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Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure–function correlations
- Source :
- Br J Ophthalmol
- Publication Year :
- 2020
- Publisher :
- BMJ, 2020.
-
Abstract
- Background/aimsTo quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss.MethodsOptical coherence tomography (OCT) macula volume scans from sham eyes included in a prospective, phase II clinical trial of human ciliary neutrophic factor for MacTel at baseline, 1 year and 2 years of follow-up were analysed. Cavitations were segmented by two independent readers. Total cavitation volume was compared with area of ellipsoid zone loss and best-corrected visual acuity (BCVA).ResultsFifty-one eyes from 51 unique patients (mean age 62 years, range 45–79 years) were included. Intraclass correlation between readers for cavitation volume was excellent (>0.99). Average cavitation volume was 0.0109 mm3, 0.0113 mm3and 0.0124 mm3at baseline, 1 year and 2 years, respectively. The average rate of cavitation volume change was +0.0039 mm3/year. 10 eyes (20%) had a significant change in cavitation volume during the study (3 decreased, 7 increased). Eyes with increased cavitation volume had worse BCVA compared with eyes with no change/decreased cavitation volume (71.5 vs 76.1 ETDRS letters, respectively). Cavitation volume was negatively correlated to BCVA (r=−0.37) but not to area of ellipsoid zone loss. Cavitation volume was negatively predictive of BCVA in both univariate and multivariate mixed-effects modelling with ellipsoid zone loss.ConclusionsRetinal cavitations and their rate of change in MacTel can be reliably quantified using OCT. Cavitations are negatively correlated with visual acuity and may be a useful OCT-based biomarker for disease progression and visual function in MacTel.
- Subjects :
- Male
medicine.medical_specialty
Visual acuity
genetic structures
Intraclass correlation
Visual Acuity
Retina
Article
Cellular and Molecular Neuroscience
chemistry.chemical_compound
Optical coherence tomography
Ophthalmology
Humans
Medicine
Prospective Studies
Aged
Macular telangiectasia
medicine.diagnostic_test
business.industry
Structure function
Disease progression
Retinal
Middle Aged
medicine.disease
eye diseases
Sensory Systems
medicine.anatomical_structure
chemistry
Retinal Telangiectasis
Female
sense organs
medicine.symptom
business
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 14682079 and 00071161
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....1fd955c5242c100dec5e6217f0373a93