparing hospitals to be able to respond to conventional MCIs. The standard Israeli emergency protocols have proved to be universally adaptable, flexible, and designed to be adapted by any healthcare institution, regardless of its size and location.
- Published
- 2006
16. An update on the surgeons scope and depth of practice to all hazards emergency response
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Jeannette Capella, J. Chistopher Digiacomo, Jeffrey S. Hammond, Philip S. Barie, Donald H. Jenkins, David V. Shatz, Ronald I. Gross, Thomas E. Knuth, H. Scott Bjerke, David L. Ciraulo, Leopoldo C. Cancio, Mauricio Lynn, Christopher T. Born, Andrew Dennis, Susan M. Briggs, Patricia A. O'neill, Jeffrey P. Salomone, Peter B. Letarte, and John B. Holcomb
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medicine.medical_specialty ,Emergency Medical Services ,Warning system ,business.industry ,Public health ,Debriefing ,Homeland security ,Legislation ,Disaster Planning ,Crisis management ,Critical Care and Intensive Care Medicine ,medicine.disease ,United States ,Mass-casualty incident ,General Surgery ,Terrorism ,medicine ,Humans ,Surgery ,Medical emergency ,Public Health ,business ,Physician's Role ,Information Systems - Abstract
This article outlines the position of The Eastern Association of the Surgery of Trauma (EAST) in defining the role of surgeons, and specifically trauma/critical care surgeons, in the development of public health initiatives that are designed to react to and deal effectively with acts of terrorism. All aspects of the surgeon's role in response to mass casualty incidents are considered, from prehospital response teams to the postevent debriefing. The role of the surgeon in response to mass casualty incidents (MCIs) is substantial in response to threats and injury from natural, unintentional, and intentional disasters. The surgeon must take an active role in pre-event community preparation in training, planning, and executing the response to MCI. The marriage of initiatives among Departments of Public Health, the Department of Homeland Security, and existing trauma systems will provide a template for successful responses to terrorist acts.
- Published
- 2006
17. A burn mass casualty event due to boiler room explosion on a cruise ship: preparedness and outcomes
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Louis R. Pizano, Jennifer Lefton, Mary Ishii, Sharon Lessner-Eisenberg, Robin Prater-Varas, Seong K Lee, Angel Alvarez, Leda Borges, Peter P. Lopez, Katherine Sapnas, Akin Tekin, Olga Quintana, Mauricio Lynn, Nicholas Namias, C. G. Ward, Tom Ellison, and Terence O'Keeffe
- Subjects
Male ,Patient Transfer ,medicine.medical_specialty ,Resuscitation ,Emergency Medical Services ,Abdominal compartment syndrome ,Body Surface Area ,medicine.medical_treatment ,Burn Units ,Explosions ,Disaster Planning ,Risk Assessment ,Injury Severity Score ,Laparotomy ,medicine ,Intubation ,First Aid ,Humans ,Ships ,business.industry ,Burn center ,General Medicine ,medicine.disease ,Surgery ,Survival Rate ,Mass-casualty incident ,Anesthesia ,Escharotomy ,Practice Guidelines as Topic ,Florida ,Female ,Triage ,business ,Burns ,Follow-Up Studies - Abstract
The purpose of this study was to review our experience with a mass casualty incident resulting from a boiler room steam explosion aboard a cruise ship. Experience with major, moderate, and minor burns, steam inhalation, mass casualty response systems, and psychological sequelae will be discussed. Fifteen cruise ship employees were brought to the burn center after a boiler room explosion on a cruise ship. Eleven were triaged to the trauma resuscitation area and four to the surgical emergency room. Seven patients were intubated for respiratory distress or airway protection. Six patients had >80 per cent burns with steam inhalation, and all of these died. One of the 6 patients had 99 per cent burns with steam inhalation and died after withdrawal of support within the first several hours. All patients with major burns required escharotomy on arrival to trauma resuscitation. One patient died in the operating room, despite decompression by laparotomy for abdominal compartment syndrome and pericardiotomy via thoracotomy for cardiac tamponade. Four patients required crystalloid, 20,000 mls/m2–27,000 ml/m2 body surface area (BSA) in the first 48 hours to maintain blood pressure and urine output. Three of these four patients subsequently developed abdominal compartment syndrome and died in the first few days. The fourth patient of this group died after 26 days due to sepsis. Five patients had 13–20 per cent burns and four patients had less than 10 per cent burns. Two of the patients with 20 per cent burns developed edema of the vocal cords with mild hoarseness. They improved and recovered without intubation. The facility was prepared for the mass casualty event, having just completed a mass casualty drill several days earlier. Twenty-six beds were made available in 50 minutes for anticipated casualties. Fifteen physicians reported immediately to the trauma resuscitation area to assist in initial stabilization. The event occurred at shift change; thus, adequate support personnel were instantaneously to hand. Our mass casualty preparation proved useful in managing this event. Most of the patients who survived showed signs of post-traumatic stress syndrome, which was diagnosed and treated by the burn center psychology team. Despite our efforts at treating large burns (>80%) with steam inhalation, mortality was 100 per cent. Fluid requirements far exceeded those predicted by the Parkland (Baxter) formula. Abdominal compartment syndrome proved to be a significant complication of this fluid resuscitation. A coordinated effort by the facility and preparation for mass casualty events are needed to respond to such events.
- Published
- 2005
18. Spine injuries are common among asymptomatic patients after gunshot wounds
- Author
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Yoram Klein, Amir Hasharoni, Christiana M. Shaw, Stephen M. Cohn, Dror Soffer, and Mauricio Lynn
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Injury control ,Poison control ,Abdominal Injuries ,Critical Care and Intensive Care Medicine ,Asymptomatic ,Neck Injuries ,Injury prevention ,medicine ,Humans ,Facial Injuries ,Rachis ,Retrospective Studies ,integumentary system ,business.industry ,musculoskeletal system ,medicine.disease ,Spinal column ,humanities ,Surgery ,body regions ,Spine (zoology) ,Spinal Injuries ,Wounds, Gunshot ,medicine.symptom ,Gunshot wound ,business - Abstract
Spine injuries after gunshot wounds are thought to be rare among asymptomatic patients. The occurrence of spine injuries among asymptomatic patients with gunshot wounds was studied to determine the necessity for mandatory spine immobilization and radiographic imaging.In this retrospective cohort study, initial physical examination, radiographic findings, and final diagnosis and treatment were reviewed. Patients were included if they were admitted to the authors' level 1 trauma center with gunshot wounds to the head, neck, or trunk during a 10-year period. Spine injuries were considered "significant" if the injury was associated with spinal cord injury or required spine-related surgical procedures or prolonged spine immobilization. Spine injuries were defined as "unsuspected" if there were no neurologic findings at admission.During the study period, 2,450 patients who survived more than 24 hours were admitted with gunshot wounds to the trunk, neck, or head. Of these patients, 244 (approximately 10%) had spine injuries, and 228 of them had complete records. Two thirds of the spine injuries were found to be significant, requiring surgery or prolonged immobilization, and 13% were unsuspected.Spine injuries without neurologic signs are not uncommon among patients with gunshot wounds. Complete radiographic spine imaging is therefore recommended to ensure that spine injuries are not missed in this population.
- Published
- 2005
19. Secondary ultrasound examination increases the sensitivity of the FAST exam in blunt trauma
- Author
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Bruce A. Crookes, Carl I. Schulman, Mauricio Lynn, Lorne H. Blackbourne, Jose Amortegui, Stephen M. Cohn, Fahim Habib, Dror Soffer, Peter P. Lopez, Robert Benjamin, Mark G. McKenney, and Nicholas Namias
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.medical_treatment ,Abdominal Injuries ,Critical Care and Intensive Care Medicine ,Wounds, Nonpenetrating ,Sensitivity and Specificity ,Diagnosis, Differential ,Hospitals, University ,Trauma Centers ,Predictive Value of Tests ,Laparotomy ,Abdomen ,Medicine ,Humans ,Hemoperitoneum ,Prospective Studies ,Prospective cohort study ,Child ,Aged ,Ultrasonography ,Aged, 80 and over ,business.industry ,Ultrasound ,Infant ,Middle Aged ,medicine.anatomical_structure ,Effusion ,Blunt trauma ,Predictive value of tests ,Child, Preschool ,Florida ,Surgery ,Female ,Radiology ,medicine.symptom ,business - Abstract
Approximately one third of stable patients with significant intra-abdominal injury do not have significant intraperitoneal blood evident on admission. We hypothesized that a delayed, repeat ultrasound study (Secondary Ultrasound--SUS) will reveal additional intra-abdominal injuries and hemoperitoneum.We performed a prospective observational study of trauma patients at our Level I trauma center from April 2003 to December 2003. Patients underwent an initial ultrasound (US), followed by a SUS examination within 24 hours of admission. Patients not eligible for a SUS because of early discharge, operative intervention or death were excluded. All US and SUS exams were performed and evaluated by surgical/emergency medicine house staff or surgical attendings.Five hundred forty-seven patients had both an initial US and a SUS examination. The sensitivity of the initial US in this patient population was 31.1% and increased to 72.1% on SUS (p0.001) for intra-abdominal injury or intra-abdominal fluid. The specificity for the initial US was 99.8% and 99.8% for SUS. The negative predictive value was 92.0% for the initial US and increased to 96.6% for SUS (p = 0.002). The accuracy of the initial ultrasound was 92.1% and increased to 96.7% on the SUS (p0.002). No patient with a negative SUS after 4 hours developed clinically significant hemoperitoneum.A secondary ultrasound of the abdomen significantly increases the sensitivity of ultrasound to detect intra-abdominal injury.
- Published
- 2004
20. Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries
- Author
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Jeffrey S. Augenstein, Kenneth G. Proctor, David V. Shatz, Robert Benjamin, Nicholas Namias, Stephen M. Cohn, Lourne H. Blackbourne, Enrique Ginzburg, Mauricio Lynn, David R. King, Peter P. Lopez, and Louis R. Pizano
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Hemorrhage ,Abdominal Injuries ,Critical Care and Intensive Care Medicine ,Risk Assessment ,Sensitivity and Specificity ,Injury Severity Score ,Trauma Centers ,Laparotomy ,Coagulopathy ,Medicine ,Humans ,Survival rate ,Hemostat ,business.industry ,Hemostatic Techniques ,Trauma center ,Blood Coagulation Disorders ,medicine.disease ,Prognosis ,Bandages ,Surgery ,Survival Rate ,Treatment Outcome ,Hemostasis ,Anesthesia ,Female ,business ,Bandage - Abstract
Background We recently reported that a new dressing, the Modified Rapid Deployment Hemostat (MRDH) controlled bleeding in hypothermic coagulopathic swine after traumatic liver avulsion. The purpose of this study was to evaluate the MRDH in coagulopathic trauma patients undergoing abbreviated laparotomy. Methods A prospective, observational clinical trial of the MRDH dressing was performed at our Level One Trauma Center in patients with high-grade visceral injuries with coagulopathy who failed conventional therapy and required packing. Attending surgeons graded the injury and the adequacy of hemostasis following application of the dressing. Patients were followed until discharge or death. Results Ten patients were enrolled: nine severe hepatic injuries, and one major abdominal vascular injury. All patients were hypothermic, acidotic, and clinically coagulopathic. Intraoperative hemostasis was immediately obtained after MRDH placement in all cases except one. There was one death. Conclusion The Modified Rapid Deployment Hemostat terminates bleeding from severe visceral injuries in coagulopathic patients undergoing abbreviated laparotomy.
- Published
- 2004
21. Diagnostic peritoneal lavage through an abdominal stab wound
- Author
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Hani H. Haider, Stephen M. Cohn, Mauricio Lynn, Mark G. McKenney, and Yoram Klein
- Subjects
Male ,medicine.medical_specialty ,Adolescent ,Abdominal Injuries ,Wounds, Stab ,Peritoneal cavity ,Diagnostic peritoneal lavage ,medicine ,Humans ,Peritoneal Lavage ,Stab wound ,Catheter insertion ,integumentary system ,medicine.diagnostic_test ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,body regions ,Catheter ,medicine.anatomical_structure ,cardiovascular system ,Emergency Medicine ,Side arm ,Abdomen ,Peritoneum ,business ,Surgical incision - Abstract
Diagnostic peritoneal lavage (DPL) is one of the most useful tools in the diagnosis of intraperitoneal injuries secondary to stab wounds. The lavage catheter is inserted into the peritoneal cavity through a surgical incision or a blind puncture. Complications related to the catheter insertion were previously reported in both techniques. We describe 2 cases in which the lavage catheter was inserted through the stab wound itself after local wound exploration clearly demonstrated violation of the peritoneum. We suggest that in anterior abdominal stab wounds, the DPL can be safely and effectively performed through the stab wound if penetration to the peritoneum is diagnosed.
- Published
- 2003
22. Early coagulopathy predicts mortality in trauma
- Author
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Mauricio Lynn, Jana B.A. MacLeod, Mark G. McKenney, Mary Murtha, and Stephen M. Cohn
- Subjects
Adult ,Male ,medicine.medical_specialty ,Critical Care and Intensive Care Medicine ,Permissive hypotension ,Trauma Centers ,Predictive Value of Tests ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Coagulopathy ,Humans ,Prospective Studies ,Registries ,Prospective cohort study ,Survival analysis ,Prothrombin time ,medicine.diagnostic_test ,business.industry ,Blood Coagulation Disorders ,medicine.disease ,Predictive value ,Survival Analysis ,Surgery ,Logistic Models ,Predictive value of tests ,Cardiology ,Prothrombin Time ,Wounds and Injuries ,Female ,Partial Thromboplastin Time ,business ,circulatory and respiratory physiology ,Partial thromboplastin time - Abstract
Coagulopathy and hemorrhage are known contributors to trauma mortality; however, the actual relationship of prothrombin time (PT) and partial thromboplastin time (PTT) to mortality is unknown. Our objective was to measure the predictive value of the initial coagulopathy profile for trauma-related mortality.We reviewed prospectively collected data on trauma patients presenting to a Level I trauma center. A logistic regression analysis was performed of PT, PTT, platelet count, and confounders to determine whether coagulopathy is a predictor of all-cause mortality.From a trauma registry cohort of 20103 patients, 14397 had complete disposition data for initial analysis and 7638 had complete data for all variables in the final analysis. The total cohort was 76.2% male, the mean age was 38 years (range, 1-108 years), and the median Injury Severity Score was 9. There were 1276 deaths (all-cause mortality, 8.9%). The prevalence of coagulopathy early in the postinjury period was substantial, with 28% of patients having an abnormal PT (2994 of 10790) and 8% of patients having an abnormal PTT (826 of 10453) on arrival at the trauma bay. In patients with disposition data and a normal PT, 489 of 7796 died, as compared with 579 of 2994 with an abnormal PT (6.3% vs. 19.3%; chi2 = 414.1, p0.001). Univariate analysis generated an odds ratio of 3.6 (95% confidence interval [CI], 3.15-4.08; p0.0001) for death with abnormal PT and 7.81 (95% CI, 6.65-9.17; p0.001) for deaths with an abnormal PTT. The PT and PTT remained independent predictors of mortality in a multiple regression model, whereas platelet count did not. The model also included the independent risk factors age, Injury Severity Score, scene and trauma-bay blood pressure, hematocrit, base deficit, and head injury. The model generated an adjusted odds ratio of 1.35 for PT (95% CI, 1.11-1.68; p0.001) and 4.26 for PTT (95% CI, 3.23-5.63; p0.001).The incidence of coagulation abnormalities, early after trauma, is high and they are independent predictors of mortality even in the presence of other risk factors. An initial abnormal PT increases the adjusted odds of dying by 35% and an initial abnormal PTT increases the adjusted odds of dying by 326%.
- Published
- 2003
23. Tourniquets for hemorrhage control on the battlefield: a 4-year accumulated experience
- Author
-
Ron Ben-Abraham, Roni Bssorai, Tali Sokolov, Mauricio Lynn, Guy Lin, A. Blumenfeld, and Dror Lakstein
- Subjects
medicine.medical_specialty ,Warfare ,Medical staff ,Time Factors ,Silicones ,Hemorrhage ,Critical Care and Intensive Care Medicine ,Battlefield ,medicine ,Humans ,Israel ,Retrospective Studies ,Tourniquet ,business.industry ,Retrospective cohort study ,Tourniquets ,medicine.disease ,Surgery ,Military personnel ,Military Personnel ,Treatment Outcome ,Anesthesia ,Mechanism of injury ,Hemorrhage control ,Wounds and Injuries ,business ,Penetrating trauma - Abstract
Background: Tourniquet application is a known means for bleeding prevention in the military prehospital setting. Methods: This study was a 4-year retrospective analysis of silicone and improvised tourniquet applications by Israeli Defense Force soldiers. Results: Of 550 soldiers who were treated in the prehospital setting, tourniquets were applied to 91 (16%) patients and in less than 15 minutes in 88% of the cases with almost no complications. Penetrating trauma was the main mechanism of injury. The indication was situational and nonmedical in 58 (53%) of the cases. The patients' ischemic time was 83 ± 52 minutes (range, 1-305 minutes). A total of 78% of applications were effective, with higher success rates for medical staff compared with fellow soldiers and for upper limbs (94%) compared with lower limbs (71%,p < 0.01). Conclusion: Tourniquet application is an effective and easily applied (by medical and nonmedical personnel) method for prevention of exsanguination in the military prehospital setting.
- Published
- 2003
24. Early injection of high-dose recombinant factor VIIa decreases blood loss and prolongs time from injury to death in experimental liver injury
- Author
-
Marlies Ledford, Eleanor Gomez-Fein, Qammar Rashid, Dory D. Jewelewicz, Mauricio Lynn, Igor Jeroukhimov, Jana B.A. MacLeod, Julia Zaias, George T. Hensley, Francisco G. Pernas, and Stephen M. Cohn
- Subjects
Male ,Mean arterial pressure ,Time Factors ,Swine ,Hemodynamics ,Factor VIIa ,Shock, Hemorrhagic ,Critical Care and Intensive Care Medicine ,Placebo ,Sensitivity and Specificity ,Severity of Illness Index ,Drug Administration Schedule ,chemistry.chemical_compound ,Reference Values ,medicine ,Animals ,Probability ,Liver injury ,Analysis of Variance ,biology ,Factor VII ,Dose-Response Relationship, Drug ,business.industry ,medicine.disease ,Thrombosis ,Survival Analysis ,Recombinant Proteins ,Disease Models, Animal ,Treatment Outcome ,chemistry ,Liver ,Recombinant factor VIIa ,Anesthesia ,Injections, Intravenous ,biology.protein ,Surgery ,Female ,Blood Coagulation Tests ,business ,Blood sampling - Abstract
Background: Recombinant factor VIIa (rFVIIa) is used for treatment of bleeding episodes in hemophilia patients who develop inhibitors to factors VIII and IX. We tested the hypothesis that administration of rFVIIa early after injury would decrease bleeding and prolong the time from injury to death after experimental hepatic trauma. Methods: Anesthetized swine were cannulated for blood sampling and hemodynamic monitoring. Avulsion of the left median lobe of the liver induced uncontrolled hemorrhage. After a 10% reduction in mean arterial pressure, animals (n = 8 per group) were blindly randomized to receive intravenous rFVIIa 180 μg/kg, rFVIIa 720 μg/kg, or placebo. Pathologic examination of brain, lung, kidney, heart, and small bowel was performed to assess intravascular thrombosis. Results: Mortality during the first hour was 50% (four of eight) in controls versus 0% with rFVIIa 720 μg/kg (p = 0.02, X 2 ). Blood loss was decreased in the rFVIIa 720 μg/kg group versus the placebo group (13.2 ± 5.5 mL/kg vs. 21.9 ± 7.7 mL/kg; p = 0.0223). Time from injury to death was significantly prolonged in the rFVIIa 720 μg/kg group compared with placebo (116 minutes vs. 8.5 ± 3.5 minutes; p = 0.02). No macro- or microthrombi in vital organs were identified on pathologic examination. Conclusion: Intravenous administration of high-dose rFVIIa early after induction of hemorrhage decreased bleeding and prolonged survival. No evidence of thrombosis in vital organs was observed.
- Published
- 2002
25. Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: a pilot study
- Author
-
Margareth Brown, Stephen M. Cohn, Edward W. Johnson, Qammar Rashid, Dory D. Jewelewicz, Mauricio Lynn, Uri Martinowitz, Igor Jerokhimov, and Charles A. Popkin
- Subjects
Mean arterial pressure ,Time Factors ,Swine ,Hemodynamics ,Blood Pressure ,Pilot Projects ,Factor VIIa ,Shock, Hemorrhagic ,Critical Care and Intensive Care Medicine ,Placebo ,Random Allocation ,medicine ,Animals ,Prothrombin time ,medicine.diagnostic_test ,biology ,business.industry ,Recombinant Proteins ,Blood pressure ,Liver ,Recombinant factor VIIa ,Anesthesia ,Shock (circulatory) ,biology.protein ,Prothrombin Time ,Surgery ,medicine.symptom ,business ,Blood sampling - Abstract
Background: Recombinant factor VIIa (rFVIIa) is used for treatment of bleeding episodes in hemophilia patients who develop inhibitors to factors VIII and IX. We tested the hypothesis that administration of rFVIIa early after injury would decrease bleeding and improve survival after experimental hepatic trauma. Methods: Anesthetized swine were cannulated for blood sampling and hemodynamic monitoring. Avulsion of left median lobe of the liver induced uncontrolled hemorrhage. After a 10% reduction of mean arterial pressure, animals were blindly randomized to receive intravenous rFVIIa (180 μg/kg) (n = 6) or placebo (n = 7). Results: Mortality was 43% (three of seven) in controls versus 0% with rFVIIa (p = 0.08, X 2 ). Significantly shorter prothrombin time and higher mean arterial pressures were observed in the rFVIIa group. Conclusion: Intravenous administration of rFVIIa early after induction of hemorrhage shortens prothrombin time and improves mean arterial pressure. A trend toward improved survival was observed.
- Published
- 2002
26. The incision of choice for pregnant women with appendicitis is through McBurney's point
- Author
-
Peter P. Lopez, Mauricio Lynn, Stephen M. Cohn, Margaret Brown, and Charles A. Popkin
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Third trimester ,Pregnancy ,Abdomen ,medicine ,Appendectomy ,Humans ,Retrospective Studies ,Laparotomy ,business.industry ,General Medicine ,medicine.disease ,Appendicitis ,Appendix ,Surgery ,Pregnancy Complications ,medicine.anatomical_structure ,Childbearing age ,Acute appendicitis ,Abdomen surgery ,Female ,business ,Surgical incision ,McBurney's point - Abstract
Background: There is uncertainty over the optimal incision for gravid patients with appendicitis. Methods: Data were collected retrospectively from January 1, 1995, through December 31, 2000, on 374 women of childbearing age who underwent appendectomies. Of these, 23 gravid patients were evaluated. Results: Eighteen incisions were made over McBurney’s point and five were created superior to McBurney’s point. Patients in the third trimester of pregnancy all received incisions over McBurney’s point. The appendix was located without difficulty in all 4 of the third trimester patients. The appendix was easily located in 94% of the incisions made through McBurney’s point and 80% of the incisions made above McBurney’s point. Conclusions: Our clinical experience indicates that the incision for the removal of the appendix in pregnant patients in all trimesters can be successfully made over McBurney’s point.
- Published
- 2002
27. Mortality epidemiology in low-intensity warfare: Israel Defense Forces' experience
- Author
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Mauricio Lynn, Arieh Eldad, Uri Farkash, Avi Abargel, and Alon Scope
- Subjects
Adult ,medicine.medical_specialty ,Warfare ,Adolescent ,Poison control ,Autopsy ,Injury Severity Score ,Cause of Death ,Injury prevention ,Epidemiology ,Medicine ,Humans ,Israel ,General Environmental Science ,Cause of death ,Retrospective Studies ,business.industry ,medicine.disease ,Surgery ,Military Personnel ,Emergency medicine ,General Earth and Planetary Sciences ,Wounds and Injuries ,Body region ,business ,Penetrating trauma - Abstract
Purpose: an analysis of the mortality epidemiology in low-intensity warfare. Basic procedures: we retrospectively reviewed all cases of Israeli soldiers killed in small-scale warfare during 1996–1998, using field data, hospital charts and autopsy reports. Data on injury pattern, offending munitions and time of death were analyzed. Main findings: in the study period, 106 soldiers were killed. Penetrating trauma was the common injury mechanism (95%) most frequently due to claymore bombs and gunshot bullets. The percentage dying in the prehospital phase and in the first 30-min were 77 and 88%, respectively. The average injury severity score (ISS) was 42.5. Seriously injured body regions were thorax (38%), head (24%), abdomen and pelvis (13%) and neck (12%). Conclusions: there is no trimodal death distribution in military trauma. Most casualties of low-scale conflicts die very early after injury. Most fatal injuries involve the head and trunk regions. The distribution of injury depends on the type of assaulting munitions.
- Published
- 2001
28. Preliminary experience with postmortem computed tomography in military penetrating trauma
- Author
-
Arieh Eldad, Alon Scope, Uri Farkash, Chen Kugel, Avi Abargel, R. Maor, and Mauricio Lynn
- Subjects
Adult ,Male ,medicine.medical_specialty ,Warfare ,Adolescent ,Poison control ,Autopsy ,Wounds, Penetrating ,Critical Care and Intensive Care Medicine ,Occupational safety and health ,Injury prevention ,Medicine ,Humans ,Israel ,Cause of death ,Retrospective Studies ,business.industry ,Retrospective cohort study ,medicine.disease ,Surgery ,Military personnel ,Military Personnel ,Medical emergency ,business ,Tomography, X-Ray Computed ,Penetrating trauma - Abstract
BACKGROUND: Postmortem examination serves as a tool for confirmation of clinical diagnosis, "quality" assurance, and education. In Israel, mostly because of religious reasons, most families withhold their permission to perform autopsies. To obtain objective information regarding the death of soldiers, the Israel Defense Forces Medical Corps started in September of 1997 to perform postmortem computed tomographic (PMCT) scans. The purpose of our study is to determine what information can be obtained from the PMCT scans. METHODS: In a period of 16 months, 27 soldiers were killed in low-intensity conflicts and PMCT was obtained in 22 cases. Medical data obtained from the field medical care providers were collected and compared with PMCT results. RESULTS: Several examples of patients whose death was determined at the scene either before any medical intervention or after initiation of resuscitative treatment are shown in our study and compared with the clinical impression of the treating physician. Two examples of autopsy results are compared with PMCT results. Gas was detected in various parts of the circulatory system in many cases. The significance of this finding, described in our study for the first time, needs further investigation. CONCLUSION: PMCT scanning has limits in detecting superficial injuries and injuries of the extremities and determining the exact route of fragments through body tissues in penetrating military trauma. It also cannot serve as a tool for examining ammunition or the protection provided by various armors. However, it can provide a substantial amount of evidence that, when reviewed with the clinical information obtained from the physician at the scene, can help in assessing the treatment given at the field and point toward the probable cause of death. Language: en
- Published
- 2000
29. Prolonged Clamping of the Liver Parenchyma: A Salvage Maneuver in Exsanguinating Liver Injury
- Author
-
Michael Sutherland, Yoram Klein, Enrique Ginzburg, David V. Shatz, David Levi, Dean Goldberg, Jose Nery, Danny Sleeman, Mauricio Lynn, and Stephen M. Cohn
- Subjects
Adult ,Liver injury ,medicine.medical_specialty ,Resuscitation ,business.industry ,Surgical Instruments ,Critical Care and Intensive Care Medicine ,medicine.disease ,Clamping ,Surgery ,Debridement ,Liver ,Anesthesia ,Orthopedic surgery ,medicine ,Humans ,Female ,Wounds, Gunshot ,business ,Liver parenchyma - Published
- 2004
30. The use of a computed tomography scan to rule out appendicitis in women of childbearing age is as accurate as clinical examination: A prospective randomized trial
- Author
-
Margaret Brown, Suzanne D. LeBlang, Martin Newman, Julie Jackowski, Jeffrey S. Augenstein, Fahim Habib, Mark G. McKenney, Peter Ekeh, Enrique Ginzburg, Stephen M. Cohn, Carl I. Schulman, Robb R. Whinney, Joel E. Michalek, Danny Sleeman, Charles A. Popkin, Louis R. Pizano, S. Morad Hameed, Patricia Byers, David V. Shatz, Peter P. Lopez, Mauricio Lynn, Erik Barquist, and Nicholas Namias
- Subjects
medicine.medical_specialty ,Randomization ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Physical examination ,General Medicine ,medicine.disease ,Appendicitis ,law.invention ,Surgery ,Clinical trial ,Randomized controlled trial ,Alvarado score ,law ,Laparotomy ,Childbearing age ,Medicine ,Radiology ,business - Abstract
Diagnosing appendicitis continues to be a difficult task for clinicians. The use of routine CT scan has been advocated to improve the accuracy of diagnosing appendicitis. When compared with the use of clinical examination alone, CT scan was not significantly different with regard to making the diagnosis of appendicitis in women of childbearing age. The use of computed tomography in making the diagnosis of appendicitis has become the current standard of practice in most emergency rooms. In women of childbearing age, with possible appendicitis, we prospectively compared clinical observation alone (OBS) to appendiceal CT scan with clinical observation (CT). Ninety women (OBS: 48, CT: 42) with questionable appendicitis and an Alvarado Score ranging from two to eight were prospectively randomized. A true positive study/exam resulted in a laparotomy that revealed a lesion requiring operation (confirmed by pathology). A true negative exam/study did not require operation. Hospital stay (OBS = 1.9 ± 1.6 vs CT = 1.3 ± 1.4 days) and charges (OBS = $9,459 ± 7,358 vs CT = $9,443 ± 8,773) were similar. The OBS group had an accuracy of 93 per cent, sensitivity of 100 per cent, and a specificity of 87.5 per cent. The CT group had an accuracy of 93 per cent, sensitivity of 89.5 per cent, and specificity of 95.6 per cent. Although this study is too small to statistically establish equivalence, the data suggest that a CT scan reliably identifies women who need an operation for appendicitis and seems to be as good as clinical examination.
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