1. COMPARISON OF SINGLE DRUSEN SIZE ON COLOR FUNDUS PHOTOGRAPHY AND SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY
- Author
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Jessica Loo, Glenn J. Jaffe, Dong Yoon Kim, and Sina Farsiu
- Subjects
genetic structures ,Fundus Oculi ,Retinal Drusen ,Spectral domain ,Drusen ,Fundus (eye) ,complex mixtures ,Retina ,Optical coherence tomography ,Photography ,Humans ,Medicine ,Fluorescein Angiography ,Color fundus photography ,medicine.diagnostic_test ,business.industry ,General Medicine ,bacterial infections and mycoses ,medicine.disease ,eye diseases ,Scanning laser ophthalmoscopy ,Ophthalmoscopy ,Ophthalmology ,sense organs ,business ,Imaging processing ,Algorithms ,Tomography, Optical Coherence ,Grading scale ,Biomedical engineering - Abstract
PURPOSE To determine the relationship of drusen size as determined by spectral-domain optical coherence tomography (SD-OCT) with that measured on registered color fundus photography (CFP) images and to derive an OCT-based classification system that was comparable with that determined by CFP. METHODS Custom software was developed to register CFP images to the scanning laser ophthalmoscopy fundus images obtained simultaneously with the corresponding SD-OCT images, so that individual drusen observed on CFP could be matched with those seen on SD-OCT. Single druse size (diameter, area, volume, and height) on CFP and SD-OCT images from a phase two clinical trial was determined with the Duke OCT Retinal Analysis Program. RESULTS The sizes of 213 individual drusen were measured on CFP and SD-OCT. The drusen diameter measured on CFP was significantly correlated with those determined on SD-OCT (R: 0.879, P < 0.001). Based on the corresponding formula: drusen diameter on SD-OCT = 0.77 × (drusen diameter on CFP) + 50.67 µm, large drusen defined as ≥125 µm on CFP had a diameter ≥145 µm on OCT, medium drusen defined as 63 µm to 124 µm on CFP had diameters 100 µm to 144 µm on OCT, and small drusen defined as
- Published
- 2021