8 results on '"Zeidler, Claudia"'
Search Results
2. Perceived Stigmatization among Dermatological Outpatients Compared with Controls: An Observational Multicentre Study in 17 European Countries.
- Author
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Van Beugen S, Schut C, Kupfer J, Bewley AP, Finlay AY, Gieler U, Thompson AR, Gracia-Cazaña T, Balieva F, Ferreira BR, Jemec GB, Lien L, Misery L, Marron SE, Ständer S, Zeidler C, Szabó C, Szepietowski JC, Reich A, Elyas A, Altunay IK, Legat FJ, Grivcheva-Panovska V, Romanov DV, Lvov AN, Titeca G, Sampogna F, Vulink NC, Tomás-Aragones L, Evers AWM, and Dalgard FJ
- Subjects
- Humans, Male, Stereotyping, Outpatients, Quality of Life psychology, Surveys and Questionnaires, Skin Diseases diagnosis, Skin Diseases psychology, Psoriasis diagnosis, Psoriasis psychology
- Abstract
Perceived stigmatization places a large psychosocial burden on patients with some skin conditions. Little is known about the experience of stigmatization across a wide range of skin diseases. This observational cross-sectional study aimed to quantify perceived stigmatization and identify its predictors among patients with a broad spectrum of skin diseases across 17 European countries. Self-report questionnaires assessing perceived stigmatization and its potential predictors were completed by 5,487 dermatology outpatients and 2,808 skin-healthy controls. Dermatological diagnosis, severity, and comorbidity were clinician-assessed. Patients experienced higher levels of perceived stigmatization than controls (p < 0.001, d = 0.26); patients with psoriasis, atopic dermatitis, alopecia, and bullous disorders were particularly affected. Multivariate regression analyses showed that perceived stigmatization was related to sociodemographic (lower age, male sex, being single), general health-related (higher body mass index, lower overall health), disease-related (higher clinician-assessed disease severity, presence of itch, longer disease duration), and psychological (greater distress, presence of suicidal ideation, greater body dysmorphic concerns, lower appearance satisfaction) variables. To conclude, perceived stigmatization is common in patients with skin diseases. Factors have been identified that will help clinicians and policymakers to target vulnerable patient groups, offer adequate patient management, and to ultimately develop evidence-based interventions.
- Published
- 2023
- Full Text
- View/download PDF
3. Woad extract containing cream improves significantly dry, irritated, and pruritic skin.
- Author
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Forner C, Zeidler C, Stein P, Stössel E, Wefelmeier L, Peukert N, Isermann D, and Ständer S
- Subjects
- Female, Humans, Male, Middle Aged, Plant Extracts adverse effects, Prospective Studies, Pruritus pathology, Quality of Life, Skin Cream, Skin Diseases pathology, Treatment Outcome, Isatis chemistry, Plant Extracts administration & dosage, Pruritus drug therapy, Skin Diseases drug therapy
- Abstract
Objective of this open, noninterventional, noncontrolled study was to investigate the tolerability and performance of a woad extract containing cream in subjects with dry, pruritic skin after twice daily application over 2 weeks. Assessments included sensorial characteristics, skin condition, pruritus (numeric rating scale [NRS], dynamic pruritus score [DPS]), skin dryness (itch-controlled days [ItchCD], overall dry skin [ODS]), transepidermal water loss (TEWL), skin hydration and quality of life (5PLQ, DLQI). All sensorial characteristics were well perceived (>4), with tolerability (4.77 ± 0.47) and no negative skin feelings (4.73 ± 0.74) achieving the highest scores (0-5 scale). Dry skin and symptoms improved significantly (p < .001) for all variables: NRS (from 4.8 ± 1.74 to 1.83 ± 2.18), ItchCD (from 8.23 ± 4.40 to 4.81 ± 4.07), ODS (from 1.80 ± 0.85 to 0.65 ± 0.65), hydration (23.33 ± 1.33 to 40.70 ± 1.86), and quality of life (5PLQ: from 7.12 ± 4.25 to 4.24 ± 3.67; DLQI: from 5.29 ± 4.79 to 3.00 ± 3.98). The DPS revealed a moderate antipruritic effect. The TEWL decreased slightly (p = .511). No side effects were reported. The study suggests that, the cream is effective, and well tolerated in treating dry, irritated, and pruritic skin., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
- Full Text
- View/download PDF
4. Pruritus in Autoimmune and Inflammatory Dermatoses
- Author
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Zeidler, Claudia, Pereira, Manuel Pedro, Huet, Flavien, Misery, Laurent, Steinbrink, Kerstin, Ständer, Sonja, and Universitäts- und Landesbibliothek Münster
- Subjects
bullous pemphigoid ,atopic dermatitis ,integumentary system ,Mini Review ,substance P ,Pruritus ,Immunology ,Dermatitis ,psoriasis ,Skin Diseases ,Autoimmune Diseases ,body regions ,Medicine and health ,Humans ,itch ,ddc:610 ,skin and connective tissue diseases ,pruritus ,IL31 - Abstract
Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. In some diseases, pruritus is related to disorders activity and severity or may occur independent of the disease. Despite the high prevalence, the symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. In this review, the characteristics and possible pathomechanisms of pruritus in various dermatoses like autoimmune bullous diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, psoriasis vulgaris) is illustrated. Additionally, studies analyzing the antipruritic treatment are discussed. Summarizing, the prevalence of pruritus in these diseases demonstrates the importance for symptom recognition and the need for an efficient antipruritic therapy.
- Published
- 2020
5. The Neuromodulatory Effect of Antipruritic Treatment of Chronic Prurigo.
- Author
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Zeidler, Claudia, Pereira, Manuel, and Ständer, Sonja
- Subjects
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TREATMENT effectiveness , *RECEPTOR antibodies , *REGULATORY approval , *GOVERNMENT agencies , *SKIN diseases - Abstract
Chronic prurigo is an extremely severe pruritic skin disease which presents with multiple, hyperkeratotic and erosive papules, nodules and/or plaques. Patients with this high-burden disease require effective therapies, but effective treatments with regulatory agency approval are currently lacking. Deeper understanding of the pathophysiology suggests that hypersensitive nerves play an important role in the development of chronic prurigo. Accordingly, a treatment with neuroactive substances which modulate hypersensitivity seems promising. Here, we review antipruritic therapies with a neuromodulative effect. Current treatment options, such as topical capsaicin or opioid-receptor modulators, and also novel and future treatment regimens, such as, for example, interleukin-31 antibodies and neurokinin-1 receptor antagonists, are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. Pruritus in Autoimmune and Inflammatory Dermatoses.
- Author
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Zeidler, Claudia, Pereira, Manuel Pedro, Huet, Flavien, Misery, Laurent, Steinbrink, Kerstin, and Ständer, Sonja
- Subjects
ITCHING ,SKIN diseases ,CONNECTIVE tissue diseases ,ATOPIC dermatitis ,DRUG efficacy ,BULLOUS pemphigoid - Abstract
Pruritus in autoimmune and inflammatory dermatoses is a common symptom that can be severe and affect the quality of life of patients. In some diseases, pruritus is related to disorders activity and severity or may occur independent of the disease. Despite the high prevalence, the symptom is still underrated and there are only a few trials investigating the efficacy of drugs for disease-specific pruritus. In this review, the characteristics and possible pathomechanisms of pruritus in various dermatoses like autoimmune bullous diseases, connective tissue diseases as well as autoimmune-associated dermatoses (atopic dermatitis, psoriasis vulgaris) is illustrated. Additionally, studies analyzing the antipruritic treatment are discussed. Summarizing, the prevalence of pruritus in these diseases demonstrates the importance for symptom recognition and the need for an efficient antipruritic therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
7. Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies.
- Author
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PEREIRA, Manuel P., LÜLING, Hannah, DIECKHÖFER, Annette, STEINKE, Sabine, ZEIDLER, Claudia, and STÄNDER, Sonja
- Subjects
ITCHING ,BACK diseases ,ARM diseases ,SKIN diseases ,QUALITY of life ,CAPSAICIN ,NEUROPATHY ,PAIN management - Abstract
Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. In the BRP group structural magnetic resonance imaging abnormalities more frequently correlated with localization of the symptoms compared with in patients with NP. In addition, intraepidermal nerve fibre density was decreased in lesional skin in patients with BRP, but not in those with NP, confirming the neuropathic origin in BRP. Topical capsaicin resulted in a significantly higher alleviation of itch and pain intensity and improvement in quality of life in patients with BRP compared with those with NP, which may reflect clinical and aetiological differences between the conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
8. Intraepidermal Nerve Fibre Density is Decreased in Lesional and Inter-lesional Prurigo Nodularis and Reconstitutes on Healing of Lesions.
- Author
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Bobko, Svetlana, Zeidler, Claudia, Osada, Nani, Riepe, Claudia, Pfleiderer, Bettina, Pogatzki-Zahn, Esther, Lvov, Andrey, and Ständer, Sonja
- Subjects
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NERVE fibers , *PRURIGO , *TISSUE wounds , *SKIN biopsy , *SKIN diseases , *DIAGNOSIS - Abstract
The article discusses research concerning the major role of nerve fibres in prurigo nodularis (PN). It examines the intraepidermal nerve fibre density (IENFD) of PN at various stages which is reduced in lesional and inter-lesional prurigo nodularis. Also investigated is the skin biopsies from representative lesional and non-lesional areas and healed skin in patients with PN.
- Published
- 2016
- Full Text
- View/download PDF
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