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A recent study conducted at the University of Ljubljana in Slovenia focused on the spontaneous cyclization of 2-methylthiosemicarbazones to produce new 1,2,4-triazolidine-3-thiones, which are potential building blocks for drug design. The research aimed to synthesize fifteen new compounds using a green procedure with minimal hazardous solvents, characterizing them through various analytical techniques. The study also included cytotoxicity assays, microbiological tests, and assessments of inhibitory effects on antimicrobial resistance. This peer-reviewed research provides valuable insights into the potential applications of these synthesized compounds in drug development. [Extracted from the article]

A recent study conducted by the University of Ljubljana in Slovenia focused on gastric intestinal metaplasia (GIM) in children and adolescents, a precursor to gastric adenocarcinoma in adults. The research found that childhood GIM, although rare, showed a high rate of reversibility by adulthood, with no cases of dysplasia or carcinoma observed during long-term follow-up. The study involved 50 adult patients with childhood GIM, and it concluded that GIM in children is reversible upon reaching adulthood, regardless of certain host-related factors. [Extracted from the article]

Researchers from the University of Ljubljana in Slovenia have conducted a study on the role of Biliverdin Reductase (BVR) in reducing oxidative stress in rat arterial rings. The study found that inhibiting ERK1/2, a signaling pathway, enhanced the antioxidant effects of BVR, reducing oxidative damage in the arteries. This research suggests that targeting the interaction between BVR and ERK1/2 could be a potential therapeutic strategy for conditions characterized by high levels of reactive oxygen species, such as cardiovascular diseases. [Extracted from the article]

A recent study conducted by the University of Ljubljana in Slovenia focused on the electrochemical reactions induced by electroporation pulses in surrogate tissue. The research involved numerical modeling and experimental validation to explore pH changes caused by faradaic currents. The study developed a mechanistic multiphysics model to predict pH changes due to high-voltage electric pulse delivery, particularly in electroporation-based treatments and therapies. The findings suggest that while the model provides a theoretical foundation for understanding pH changes, further advancements are needed for more accurate predictions. [Extracted from the article]

A study conducted at the University of Ljubljana in Slovenia examined the impact of online education on students' knowledge of human evolution during the COVID-19 pandemic lockdown in the 2020/21 school year. The study compared two groups of students, one taught online and the other in a traditional classroom setting, and found no significant differences in knowledge between the two groups. The research also explored the influence of contextual factors such as parental education, gender, religiosity, and attitudes toward biology on students' understanding of human evolution. Further studies are recommended to better understand the long-term consequences of the lockdown on students' education. [Extracted from the article]

The article from Drug Week discusses recent advances in the purification and isolation of therapeutic oligonucleotides in the field of Life Science. Researchers at Lek Pharmaceuticals in Ljubljana, Slovenia, emphasize the importance of scalable and economically sustainable production methods for these novel chemical entities. The review highlights traditional purification techniques and emerging separation technologies that could enhance the quality, yield, scale, and cost-efficiency of therapeutic oligonucleotide production. This research, which has been peer-reviewed, provides valuable insights for the pharmaceutical industry. [Extracted from the article]

A recent study conducted by the Jozef Stefan Institute in Ljubljana, Slovenia, focused on Campylobacter jejuni, a Gram-Negative Bacteria responsible for foodborne infections. The research utilized NanoLuc bioluminescence to monitor the development of C. jejuni biofilms on various substrates, highlighting the bacterium's ability to survive in adverse conditions. The study suggests that the NanoLuc assay offers a precise and efficient method for biofilm quantification, complementing traditional monitoring techniques and providing valuable insights into biofilm dynamics. This research, which has been peer-reviewed, emphasizes the importance of a versatile approach in understanding biofilm development and structure. [Extracted from the article]

Researchers at the Institute of Criminology in Ljubljana, Slovenia, conducted a critical discourse analysis of parliamentary discussions on cannabis regulation in Slovenia from 2013 to 2024. The study revealed that proponents of less stringent regulation emphasized the medical benefits of cannabis, while opponents focused on public health risks and moral concerns. Despite efforts to change cannabis regulation, the status quo remains unchanged, with public health experts playing a dominant role in shaping the discourse. The full report, titled "Poison or Panacea: a Decade of Parliamentary Discourse On Cannabis Regulation In Slovenia," was published in Revija Za Kriminalistiko In Kriminologijo. [Extracted from the article]

A recent study conducted at the University of Ljubljana in Slovenia explored the role of biliverdin reductase (BVR) in protecting endothelial cells against oxidative stress-induced injury. The research found that inhibition of BVR diminished the protective effects of biliverdin (BV) and bilirubin (BR), leading to decreased cell viability and antioxidant activity. The study suggests that targeting the BVR-ERK interaction sites could be a potential therapeutic strategy for addressing oxidative stress-induced endothelial dysfunction. For more information, the study can be found in Acta Chimica Slovenica, with contact information available for the researchers involved. [Extracted from the article]

A recent study conducted by researchers from the University of Ljubljana in Slovenia focused on enhancing primary healthcare for LGBT+ individuals in the country. The study found that while general practitioners claimed to treat all patients equally, LGBT+ individuals reported varied experiences and highlighted the need for improved training and attitudes among healthcare providers. The research emphasized the importance of creating safe spaces and fostering trust between patients and healthcare providers to provide inclusive and affirming healthcare for LGBT+ individuals. [Extracted from the article]

A recent report from the University of Ljubljana in Slovenia discusses the findings on sexually transmitted shigellosis, highlighting the increased risk among gay, bisexual, and other men who have sex with men. The research emphasizes the importance of preventive measures such as safe sexual practices, hygiene, and avoiding contact during and after symptoms of diarrhea. The study underscores the need for raising awareness among clinicians and at-risk groups to address the potential sexual transmission of shigellosis. [Extracted from the article]

Researchers from the University of Ljubljana conducted a study to evaluate the effectiveness of locally sourced inert dusts as insecticides against the Cereal Leaf Beetle, a threat to wheat production. The study found that diatomaceous earth and Norway spruce wood ash were highly effective in laboratory trials, but field efficacy was hindered by wet weather. The research highlights the potential of inert dusts for pest management, but further studies are needed to develop practical and sustainable strategies. [Extracted from the article]

Research conducted at the Jozef Stefan Institute in Ljubljana, Slovenia, has provided new insights into Listeria bacteria and their biofilm formation on surfaces. The study focused on the antibiofilm activity of fungal proteins, which showed potential in reducing surface contamination by Listeria. The research, supported by the Slovenian Research Agency, highlighted the impact of specific fungal lectins on impairing biofilm development, offering a promising avenue for future applications in controlling bacterial interactions and surface contamination. [Extracted from the article]

Researchers at the University Psychiatric Clinic in Ljubljana, Slovenia, have reported on the occurrence of complex visual hallucinations in an elderly diabetic patient undergoing ranolazine therapy for chronic angina pectoris. The patient developed visual hallucinations after a decline in kidney function, despite previously tolerating the medication for six years. The study emphasizes the importance of regular monitoring for potential adverse effects, including psychiatric and neurologic symptoms, in elderly patients receiving ranolazine treatment. [Extracted from the article]

Researchers at the Sandoz Development Center in Slovenia have highlighted the importance of controlling the stereochemical composition of phosphorothioated therapeutic oligonucleotides, which are essential for addressing rare or difficult-to-treat diseases. The manufacturing process of these complex drugs presents challenges due to oligonucleotide-specific impurities. The research discusses the regulatory framework, biological significance, and analytical methods for determining the stereochemical composition of these therapeutic oligonucleotides. Enzymatic methods for cleaving the oligonucleotides into smaller fragments for analysis are also highlighted in the study. [Extracted from the article]

A recent study conducted at the University Medical Center Ljubljana in Slovenia explored the relationship between postnatal levels of glycated albumin and glycated hemoglobin A1c in mothers of large-for-gestational-age newborns. The study aimed to investigate the potential of using glycated albumin as a screening tool for gestational diabetes mellitus in the last trimester of pregnancy. The findings suggested that mothers of large-for-gestational-age newborns who were not diagnosed with GDM during pregnancy had higher median levels of glycated albumin and lower HbA1c levels. The research was supported by the Slovenian Research and Innovation Agency and published in Frontiers in Pediatrics. [Extracted from the article]

Researchers from the National Institute of Chemistry in Ljubljana, Slovenia, have discovered novel bacterial topoisomerase inhibitors that effectively target Mycobacterium tuberculosis DNA gyrase, showing promising antimycobacterial activity. The study reveals the crystal structure of M. tuberculosis DNA gyrase in complex with the inhibitors, highlighting the importance of halogen bonding for their potency. This research, funded by various organizations including the Slovenian Research Agency and NIH, provides valuable insights into potential treatments for tuberculosis. [Extracted from the article]

Researchers from the Agricultural Institute of Slovenia conducted a study on the nutritional profile and color parameters of four sweet potato varieties. The study found that variations in these parameters were mainly due to genetic makeup, with Purple Speclet having the highest nutritional content. Factors such as cropping system, mulching, and growing season significantly influenced the nutritional quality of sweet potatoes. The results could potentially lead to the introduction of nutrient-rich sweet potato varieties into sustainable cropping systems in Europe. [Extracted from the article]

Researchers at the Jozef Stefan Institute in Ljubljana, Slovenia, have developed a new data-augmentation method called PCGmix for heart-sound classification to aid in the early detection of cardiovascular diseases (CVDs). This method aims to enhance the accuracy of deep-learning models for CVD detection, particularly in data-constrained environments. The study, which has been peer-reviewed, demonstrates that PCGmix outperforms existing time-series augmentation methods, showing promise for improving CVD risk assessment and prevention strategies. For more information, readers can refer to the article "Pcgmix: a Data-augmentation Method for Heart-sound Classification" published in the IEEE Journal of Biomedical and Health Informatics. [Extracted from the article]

A study conducted at the University Children's Hospital in Ljubljana, Slovenia, aimed to assess the prevalence, clinical characteristics, and genetics of hypocholesterolemia in children and adolescents. The research found that among 3538 children, 2.66% had hypocholesterolemia, with 15 subjects identified with pathogenic alterations. The study provides new clinical and genetic insights into hypocholesterolemia, suggesting that asymptomatic patients may not require further evaluation. Further research is needed to better understand this condition. [Extracted from the article]

A recent study conducted at University Children's Hospital in Ljubljana, Slovenia, focused on C3 glomerulopathy in children, a rare condition affecting the alternative complement pathway in glomerular disease. The study included 108 pediatric patients from 12 European pediatric nephrology units and found that complete remission was achieved in 65.7% of patients, with prognostic factors including eGFR, UPCR, and the presence of endocapillary proliferation. The research suggests that C3 glomerulopathy has a more favorable outcome in children compared to adults, with endocapillary proliferation and proteinuria levels at onset being key prognostic indicators. [Extracted from the article]

A study conducted by researchers at the Jozef Stefan Institute in Ljubljana, Slovenia, focused on the impact of different metallographic preparation methods on the surface characteristics and corrosion behavior of Ti-6Al-4V alloy. The study found that chemo-mechanical polishing resulted in a smoother surface with superior corrosion resistance compared to grinding. The research was supported by the Slovenian Research and Innovation Agency (ARIS) and has been peer-reviewed. For more information, readers can refer to the Journal of The Electrochemical Society. [Extracted from the article]

A recent study conducted in Slovenia examined the nutrition intake of older adults living in nursing homes, revealing variability in energy and macronutrient intake among participants. The study found that a high prevalence of BMI > 30 kg/m was observed, indicating potential discrepancies between total energy intake and expenditure. Recommendations were made for careful meal planning and regular monitoring of the nutritional status of nursing home residents. The study highlights the need for optimization in dietary patterns and menu offers in nursing homes to improve the overall health and well-being of residents. [Extracted from the article]

A study conducted at the University Psychiatric Hospital in Ljubljana, Slovenia, explored the use of micro-dosing with buprenorphine when transitioning from full opioid agonists like methadone to buprenorphine treatment in opioid agonist-assisted treatment programs. The research highlighted the importance of slowly increasing buprenorphine dosage to manage withdrawal symptoms effectively. The study suggested that this method could be beneficial for transitioning from various opioids, including methadone, SR-morphine, and even heavy use of fentanyl. [Extracted from the article]

A recent study conducted by researchers at the National Institute of Chemistry in Ljubljana, Slovenia, focused on optimizing 4,6-substituted 1,3,5-triazin-2(1H)-ones as inhibitors of human DNA topoisomerase II alpha. The research utilized molecular simulations, dynamic pharmacophores, and free energy calculations to develop compounds with promising inhibitory activity. The study highlighted the importance of simulation and AI-based approaches in guiding molecular design for drug optimization, with implications for further preclinical development of these compounds. For more information, the full article can be accessed in the Computational and Structural Biotechnology Journal. [Extracted from the article]

Researchers at the University of Ljubljana conducted a study on corporate sustainability reporting and ESG scores, analyzing a ten-year corpus of annual reports from FTSE 350 companies. The study used advanced topic modeling techniques to identify and cluster important ESG topics, revealing insights into the reporting landscape. Findings showed that regulatory changes and events like Covid-19 influence ESG topic prominence, with extensive disclosure on topics like climate risk and stakeholder engagement positively associated with higher ESG scores. The research contributes a novel methodological approach to ESG analysis and highlights gaps between reporting standards and practices, relevant to standard-setting bodies and regulators. [Extracted from the article]

The article discusses research conducted at the Jozef Stefan Institute in Ljubljana, Slovenia, focusing on the development of antiviral respiratory masks using plasma-functionalized polypropylene textiles. The study found that the treated textiles were able to inactivate enveloped viruses like SARS-CoV-2 and retain their antiviral properties for over 100 days without compromising filtration efficiency or breathability. The research suggests that this method has the potential to produce antiviral textiles for future outbreaks, with financial support from the Slovenian Research and Innovation Agency. [Extracted from the article]

A recent study conducted by the University of Ljubljana in Slovenia focused on understanding the mechanisms of microbubble formation in intracardiac pulsed field ablation. The research highlighted the importance of treatment parameters, electrode geometry, and treatment protocols in minimizing gas release during pulsed field applications in the cardiovascular system. The findings have implications for various applications, from lab-on-a-chip cell electroporation devices to pulsed field ablation procedures. The research was funded by Medtronic and the Slovenian Research Agency (ARIS) and has been peer-reviewed. [Extracted from the article]

The University Medical Center Ljubljana conducted research on the relationship between diet, exercise, and lower extremity artery disease (LEAD). The study found that adherence to the Mediterranean diet may reduce the incidence of LEAD, while physical activity is beneficial for cardiovascular health. The research recommends supervised walking training as a first-line treatment for LEAD. This peer-reviewed study provides valuable insights into the prevention and management of peripheral artery disease. [Extracted from the article]

A new report from the Agricultural Institute of Slovenia introduces AmiCa, a web server designed for analyzing microRNA-gene interactions in cancer and normal tissues. The tool provides data on miRNA and gene expression in 32 cancer types, using RNA sequencing data from tumor and normal samples. AmiCa includes a ranking system for identifying highly expressed genes and miRNAs in specific cancers, facilitating targeted research. For more information, refer to the Computational and Structural Biotechnology Journal. [Extracted from the article]

A report from the University Medical Center Ljubljana in Slovenia discusses the use of hemoperfusion with CytoSorb in pediatric patients to treat cytokine storms, which are dysregulated cytokine responses associated with conditions like sepsis. The study found that this treatment was successful in five children weighing more than 10 kg, all of whom survived, while three patients weighing less than 10 kg did not survive. The researchers concluded that hemoperfusion with CytoSorb could be a potential adjunctive treatment for cytokine storms in critically ill children. [Extracted from the article]

A report from the University Children's Hospital in Ljubljana, Slovenia, discusses the global health challenge of childhood obesity, with prevalence rates increasing significantly over the past 50 years. The research explores the role of genetics in pediatric obesity, highlighting the importance of integrating genetic screening into clinical practice for personalized treatment strategies. The study emphasizes the need for early identification and interventions to address this epidemic. [Extracted from the article]

A recent study conducted by the University of Ljubljana in Slovenia focused on the genetic background of high myopia in children. The research aimed to identify causative genetic variants for high myopia in Slovenian children, with genetic analysis revealing a genetic cause in 61.1% of children tested. The study highlighted the importance of genetic testing for diagnosis and proactive counseling in children with high myopia. The findings were published in PLOS ONE and can provide valuable insights for healthcare professionals working in pediatric ophthalmology. [Extracted from the article]

A recent study conducted in Ljubljana, Slovenia, focused on the unique challenges of diagnosing and treating ovarian cancer in children and adolescents. The research emphasized the importance of a multidisciplinary approach to care, including imaging, tumor markers, surgical management, and adjuvant chemotherapy. The study highlighted the good prognosis associated with early diagnosis and treatment, with survival rates exceeding 90% in many cases. The researchers concluded that optimal care for this patient population should balance oncological control with the preservation of future fertility and quality of life. [Extracted from the article]

Researchers at the Jozef Stefan Institute in Ljubljana, Slovenia, have conducted a study on deoxyfluorination, a process that involves converting hydroxyl groups into fluorides to create carbon-fluorine bonds in biologically active molecules. This research, supported by the Slovenian Research and Innovation Agency, focuses on summarizing and categorizing deoxyfluorination reaction protocols developed between 2015 and 2024. The study highlights the importance of fluorine organic compounds in pharmaceutical chemistry and their increasing presence in the market. For more information, readers can refer to the article "Deoxyfluorination: a Detailed Overview of Recent Developments" published in Synthesis. [Extracted from the article]

A scoping review conducted by the University of Ljubljana in Slovenia explored the role of assistive digital technologies in enhancing the quality of life and promoting independent living for older adults. The review identified 19 relevant articles published between 2012 and 2022, highlighting the importance of older adults' trust in technology and the benefits of technological support. The research emphasized the need for early involvement of older adults in the development of assistive technologies to enhance their technological self-efficacy. The study concluded by discussing the limitations of the reviewed studies and suggesting guidelines for future research in this area. [Extracted from the article]

A recent study conducted by the University of Ljubljana in Slovenia focused on assessing basic psychological need fulfillment through self-report scales. The research aimed to identify and analyze existing scales used to measure psychological needs, with a focus on Self-Determination Theory as the predominant theoretical basis. Despite efforts to develop and validate these scales, the study highlighted issues related to diverse perspectives on psychological needs and inconsistencies in measurement approaches. This research provides valuable insights for researchers interested in studying psychological need fulfillment. [Extracted from the article]

A recent report from the University of Ljubljana in Slovenia discusses the history and mechanisms of action of lactulose therapy, a synthetic disaccharide used in functional foods like confectionery and beverages. Lactulose acts as a selective modulator of bacterial growth in the colon, generating organic acids that lower pH and act as an osmotic laxative. With over 60 years of safe use, lactulose is considered an ideal ingredient for prebiotic functional foods, offering technological properties that allow for the development of candy and beverages similar to those made with sucrose. The research has been peer-reviewed and provides valuable insights into the potential applications of lactulose in food products. [Extracted from the article]

A recent report from University Children's Hospitals in Ljubljana, Slovenia, discusses the impact of Antiphospholipid Syndrome (APS) in children, highlighting its severity and potential complications. The research emphasizes the need for new classification criteria and emerging therapies, such as B cell and complement inhibitors, to address the challenges posed by pediatric APS. Additionally, the study explores the rare occurrence of APS in infants due to maternal transmission, which can lead to long-term neurodevelopmental issues rather than acute thrombotic events. [Extracted from the article]

A recent study conducted at the Jozef Stefan Institute in Ljubljana, Slovenia, explored the feasibility of remotely estimating blood pressure using a narrow-band multi-wavelength pulse transit time method. The research utilized a modified RGB camera and a triple band-pass filter to measure pulse transit time between different skin layers, showing promising results in estimating systolic and diastolic blood pressure. The study was supported by various institutions and has been peer-reviewed, offering potential advancements in remote health monitoring technology. For more information, readers can access the full article in the ACM Transactions on Sensor Networks. [Extracted from the article]

A recent study conducted by investigators at the University of Ljubljana in Slovenia explored the use of Sodium-glucose Co-transporter-2 (SGLT2) inhibitors as an adjunct therapy to insulin in individuals with Type 1 Diabetes (T1D). The research aimed to assess the efficacy and safety of SGLT2 inhibitors in adults and youth with T1D through a scoping review of relevant clinical trials. While the study confirmed the potential benefits of SGLT2 inhibitors in improving glycemic outcomes, it also highlighted an increased risk of Diabetic Ketoacidosis (DKA) associated with their use. The researchers concluded that the role of SGLT2 inhibitors as an adjunct therapy to insulin in individuals with T1D is still under investigation. [Extracted from the article]

A recent study conducted by researchers at the University of Ljubljana in Slovenia explored the effects of organometallic ruthenium complexes on nicotinic acetylcholine receptors (nAChRs). These receptors are found in both excitable and non-excitable cells in the body and have potential therapeutic applications for neurological and psychiatric disorders. The study found that three organometallic ruthenium complexes did not have agonistic activity on the nAChR subtypes studied, but one of the compounds, C1-Cl, showed potential as a myorelaxant drug. Further research is needed to fully understand the effects of these compounds on nAChRs. [Extracted from the article]